The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform

Wei Yong Lin - One of the best experts on this subject based on the ideXlab platform.

  • Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    International journal of antimicrobial agents, 2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2',5'-oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC(50)) of aloe-emodin ranged from 0.50microg/mL to 1.51microg/mL for JEV and from 0.14microg/mL to 0.52microg/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.

  • Short communication Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2 � ,5 � -oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC50) of aloe-emodin ranged from 0.50g/mL to 1.51g/mL for JEV and from 0.14g/mL to 0.52g/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.

Shabbir Moochhala - One of the best experts on this subject based on the ideXlab platform.

  • The effects of an Interferon inducer, polyriboinosinic polyribocytidylic acid on cytochrome P-450 dependent hepatic progesterone metabolism.
    Life sciences, 1993
    Co-Authors: J.y.y. Wong, Edmund J.d. Lee, Shabbir Moochhala
    Abstract:

    A time course study on the effects of an Interferon Inducing Agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect on liver weight, microsomal protein and total cytochrome P-450 levels, as well as the 16 alpha and 6 beta hydroxylation of progesterone. The response was multiphasic, with a maximal depression of both hydroxylase activity 48 hours post-injection, followed by enhanced activity at 72 hours and subsequent return to control activity twenty-four hours later. A second less dramatic rise in the activities followed, bringing the 16 alpha and 6 beta hydroxylase activity to 159% and 141% of their respective control values by 336 hours, at which point of time, the trend appeared to be still on the rise. The enhanced activity at 72 hours was preceded by an increase in serum cortisol and corticosterone levels, the ability of which to enhance the activity of 6 beta hydroxylation of steroids may partly explain the phenomenon.

Cheng Wen Lin - One of the best experts on this subject based on the ideXlab platform.

  • Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    International journal of antimicrobial agents, 2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2',5'-oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC(50)) of aloe-emodin ranged from 0.50microg/mL to 1.51microg/mL for JEV and from 0.14microg/mL to 0.52microg/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.

  • Short communication Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2 � ,5 � -oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC50) of aloe-emodin ranged from 0.50g/mL to 1.51g/mL for JEV and from 0.14g/mL to 0.52g/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.

J.y.y. Wong - One of the best experts on this subject based on the ideXlab platform.

  • The effects of an Interferon inducer, polyriboinosinic polyribocytidylic acid on cytochrome P-450 dependent hepatic progesterone metabolism.
    Life sciences, 1993
    Co-Authors: J.y.y. Wong, Edmund J.d. Lee, Shabbir Moochhala
    Abstract:

    A time course study on the effects of an Interferon Inducing Agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect on liver weight, microsomal protein and total cytochrome P-450 levels, as well as the 16 alpha and 6 beta hydroxylation of progesterone. The response was multiphasic, with a maximal depression of both hydroxylase activity 48 hours post-injection, followed by enhanced activity at 72 hours and subsequent return to control activity twenty-four hours later. A second less dramatic rise in the activities followed, bringing the 16 alpha and 6 beta hydroxylase activity to 159% and 141% of their respective control values by 336 hours, at which point of time, the trend appeared to be still on the rise. The enhanced activity at 72 hours was preceded by an increase in serum cortisol and corticosterone levels, the ability of which to enhance the activity of 6 beta hydroxylation of steroids may partly explain the phenomenon.

Lei Wan - One of the best experts on this subject based on the ideXlab platform.

  • Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    International journal of antimicrobial agents, 2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2',5'-oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC(50)) of aloe-emodin ranged from 0.50microg/mL to 1.51microg/mL for JEV and from 0.14microg/mL to 0.52microg/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.

  • Short communication Aloe-emodin is an Interferon-Inducing Agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
    2008
    Co-Authors: Cheng Wen Lin, Lei Wan, Ying Ju Lin, Hsiao Nai-wan, Ching Yao Chang, Wei Yong Lin
    Abstract:

    In this study, aloe-emodin was identified as a potential Interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated Interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2 � ,5 � -oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC50) of aloe-emodin ranged from 0.50g/mL to 1.51g/mL for JEV and from 0.14g/mL to 0.52g/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.