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Carmen Perezterzic - One of the best experts on this subject based on the ideXlab platform.
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stem cell therapy for Intervertebral Disk regeneration
American Journal of Physical Medicine & Rehabilitation, 2014Co-Authors: Shanmiao Gou, Shawn C Oxentenko, Jason S Eldrige, Lizu Xiao, Mathew J Pingree, Zhen Wang, Carmen PerezterzicAbstract:Intervertebral Disk degeneration has been considered an irreversible process characterized by a decrease in cell viability, attenuation of proteoglycan and type II collagen synthesis, and dehydration of nucleus pulposus. Stem cell therapy specifically addresses the degenerative process and offers a potentially effective treatment modality. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative Disks by differentiation toward chondrocyte-like cells, which produce proteoglycans and type II collagen. There has been evidence that mesenchymal stem cell transplantation into the Intervertebral Disk increases the intraDiskal magnetic resonance imaging T2 signal intensity, increases the Disk height, and decreases the degenerative grade in animal models. Appropriate selection of cell carriers/matrix is important because it may prevent cell leakage into the spinal canal and provide an environment that facilitates cell proliferation and differentiation. Although human cell therapy trials for degenerative Disk disease are on the horizon, potential issues might arise. The authors hereby review the current state of regenerative cell therapy in degenerative Disk disease, with emphasis in cell source, techniques for cellular expansion, induction, transplantation, potential benefit, and risks of the use of this novel medical armamentarium in the treatment of degenerative Disk disease.
Shanmiao Gou - One of the best experts on this subject based on the ideXlab platform.
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stem cell therapy for Intervertebral Disk regeneration
American Journal of Physical Medicine & Rehabilitation, 2014Co-Authors: Shanmiao Gou, Shawn C Oxentenko, Jason S Eldrige, Lizu Xiao, Mathew J Pingree, Zhen Wang, Carmen PerezterzicAbstract:Intervertebral Disk degeneration has been considered an irreversible process characterized by a decrease in cell viability, attenuation of proteoglycan and type II collagen synthesis, and dehydration of nucleus pulposus. Stem cell therapy specifically addresses the degenerative process and offers a potentially effective treatment modality. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative Disks by differentiation toward chondrocyte-like cells, which produce proteoglycans and type II collagen. There has been evidence that mesenchymal stem cell transplantation into the Intervertebral Disk increases the intraDiskal magnetic resonance imaging T2 signal intensity, increases the Disk height, and decreases the degenerative grade in animal models. Appropriate selection of cell carriers/matrix is important because it may prevent cell leakage into the spinal canal and provide an environment that facilitates cell proliferation and differentiation. Although human cell therapy trials for degenerative Disk disease are on the horizon, potential issues might arise. The authors hereby review the current state of regenerative cell therapy in degenerative Disk disease, with emphasis in cell source, techniques for cellular expansion, induction, transplantation, potential benefit, and risks of the use of this novel medical armamentarium in the treatment of degenerative Disk disease.
Steven De Decker - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar Intervertebral Disk extrusions and Intervertebral Disk protrusions in dogs.
Veterinary Radiology & Ultrasound, 2016Co-Authors: Steven De Decker, Sergio A. Gomes, Rowena M. A. Packer, Patrick J. Kenny, Elsa Beltran, Birgit Parzefall, Joe Fenn, Devi Nair, George Nye, Holger A. VolkAbstract:Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion. Midline Intervertebral Disk herniation, and partial Intervertebral Disk degeneration were associated with Intervertebral Disk protrusion, while presence of a single Intervertebral Disk herniation and Disk material dispersed beyond the boundaries of the Intervertebral Disk space were associated with Intervertebral Disk extrusion. The aim of this retrospective, cross-sectional study was to determine whether using these MRI variables improves differentiation between thoracolumbar Intervertebral Disk extrusions and protrusions. Eighty large breed dogs with surgically confirmed thoracolumbar Intervertebral Disk extrusions or protrusions were included. Randomized MRI studies were presented on two occasions to six blinded observers, which were divided into three experience categories. During the first assessment, observers made a presumptive diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion without guidelines. During the second assessment they were asked to make a presumptive diagnosis with the aid of guidelines. Agreement was evaluated by Kappa-statistics. Diagnostic accuracy significantly improved from 70.8 to 79.6% and interobserver agreement for making a diagnosis of Intervertebral Disk extrusion or Intervertebral Disk protrusion improved from fair (κ = 0.27) to moderate (κ = 0.41) after using the proposed guidelines. Diagnostic accuracy was significantly influenced by degree of observer experience. Intraobserver agreement for the assessed variables ranged from fair to excellent and interobserver agreement ranged from fair to moderate. The results of this study suggest that the proposed imaging guidelines can aid in differentiating thoracolumbar Intervertebral Disk extrusions from protrusions.
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CLINICAL AND MAGNETIC RESONANCE IMAGING CHARACTERISTICS OF THORACOLUMBAR Intervertebral Disk EXTRUSIONS AND PROTRUSIONS IN LARGE BREED DOGS.
Veterinary Radiology & Ultrasound, 2016Co-Authors: Sergio A. Gomes, Rowena M. A. Packer, Patrick J. Kenny, Elsa Beltran, Holger A. Volk, Steven De DeckerAbstract:Treatment recommendations differ for dogs with Intervertebral Disk extrusion vs. Intervertebral Disk protrusion. The aim of this retrospective, cross-sectional study was to determine whether clinical and magnetic resonance imaging (MRI) variables could be used to predict a diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion in dogs. Dogs were included if they were large breed dogs, had an MRI study of the thoracolumbar or lumbar vertebral column, had undergone spinal surgery, and had the type of Intervertebral Disk herniation (Intervertebral Disk extrusion or protrusion) clearly stated in surgical reports. A veterinary neurologist unaware of surgical findings reviewed MRI studies and recorded number, location, degree of degeneration and morphology of Intervertebral Disks, presence of nuclear clefts, Disk space narrowing, extent, localization and lateralization of herniated Disk material, degree of spinal cord compression, intraparenchymal intensity changes, spondylosis deformans, spinal cord swelling, spinal cord atrophy, vertebral endplate changes, and presence of extradural hemorrhage. Ninety-five dogs were included in the sample. Multivariable statistical models indicated that longer duration of clinical signs (P = 0.01), midline instead of lateralized Disk herniation (P = 0.007), and partial instead of complete Disk degeneration (P = 0.01) were associated with a diagnosis of Intervertebral Disk protrusion. The presence of a single Intervertebral herniation (P = 0.023) and dispersed Intervertebral Disk material not confined to the Disk space (P = 0.06) made a diagnosis of Intervertebral Disk extrusion more likely. Findings from this study identified one clinical and four MRI variables that could potentially facilitate differentiating Intervertebral Disk extrusions from protrusions in dogs.
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Clinical characterization of thoracolumbar and lumbar Intervertebral Disk extrusions in English Cocker Spaniels
Javma-journal of The American Veterinary Medical Association, 2016Co-Authors: Thomas J.a. Cardy, Holger A. Volk, Caitlin E. Tzounos, Steven De DeckerAbstract:OBJECTIVE To assess the anatomic distribution of thoracolumbar and lumbar Intervertebral Disk extrusions (IVDEs) in English Cocker Spaniels as compared with findings in Dachshunds and to characterize clinical findings in English Cocker Spaniels with thoracolumbar or lumbar IVDEs affecting various regions of the vertebral column. DESIGN Retrospective observational study. ANIMALS 81 English Cocker Spaniels and 81 Dachshunds with IVDEs. PROCEDURES Signalment, clinical signs, neurologic examination findings, and affected Intervertebral Disk spaces (IVDSs) were recorded for both breeds. Management methods and outcomes were recorded for English Cocker Spaniels. Lesions were categorized as thoracolumbar (IVDSs T9–10 through L1–2), midlumbar (L2–3 through L4–5), or caudal lumbar (L5–6 through L7–S1). RESULTS Midlumbar and caudal lumbar IVDEs were significantly more common in English Cocker Spaniels than in Dachshunds. English Cocker Spaniels with caudal lumbar IVDEs had a longer median duration of clinical signs ...
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Intervertebral Disk width in dogs with and without clinical signs of Disk associated cervical spondylomyelopathy
BMC Veterinary Research, 2012Co-Authors: Steven De Decker, Ingrid Mvl Gielen, Luc Duchateau, Holger A. VolkAbstract:Background Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more Intervertebral Disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider Intervertebral Disks have been put forward as a risk factor for development of clinically relevant DA-CSM. However, little is known about other factors affecting Intervertebral Disk width. Therefore the aim of this study was to assess the association between Intervertebral Disk width, measured on magnetic resonance imaging (MRI), and clinical status, age, gender and Intervertebral Disk location in dogs with and without clinical signs of DA-CSM. Methods Doberman pinschers with clinical signs of DA-CSM (N=17),clinically normal Doberman pinschers (N=20), and clinically normal English Foxhounds (N = 17), underwent MRI of the cervical vertebral column. On sagittal T2-weighted images, Intervertebral Disk width was measured from C2-C3 to C6-C7. Intra –and interobserver agreement were assessed on a subset of 20 of the 54 imaging studies. Results Intervertebral Disk width was not significantly different between Doberman pinschers with clinical signs of DA-CSM, clinically normal Doberman pinschers or clinically normal English Foxhounds (p=0.43). Intervertebral Disk width was positively associated with increasing age (p=0.029). Each monthly increase in age resulted in an increase of Disk width by 0.0057mm. Intervertebral Disk width was not significantly affected by gender (p=0.056), but was significantly influenced by Intervertebral Disk location (p
Holger A. Volk - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar Intervertebral Disk extrusions and Intervertebral Disk protrusions in dogs.
Veterinary Radiology & Ultrasound, 2016Co-Authors: Steven De Decker, Sergio A. Gomes, Rowena M. A. Packer, Patrick J. Kenny, Elsa Beltran, Birgit Parzefall, Joe Fenn, Devi Nair, George Nye, Holger A. VolkAbstract:Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion. Midline Intervertebral Disk herniation, and partial Intervertebral Disk degeneration were associated with Intervertebral Disk protrusion, while presence of a single Intervertebral Disk herniation and Disk material dispersed beyond the boundaries of the Intervertebral Disk space were associated with Intervertebral Disk extrusion. The aim of this retrospective, cross-sectional study was to determine whether using these MRI variables improves differentiation between thoracolumbar Intervertebral Disk extrusions and protrusions. Eighty large breed dogs with surgically confirmed thoracolumbar Intervertebral Disk extrusions or protrusions were included. Randomized MRI studies were presented on two occasions to six blinded observers, which were divided into three experience categories. During the first assessment, observers made a presumptive diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion without guidelines. During the second assessment they were asked to make a presumptive diagnosis with the aid of guidelines. Agreement was evaluated by Kappa-statistics. Diagnostic accuracy significantly improved from 70.8 to 79.6% and interobserver agreement for making a diagnosis of Intervertebral Disk extrusion or Intervertebral Disk protrusion improved from fair (κ = 0.27) to moderate (κ = 0.41) after using the proposed guidelines. Diagnostic accuracy was significantly influenced by degree of observer experience. Intraobserver agreement for the assessed variables ranged from fair to excellent and interobserver agreement ranged from fair to moderate. The results of this study suggest that the proposed imaging guidelines can aid in differentiating thoracolumbar Intervertebral Disk extrusions from protrusions.
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CLINICAL AND MAGNETIC RESONANCE IMAGING CHARACTERISTICS OF THORACOLUMBAR Intervertebral Disk EXTRUSIONS AND PROTRUSIONS IN LARGE BREED DOGS.
Veterinary Radiology & Ultrasound, 2016Co-Authors: Sergio A. Gomes, Rowena M. A. Packer, Patrick J. Kenny, Elsa Beltran, Holger A. Volk, Steven De DeckerAbstract:Treatment recommendations differ for dogs with Intervertebral Disk extrusion vs. Intervertebral Disk protrusion. The aim of this retrospective, cross-sectional study was to determine whether clinical and magnetic resonance imaging (MRI) variables could be used to predict a diagnosis of thoracolumbar Intervertebral Disk extrusion or protrusion in dogs. Dogs were included if they were large breed dogs, had an MRI study of the thoracolumbar or lumbar vertebral column, had undergone spinal surgery, and had the type of Intervertebral Disk herniation (Intervertebral Disk extrusion or protrusion) clearly stated in surgical reports. A veterinary neurologist unaware of surgical findings reviewed MRI studies and recorded number, location, degree of degeneration and morphology of Intervertebral Disks, presence of nuclear clefts, Disk space narrowing, extent, localization and lateralization of herniated Disk material, degree of spinal cord compression, intraparenchymal intensity changes, spondylosis deformans, spinal cord swelling, spinal cord atrophy, vertebral endplate changes, and presence of extradural hemorrhage. Ninety-five dogs were included in the sample. Multivariable statistical models indicated that longer duration of clinical signs (P = 0.01), midline instead of lateralized Disk herniation (P = 0.007), and partial instead of complete Disk degeneration (P = 0.01) were associated with a diagnosis of Intervertebral Disk protrusion. The presence of a single Intervertebral herniation (P = 0.023) and dispersed Intervertebral Disk material not confined to the Disk space (P = 0.06) made a diagnosis of Intervertebral Disk extrusion more likely. Findings from this study identified one clinical and four MRI variables that could potentially facilitate differentiating Intervertebral Disk extrusions from protrusions in dogs.
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Clinical characterization of thoracolumbar and lumbar Intervertebral Disk extrusions in English Cocker Spaniels
Javma-journal of The American Veterinary Medical Association, 2016Co-Authors: Thomas J.a. Cardy, Holger A. Volk, Caitlin E. Tzounos, Steven De DeckerAbstract:OBJECTIVE To assess the anatomic distribution of thoracolumbar and lumbar Intervertebral Disk extrusions (IVDEs) in English Cocker Spaniels as compared with findings in Dachshunds and to characterize clinical findings in English Cocker Spaniels with thoracolumbar or lumbar IVDEs affecting various regions of the vertebral column. DESIGN Retrospective observational study. ANIMALS 81 English Cocker Spaniels and 81 Dachshunds with IVDEs. PROCEDURES Signalment, clinical signs, neurologic examination findings, and affected Intervertebral Disk spaces (IVDSs) were recorded for both breeds. Management methods and outcomes were recorded for English Cocker Spaniels. Lesions were categorized as thoracolumbar (IVDSs T9–10 through L1–2), midlumbar (L2–3 through L4–5), or caudal lumbar (L5–6 through L7–S1). RESULTS Midlumbar and caudal lumbar IVDEs were significantly more common in English Cocker Spaniels than in Dachshunds. English Cocker Spaniels with caudal lumbar IVDEs had a longer median duration of clinical signs ...
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Intervertebral Disk width in dogs with and without clinical signs of Disk associated cervical spondylomyelopathy
BMC Veterinary Research, 2012Co-Authors: Steven De Decker, Ingrid Mvl Gielen, Luc Duchateau, Holger A. VolkAbstract:Background Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more Intervertebral Disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider Intervertebral Disks have been put forward as a risk factor for development of clinically relevant DA-CSM. However, little is known about other factors affecting Intervertebral Disk width. Therefore the aim of this study was to assess the association between Intervertebral Disk width, measured on magnetic resonance imaging (MRI), and clinical status, age, gender and Intervertebral Disk location in dogs with and without clinical signs of DA-CSM. Methods Doberman pinschers with clinical signs of DA-CSM (N=17),clinically normal Doberman pinschers (N=20), and clinically normal English Foxhounds (N = 17), underwent MRI of the cervical vertebral column. On sagittal T2-weighted images, Intervertebral Disk width was measured from C2-C3 to C6-C7. Intra –and interobserver agreement were assessed on a subset of 20 of the 54 imaging studies. Results Intervertebral Disk width was not significantly different between Doberman pinschers with clinical signs of DA-CSM, clinically normal Doberman pinschers or clinically normal English Foxhounds (p=0.43). Intervertebral Disk width was positively associated with increasing age (p=0.029). Each monthly increase in age resulted in an increase of Disk width by 0.0057mm. Intervertebral Disk width was not significantly affected by gender (p=0.056), but was significantly influenced by Intervertebral Disk location (p
Jason S Eldrige - One of the best experts on this subject based on the ideXlab platform.
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stem cell therapy for Intervertebral Disk regeneration
American Journal of Physical Medicine & Rehabilitation, 2014Co-Authors: Shanmiao Gou, Shawn C Oxentenko, Jason S Eldrige, Lizu Xiao, Mathew J Pingree, Zhen Wang, Carmen PerezterzicAbstract:Intervertebral Disk degeneration has been considered an irreversible process characterized by a decrease in cell viability, attenuation of proteoglycan and type II collagen synthesis, and dehydration of nucleus pulposus. Stem cell therapy specifically addresses the degenerative process and offers a potentially effective treatment modality. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative Disks by differentiation toward chondrocyte-like cells, which produce proteoglycans and type II collagen. There has been evidence that mesenchymal stem cell transplantation into the Intervertebral Disk increases the intraDiskal magnetic resonance imaging T2 signal intensity, increases the Disk height, and decreases the degenerative grade in animal models. Appropriate selection of cell carriers/matrix is important because it may prevent cell leakage into the spinal canal and provide an environment that facilitates cell proliferation and differentiation. Although human cell therapy trials for degenerative Disk disease are on the horizon, potential issues might arise. The authors hereby review the current state of regenerative cell therapy in degenerative Disk disease, with emphasis in cell source, techniques for cellular expansion, induction, transplantation, potential benefit, and risks of the use of this novel medical armamentarium in the treatment of degenerative Disk disease.
