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Jenni Lehtisalo - One of the best experts on this subject based on the ideXlab platform.
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dietary changes and cognition over 2 years within a multidomain Intervention trial the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger
Alzheimers & Dementia, 2019Co-Authors: Riitta Antikainen, Esko Levalahti, Jenni Lehtisalo, Tuomo Hanninen, Jaana Lindstrom, Teemu Paajanen, Markku Peltonen, Tiina LaatikainenAbstract:Abstract Introduction Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. Methods We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60–77 years) who were randomized to intensive multidomain Intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. Results Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of Intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the Intervention group (P = .008; P = .051 for groups combined). Discussion Dietary changes initiated during the Intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
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the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger Study design and progress
Alzheimers & Dementia, 2013Co-Authors: Miia Kivipelto, Tiia Ngandu, Riitta Antikainen, Alina Solomon, Satu Ahtiluoto, Jenni Lehtisalo, Lars Backman, Tuomo HanninenAbstract:Abstract Background Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-Intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain Intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the Intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle–related factors are present, creating a window of opportunity for prevention. The Intervention will be completed during 2014. Conclusions The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing Intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
Riitta Antikainen - One of the best experts on this subject based on the ideXlab platform.
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brain volumes and cortical thickness on mri in the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger
Alzheimer's Research & Therapy, 2019Co-Authors: Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lotjonen, Esko Levalahti, Riitta ParkkolaAbstract:Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal Intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This Study reports exploratory analyses of brain MRI measures.
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dietary changes and cognition over 2 years within a multidomain Intervention trial the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger
Alzheimers & Dementia, 2019Co-Authors: Riitta Antikainen, Esko Levalahti, Jenni Lehtisalo, Tuomo Hanninen, Jaana Lindstrom, Teemu Paajanen, Markku Peltonen, Tiina LaatikainenAbstract:Abstract Introduction Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. Methods We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60–77 years) who were randomized to intensive multidomain Intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. Results Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of Intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the Intervention group (P = .008; P = .051 for groups combined). Discussion Dietary changes initiated during the Intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
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the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger Study design and progress
Alzheimers & Dementia, 2013Co-Authors: Miia Kivipelto, Tiia Ngandu, Riitta Antikainen, Alina Solomon, Satu Ahtiluoto, Jenni Lehtisalo, Lars Backman, Tuomo HanninenAbstract:Abstract Background Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-Intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain Intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the Intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle–related factors are present, creating a window of opportunity for prevention. The Intervention will be completed during 2014. Conclusions The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing Intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
Tuomo Hanninen - One of the best experts on this subject based on the ideXlab platform.
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dietary changes and cognition over 2 years within a multidomain Intervention trial the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger
Alzheimers & Dementia, 2019Co-Authors: Riitta Antikainen, Esko Levalahti, Jenni Lehtisalo, Tuomo Hanninen, Jaana Lindstrom, Teemu Paajanen, Markku Peltonen, Tiina LaatikainenAbstract:Abstract Introduction Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. Methods We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60–77 years) who were randomized to intensive multidomain Intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. Results Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of Intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the Intervention group (P = .008; P = .051 for groups combined). Discussion Dietary changes initiated during the Intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.
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the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger Study design and progress
Alzheimers & Dementia, 2013Co-Authors: Miia Kivipelto, Tiia Ngandu, Riitta Antikainen, Alina Solomon, Satu Ahtiluoto, Jenni Lehtisalo, Lars Backman, Tuomo HanninenAbstract:Abstract Background Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-Intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain Intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the Intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle–related factors are present, creating a window of opportunity for prevention. The Intervention will be completed during 2014. Conclusions The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing Intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
Heidi Sosted - One of the best experts on this subject based on the ideXlab platform.
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prevention of hand eczema among danish hairdressing apprentices an Intervention Study
Chemical Hazards in Industry, 2012Co-Authors: Anne Bregnhoj, Torkil Menné, Jeanne D. Johansen, Heidi SostedAbstract:To investigate whether an evidence-based Intervention could reduce the incidence of hand eczema in a cohort of Danish hairdressing apprentices during their training, as hairdressing apprentices are known to have a high risk of developing hand eczema. This Study was a clinically controlled, prospective Intervention Study. Within 2 weeks of starting their training, 502 hairdressing apprentices were enrolled in the Study on occupational hand eczema. Approximately half of the apprentices were assigned to an Intervention group and received an evidence-based training program developed for this Study and delivered by teachers specially trained in the prevention of hand eczema; the other half received normal training and served as a control group. All apprentices completed self-administered questionnaires including questions regarding hand eczema, use of gloves and degree of wet work, and were all clinically examined for hand eczema three times during the 18-month Study period. The three examinations were scheduled as school visits and consisted of a baseline examination and two follow-up examinations approximately 8 and 18 months later. More apprentices from the Intervention group used gloves during wet work procedures and significantly fewer developed hand eczema compared with apprentices from the control group (p=0.04). A logistic regression model showed that atopic dermatitis had a significant influence on the development of hand eczema in the cohort irrespective of the Intervention. The authors were able to increase the use of gloves and reduce the incidence of hand eczema in hairdressing apprentices by implementing a training program in hairdressing schools.
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prevention of hand eczema among danish hairdressing apprentices an Intervention Study
Occupational and Environmental Medicine, 2012Co-Authors: Anne Bregnhoj, Torkil Menné, Jeanne D. Johansen, Heidi SostedAbstract:Objectives To investigate whether an evidence-based Intervention could reduce the incidence of hand eczema in a cohort of Danish hairdressing apprentices during their training, as hairdressing apprentices are known to have a high risk of developing hand eczema. Methods This Study was a clinically controlled, prospective Intervention Study. Within 2 weeks of starting their training, 502 hairdressing apprentices were enrolled in the Study on occupational hand eczema. Approximately half of the apprentices were assigned to an Intervention group and received an evidence-based training program developed for this Study and delivered by teachers specially trained in the prevention of hand eczema; the other half received normal training and served as a control group. All apprentices completed self-administered questionnaires including questions regarding hand eczema, use of gloves and degree of wet work, and were all clinically examined for hand eczema three times during the 18-month Study period. The three examinations were scheduled as school visits and consisted of a baseline examination and two follow-up examinations approximately 8 and 18 months later. Results More apprentices from the Intervention group used gloves during wet work procedures and significantly fewer developed hand eczema compared with apprentices from the control group (p=0.04). A logistic regression model showed that atopic dermatitis had a significant influence on the development of hand eczema in the cohort irrespective of the Intervention. Conclusions We were able to increase the use of gloves and reduce the incidence of hand eczema in hairdressing apprentices by implementing a training program in hairdressing schools.
Tiia Ngandu - One of the best experts on this subject based on the ideXlab platform.
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brain volumes and cortical thickness on mri in the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger
Alzheimer's Research & Therapy, 2019Co-Authors: Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lotjonen, Esko Levalahti, Riitta ParkkolaAbstract:Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal Intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This Study reports exploratory analyses of brain MRI measures.
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the finnish geriatric Intervention Study to prevent cognitive impairment and disability finger Study design and progress
Alzheimers & Dementia, 2013Co-Authors: Miia Kivipelto, Tiia Ngandu, Riitta Antikainen, Alina Solomon, Satu Ahtiluoto, Jenni Lehtisalo, Lars Backman, Tuomo HanninenAbstract:Abstract Background Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland. Materials Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-Intervention studies. Inclusion criteria are CAIDE Dementia Risk Score ≥6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain Intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures. Results Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the Intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle–related factors are present, creating a window of opportunity for prevention. The Intervention will be completed during 2014. Conclusions The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing Intervention strategies to prevent or delay the onset of cognitive impairment and dementia.
