The Experts below are selected from a list of 1710 Experts worldwide ranked by ideXlab platform
Benjamin S. Terry - One of the best experts on this subject based on the ideXlab platform.
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design of a wireless medical capsule for measuring the contact pressure between a capsule and the small Intestine
Journal of Biomechanical Engineering-transactions of The Asme, 2017Co-Authors: Craig Kreikemeierbower, Vishal Kothari, Wanchuan Xie, Benjamin S. TerryAbstract:A wireless medical capsule for measuring the contact pressure between a mobile capsule and the small Intestine lumen was developed. Two pressure sensors were used to measure and differentiate the contact pressure and the small Intestine intraluminal pressure. After in vitro tests of the capsule, it was surgically placed and tested in the proximal small Intestine of a pig model. The capsule successfully gathered and transmitted the pressure data to a receiver outside the body. The measured pressure signals in the animal test were analyzed in the time and frequency domains, and a mathematic model was presented to describe the different factors influencing the contact pressure. A novel signal processing method was applied to isolate the Contraction information from the contact pressure. The result shows that the measured contact pressure was 1.08 ± 0.08 kPa, and the small Intestine Contraction pressure's amplitude and rate were 0.29 ± 0.046 kPa and 12 min-1. Moreover, the amplitudes and rates of pressure from respiration and heartbeat were also estimated. The successful preliminary evaluation of this capsule implies that it could be used in further systematic investigation of small Intestine contact pressure on a mobile capsule-shaped bolus.
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Design and Preliminary Experimental Investigation of a Capsule for Measuring the Small Intestine Contraction Pressure
IEEE Transactions on Biomedical Engineering, 2015Co-Authors: Pengbo Li, Vishal Kothari, Benjamin S. TerryAbstract:A tethered pressure measurement capsule was developed for measuring the small Intestine Contraction pressure to assist in locating capsules within the gastrointestinal (GI) tract and quantifying the contact force between the capsule and the small Intestine lumen. The capsule was calibrated statically and dynamically in depth-controlled water at body temperature (37-38 °C). In vitro tests were performed on an intestinal simulator to verify the measurement function of the capsule. To perform a preliminary evaluation of its pressure measuring capabilities, the capsule was tested at a single location in a live pig model. The pressure signal from the live animal test was analyzed in the time domain, and then, the empirical mode decomposition and fast Fourier transformation were applied to analyze the Contraction pressure and ambient pressure in the frequency domain. The Contraction rate was 9.4 to 11.0 times per minute. The peak value of the Contraction pressure was 0.24 ± 0.05 kPa. The successful test of this prototype lays the groundwork for a future untethered, swallowable version of the capsule, which will be capable of measuring dynamic pressures while in transit.
Pengbo Li - One of the best experts on this subject based on the ideXlab platform.
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Design and Preliminary Experimental Investigation of a Capsule for Measuring the Small Intestine Contraction Pressure
IEEE Transactions on Biomedical Engineering, 2015Co-Authors: Pengbo Li, Vishal Kothari, Benjamin S. TerryAbstract:A tethered pressure measurement capsule was developed for measuring the small Intestine Contraction pressure to assist in locating capsules within the gastrointestinal (GI) tract and quantifying the contact force between the capsule and the small Intestine lumen. The capsule was calibrated statically and dynamically in depth-controlled water at body temperature (37-38 °C). In vitro tests were performed on an intestinal simulator to verify the measurement function of the capsule. To perform a preliminary evaluation of its pressure measuring capabilities, the capsule was tested at a single location in a live pig model. The pressure signal from the live animal test was analyzed in the time domain, and then, the empirical mode decomposition and fast Fourier transformation were applied to analyze the Contraction pressure and ambient pressure in the frequency domain. The Contraction rate was 9.4 to 11.0 times per minute. The peak value of the Contraction pressure was 0.24 ± 0.05 kPa. The successful test of this prototype lays the groundwork for a future untethered, swallowable version of the capsule, which will be capable of measuring dynamic pressures while in transit.
Vishal Kothari - One of the best experts on this subject based on the ideXlab platform.
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design of a wireless medical capsule for measuring the contact pressure between a capsule and the small Intestine
Journal of Biomechanical Engineering-transactions of The Asme, 2017Co-Authors: Craig Kreikemeierbower, Vishal Kothari, Wanchuan Xie, Benjamin S. TerryAbstract:A wireless medical capsule for measuring the contact pressure between a mobile capsule and the small Intestine lumen was developed. Two pressure sensors were used to measure and differentiate the contact pressure and the small Intestine intraluminal pressure. After in vitro tests of the capsule, it was surgically placed and tested in the proximal small Intestine of a pig model. The capsule successfully gathered and transmitted the pressure data to a receiver outside the body. The measured pressure signals in the animal test were analyzed in the time and frequency domains, and a mathematic model was presented to describe the different factors influencing the contact pressure. A novel signal processing method was applied to isolate the Contraction information from the contact pressure. The result shows that the measured contact pressure was 1.08 ± 0.08 kPa, and the small Intestine Contraction pressure's amplitude and rate were 0.29 ± 0.046 kPa and 12 min-1. Moreover, the amplitudes and rates of pressure from respiration and heartbeat were also estimated. The successful preliminary evaluation of this capsule implies that it could be used in further systematic investigation of small Intestine contact pressure on a mobile capsule-shaped bolus.
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Design and Preliminary Experimental Investigation of a Capsule for Measuring the Small Intestine Contraction Pressure
IEEE Transactions on Biomedical Engineering, 2015Co-Authors: Pengbo Li, Vishal Kothari, Benjamin S. TerryAbstract:A tethered pressure measurement capsule was developed for measuring the small Intestine Contraction pressure to assist in locating capsules within the gastrointestinal (GI) tract and quantifying the contact force between the capsule and the small Intestine lumen. The capsule was calibrated statically and dynamically in depth-controlled water at body temperature (37-38 °C). In vitro tests were performed on an intestinal simulator to verify the measurement function of the capsule. To perform a preliminary evaluation of its pressure measuring capabilities, the capsule was tested at a single location in a live pig model. The pressure signal from the live animal test was analyzed in the time domain, and then, the empirical mode decomposition and fast Fourier transformation were applied to analyze the Contraction pressure and ambient pressure in the frequency domain. The Contraction rate was 9.4 to 11.0 times per minute. The peak value of the Contraction pressure was 0.24 ± 0.05 kPa. The successful test of this prototype lays the groundwork for a future untethered, swallowable version of the capsule, which will be capable of measuring dynamic pressures while in transit.
Tao Wang - One of the best experts on this subject based on the ideXlab platform.
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citrus aurantium l and its flavonoids regulate tnbs induced inflammatory bowel disease through anti inflammation and suppressing isolated jejunum Contraction
International Journal of Molecular Sciences, 2018Co-Authors: Mengyang Liu, Zhijuan Ding, Jingya Ruan, Yi Zhang, Qian Chen, Yue Chen, Tao WangAbstract:Inflammatory bowel disease (IBD) is a serious digestive system disease, for which the clinical therapeutic choices remain limited. Dried fruits of Citrus aurantium L. (CAL) are a traditional medicine used for regulation of the digestive system. The aim of this study was to identify the regulatory effects of CAL on IBD and to clarify the mechanism of the active compounds. In trinitrobenzene sulfonic acid-induced IBD rats, 125 to 500 mg/kg of oral CAL significantly alleviated weight loss and diarrhea, decreased colitis inflammatory cell infiltration, and inhibited pro-inflammatory cytokine production. The mechanisms of characteristic flavonoids in CAL were evaluated involving inflammation and Intestine Contraction aspects. Naringenin, nobiletin, and hesperetin showed anti-inflammatory effects on lipopolysaccharide-induced RAW cells. The mechanism may be related to the inhibition of the tumor necrosis factor-α (TNF-α)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to suppress cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions. Naringenin and nobiletin showed inhibitory effects on isolated jejunum Contraction. The mechanism of naringenin is partly related to COX, NOS, inositol triphosphate (IP3), and finally, to decreased jejunum motility. This study demonstrated that CAL, and its flavonoids’ regulatory effects on IBD through anti-inflammation and inhibition of Intestine muscle Contraction, can provide basic information on developing new drugs or supplements against IBD based on CAL.
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Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten.
Molecules, 2017Co-Authors: Zhijuan Ding, Shengcai Yang, Haiyang Yu, Meiling Chen, Jingya Ruan, Yi Zhang, Tao WangAbstract:As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated Intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on Intestine Contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated Intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (7–10, 13–16, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 12–14, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on Contraction tension at 40 μM.
Shouliang Dong - One of the best experts on this subject based on the ideXlab platform.
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Peptides 7 and 8 (both with 10 μM) for small Intestine Contraction with acetylcholine (10 μM) as positive control.
2015Co-Authors: Lanxia Zhou, Jing Zhang, Shouliang DongAbstract:Peptides 7 and 8 (both with 10 μM) for small Intestine Contraction with acetylcholine (10 μM) as positive control.
