The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Gerry H Taylor - One of the best experts on this subject based on the ideXlab platform.
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long term benefits of an early online problem solving intervention for executive dysfunction after traumatic brain injury in children a randomized clinical trial
JAMA Pediatrics, 2014Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:Importance Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant short- and long-term problems in functioning across multiple settings. We hypothesized that improvements in short-term executive function would be maintained to 24 months after injury and that improvements would increase over time in a counselor-assisted problem-solving (CAPS) intervention. Objective To evaluate the efficacy of a CAPS intervention administered within 7 months of complicated mild to severe TBI compared with an Internet Resource condition in improving long-term executive dysfunction. Design, Setting, and Participants Multisite, assessor-blinded, randomized clinical trial at 3 tertiary pediatric hospitals and 2 tertiary general medical centers. Participants included 132 adolescents aged 12 to 17 years who sustained a moderate to severe TBI 1 to 7 months before study enrollment. Intervention Web-based CAPS intervention. Main Outcomes and Measures The primary outcome was the parent-reported Global Executive Composite (GEC) of the Behavior Rating Inventory of Executive Function. Secondary outcomes included the Behavioral Regulation Index (BRI) and Metacognition Index (MI) of the GEC. Results In older (>14 to 17 years) adolescents, the CAPS intervention was associated with lower GEC ratings at 12 (β = −0.46; P = .03) and 18 (β = −0.52; P = .02) months after enrollment. Trends were also observed for older adolescents toward lower GEC ratings at 6 months (β = −0.40; P = .05), lower BRI ratings at 12 (β = −0.40; P = .06) and 18 (β = −0.47; P = .04) months, and lower MI ratings at 6 (β = −0.41; P = .05), 12 (β = −0.46; P = .03), and 18 (β = −0.50; P = .03) months. In younger (12-14 years) adolescents, no group differences were found on the GEC, BRI, or MI ratings. Conclusions and Relevance Delivery of the CAPS intervention early after TBI in older adolescents improves long-term executive function. This trial is, to our knowledge, one of the few large, randomized clinical treatment trials performed in pediatric TBI to demonstrate the efficacy of an intervention for management of executive dysfunction and long-term benefits of an intervention delivered soon after injury. Use of the CAPS intervention clinically should be considered; however, further research should explore ways to optimize delivery. Trial Registration clinicaltrials.gov Identifier:NCT00409448
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online problem solving therapy for executive dysfunction after child traumatic brain injury
Pediatrics, 2013Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:OBJECTIVE: Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant problems in functioning across multiple settings. The objective of this study was to evaluate the efficacy of a web-based counselor-assisted problem solving (CAPS) intervention compared with an Internet Resource comparison (IRC) for treatment of executive dysfunction within 12 months after complicated mild to severe TBI in adolescents. We hypothesized that CAPS would significantly improve parent ratings of executive dysfunction compared with an IRC. METHODS: Participants included 132 adolescents aged 12 to 17 years who sustained a complicated mild to severe TBI within 1 to 6 months before study enrollment. Study design was a multisite, assessor-blinded, randomized controlled trial. Study sites included 3 tertiary pediatric hospitals and 2 tertiary general medical centers. The main outcome measure was primary caregiver Behavioral Rating Inventory of Executive Function Global Executive Composite at baseline and 6-month follow-up. Generalized linear models that controlled for baseline scores were used to compare the CAPS and IRC scores. RESULTS: In older teens, the CAPS group showed significant improvement in executive function behaviors at 6-month follow-up compared with the IRC group ( F = 6.74, P = .01, Cohen’s d = 0.63). CONCLUSIONS: Findings indicate that web-based CAPS improves primary caregiver-rated executive functioning within the first 12 months after TBI in older adolescents. Future research needs to define the optimal timing after injury for delivery of CAPS and characteristics of individuals and families who are most likely to benefit from CAPS. * Abbreviations: BRI — : Behavioral Regulation Index BRIEF — : Behavior Rating Inventory of Executive Function CAPS — : counselor-assisted problem solving CT — : computerized tomography GCS — : Glasgow Coma Scale GEC — : Global Executive Composite IRC — : Internet Resource Comparison MI — : Metacognition Index TBI — : traumatic brain injury
Brad G Kurowski - One of the best experts on this subject based on the ideXlab platform.
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long term benefits of an early online problem solving intervention for executive dysfunction after traumatic brain injury in children a randomized clinical trial
JAMA Pediatrics, 2014Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:Importance Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant short- and long-term problems in functioning across multiple settings. We hypothesized that improvements in short-term executive function would be maintained to 24 months after injury and that improvements would increase over time in a counselor-assisted problem-solving (CAPS) intervention. Objective To evaluate the efficacy of a CAPS intervention administered within 7 months of complicated mild to severe TBI compared with an Internet Resource condition in improving long-term executive dysfunction. Design, Setting, and Participants Multisite, assessor-blinded, randomized clinical trial at 3 tertiary pediatric hospitals and 2 tertiary general medical centers. Participants included 132 adolescents aged 12 to 17 years who sustained a moderate to severe TBI 1 to 7 months before study enrollment. Intervention Web-based CAPS intervention. Main Outcomes and Measures The primary outcome was the parent-reported Global Executive Composite (GEC) of the Behavior Rating Inventory of Executive Function. Secondary outcomes included the Behavioral Regulation Index (BRI) and Metacognition Index (MI) of the GEC. Results In older (>14 to 17 years) adolescents, the CAPS intervention was associated with lower GEC ratings at 12 (β = −0.46; P = .03) and 18 (β = −0.52; P = .02) months after enrollment. Trends were also observed for older adolescents toward lower GEC ratings at 6 months (β = −0.40; P = .05), lower BRI ratings at 12 (β = −0.40; P = .06) and 18 (β = −0.47; P = .04) months, and lower MI ratings at 6 (β = −0.41; P = .05), 12 (β = −0.46; P = .03), and 18 (β = −0.50; P = .03) months. In younger (12-14 years) adolescents, no group differences were found on the GEC, BRI, or MI ratings. Conclusions and Relevance Delivery of the CAPS intervention early after TBI in older adolescents improves long-term executive function. This trial is, to our knowledge, one of the few large, randomized clinical treatment trials performed in pediatric TBI to demonstrate the efficacy of an intervention for management of executive dysfunction and long-term benefits of an intervention delivered soon after injury. Use of the CAPS intervention clinically should be considered; however, further research should explore ways to optimize delivery. Trial Registration clinicaltrials.gov Identifier:NCT00409448
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online problem solving therapy for executive dysfunction after child traumatic brain injury
Pediatrics, 2013Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:OBJECTIVE: Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant problems in functioning across multiple settings. The objective of this study was to evaluate the efficacy of a web-based counselor-assisted problem solving (CAPS) intervention compared with an Internet Resource comparison (IRC) for treatment of executive dysfunction within 12 months after complicated mild to severe TBI in adolescents. We hypothesized that CAPS would significantly improve parent ratings of executive dysfunction compared with an IRC. METHODS: Participants included 132 adolescents aged 12 to 17 years who sustained a complicated mild to severe TBI within 1 to 6 months before study enrollment. Study design was a multisite, assessor-blinded, randomized controlled trial. Study sites included 3 tertiary pediatric hospitals and 2 tertiary general medical centers. The main outcome measure was primary caregiver Behavioral Rating Inventory of Executive Function Global Executive Composite at baseline and 6-month follow-up. Generalized linear models that controlled for baseline scores were used to compare the CAPS and IRC scores. RESULTS: In older teens, the CAPS group showed significant improvement in executive function behaviors at 6-month follow-up compared with the IRC group ( F = 6.74, P = .01, Cohen’s d = 0.63). CONCLUSIONS: Findings indicate that web-based CAPS improves primary caregiver-rated executive functioning within the first 12 months after TBI in older adolescents. Future research needs to define the optimal timing after injury for delivery of CAPS and characteristics of individuals and families who are most likely to benefit from CAPS. * Abbreviations: BRI — : Behavioral Regulation Index BRIEF — : Behavior Rating Inventory of Executive Function CAPS — : counselor-assisted problem solving CT — : computerized tomography GCS — : Glasgow Coma Scale GEC — : Global Executive Composite IRC — : Internet Resource Comparison MI — : Metacognition Index TBI — : traumatic brain injury
Peter Schuck - One of the best experts on this subject based on the ideXlab platform.
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characterizing protein protein interactions by sedimentation velocity analytical ultracentrifugation
Current protocols in immunology, 2008Co-Authors: P Brown, Andrea Balbo, Peter SchuckAbstract:This unit introduces the basic principles and practice of sedimentation velocity analytical ultracentrifugation for the study of reversible protein interactions, such as the characterization of self-association, heterogeneous association, multi-protein complexes, binding stoichiometry, and the determination of association constants. The analytical tools described include sedimentation coefficient and molar mass distributions, multi-signal sedimentation coefficient distributions, Gilbert-Jenkins theory, different forms of isotherms, and global Lamm equation modeling. Concepts for the experimental design are discussed, and a detailed step-by-step protocol guiding the reader through the experiment and the data analysis is available as an Internet Resource. Curr. Protoc. Immunol. 81:18.15.1-18.15.39. © 2008 by John Wiley & Sons, Inc. Keywords: sedimentation equilibrium; sedimentation velocity; chemical equilibria; reversible interactions; multi-protein complex; analytical ultracentrifugation; size-distribution; Gilbert-Jenkins theory; Lamm equation; Bayesian analysis
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measuring protein protein interactions by equilibrium sedimentation
Current protocols in immunology, 2000Co-Authors: Andrea Balbo, P Brown, Emory H Braswell, Peter SchuckAbstract:This unit describes basic principles and practice of sedimentation equilibrium analytical ultracentrifugation for the study of reversible protein interactions, such as the characterization of self-association, heterogeneous association, and binding stoichiometry, as well as the determination of association constants. Advanced tools such as mass conservation analysis, multiwavelength analysis, and global analysis are introduced and discussed in the context of the experimental design. A detailed protocol guiding the investigator through the experimental steps and the data analysis is available as an Internet Resource. Curr. Protoc. Immunol. 79:18.8.1-8.18.28. © 2007 by John Wiley & Sons, Inc. Keywords: sedimentation equilibrium; sedimentation velocity; chemical equilibria; reversible interactions; multi-protein complex; analytical ultracentrifugation
Michael W Kirkwood - One of the best experts on this subject based on the ideXlab platform.
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long term benefits of an early online problem solving intervention for executive dysfunction after traumatic brain injury in children a randomized clinical trial
JAMA Pediatrics, 2014Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:Importance Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant short- and long-term problems in functioning across multiple settings. We hypothesized that improvements in short-term executive function would be maintained to 24 months after injury and that improvements would increase over time in a counselor-assisted problem-solving (CAPS) intervention. Objective To evaluate the efficacy of a CAPS intervention administered within 7 months of complicated mild to severe TBI compared with an Internet Resource condition in improving long-term executive dysfunction. Design, Setting, and Participants Multisite, assessor-blinded, randomized clinical trial at 3 tertiary pediatric hospitals and 2 tertiary general medical centers. Participants included 132 adolescents aged 12 to 17 years who sustained a moderate to severe TBI 1 to 7 months before study enrollment. Intervention Web-based CAPS intervention. Main Outcomes and Measures The primary outcome was the parent-reported Global Executive Composite (GEC) of the Behavior Rating Inventory of Executive Function. Secondary outcomes included the Behavioral Regulation Index (BRI) and Metacognition Index (MI) of the GEC. Results In older (>14 to 17 years) adolescents, the CAPS intervention was associated with lower GEC ratings at 12 (β = −0.46; P = .03) and 18 (β = −0.52; P = .02) months after enrollment. Trends were also observed for older adolescents toward lower GEC ratings at 6 months (β = −0.40; P = .05), lower BRI ratings at 12 (β = −0.40; P = .06) and 18 (β = −0.47; P = .04) months, and lower MI ratings at 6 (β = −0.41; P = .05), 12 (β = −0.46; P = .03), and 18 (β = −0.50; P = .03) months. In younger (12-14 years) adolescents, no group differences were found on the GEC, BRI, or MI ratings. Conclusions and Relevance Delivery of the CAPS intervention early after TBI in older adolescents improves long-term executive function. This trial is, to our knowledge, one of the few large, randomized clinical treatment trials performed in pediatric TBI to demonstrate the efficacy of an intervention for management of executive dysfunction and long-term benefits of an intervention delivered soon after injury. Use of the CAPS intervention clinically should be considered; however, further research should explore ways to optimize delivery. Trial Registration clinicaltrials.gov Identifier:NCT00409448
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online problem solving therapy for executive dysfunction after child traumatic brain injury
Pediatrics, 2013Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:OBJECTIVE: Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant problems in functioning across multiple settings. The objective of this study was to evaluate the efficacy of a web-based counselor-assisted problem solving (CAPS) intervention compared with an Internet Resource comparison (IRC) for treatment of executive dysfunction within 12 months after complicated mild to severe TBI in adolescents. We hypothesized that CAPS would significantly improve parent ratings of executive dysfunction compared with an IRC. METHODS: Participants included 132 adolescents aged 12 to 17 years who sustained a complicated mild to severe TBI within 1 to 6 months before study enrollment. Study design was a multisite, assessor-blinded, randomized controlled trial. Study sites included 3 tertiary pediatric hospitals and 2 tertiary general medical centers. The main outcome measure was primary caregiver Behavioral Rating Inventory of Executive Function Global Executive Composite at baseline and 6-month follow-up. Generalized linear models that controlled for baseline scores were used to compare the CAPS and IRC scores. RESULTS: In older teens, the CAPS group showed significant improvement in executive function behaviors at 6-month follow-up compared with the IRC group ( F = 6.74, P = .01, Cohen’s d = 0.63). CONCLUSIONS: Findings indicate that web-based CAPS improves primary caregiver-rated executive functioning within the first 12 months after TBI in older adolescents. Future research needs to define the optimal timing after injury for delivery of CAPS and characteristics of individuals and families who are most likely to benefit from CAPS. * Abbreviations: BRI — : Behavioral Regulation Index BRIEF — : Behavior Rating Inventory of Executive Function CAPS — : counselor-assisted problem solving CT — : computerized tomography GCS — : Glasgow Coma Scale GEC — : Global Executive Composite IRC — : Internet Resource Comparison MI — : Metacognition Index TBI — : traumatic brain injury
Terry Stancin - One of the best experts on this subject based on the ideXlab platform.
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long term benefits of an early online problem solving intervention for executive dysfunction after traumatic brain injury in children a randomized clinical trial
JAMA Pediatrics, 2014Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:Importance Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant short- and long-term problems in functioning across multiple settings. We hypothesized that improvements in short-term executive function would be maintained to 24 months after injury and that improvements would increase over time in a counselor-assisted problem-solving (CAPS) intervention. Objective To evaluate the efficacy of a CAPS intervention administered within 7 months of complicated mild to severe TBI compared with an Internet Resource condition in improving long-term executive dysfunction. Design, Setting, and Participants Multisite, assessor-blinded, randomized clinical trial at 3 tertiary pediatric hospitals and 2 tertiary general medical centers. Participants included 132 adolescents aged 12 to 17 years who sustained a moderate to severe TBI 1 to 7 months before study enrollment. Intervention Web-based CAPS intervention. Main Outcomes and Measures The primary outcome was the parent-reported Global Executive Composite (GEC) of the Behavior Rating Inventory of Executive Function. Secondary outcomes included the Behavioral Regulation Index (BRI) and Metacognition Index (MI) of the GEC. Results In older (>14 to 17 years) adolescents, the CAPS intervention was associated with lower GEC ratings at 12 (β = −0.46; P = .03) and 18 (β = −0.52; P = .02) months after enrollment. Trends were also observed for older adolescents toward lower GEC ratings at 6 months (β = −0.40; P = .05), lower BRI ratings at 12 (β = −0.40; P = .06) and 18 (β = −0.47; P = .04) months, and lower MI ratings at 6 (β = −0.41; P = .05), 12 (β = −0.46; P = .03), and 18 (β = −0.50; P = .03) months. In younger (12-14 years) adolescents, no group differences were found on the GEC, BRI, or MI ratings. Conclusions and Relevance Delivery of the CAPS intervention early after TBI in older adolescents improves long-term executive function. This trial is, to our knowledge, one of the few large, randomized clinical treatment trials performed in pediatric TBI to demonstrate the efficacy of an intervention for management of executive dysfunction and long-term benefits of an intervention delivered soon after injury. Use of the CAPS intervention clinically should be considered; however, further research should explore ways to optimize delivery. Trial Registration clinicaltrials.gov Identifier:NCT00409448
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online problem solving therapy for executive dysfunction after child traumatic brain injury
Pediatrics, 2013Co-Authors: Brad G Kurowski, Shari L Wade, Michael W Kirkwood, Tanya M Brown, Terry Stancin, Gerry H TaylorAbstract:OBJECTIVE: Executive dysfunction after traumatic brain injury (TBI) in children is common and leads to significant problems in functioning across multiple settings. The objective of this study was to evaluate the efficacy of a web-based counselor-assisted problem solving (CAPS) intervention compared with an Internet Resource comparison (IRC) for treatment of executive dysfunction within 12 months after complicated mild to severe TBI in adolescents. We hypothesized that CAPS would significantly improve parent ratings of executive dysfunction compared with an IRC. METHODS: Participants included 132 adolescents aged 12 to 17 years who sustained a complicated mild to severe TBI within 1 to 6 months before study enrollment. Study design was a multisite, assessor-blinded, randomized controlled trial. Study sites included 3 tertiary pediatric hospitals and 2 tertiary general medical centers. The main outcome measure was primary caregiver Behavioral Rating Inventory of Executive Function Global Executive Composite at baseline and 6-month follow-up. Generalized linear models that controlled for baseline scores were used to compare the CAPS and IRC scores. RESULTS: In older teens, the CAPS group showed significant improvement in executive function behaviors at 6-month follow-up compared with the IRC group ( F = 6.74, P = .01, Cohen’s d = 0.63). CONCLUSIONS: Findings indicate that web-based CAPS improves primary caregiver-rated executive functioning within the first 12 months after TBI in older adolescents. Future research needs to define the optimal timing after injury for delivery of CAPS and characteristics of individuals and families who are most likely to benefit from CAPS. * Abbreviations: BRI — : Behavioral Regulation Index BRIEF — : Behavior Rating Inventory of Executive Function CAPS — : counselor-assisted problem solving CT — : computerized tomography GCS — : Glasgow Coma Scale GEC — : Global Executive Composite IRC — : Internet Resource Comparison MI — : Metacognition Index TBI — : traumatic brain injury
