The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Anthony Dickenson - One of the best experts on this subject based on the ideXlab platform.
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differential effects of a distant noxious stimulus on hindlimb nociceptive withdrawal reflexes in the rat
European Journal of Neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of <0.5 s and outlasted the conditioning stimulation by up to 2 s. The monosynaptic la reflex to the deep peroneal nerve, innervating dorsiflexors of the digits and ankle, was not significantly changed during noxious pinch of the nose. Hence, the inhibitory effects on the hindlimb withdrawal reflexes induced by the conditioning stimulation were presumably exerted on reflex interneurons. It is concluded that nociceptive withdrawal reflexes to different hindlimb muscles are differentially controlled by descending pathways activated by a distant noxious stimulus. The results support our previous conclusion that there are separate nociceptive withdrawal reflex pathways to different hindlimb muscles. (Less)
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Differential Effects of a Distant Noxious Stimulus on Hindlimb Nociceptive Withdrawal Reflexes in the Rat.
The European journal of neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of
David C. Preston - One of the best experts on this subject based on the ideXlab platform.
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Optimal recording electrode placement in the lumbrical-Interossei comparison study.
Muscle & nerve, 2006Co-Authors: Amer Alshekhlee, Jose A. Fernandes Filho, Devraj Sukul, David C. PrestonAbstract:The lumbrical-Interossei comparison study is commonly employed in the electrodiagnosis of carpal tunnel syndrome. Placement of the recording electrodes relies on anatomic landmarks as the muscles being recorded cannot be seen or palpated. To determine the optimal active electrode location, 15 controls and 5 patients were studied using a grid of 12 electrodes placed over the lateral palm. Amplitudes, rise-times, and latencies of the responses at each location were measured. The lowest control latency difference was located in the lateral mid-proximal palm (mean 0 ms, upper range of 0.5 ms). This location also had the highest lumbrical amplitude and rise-time. More distal in the palm, the mean latency difference increased to 0.5 ms with an upper range of 0.9 ms. When performing the lumbrical-Interossei comparison study, it is essential to place the active recording electrode in the optimal location. Failure to do so will result in an increased number of false-positive studies.
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lumbrical and Interossei recording in severe carpal tunnel syndrome
Muscle & Nerve, 2002Co-Authors: Kanokwan Boonyapisit, Bashar Katirji, Barbara E Shapiro, David C. PrestonAbstract:Patients with severe carpal tunnel syndrome (CTS) may occasionally have absent median motor and sensory responses; in these cases, it is not possible to accurately localize the median mononeuropathy to the wrist using standard electrodiagnostic tests. We prospectively investigated the use of comparing the median motor latency to the second lumbrical and the ulnar motor latency to the Interossei muscles in 28 patient hands with severe CTS and absent median motor and sensory responses. We found a prolonged latency difference in 92.8%. Along with its use in mild CTS, study of the lumbrical-Interossei latency difference is helpful in patients with severe CTS with absent median motor and sensory responses.
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lumbrical Interossei motor studies localize ulnar neuropathy at the wrist
Muscle & Nerve, 1996Co-Authors: Milind J Kothari, David C. Preston, Eric L LogigianAbstract:Ulnar nerve entrapment at the wrist (UNW) is uncommon and often difficult to localize electrophysiologically. The difference between the motor latencies to the median-innervated second lumbrical (2L) and ulnar-innervated palmar interosseous (Pl) (Diff 2L-Pl) has been shown to be of localizing value in patients with median neuropathy at the wrist. In the last year, we evaluated 2 patients with clinically definite ulnar neuropathy at the wrist. We performed motor studies to the 2L-Pl on the 2 patients and 12 disease controls with ulnar neuropathy at the elbow as follows: Using the same electrodes to record both the 2L and Pl, the median and ulnar nerves were each stimulated supramaximally above the wrist using identical distances. In the disease control subjects, the Diff 2L-Pl was essentially the same as normal controls (mean [0.13], range [(-0.3)-0.4]). In both patients with UNW, the Diff 2L-Pl clearly supported the routine electrophysiological studies in localizing the lesion (ulnar latencies were 1.1 and 1.8 ms longer than the median latencies). We conclude that the lumbrical-interosseous latency difference is useful in localizing ulnar nerve entrapment to the wrist.
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lumbrical and Interossei recording in carpal tunnel syndrome
Muscle & Nerve, 1992Co-Authors: David C. Preston, Eric L LogigianAbstract:Median motor studies are commonly "normal" in mild carpal tunnel syndrome (CTS). This reflects either the sparing of motor compared to sensory fibers, or the inability of conventional studies to detect an abnormality. A novel approach to demonstrate early motor fiber involvement in CTS is the placement of the same active electrode lateral to the third metacarpal, allowing recording from the second lumbrical or the deeper Interossei, when stimulating the median or ulnar nerves at the wrist, respectively. We compared the difference between these latencies in 51 normal control hands to 107 consecutive patient hands referred with symptoms and signs suggestive of CTS, who were subsequently proven to have electrophysiologic CTS by standard nerve conduction criteria. A prolonged lumbrical-Interossei latency difference (> 0.4 ms) was found to be a sensitive indicator of CTS in all patient groups. It was also helpful in patients with coexistent polyneuropathy, where localization at the wrist was otherwise difficult.
Jarkko Kalliomaki - One of the best experts on this subject based on the ideXlab platform.
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differential effects of a distant noxious stimulus on hindlimb nociceptive withdrawal reflexes in the rat
European Journal of Neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of <0.5 s and outlasted the conditioning stimulation by up to 2 s. The monosynaptic la reflex to the deep peroneal nerve, innervating dorsiflexors of the digits and ankle, was not significantly changed during noxious pinch of the nose. Hence, the inhibitory effects on the hindlimb withdrawal reflexes induced by the conditioning stimulation were presumably exerted on reflex interneurons. It is concluded that nociceptive withdrawal reflexes to different hindlimb muscles are differentially controlled by descending pathways activated by a distant noxious stimulus. The results support our previous conclusion that there are separate nociceptive withdrawal reflex pathways to different hindlimb muscles. (Less)
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Differential Effects of a Distant Noxious Stimulus on Hindlimb Nociceptive Withdrawal Reflexes in the Rat.
The European journal of neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of
Eric L Logigian - One of the best experts on this subject based on the ideXlab platform.
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lumbrical Interossei motor studies localize ulnar neuropathy at the wrist
Muscle & Nerve, 1996Co-Authors: Milind J Kothari, David C. Preston, Eric L LogigianAbstract:Ulnar nerve entrapment at the wrist (UNW) is uncommon and often difficult to localize electrophysiologically. The difference between the motor latencies to the median-innervated second lumbrical (2L) and ulnar-innervated palmar interosseous (Pl) (Diff 2L-Pl) has been shown to be of localizing value in patients with median neuropathy at the wrist. In the last year, we evaluated 2 patients with clinically definite ulnar neuropathy at the wrist. We performed motor studies to the 2L-Pl on the 2 patients and 12 disease controls with ulnar neuropathy at the elbow as follows: Using the same electrodes to record both the 2L and Pl, the median and ulnar nerves were each stimulated supramaximally above the wrist using identical distances. In the disease control subjects, the Diff 2L-Pl was essentially the same as normal controls (mean [0.13], range [(-0.3)-0.4]). In both patients with UNW, the Diff 2L-Pl clearly supported the routine electrophysiological studies in localizing the lesion (ulnar latencies were 1.1 and 1.8 ms longer than the median latencies). We conclude that the lumbrical-interosseous latency difference is useful in localizing ulnar nerve entrapment to the wrist.
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lumbrical and Interossei recording in carpal tunnel syndrome
Muscle & Nerve, 1992Co-Authors: David C. Preston, Eric L LogigianAbstract:Median motor studies are commonly "normal" in mild carpal tunnel syndrome (CTS). This reflects either the sparing of motor compared to sensory fibers, or the inability of conventional studies to detect an abnormality. A novel approach to demonstrate early motor fiber involvement in CTS is the placement of the same active electrode lateral to the third metacarpal, allowing recording from the second lumbrical or the deeper Interossei, when stimulating the median or ulnar nerves at the wrist, respectively. We compared the difference between these latencies in 51 normal control hands to 107 consecutive patient hands referred with symptoms and signs suggestive of CTS, who were subsequently proven to have electrophysiologic CTS by standard nerve conduction criteria. A prolonged lumbrical-Interossei latency difference (> 0.4 ms) was found to be a sensitive indicator of CTS in all patient groups. It was also helpful in patients with coexistent polyneuropathy, where localization at the wrist was otherwise difficult.
Jens Schouenborg - One of the best experts on this subject based on the ideXlab platform.
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differential effects of a distant noxious stimulus on hindlimb nociceptive withdrawal reflexes in the rat
European Journal of Neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of <0.5 s and outlasted the conditioning stimulation by up to 2 s. The monosynaptic la reflex to the deep peroneal nerve, innervating dorsiflexors of the digits and ankle, was not significantly changed during noxious pinch of the nose. Hence, the inhibitory effects on the hindlimb withdrawal reflexes induced by the conditioning stimulation were presumably exerted on reflex interneurons. It is concluded that nociceptive withdrawal reflexes to different hindlimb muscles are differentially controlled by descending pathways activated by a distant noxious stimulus. The results support our previous conclusion that there are separate nociceptive withdrawal reflex pathways to different hindlimb muscles. (Less)
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Differential Effects of a Distant Noxious Stimulus on Hindlimb Nociceptive Withdrawal Reflexes in the Rat.
The European journal of neuroscience, 1992Co-Authors: Jarkko Kalliomaki, Jens Schouenborg, Anthony DickensonAbstract:Recent studies indicate that the nociceptive withdrawal reflexes to individual muscles are evoked by separate reflex pathways. The present study examines whether nociceptive withdrawal reflexes to different muscles are subject to differential supraspinal control in rats. A distant noxious stimulus was used to activate a bulbospinal system which selectively inhibits ‘multireceptive’ neurons (i.e. neurons receiving excitatory tactile and nociceptive inputs) in the dorsal horn of the spinal cord. Withdrawal reflexes, recorded with electromyographic techniques in single hindlimb muscles, were evoked by standardized noxious pinch. Thirty‐seven rats, anaesthetized with halothane and nitrous oxide, were used. Whereas withdrawal reflexes to the extensor digitorum longus and brevis, tibialis anterior and biceps posterior muscles were strongly inhibited, reflexes to Interossei muscles were potentiated during noxious pinch of the nose. Reflexes to peronei muscles were not significantly changed. The effects on the reflexes usually had an onset latency of
