The Experts below are selected from a list of 156 Experts worldwide ranked by ideXlab platform
Juanita Crook - One of the best experts on this subject based on the ideXlab platform.
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comparison of health related quality of life 5 years after spirit surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2011Co-Authors: Juanita Crook, Kris Wallace, Michael A.s. Jewett, Alfonso Gomeziturriaga, Sharon Fung, Shabbir M H Alibhai, Neil FleshnerAbstract:Purpose The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual. We report health-related quality of life (HRQOL) at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to RP or BT following a multidisciplinary educational session.
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impact of a multi disciplinary patient education session on accrual to a difficult clinical trial the toronto experience with the surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2006Co-Authors: Kris Wallace, Joan Basiuk, Neil Fleshner, Michael A.s. Jewett, Juanita CrookAbstract:Purpose Random assignment to clinical trials involving different treatment modalities can be difficult. We describe our experience with the Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial (SPIRIT; ACOSOG Z0070 NCIC PR10), a randomized trial for early-stage prostate cancer comparing radical prostatectomy (RP), and brachytherapy (BT). A multidisciplinary educational session was developed to improve patient understanding of treatment options and to facilitate accrual. Patients and Methods Prostate cancer referrals were screened and men who met favorable risk criteria (T1c/T2a, prostate-specific antigen [PSA] < 10 ng/mL, Gleason ≤ 6) were invited to a structured education session before a specialty consultation. Men and their partners viewed the SPIRIT informed-consent video and heard from a cancer patient who described his participation in a randomized trial. Then, a urologist and Radiation oncologist together compared and contrasted RP and BT to establish the rationale for the trial....
Neil Fleshner - One of the best experts on this subject based on the ideXlab platform.
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comparison of health related quality of life 5 years after spirit surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2011Co-Authors: Juanita Crook, Kris Wallace, Michael A.s. Jewett, Alfonso Gomeziturriaga, Sharon Fung, Shabbir M H Alibhai, Neil FleshnerAbstract:Purpose The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual. We report health-related quality of life (HRQOL) at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to RP or BT following a multidisciplinary educational session.
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impact of a multi disciplinary patient education session on accrual to a difficult clinical trial the toronto experience with the surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2006Co-Authors: Kris Wallace, Joan Basiuk, Neil Fleshner, Michael A.s. Jewett, Juanita CrookAbstract:Purpose Random assignment to clinical trials involving different treatment modalities can be difficult. We describe our experience with the Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial (SPIRIT; ACOSOG Z0070 NCIC PR10), a randomized trial for early-stage prostate cancer comparing radical prostatectomy (RP), and brachytherapy (BT). A multidisciplinary educational session was developed to improve patient understanding of treatment options and to facilitate accrual. Patients and Methods Prostate cancer referrals were screened and men who met favorable risk criteria (T1c/T2a, prostate-specific antigen [PSA] < 10 ng/mL, Gleason ≤ 6) were invited to a structured education session before a specialty consultation. Men and their partners viewed the SPIRIT informed-consent video and heard from a cancer patient who described his participation in a randomized trial. Then, a urologist and Radiation oncologist together compared and contrasted RP and BT to establish the rationale for the trial....
Kris Wallace - One of the best experts on this subject based on the ideXlab platform.
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comparison of health related quality of life 5 years after spirit surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2011Co-Authors: Juanita Crook, Kris Wallace, Michael A.s. Jewett, Alfonso Gomeziturriaga, Sharon Fung, Shabbir M H Alibhai, Neil FleshnerAbstract:Purpose The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual. We report health-related quality of life (HRQOL) at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to RP or BT following a multidisciplinary educational session.
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impact of a multi disciplinary patient education session on accrual to a difficult clinical trial the toronto experience with the surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2006Co-Authors: Kris Wallace, Joan Basiuk, Neil Fleshner, Michael A.s. Jewett, Juanita CrookAbstract:Purpose Random assignment to clinical trials involving different treatment modalities can be difficult. We describe our experience with the Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial (SPIRIT; ACOSOG Z0070 NCIC PR10), a randomized trial for early-stage prostate cancer comparing radical prostatectomy (RP), and brachytherapy (BT). A multidisciplinary educational session was developed to improve patient understanding of treatment options and to facilitate accrual. Patients and Methods Prostate cancer referrals were screened and men who met favorable risk criteria (T1c/T2a, prostate-specific antigen [PSA] < 10 ng/mL, Gleason ≤ 6) were invited to a structured education session before a specialty consultation. Men and their partners viewed the SPIRIT informed-consent video and heard from a cancer patient who described his participation in a randomized trial. Then, a urologist and Radiation oncologist together compared and contrasted RP and BT to establish the rationale for the trial....
Michael A.s. Jewett - One of the best experts on this subject based on the ideXlab platform.
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comparison of health related quality of life 5 years after spirit surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2011Co-Authors: Juanita Crook, Kris Wallace, Michael A.s. Jewett, Alfonso Gomeziturriaga, Sharon Fung, Shabbir M H Alibhai, Neil FleshnerAbstract:Purpose The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual. We report health-related quality of life (HRQOL) at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to RP or BT following a multidisciplinary educational session.
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impact of a multi disciplinary patient education session on accrual to a difficult clinical trial the toronto experience with the surgical prostatectomy versus Interstitial Radiation intervention trial
Journal of Clinical Oncology, 2006Co-Authors: Kris Wallace, Joan Basiuk, Neil Fleshner, Michael A.s. Jewett, Juanita CrookAbstract:Purpose Random assignment to clinical trials involving different treatment modalities can be difficult. We describe our experience with the Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial (SPIRIT; ACOSOG Z0070 NCIC PR10), a randomized trial for early-stage prostate cancer comparing radical prostatectomy (RP), and brachytherapy (BT). A multidisciplinary educational session was developed to improve patient understanding of treatment options and to facilitate accrual. Patients and Methods Prostate cancer referrals were screened and men who met favorable risk criteria (T1c/T2a, prostate-specific antigen [PSA] < 10 ng/mL, Gleason ≤ 6) were invited to a structured education session before a specialty consultation. Men and their partners viewed the SPIRIT informed-consent video and heard from a cancer patient who described his participation in a randomized trial. Then, a urologist and Radiation oncologist together compared and contrasted RP and BT to establish the rationale for the trial....
Masashi Fuse - One of the best experts on this subject based on the ideXlab platform.
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transperineal high dose rate Interstitial Radiation therapy in the management of gynecologic malignancies
Strahlentherapie Und Onkologie, 2003Co-Authors: Jun Itami, Ryusuke Hara, Takuyou Kozuka, Hideomi Yamashita, Kaori Nakajima, Kouji Shibata, Masashi FuseAbstract:BACKGROUND: High-dose-rate Interstitial Radiation therapy is a newly introduced modality, and its role in the management of gynecologic malignancies remains to be studied. Clinical experience in high-dose-rate Interstitial Radiation therapy was retrospectively investigated. PATIENTS AND METHODS: Eight patients with primary and nine with recurrent gynecologic malignancies underwent high-dose-rate Interstitial Radiation therapy with/without external-beam irRadiation. Fractional dose of the high-dose-rate Interstitial Radiation therapy ranged between 4 and 6 Gy with total doses of 15-54 Gy. Interstitial irRadiation was performed twice daily with an interval of > 6 h. RESULTS: 2-year local control rate was 75% for primary treatment and 47% for treatment of recurrence (p = 0.46). Maximum tumor size had a statistically significant impact on local control (p 100 cm(3) and < or = 100 cm(3), respectively (p < 0.04). CONCLUSION: Although high-dose-rate Interstitial Radiation therapy is a promising modality, it must be applied cautiously to patients with bulky tumors because of the high incidence of serious complications.
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Transperineal High-Dose-Rate Interstitial Radiation Therapy in the Management of Gynecologic Malignancies
Strahlentherapie und Onkologie, 2003Co-Authors: Jun Itami, Ryusuke Hara, Takuyou Kozuka, Hideomi Yamashita, Kaori Nakajima, Kouji Shibata, Masashi FuseAbstract:Hintergrund: Die interstitielle High-Dose-Rate-(HDR-)Bestrahlung ist eine neu eingeführte Modalität, deren Rolle bei der Behandlung von gynäkologischen Malignomen noch zu klären ist. Eigene klinische Erfahrungen mit der interstitiellen HDR-Bestrahlung wurden retrospektiv analysiert. Patienten und Methodik: Acht Patientinnen mit primären Malignomen und neun Patientinnen mit Redizidiven im gynäkologischen Bereich unterzogen sich einer interstitiellen HDR-Bestrahlung (mit/ohne perkutane Bestrahlung) mit 4–6 Gy bei einer Gesamtdosis von 15–54 Gy. Die interstitielle Bestrahlung wurde zweimal täglich im Abstand von > 6 h durchgeführt. Ergebnisse: Die lokale 2-Jahres-Kontrollrate betrug bei der Primärtherapie 75% und bei der Behandlung von Rezidiven 47% (p = 0,46). Die maximale Tumorgröße hatte einen statistisch signifikanten Einfluss auf die lokale Kontrollrate (p < 0,002). Spätkomplikationen Grad 2 und 4 fanden sich bei fünf Patientinnen, und ihre Häufigkeit war signifikant von dem brachytherapeutisch behandelten Volumen abhängig. Bei 78% der Patientinnen mit einem Volumen > 100 cm^3 fanden sich nach 18 Monaten Komplikationen Grad 2 und 4, dagegen bei 0% der Patientinnen mit kleinerem Volumen (p < 0,04). Schlussfolgerung: Obwohl die interstitielle HDR-Bestrahlung eine viel versprechende Modalität ist, muss sie bei Patientinnen mit großen Tumoren wegen der hohen Inzidenz schwerer Komplikationen vorsichtig angewandt werden. Background: High-dose-rate Interstitial Radiation therapy is a newly introduced modality, and its role in the management of gynecologic malignancies remains to be studied. Clinical experience in high-dose-rate Interstitial Radiation therapy was retrospectively investigated. Patients and Methods: Eight patients with primary and nine with recurrent gynecologic malignancies underwent high-dose-rate Interstitial Radiation therapy with/without external-beam irRadiation. Fractional dose of the high-dose-rate Interstitial Radiation therapy ranged between 4 and 6 Gy with total doses of 15–54 Gy. Interstitial irRadiation was performed twice daily with an interval of > 6 h. Results: 2-year local control rate was 75% for primary treatment and 47% for treatment of recurrence (p = 0.46). Maximum tumor size had a statistically significant impact on local control (p < 0.002). Grade 2 and 4 late complications were seen in five patients, and the incidence was significantly higher in patients with a larger volume enclosed by the prescribed fractional dose of high-dose-rate Interstitial Radiation therapy. The incidence of grade 2 and 4 complications at 18 months was 78% and 0% with a volume > 100 cm^3 and ≤ 100 cm^3, respectively (p < 0.04). Conclusion: Although high-dose-rate Interstitial Radiation therapy is a promising modality, it must be applied cautiously to patients with bulky tumors because of the high incidence of serious complications.
