The Experts below are selected from a list of 14664 Experts worldwide ranked by ideXlab platform
Neda Drndarevic - One of the best experts on this subject based on the ideXlab platform.
-
diapedesis of thrombocytes from capillary into the intercellular space of interscapular brown adipose tissue and their increase by ca sandoz
Histology and Histopathology, 1998Co-Authors: J Radovanovic, Vesna Koko, Maja Nedeljkovic, Aleksandra Korac, Neda DrndarevicAbstract:Diapedetic capacity of the rat thrombocytes to leave capillaries of the interscapular brown adipose tissue (IBAT) and infiltrate the Interstitium has been observed by conventional electron-microscopy. Thrombocytes that reach IBAT Interstitium are morphologically completely different from lumenary ones. The interstitial thrombocyte has a prominet head region (1.51x2.12 ,urn) and very long phylopodium (3.43 ,urn). Experimental conditions which induced drastic changes in morphology of interstitial thrombocytes were: sucrose overfeeding (10% over 2 days); a 24 hour starving after sucrose overfeeding and Ca-Sandoz drinking (480 mg/L Ca2+ during 2 days). The thrombocytes in the IBAT Interstitium can be classified as activated according to: a) pseudopode extension; b) swollen open canalicullar system (OCS); c) endocytosis via coated pits and vesicles; and d) structural changes in a granules excreted to the Interstitium through OCS. In the IBAT Interstitium of 24-hour starved rats after sucrose overfeeding, a thrombocytic layer was observed. It was suggested that thrombocyte adrenalin, stored in dense bodies, was selectevely included in the !BAT supply without mediation of the central nervous system.
-
diapedesis of thrombocytes from capillary into the intercellular space of interscapular brown adipose tissue and their increase by ca sandoz
Histology and Histopathology, 1998Co-Authors: J Radovanovic, Vesna Koko, Maja Nedeljkovic, Aleksandra Korac, Neda DrndarevicAbstract:Diapedetic capacity of the rat thrombocytes to leave capillaries of the interscapular brown adipose tissue (IBAT) and infiltrate the Interstitium has been observed by conventional electron-microscopy. Thrombocytes that reach IBAT Interstitium are morphologically completely different from lumenary ones. The interstitial thrombocyte has a prominet head region (1.51 x 2.12 microns) and very long phylopodium (3.43 microns). Experimental conditions which induced drastic changes in morphology of interstitial thrombocytes were: sucrose overfeeding (10% over 2 days); a 24 hour starving after sucrose overfeeding and Ca-Sandoz drinking (480 mg/L Ca2+ during 2 days). The thrombocytes in the IBAT Interstitium can be classified as activated according to: a) pseudopode extension; b) swollen open canalicullar system (OCS); c) endocytosis via coated pits and vesicles; and d) structural changes in alpha granules excreted to the Interstitium through OCS. In the IBAT Interstitium of 24-hour starved rats after sucrose overfeeding, a thrombocytic layer was observed. It was suggested that thrombocyte adrenalin, stored in dense bodies, was selectively included in the IBAT supply without mediation of the central nervous system.
Aurélie Edwards - One of the best experts on this subject based on the ideXlab platform.
-
countercurrent exchange in the renal medulla
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2003Co-Authors: Thomas L Pallone, Aurélie Edwards, Malcolm R Turner, Rex L JamisonAbstract:The microcirculation of the renal medulla traps NaCl and urea deposited to the Interstitium by the loops of Henle and collecting ducts. Theories have predicted that countercurrent exchanger efficie...
-
oxygen transport across vasa recta in the renal medulla
American Journal of Physiology-heart and Circulatory Physiology, 2002Co-Authors: Wensheng Zhang, Aurélie EdwardsAbstract:In this model of oxygen transport in the renal medullary microcirculation, we predicted that the net amount of oxygen reabsorbed from vasa recta into the Interstitium is on the order of 10−6 mmol/s...
-
interstitial water and solute recovery by inner medullary vasa recta
American Journal of Physiology-renal Physiology, 2000Co-Authors: Aurélie Edwards, Mark J Delong, Thomas L PalloneAbstract:A recent model of volume and solute microvascular exchange in the renal medulla was extended by simulating the deposition of NaCl, urea, and water into the medullary Interstitium from the loops of ...
J Radovanovic - One of the best experts on this subject based on the ideXlab platform.
-
diapedesis of thrombocytes from capillary into the intercellular space of interscapular brown adipose tissue and their increase by ca sandoz
Histology and Histopathology, 1998Co-Authors: J Radovanovic, Vesna Koko, Maja Nedeljkovic, Aleksandra Korac, Neda DrndarevicAbstract:Diapedetic capacity of the rat thrombocytes to leave capillaries of the interscapular brown adipose tissue (IBAT) and infiltrate the Interstitium has been observed by conventional electron-microscopy. Thrombocytes that reach IBAT Interstitium are morphologically completely different from lumenary ones. The interstitial thrombocyte has a prominet head region (1.51x2.12 ,urn) and very long phylopodium (3.43 ,urn). Experimental conditions which induced drastic changes in morphology of interstitial thrombocytes were: sucrose overfeeding (10% over 2 days); a 24 hour starving after sucrose overfeeding and Ca-Sandoz drinking (480 mg/L Ca2+ during 2 days). The thrombocytes in the IBAT Interstitium can be classified as activated according to: a) pseudopode extension; b) swollen open canalicullar system (OCS); c) endocytosis via coated pits and vesicles; and d) structural changes in a granules excreted to the Interstitium through OCS. In the IBAT Interstitium of 24-hour starved rats after sucrose overfeeding, a thrombocytic layer was observed. It was suggested that thrombocyte adrenalin, stored in dense bodies, was selectevely included in the !BAT supply without mediation of the central nervous system.
-
diapedesis of thrombocytes from capillary into the intercellular space of interscapular brown adipose tissue and their increase by ca sandoz
Histology and Histopathology, 1998Co-Authors: J Radovanovic, Vesna Koko, Maja Nedeljkovic, Aleksandra Korac, Neda DrndarevicAbstract:Diapedetic capacity of the rat thrombocytes to leave capillaries of the interscapular brown adipose tissue (IBAT) and infiltrate the Interstitium has been observed by conventional electron-microscopy. Thrombocytes that reach IBAT Interstitium are morphologically completely different from lumenary ones. The interstitial thrombocyte has a prominet head region (1.51 x 2.12 microns) and very long phylopodium (3.43 microns). Experimental conditions which induced drastic changes in morphology of interstitial thrombocytes were: sucrose overfeeding (10% over 2 days); a 24 hour starving after sucrose overfeeding and Ca-Sandoz drinking (480 mg/L Ca2+ during 2 days). The thrombocytes in the IBAT Interstitium can be classified as activated according to: a) pseudopode extension; b) swollen open canalicullar system (OCS); c) endocytosis via coated pits and vesicles; and d) structural changes in alpha granules excreted to the Interstitium through OCS. In the IBAT Interstitium of 24-hour starved rats after sucrose overfeeding, a thrombocytic layer was observed. It was suggested that thrombocyte adrenalin, stored in dense bodies, was selectively included in the IBAT supply without mediation of the central nervous system.
Jeffrey J Heys - One of the best experts on this subject based on the ideXlab platform.
-
analysis of convective and diffusive transport in the brain Interstitium
Fluids and Barriers of the CNS, 2019Co-Authors: Lori Ray, Jeffrey J Iliff, Jeffrey J HeysAbstract:Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a powerful tool for investigating hypotheses regarding extracellular transport of molecules in brain tissue. Here we describe a tool developed to aid in investigation of interstitial transport mechanisms, especially the potential for convection (or bulk flow) and its relevance to interstitial solute transport, for which there is conflicting evidence. In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain Interstitium, incorporating current theories of perivascular influx and efflux. The simulations show (1) convective flow in the Interstitium potentially of a similar magnitude to diffusive transport for molecules of interest and (2) exchange between the Interstitium and perivascular space, whereby fluid and solutes may enter or exit the Interstitium, are consistent with the experimental data. Simulations provide an upper limit for superficial convective velocity magnitude (approximately $$v$$ = 50 μm min−1), a useful finding for researchers developing techniques to measure interstitial bulk flow. For the large molecules of interest in neuropathology, bulk flow may be an important mechanism of interstitial transport. Further work is warranted to investigate the potential for bulk flow.
-
Analysis of convective and diffusive transport in the brain Interstitium
Fluids and Barriers of the CNS, 2019Co-Authors: Lori Ray, Jeffrey J Iliff, Jeffrey J HeysAbstract:Background Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a powerful tool for investigating hypotheses regarding extracellular transport of molecules in brain tissue. Here we describe a tool developed to aid in investigation of interstitial transport mechanisms, especially the potential for convection (or bulk flow) and its relevance to interstitial solute transport, for which there is conflicting evidence. Methods In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain Interstitium, incorporating current theories of perivascular influx and efflux. Results The simulations show (1) convective flow in the Interstitium potentially of a similar magnitude to diffusive transport for molecules of interest and (2) exchange between the Interstitium and perivascular space, whereby fluid and solutes may enter or exit the Interstitium, are consistent with the experimental data. Simulations provide an upper limit for superficial convective velocity magnitude (approximately $$v$$ v = 50 μm min^−1), a useful finding for researchers developing techniques to measure interstitial bulk flow. Conclusions For the large molecules of interest in neuropathology, bulk flow may be an important mechanism of interstitial transport. Further work is warranted to investigate the potential for bulk flow.
Wilhelm Kriz - One of the best experts on this subject based on the ideXlab platform.
-
anatomy of the renal Interstitium
Kidney International, 1991Co-Authors: Kevin V Lemley, Wilhelm KrizAbstract:The Interstitium of the kidney comprises the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances. As we define it here, the Interstitium is bounded on all sides by tubular and vascular basement membranes. This suggests including the lymphatics within the Interstitium. That the vascular compartment on the other hand should be distinguished from the Interstitium—in contrast to what is often assumed—is suggested by evidence of significant solute polarization between capillary plasma and the Interstitium [1]. The Interstitium of the kidney is not a simple passive space in which the "true" functional units—nephrons and vessels—are embedded. Rather, it mediates and in fact modulates almost all exchange among the tubular and vascular elements of the renal parenchyma; along with segmental specialization of the nephron, it underlies the functional zonation of the kidney; it probably influences glomerular filtration through its effects on tubuloglomerular feedback; it decisively affects growth and differentiation of parenchymal cells; it determines the compliance of the peritubular micro vasculature; the cells of the Interstitium produce a variety of local (autocoid) and systemic hormones; and alterations in the Interstitium contribute to the clinical manifestations of renal disease. This review will deal with the various cellular and extracellular elements of the renal Interstitium under normal conditions. The studies on which our conclusions are based were conducted principally in experimental animals, in particular the rat.
