The Experts below are selected from a list of 548271 Experts worldwide ranked by ideXlab platform
Shizuo Akira - One of the best experts on this subject based on the ideXlab platform.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
Ken Takahashi - One of the best experts on this subject based on the ideXlab platform.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
Taro Kawai - One of the best experts on this subject based on the ideXlab platform.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
Hiroki Kato - One of the best experts on this subject based on the ideXlab platform.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
Himanshu Kumar - One of the best experts on this subject based on the ideXlab platform.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-β promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-κB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
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ips 1 an adaptor triggering rig i and mda5 mediated type i Interferon induction
Nature Immunology, 2005Co-Authors: Taro Kawai, Hiroki Kato, Ken J Ishii, Cevayir Coban, Himanshu Kumar, Osamu Takeuchi, Shintaro Sato, Ken Takahashi, Shizuo AkiraAbstract:Type I Interferons are central mediators for antiviral responses. Using high-throughput functional screening of Interferon inducers, we have identified here a molecule we call Interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I Interferon and Interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated Interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked Interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
