The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

Xiaolin He - One of the best experts on this subject based on the ideXlab platform.

  • Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
    Nature Structural and Molecular Biology, 2008
    Co-Authors: Xiaoyan Chen, Ann H.r. Shim, Pamela J. Focia, Heli Liu, Xiaolin He
    Abstract:

    The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented Interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta Interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.

  • Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
    Nature Structural & Molecular Biology, 2008
    Co-Authors: Xiaoyan Chen, Ann H.r. Shim, Pamela J. Focia, Xiaolin He
    Abstract:

    The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca^2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 Å between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1β (NX1β) LNS (laminin, neurexin and sex hormone–binding globulin–like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca^2+-mediated and solvent-supplemented Interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1β Interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.

B. Matichuk - One of the best experts on this subject based on the ideXlab platform.

  • WCRE - Reverse engineering legacy Interfaces: an interaction-driven approach
    Sixth Working Conference on Reverse Engineering (Cat. No.PR00303), 1999
    Co-Authors: E. Stroulia, M. El-ramly, L. Kong, Paul G. Sorenson, B. Matichuk
    Abstract:

    Legacy systems constitute valuable assets to the organizations that own them. However, due to the development of newer and faster hardware platforms and the invention of novel Interface styles, there is a great demand for their migration to new platforms. We present a method for reverse engineering the system Interface that consists of two tasks. Based on traces of the users interaction with the system, the "Interface Mapping" task constructs a "map" of the system Interface, in terms of the individual system screens and the transitions between them. The subsequent "task and domain modeling" task uses the Interface map and task-specific traces to construct an abstract model of a user's task as an information exchange plan. The task model specifies the screen transition diagram that the user has to traverse in order to accomplish the task in question, and the flow of information that the user exchanges with the system at each screen. This task model is later used as the basis for specifying a new graphical user Interface tailored to the task in question.

  • Reverse engineering legacy Interfaces: an interaction-driven approach
    Sixth Working Conference on Reverse Engineering (Cat. No.PR00303), 1999
    Co-Authors: E. Stroulia, M. El-ramly, L. Kong, P. Sorenson, B. Matichuk
    Abstract:

    Legacy systems constitute valuable assets to the organizations that own them. However, due to the development of newer and faster hardware platforms and the invention of novel Interface styles, there is a great demand for their migration to new platforms. We present a method for reverse engineering the system Interface that consists of two tasks. Based on traces of the users interaction with the system, the "Interface Mapping" task constructs a "map" of the system Interface, in terms of the individual system screens and the transitions between them. The subsequent "task and domain modeling" task uses the Interface map and task-specific traces to construct an abstract model of a user's task as an information exchange plan. The task model specifies the screen transition diagram that the user has to traverse in order to accomplish the task in question, and the flow of information that the user exchanges with the system at each screen. This task model is later used as the basis for specifying a new graphical user Interface tailored to the task in question.

Xiaoyan Chen - One of the best experts on this subject based on the ideXlab platform.

  • Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
    Nature Structural and Molecular Biology, 2008
    Co-Authors: Xiaoyan Chen, Ann H.r. Shim, Pamela J. Focia, Heli Liu, Xiaolin He
    Abstract:

    The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented Interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta Interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.

  • Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
    Nature Structural & Molecular Biology, 2008
    Co-Authors: Xiaoyan Chen, Ann H.r. Shim, Pamela J. Focia, Xiaolin He
    Abstract:

    The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca^2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 Å between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1β (NX1β) LNS (laminin, neurexin and sex hormone–binding globulin–like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca^2+-mediated and solvent-supplemented Interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1β Interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.

T. Kimura - One of the best experts on this subject based on the ideXlab platform.

  • Web Intelligence - Proposal and Verification of Flexible Interface Mapping Technique for Automatic System Cooperation Based on Semantics
    The 2005 IEEE WIC ACM International Conference on Web Intelligence (WI'05), 2005
    Co-Authors: M. Nakatsuji, Y. Miyoshi, T. Kimura
    Abstract:

    These days, many companies are executing their business aims based on decentralized cooperation of software components which work on various systems over a network. However, messages and processes between systems are designed individually in each operations division. Therefore, the system development for adjusting Interfaces is expensive, so the companies cannot introduce their services in a dynamic business environment. To resolve such problems, we propose Interface modeling technique and message Mapping technique which model the relationship between the message formats and semantics on the formats by using Web Ontology Language (OWL) and execute the Mapping between the message formats by using semantics. We developed the user interactive message Mapping tool and evaluated our proposed methods based on the Interface specifications of real network management systems.

  • Proposal and verification of flexible Interface Mapping technique for automatic system cooperation based on semantics
    The 2005 IEEE WIC ACM International Conference on Web Intelligence (WI'05), 2005
    Co-Authors: M. Nakatsuji, Y. Miyoshi, T. Kimura
    Abstract:

    These days, many companies are executing their business aims based on decentralized cooperation of software components which work on various systems over a network. However, messages and processes between systems are designed individually in each operations division. Therefore, the system development for adjusting Interfaces is expensive, so the companies cannot introduce their services in a dynamic business environment. To resolve such problems, we propose Interface modeling technique and message Mapping technique which model the relationship between the message formats and semantics on the formats by using Web Ontology Language (OWL) and execute the Mapping between the message formats by using semantics. We developed the user interactive message Mapping tool and evaluated our proposed methods based on the Interface specifications of real network management systems.

E. Stroulia - One of the best experts on this subject based on the ideXlab platform.

  • WCRE - Reverse engineering legacy Interfaces: an interaction-driven approach
    Sixth Working Conference on Reverse Engineering (Cat. No.PR00303), 1999
    Co-Authors: E. Stroulia, M. El-ramly, L. Kong, Paul G. Sorenson, B. Matichuk
    Abstract:

    Legacy systems constitute valuable assets to the organizations that own them. However, due to the development of newer and faster hardware platforms and the invention of novel Interface styles, there is a great demand for their migration to new platforms. We present a method for reverse engineering the system Interface that consists of two tasks. Based on traces of the users interaction with the system, the "Interface Mapping" task constructs a "map" of the system Interface, in terms of the individual system screens and the transitions between them. The subsequent "task and domain modeling" task uses the Interface map and task-specific traces to construct an abstract model of a user's task as an information exchange plan. The task model specifies the screen transition diagram that the user has to traverse in order to accomplish the task in question, and the flow of information that the user exchanges with the system at each screen. This task model is later used as the basis for specifying a new graphical user Interface tailored to the task in question.

  • Reverse engineering legacy Interfaces: an interaction-driven approach
    Sixth Working Conference on Reverse Engineering (Cat. No.PR00303), 1999
    Co-Authors: E. Stroulia, M. El-ramly, L. Kong, P. Sorenson, B. Matichuk
    Abstract:

    Legacy systems constitute valuable assets to the organizations that own them. However, due to the development of newer and faster hardware platforms and the invention of novel Interface styles, there is a great demand for their migration to new platforms. We present a method for reverse engineering the system Interface that consists of two tasks. Based on traces of the users interaction with the system, the "Interface Mapping" task constructs a "map" of the system Interface, in terms of the individual system screens and the transitions between them. The subsequent "task and domain modeling" task uses the Interface map and task-specific traces to construct an abstract model of a user's task as an information exchange plan. The task model specifies the screen transition diagram that the user has to traverse in order to accomplish the task in question, and the flow of information that the user exchanges with the system at each screen. This task model is later used as the basis for specifying a new graphical user Interface tailored to the task in question.