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Machado D.d.r.s. - One of the best experts on this subject based on the ideXlab platform.
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction.329817823Aljada, A., Ganhim, H., Mohanty, P., Hofmeyer, D., Tripathy, D., Dandona, P., Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) (2001) J. Clin. Endocrinol. Metabol., 86 (12), pp. 5988-5991Annane, D., Cavaillon, J.M., Corticosteroids in sepsis: From bench to bedside? (2003) Shock, 20, pp. 197-207Bai, J.W., Deng, W.W., Lin, M.J., Xu, S.M., Zhang, D.X., The effects of vitamin E and dexamethasone on inflammation of acute lung injury and expression of myosin light chain kinase (2009) Chinese J. Tubercul. Resp. Dis., 32 (1), pp. 46-50Bailey, S.R., Menzies-Gow, N.J., Harris, P.A., Habershon-Butcher, J.L., Crawford, C., Berhane, Y., Boston, R.C., Elliott, J., Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis (2007) J. Am. Vet. Med. Assoc., 231 (9), pp. 1365-1373Belknap, J., Moore, J.N., Crouser, E.C., Sepsis: From human organ failure to laminar failure (2009) Vet. Immun. Immunopathol., 129 (3-4), pp. 155-157Belknap, J.K., Black, S.J., Review of the pathophysiology of the developmental stages of equine laminitis. American Association of Equine Pratitioners (2005), http://www.ivis.org/proceedings/aaep/2005/belknap/chapter.asp?LA=1, Disponível em Accessed on Oct. 31, 2008Benkamin, C.F., Atualização sobre mediadores e modelos experimentais de sepse (2001) Medicina, Ribeirão Preto, 34, pp. 18-26Bianco-Blatlles, M.D., Sosunov, A., Polin, R.A., Ten, V.S., Systemic in-flammation following hind-limb ischemia- reperfusion affects brain in neonatal mice (2008) Developmental Neuroscience, 30 (6), pp. 367-373Black, S.J., Lunn, D.P., Yin, C., Hwang, M., Lenz, S.D., Belknap, J.K., Leukocyte emigration in the early stages of laminitis (2006) Vet. Immun. Immunopathol., 109, pp. 161-166Bolignano, D., Basile, G., Parisi, P., Coppolino, G., Nicocia, G., Buemi, M., Increased plasma neutrophil gelatinase-associated lipocalin levels predict mortality in elderly patients with chronic heart failure (2009) Rejuvenation Res., 12 (1), pp. 1-7Borregaard, N., Cowland, J.B., Granules of the human neutrophilic polymorphonuclear leukocyte (1997) Blood, 89, pp. 3503-3521Brasil, L.A., Gomes, W.J., Salomão, R., Fonseca, J.H.P., Branco, J.N.R., Buffolo, E., Uso de corticóide como inibidor da resposta inflamatória sistêmica induzida pela circulação extracorpórea (1999) Revta Bras. Cirur. Cardiovasc., 14 (3), pp. 254-268Bradford, M.M., A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding (1976) Analytical. Biochem., 72, pp. 248-254Bu, D., Hemdahl, A.L., Gabrielsen, A., Fuxe, J., Zhu, C., Eriksson, P., Yan, Z.Q., Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kB (2006) Am. J. Pathol., 169, pp. 2245-2253Campebell, R.C., Peiro, J.R., Rosa, P.C.S., Valadao, C.A.A., Bechara, G.H., Endotoxemia por lipopolissacarídeo de Escherichia coli, em equinos: efeitos de antiinflamatórios nas concentrações sérica e peritonial do fator de necrose tumoral alfa (TNF-α) (2007) Arq. Bras. Med. Vet. Zootec., 59 (4), pp. 837-843Chakrabarti, S., Zee, J.M., Patel, K.D., Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: Novel pathways for tertiary granule release (2006) J. Leukocyte Biology, 79, pp. 214-222Cornelisse, C.J., Robinson, N.E., Berney, C.A., Eberhart, S., Hauptman, J.E., Derksen, F.J., Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse (2006) Equine Vet. J., 38 (2), pp. 119-126De Laat, M.A., Kyaw-Tanner, M.T., Nourian, A.R., McGowan, C.M., Sillence, M.N., Pollitt, C.C., The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activiy (2011) Vet. Immunol.. Immunopathol., 140 (3-4), pp. 275-281Eades, S.C., Holm, A.M.S., Moore, R.M., A Review of the pathophysiology and treatment of acute laminitis: phatophysiologic and therapeutic implications of endothelin-1 (2002) Am. Assoc. Equine Pract., 48, pp. 353-361Faleiros, R.R., Macoris, D.G., Alessi, A.C., Saquetti, C.H., Rasera, L., Effect of intraluminal distention on microvascular perfusion in the equine small colon (2002) Am. J. Vet. Res., 63, pp. 1292-1297Faleiros, R.R., Macoris, D.G., Alves, G.E., Souza, D.G., Teixeira, M.M., Moore, R.M., Local and remote lesions in horses subjected to small colon Distension and decompression (2008) Can. J. Vet. Res., 72 (1), pp. 68-76Faleiros, R.R., Nouvo, G.J., Belknap, J.K., Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extractinduced laminitis (2009) J. Vet. Intern. Med., 23 (1), pp. 174-181Faleiros, R.R., Johnson, P.J., Nuovo, G.J., Messer, N.T., Black, S.J., Belknap, J.K., Laminar leukocyte accumulation in horses with carbohydrate overload induced laminitis (2011) J. Vet. Intern. Med., 25 (1), pp. 107-115Faleiros, R.R., Nuovo, G.J., Flechtner, A.D., Beljnap, J.K., Presence of mononuclear cells in normal and affected laminae from the black walnut extract model of laminitis. Equine Vet. J. 43(1):45-53.Flower D.R. 1996. The lipocalin protein family: structure and function (2011) Biochem. J., 318, pp. 1-14French, R.K., Pollitt, C., Equine laminitis: loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: a ultrastructural study (2004) Equine Vet. J., 36 (3), pp. 230-236Green, J.A., Tran, C.T.H., Farrar, J.J., Nguyen, M.T.H., Nguyen, P.H., Dinh, S.X., Ho, N.D.T., Thwaites, G.E., Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis (2009) PloS ONE, 4 (1), p. 7277Gupta, K., Shukla, M., Cowland, J.B., Malemud, C.J., Haqq, T.M., Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9 (2007) Arthritis and Rheumatism, 56 (10), pp. 3326-3335Han, Y., Tuan, T.L., Wu, H., Hughes, M., Garner, W.L., TNF-a stimulates activation of pro-MMP-2 in human skin through NF-κB mediated induction of MT1-MMP (2001) J. Cell Sci., 114, pp. 131-139Hemdahl, A.L., Gabrielsen, A., Zhu, C., Eriksson, P., Hedin, U., Kastrup, J., Thorén, P., Hansson, G.K., Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction (2006) Arteriosclerosis Thrombosis and Vascular Biology, 26 (1), pp. 136-142Hurley, D.J., Parks, R.J., Reber, A.J., Donovan, D.C., Okinaga, T., Vandenplas, M.L., Peroni, J.F., Moore, J.N., Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract (2006) Vet. Immunol. Immunopathol., 110 (3-4), pp. 195-206Johnson, P.J., Slight, S.H., Ganjam, V.K., Kreeger, J.M., Glucocorticoids and laminitis in the horse (2002) Vet. Clin. North Am., Equine Pract., 18 (2), pp. 219-236Johnson, P.J., Bowles, D.K., Messer, N.T., Dexamethasone alters equine digital artery smooth muscle ion channel activity and contractility: Role in glucocorticoid associated laminitis? (2003) J. Vet. Intern. Med., 17 (3), pp. 457-458Kaufmann, I., Briegel, J., Schliephake, F., Hoelzl, A., Chouker, A., Hummel, T., Schelling, G., Thiel, M., Stress doses of hydrocortisone in septic shock: Beneficial effects on opsonization-dependent neutrophil functions (2008) Intensive Care Medicine, 34 (2), pp. 344-349Kumar, S., Allen, D.A., Kieswich, J.E., Patel, N.S.A., Harwood, S., Mazzon, E., Cuzzocrea, S., Yaqoob, M.A., Dexamethasona ameliorates renal ischemia-reperfusion injury (2009) J. Am. Soc. Nephronol., 20 (11), pp. 2412-2425Laskoski, L.M., Valadão, C.A.A., Vasconcelos, R.O., Pereira, R.N., Dias, A.D.P.U., Alessi, A.C., Alterações morfológicas de tecido laminar do casco e parâmetros clínicos e laboratoriais de equinos com síndrome cólica letal (2009) Pesq. Vet. Bras., 29 (9), pp. 731-735Leise, B.S., Faleiros, R.R., Watts, M., Johnson, P.J., Black, S.J., Belknap, J.K., Laminar Inflammatory gene expression in the carbohydrate overload model of equine laminitis (2011) Equine Vet. J., 43 (1), pp. 54-61Loftus, J.P., Belknap, J.K., Black, S.J., Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance (2006) Vet. Immunol. Immunopathol., 113, pp. 267-276Loftus, J.P., Black, S.J., Pettigrew, A., Abrahansen, E.J., Belknap, J.K., Early laminar events involving endothelial activation in horses with black walnut-induced laminitis (2007) Am. J. Vet. Res., 68 (11), pp. 1205-1211Lorencini, M., Silva, J.A., De La Hoz, C.L., Carvalho, H.F., Stach-Machado, D.R., Changes in MMPs in inflammatory cells in experimental gingivitis (2009) Histology Histopathol., 24 (2), pp. 157-166Maisel, A.S., Mueller, C., Fitzgerald, R., Brikhan, R., Hiestand, B.C., Iqbal, N., Clopton, P., Van Veldhuisen, D.J., Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL evaluation along with B-type natriuretic peptide in acutely decompensated heart failure (GALLANT) trial (2011) Eur. J. Heart Failure, 13 (8), pp. 846-851Mikami, Y., Dobschutz, E.V., Sommer, O., Wellner, U., Unno, M., Hopt, U., Keck, T., Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis (2009) Surgery, 145 (2), pp. 147-156Nielsen, B.S., Borregaard, N., Bundgaard, J.R., Timshel, S., Sehested, M., Kjeldsen, L., Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases (1996) Gut, 38, pp. 414-420Noschka, E., Vandenplas, M.L., Hurley, D.J., Moore, J.N., Temporal aspects of laminar gene expression during the developmental stages of equine laminitis (2009) Vet. Immunol. Immunopathol., 129 (3-4), pp. 242-253Parsons, C.S., Orsini, J.A., Krafty, R., Capewell, L., Boston, R., Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997-2004) (2007) J. Am. Vet. Med. Assoc., 230 (6), pp. 885-889Pollitt, C.C., The basement membrane at the equine hoof dermal epidermal junction (1994) Equine Vet. J., 26 (5), pp. 399-407Pollitt, C.C., Basement membrane pathology: a feature of acute equine laminitis (1996) Equine Vet. J., 28 (1), pp. 38-46Pollitt, C.C., Daradka, M., Equine laminitis basement membrane pathology: loss of type IV collagen, type VII collagen and laminin immunostaining (1998) Equine Vet. J., 26 (SUPPL.), pp. 139-144Pollitt, C.C., Equine laminitis: A revised pathophysiology (1999) Am. Assoc. Equine Pract. Proc., 45, pp. 188-192Pollitt, C.C., Pathophysiology of laminitis (2003) Diagnosis and Management of Lameness in the Horse, pp. 325-329. , Dyson S.J. & Ross M.W. (Eds), W.B. Saunders, PhiladelphiaRiggs, L.M., Franck, T., Moore, J.N., Krunkosky, T.M., Hurley, D.J., Peroni, J.F., De La Rebiere, G., Serteyn, D.A., Neutrophil myeloperoxidase measurements in plasma, laminar tissue, and skin of horses given black walnut extract (2007) Am. J. Vet. Res., 68, pp. 81-86Rio Tinto, J.J.M., Alves, G.E.S., Faleiros, R.R., Santos, R.L., Marques Júnior, A.P., Melo, E.G., Utilização de hidrocortisona em equinos submetidos a isquemia e reperfusão no jejuno e suas conseqüências sob o cório laminar (2004) Arq. Bras. Med. Vet. Zootec., 56 (3), pp. 292-299Ryu, S., Kim, B., Lee, C., Yoon, J., Lee, Y., Glucocorticoide-induced laminitis with hepatopathy in a thoroughbred filly (2004) J. Vet. Sci., 5 (3), pp. 271-274Shapiro, N.I., Trzeciak, S., Hollander, J.E., Birkhahn, R., Otero, R., Osborn, T.M., Moretti, E., Rivers, E.P., A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis (2009) Critical Care Medicine, 37 (1), pp. 96-104Smith, E.R., Zurakowski, D., Saad, A., Scott, R.M., Moses, M.A., Urinary biomarkers predict brain tumor presence and response to therapy (2008) Clin. Cancer Res., 14 (8), pp. 2378-2386Stetler-Stevenson, W.G., Type IV collagenases in tumor invasion and metastasis (1990) Cancer and Metastasis Reviews, 9 (4), pp. 289-303Suagee, J.K., Corl, B.A., Crisman, M.V., Hulver, M.W., McCutcheon, L.J., Geor, R.J., Effects of acute hyperinsulinemia on inflammatory proteins in Horses (2011) Vet. Immunol. Immunopathol., 142 (3-4), pp. 141-146Sun, W., Watanabe, Y., Toki, A., Wang, Z.Q., Beneficial Effects of hydrocortisone in induced acute pancreatitis of rats (2007) Chinese Med. J., 120 (20), pp. 1757-1761Tiley, H.A., Geor, R.J., McCutcheon, L.J., Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses (2007) Am. J. Vet. Res., 68 (7), pp. 753-759Venugopal, C.S., Eades, S., Holmes, E.P., Beadle, R.E., Insulin resistance in equine digital vessel rings: An in vitro model to study vascular dysfunction in equine laminitis (2011) Equine Vet. J., 43 (6), pp. 744-749Visser, M.B., Pollitt, C.C., Lamellar leukocyte infiltration and involvement of IL-6 during oligofrutose-induced equine laminitis development (2011) Vet. Immunol. Immunopathol., , doi:10.1016/j.vetimm.2011.07.016Visser, M.B., Pollitt, C.C., The timeline of metalloprotease eventis during Olifructose induced equine laminitis development (2011) Equine Vet. J., , doi:10.1111/j.2042-3306.2011.00393.xVisser, M.B., Pollitt, C.C., Immunohistochemical distribution of laminin-332 and collagen Type IV in the basement membrane of normal horses and horses with induced laminitis (2011) J. Comp.Pathol., 145 (1), pp. 80-87Yazar, E., Bulbul, A., Avci, G.E., Er, A., Uney, K., Elmas, M., Tras, B., Effects of enrofloxacin, flunixim meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats (2010) Acta Vet. 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Ferrucci D. - One of the best experts on this subject based on the ideXlab platform.
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil gelatinase associated lipocalin (NGAL) and calprotectin in equine laminar tissue after jejunal obstruction, treated or not with hidrocortisone
Revista Pesquisa Veterinaria Brasileira, 2015Co-Authors: Lm Laskoski, Ferrucci D., Valadao Caa, Ro Vasconcelos, Rr Faleiros, Mendes Hmf, Silva Jaf, Machado DdrsAbstract:Laskoski L.M., Valadao C.A.A., Vasconcelos R.O., Faleiros R.R., Mendes H.M.F., Ferrucci D., Silva J.A.F. & Machado D.D.R.S. 2012. [Neutrophil gelatinase associated lipocalin (NGAL) and calprotectin in equine laminar tissue after jejunal obstruction, treated or not with hidrocortisone.] Lipocalina associada a gelatinase de neutrofilos (NGAL) e calprotectina no tecido laminar de equinos apos obstrucao jejunal, tratados ou nao com hidrocortisona. Pesquisa Veterinaria Brasileira 32(9):817-823. Departamento de Clinica e Cirurgia Veterinaria, Faculdade de Ciencias Agrarias e Veterinarias, Universidade Estadual Paulista, Prof. Paulo Donato Castellane s/n, Jaboticabal, SP 14884-900, Brazil. E-mail: luciane-laskoski@hotmail.com Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte in filtration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction.329817823Aljada, A., Ganhim, H., Mohanty, P., Hofmeyer, D., Tripathy, D., Dandona, P., Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) (2001) J. Clin. Endocrinol. Metabol., 86 (12), pp. 5988-5991Annane, D., Cavaillon, J.M., Corticosteroids in sepsis: From bench to bedside? (2003) Shock, 20, pp. 197-207Bai, J.W., Deng, W.W., Lin, M.J., Xu, S.M., Zhang, D.X., The effects of vitamin E and dexamethasone on inflammation of acute lung injury and expression of myosin light chain kinase (2009) Chinese J. Tubercul. Resp. Dis., 32 (1), pp. 46-50Bailey, S.R., Menzies-Gow, N.J., Harris, P.A., Habershon-Butcher, J.L., Crawford, C., Berhane, Y., Boston, R.C., Elliott, J., Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis (2007) J. Am. Vet. Med. Assoc., 231 (9), pp. 1365-1373Belknap, J., Moore, J.N., Crouser, E.C., Sepsis: From human organ failure to laminar failure (2009) Vet. Immun. Immunopathol., 129 (3-4), pp. 155-157Belknap, J.K., Black, S.J., Review of the pathophysiology of the developmental stages of equine laminitis. American Association of Equine Pratitioners (2005), http://www.ivis.org/proceedings/aaep/2005/belknap/chapter.asp?LA=1, Disponível em Accessed on Oct. 31, 2008Benkamin, C.F., Atualização sobre mediadores e modelos experimentais de sepse (2001) Medicina, Ribeirão Preto, 34, pp. 18-26Bianco-Blatlles, M.D., Sosunov, A., Polin, R.A., Ten, V.S., Systemic in-flammation following hind-limb ischemia- reperfusion affects brain in neonatal mice (2008) Developmental Neuroscience, 30 (6), pp. 367-373Black, S.J., Lunn, D.P., Yin, C., Hwang, M., Lenz, S.D., Belknap, J.K., Leukocyte emigration in the early stages of laminitis (2006) Vet. Immun. Immunopathol., 109, pp. 161-166Bolignano, D., Basile, G., Parisi, P., Coppolino, G., Nicocia, G., Buemi, M., Increased plasma neutrophil gelatinase-associated lipocalin levels predict mortality in elderly patients with chronic heart failure (2009) Rejuvenation Res., 12 (1), pp. 1-7Borregaard, N., Cowland, J.B., Granules of the human neutrophilic polymorphonuclear leukocyte (1997) Blood, 89, pp. 3503-3521Brasil, L.A., Gomes, W.J., Salomão, R., Fonseca, J.H.P., Branco, J.N.R., Buffolo, E., Uso de corticóide como inibidor da resposta inflamatória sistêmica induzida pela circulação extracorpórea (1999) Revta Bras. Cirur. Cardiovasc., 14 (3), pp. 254-268Bradford, M.M., A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding (1976) Analytical. Biochem., 72, pp. 248-254Bu, D., Hemdahl, A.L., Gabrielsen, A., Fuxe, J., Zhu, C., Eriksson, P., Yan, Z.Q., Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kB (2006) Am. J. Pathol., 169, pp. 2245-2253Campebell, R.C., Peiro, J.R., Rosa, P.C.S., Valadao, C.A.A., Bechara, G.H., Endotoxemia por lipopolissacarídeo de Escherichia coli, em equinos: efeitos de antiinflamatórios nas concentrações sérica e peritonial do fator de necrose tumoral alfa (TNF-α) (2007) Arq. Bras. Med. Vet. Zootec., 59 (4), pp. 837-843Chakrabarti, S., Zee, J.M., Patel, K.D., Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: Novel pathways for tertiary granule release (2006) J. Leukocyte Biology, 79, pp. 214-222Cornelisse, C.J., Robinson, N.E., Berney, C.A., Eberhart, S., Hauptman, J.E., Derksen, F.J., Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse (2006) Equine Vet. J., 38 (2), pp. 119-126De Laat, M.A., Kyaw-Tanner, M.T., Nourian, A.R., McGowan, C.M., Sillence, M.N., Pollitt, C.C., The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activiy (2011) Vet. Immunol.. Immunopathol., 140 (3-4), pp. 275-281Eades, S.C., Holm, A.M.S., Moore, R.M., A Review of the pathophysiology and treatment of acute laminitis: phatophysiologic and therapeutic implications of endothelin-1 (2002) Am. Assoc. Equine Pract., 48, pp. 353-361Faleiros, R.R., Macoris, D.G., Alessi, A.C., Saquetti, C.H., Rasera, L., Effect of intraluminal distention on microvascular perfusion in the equine small colon (2002) Am. J. Vet. Res., 63, pp. 1292-1297Faleiros, R.R., Macoris, D.G., Alves, G.E., Souza, D.G., Teixeira, M.M., Moore, R.M., Local and remote lesions in horses subjected to small colon Distension and decompression (2008) Can. J. Vet. Res., 72 (1), pp. 68-76Faleiros, R.R., Nouvo, G.J., Belknap, J.K., Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extractinduced laminitis (2009) J. Vet. Intern. Med., 23 (1), pp. 174-181Faleiros, R.R., Johnson, P.J., Nuovo, G.J., Messer, N.T., Black, S.J., Belknap, J.K., Laminar leukocyte accumulation in horses with carbohydrate overload induced laminitis (2011) J. Vet. Intern. Med., 25 (1), pp. 107-115Faleiros, R.R., Nuovo, G.J., Flechtner, A.D., Beljnap, J.K., Presence of mononuclear cells in normal and affected laminae from the black walnut extract model of laminitis. Equine Vet. J. 43(1):45-53.Flower D.R. 1996. The lipocalin protein family: structure and function (2011) Biochem. J., 318, pp. 1-14French, R.K., Pollitt, C., Equine laminitis: loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: a ultrastructural study (2004) Equine Vet. J., 36 (3), pp. 230-236Green, J.A., Tran, C.T.H., Farrar, J.J., Nguyen, M.T.H., Nguyen, P.H., Dinh, S.X., Ho, N.D.T., Thwaites, G.E., Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis (2009) PloS ONE, 4 (1), p. 7277Gupta, K., Shukla, M., Cowland, J.B., Malemud, C.J., Haqq, T.M., Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9 (2007) Arthritis and Rheumatism, 56 (10), pp. 3326-3335Han, Y., Tuan, T.L., Wu, H., Hughes, M., Garner, W.L., TNF-a stimulates activation of pro-MMP-2 in human skin through NF-κB mediated induction of MT1-MMP (2001) J. Cell Sci., 114, pp. 131-139Hemdahl, A.L., Gabrielsen, A., Zhu, C., Eriksson, P., Hedin, U., Kastrup, J., Thorén, P., Hansson, G.K., Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction (2006) Arteriosclerosis Thrombosis and Vascular Biology, 26 (1), pp. 136-142Hurley, D.J., Parks, R.J., Reber, A.J., Donovan, D.C., Okinaga, T., Vandenplas, M.L., Peroni, J.F., Moore, J.N., Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract (2006) Vet. Immunol. Immunopathol., 110 (3-4), pp. 195-206Johnson, P.J., Slight, S.H., Ganjam, V.K., Kreeger, J.M., Glucocorticoids and laminitis in the horse (2002) Vet. Clin. North Am., Equine Pract., 18 (2), pp. 219-236Johnson, P.J., Bowles, D.K., Messer, N.T., Dexamethasone alters equine digital artery smooth muscle ion channel activity and contractility: Role in glucocorticoid associated laminitis? (2003) J. Vet. Intern. 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Laskoski L.m. - One of the best experts on this subject based on the ideXlab platform.
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction.329817823Aljada, A., Ganhim, H., Mohanty, P., Hofmeyer, D., Tripathy, D., Dandona, P., Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) (2001) J. Clin. Endocrinol. Metabol., 86 (12), pp. 5988-5991Annane, D., Cavaillon, J.M., Corticosteroids in sepsis: From bench to bedside? (2003) Shock, 20, pp. 197-207Bai, J.W., Deng, W.W., Lin, M.J., Xu, S.M., Zhang, D.X., The effects of vitamin E and dexamethasone on inflammation of acute lung injury and expression of myosin light chain kinase (2009) Chinese J. Tubercul. Resp. Dis., 32 (1), pp. 46-50Bailey, S.R., Menzies-Gow, N.J., Harris, P.A., Habershon-Butcher, J.L., Crawford, C., Berhane, Y., Boston, R.C., Elliott, J., Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis (2007) J. Am. Vet. Med. Assoc., 231 (9), pp. 1365-1373Belknap, J., Moore, J.N., Crouser, E.C., Sepsis: From human organ failure to laminar failure (2009) Vet. Immun. Immunopathol., 129 (3-4), pp. 155-157Belknap, J.K., Black, S.J., Review of the pathophysiology of the developmental stages of equine laminitis. American Association of Equine Pratitioners (2005), http://www.ivis.org/proceedings/aaep/2005/belknap/chapter.asp?LA=1, Disponível em Accessed on Oct. 31, 2008Benkamin, C.F., Atualização sobre mediadores e modelos experimentais de sepse (2001) Medicina, Ribeirão Preto, 34, pp. 18-26Bianco-Blatlles, M.D., Sosunov, A., Polin, R.A., Ten, V.S., Systemic in-flammation following hind-limb ischemia- reperfusion affects brain in neonatal mice (2008) Developmental Neuroscience, 30 (6), pp. 367-373Black, S.J., Lunn, D.P., Yin, C., Hwang, M., Lenz, S.D., Belknap, J.K., Leukocyte emigration in the early stages of laminitis (2006) Vet. Immun. Immunopathol., 109, pp. 161-166Bolignano, D., Basile, G., Parisi, P., Coppolino, G., Nicocia, G., Buemi, M., Increased plasma neutrophil gelatinase-associated lipocalin levels predict mortality in elderly patients with chronic heart failure (2009) Rejuvenation Res., 12 (1), pp. 1-7Borregaard, N., Cowland, J.B., Granules of the human neutrophilic polymorphonuclear leukocyte (1997) Blood, 89, pp. 3503-3521Brasil, L.A., Gomes, W.J., Salomão, R., Fonseca, J.H.P., Branco, J.N.R., Buffolo, E., Uso de corticóide como inibidor da resposta inflamatória sistêmica induzida pela circulação extracorpórea (1999) Revta Bras. Cirur. Cardiovasc., 14 (3), pp. 254-268Bradford, M.M., A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding (1976) Analytical. Biochem., 72, pp. 248-254Bu, D., Hemdahl, A.L., Gabrielsen, A., Fuxe, J., Zhu, C., Eriksson, P., Yan, Z.Q., Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kB (2006) Am. J. Pathol., 169, pp. 2245-2253Campebell, R.C., Peiro, J.R., Rosa, P.C.S., Valadao, C.A.A., Bechara, G.H., Endotoxemia por lipopolissacarídeo de Escherichia coli, em equinos: efeitos de antiinflamatórios nas concentrações sérica e peritonial do fator de necrose tumoral alfa (TNF-α) (2007) Arq. Bras. Med. Vet. Zootec., 59 (4), pp. 837-843Chakrabarti, S., Zee, J.M., Patel, K.D., Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: Novel pathways for tertiary granule release (2006) J. Leukocyte Biology, 79, pp. 214-222Cornelisse, C.J., Robinson, N.E., Berney, C.A., Eberhart, S., Hauptman, J.E., Derksen, F.J., Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse (2006) Equine Vet. J., 38 (2), pp. 119-126De Laat, M.A., Kyaw-Tanner, M.T., Nourian, A.R., McGowan, C.M., Sillence, M.N., Pollitt, C.C., The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activiy (2011) Vet. Immunol.. Immunopathol., 140 (3-4), pp. 275-281Eades, S.C., Holm, A.M.S., Moore, R.M., A Review of the pathophysiology and treatment of acute laminitis: phatophysiologic and therapeutic implications of endothelin-1 (2002) Am. Assoc. Equine Pract., 48, pp. 353-361Faleiros, R.R., Macoris, D.G., Alessi, A.C., Saquetti, C.H., Rasera, L., Effect of intraluminal distention on microvascular perfusion in the equine small colon (2002) Am. J. Vet. Res., 63, pp. 1292-1297Faleiros, R.R., Macoris, D.G., Alves, G.E., Souza, D.G., Teixeira, M.M., Moore, R.M., Local and remote lesions in horses subjected to small colon Distension and decompression (2008) Can. J. Vet. Res., 72 (1), pp. 68-76Faleiros, R.R., Nouvo, G.J., Belknap, J.K., Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extractinduced laminitis (2009) J. Vet. Intern. Med., 23 (1), pp. 174-181Faleiros, R.R., Johnson, P.J., Nuovo, G.J., Messer, N.T., Black, S.J., Belknap, J.K., Laminar leukocyte accumulation in horses with carbohydrate overload induced laminitis (2011) J. Vet. Intern. Med., 25 (1), pp. 107-115Faleiros, R.R., Nuovo, G.J., Flechtner, A.D., Beljnap, J.K., Presence of mononuclear cells in normal and affected laminae from the black walnut extract model of laminitis. Equine Vet. J. 43(1):45-53.Flower D.R. 1996. The lipocalin protein family: structure and function (2011) Biochem. J., 318, pp. 1-14French, R.K., Pollitt, C., Equine laminitis: loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: a ultrastructural study (2004) Equine Vet. J., 36 (3), pp. 230-236Green, J.A., Tran, C.T.H., Farrar, J.J., Nguyen, M.T.H., Nguyen, P.H., Dinh, S.X., Ho, N.D.T., Thwaites, G.E., Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis (2009) PloS ONE, 4 (1), p. 7277Gupta, K., Shukla, M., Cowland, J.B., Malemud, C.J., Haqq, T.M., Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9 (2007) Arthritis and Rheumatism, 56 (10), pp. 3326-3335Han, Y., Tuan, T.L., Wu, H., Hughes, M., Garner, W.L., TNF-a stimulates activation of pro-MMP-2 in human skin through NF-κB mediated induction of MT1-MMP (2001) J. Cell Sci., 114, pp. 131-139Hemdahl, A.L., Gabrielsen, A., Zhu, C., Eriksson, P., Hedin, U., Kastrup, J., Thorén, P., Hansson, G.K., Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction (2006) Arteriosclerosis Thrombosis and Vascular Biology, 26 (1), pp. 136-142Hurley, D.J., Parks, R.J., Reber, A.J., Donovan, D.C., Okinaga, T., Vandenplas, M.L., Peroni, J.F., Moore, J.N., Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract (2006) Vet. Immunol. Immunopathol., 110 (3-4), pp. 195-206Johnson, P.J., Slight, S.H., Ganjam, V.K., Kreeger, J.M., Glucocorticoids and laminitis in the horse (2002) Vet. Clin. North Am., Equine Pract., 18 (2), pp. 219-236Johnson, P.J., Bowles, D.K., Messer, N.T., Dexamethasone alters equine digital artery smooth muscle ion channel activity and contractility: Role in glucocorticoid associated laminitis? (2003) J. Vet. Intern. Med., 17 (3), pp. 457-458Kaufmann, I., Briegel, J., Schliephake, F., Hoelzl, A., Chouker, A., Hummel, T., Schelling, G., Thiel, M., Stress doses of hydrocortisone in septic shock: Beneficial effects on opsonization-dependent neutrophil functions (2008) Intensive Care Medicine, 34 (2), pp. 344-349Kumar, S., Allen, D.A., Kieswich, J.E., Patel, N.S.A., Harwood, S., Mazzon, E., Cuzzocrea, S., Yaqoob, M.A., Dexamethasona ameliorates renal ischemia-reperfusion injury (2009) J. Am. Soc. Nephronol., 20 (11), pp. 2412-2425Laskoski, L.M., Valadão, C.A.A., Vasconcelos, R.O., Pereira, R.N., Dias, A.D.P.U., Alessi, A.C., Alterações morfológicas de tecido laminar do casco e parâmetros clínicos e laboratoriais de equinos com síndrome cólica letal (2009) Pesq. Vet. Bras., 29 (9), pp. 731-735Leise, B.S., Faleiros, R.R., Watts, M., Johnson, P.J., Black, S.J., Belknap, J.K., Laminar Inflammatory gene expression in the carbohydrate overload model of equine laminitis (2011) Equine Vet. J., 43 (1), pp. 54-61Loftus, J.P., Belknap, J.K., Black, S.J., Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance (2006) Vet. Immunol. Immunopathol., 113, pp. 267-276Loftus, J.P., Black, S.J., Pettigrew, A., Abrahansen, E.J., Belknap, J.K., Early laminar events involving endothelial activation in horses with black walnut-induced laminitis (2007) Am. J. Vet. Res., 68 (11), pp. 1205-1211Lorencini, M., Silva, J.A., De La Hoz, C.L., Carvalho, H.F., Stach-Machado, D.R., Changes in MMPs in inflammatory cells in experimental gingivitis (2009) Histology Histopathol., 24 (2), pp. 157-166Maisel, A.S., Mueller, C., Fitzgerald, R., Brikhan, R., Hiestand, B.C., Iqbal, N., Clopton, P., Van Veldhuisen, D.J., Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL evaluation along with B-type natriuretic peptide in acutely decompensated heart failure (GALLANT) trial (2011) Eur. J. Heart Failure, 13 (8), pp. 846-851Mikami, Y., Dobschutz, E.V., Sommer, O., Wellner, U., Unno, M., Hopt, U., Keck, T., Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis (2009) Surgery, 145 (2), pp. 147-156Nielsen, B.S., Borregaard, N., Bundgaard, J.R., Timshel, S., Sehested, M., Kjeldsen, L., Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases (1996) Gut, 38, pp. 414-420Noschka, E., Vandenplas, M.L., Hurley, D.J., Moore, J.N., Temporal aspects of laminar gene expression during the developmental stages of equine laminitis (2009) Vet. Immunol. Immunopathol., 129 (3-4), pp. 242-253Parsons, C.S., Orsini, J.A., Krafty, R., Capewell, L., Boston, R., Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997-2004) (2007) J. Am. Vet. Med. Assoc., 230 (6), pp. 885-889Pollitt, C.C., The basement membrane at the equine hoof dermal epidermal junction (1994) Equine Vet. J., 26 (5), pp. 399-407Pollitt, C.C., Basement membrane pathology: a feature of acute equine laminitis (1996) Equine Vet. J., 28 (1), pp. 38-46Pollitt, C.C., Daradka, M., Equine laminitis basement membrane pathology: loss of type IV collagen, type VII collagen and laminin immunostaining (1998) Equine Vet. J., 26 (SUPPL.), pp. 139-144Pollitt, C.C., Equine laminitis: A revised pathophysiology (1999) Am. Assoc. Equine Pract. Proc., 45, pp. 188-192Pollitt, C.C., Pathophysiology of laminitis (2003) Diagnosis and Management of Lameness in the Horse, pp. 325-329. , Dyson S.J. & Ross M.W. (Eds), W.B. Saunders, PhiladelphiaRiggs, L.M., Franck, T., Moore, J.N., Krunkosky, T.M., Hurley, D.J., Peroni, J.F., De La Rebiere, G., Serteyn, D.A., Neutrophil myeloperoxidase measurements in plasma, laminar tissue, and skin of horses given black walnut extract (2007) Am. J. Vet. Res., 68, pp. 81-86Rio Tinto, J.J.M., Alves, G.E.S., Faleiros, R.R., Santos, R.L., Marques Júnior, A.P., Melo, E.G., Utilização de hidrocortisona em equinos submetidos a isquemia e reperfusão no jejuno e suas conseqüências sob o cório laminar (2004) Arq. Bras. Med. Vet. Zootec., 56 (3), pp. 292-299Ryu, S., Kim, B., Lee, C., Yoon, J., Lee, Y., Glucocorticoide-induced laminitis with hepatopathy in a thoroughbred filly (2004) J. Vet. Sci., 5 (3), pp. 271-274Shapiro, N.I., Trzeciak, S., Hollander, J.E., Birkhahn, R., Otero, R., Osborn, T.M., Moretti, E., Rivers, E.P., A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis (2009) Critical Care Medicine, 37 (1), pp. 96-104Smith, E.R., Zurakowski, D., Saad, A., Scott, R.M., Moses, M.A., Urinary biomarkers predict brain tumor presence and response to therapy (2008) Clin. 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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction.329817823Aljada, A., Ganhim, H., Mohanty, P., Hofmeyer, D., Tripathy, D., Dandona, P., Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) (2001) J. Clin. Endocrinol. 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J., 318, pp. 1-14French, R.K., Pollitt, C., Equine laminitis: loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: a ultrastructural study (2004) Equine Vet. J., 36 (3), pp. 230-236Green, J.A., Tran, C.T.H., Farrar, J.J., Nguyen, M.T.H., Nguyen, P.H., Dinh, S.X., Ho, N.D.T., Thwaites, G.E., Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis (2009) PloS ONE, 4 (1), p. 7277Gupta, K., Shukla, M., Cowland, J.B., Malemud, C.J., Haqq, T.M., Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9 (2007) Arthritis and Rheumatism, 56 (10), pp. 3326-3335Han, Y., Tuan, T.L., Wu, H., Hughes, M., Garner, W.L., TNF-a stimulates activation of pro-MMP-2 in human skin through NF-κB mediated induction of MT1-MMP (2001) J. Cell Sci., 114, pp. 131-139Hemdahl, A.L., Gabrielsen, A., Zhu, C., Eriksson, P., Hedin, U., Kastrup, J., Thorén, P., Hansson, G.K., Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction (2006) Arteriosclerosis Thrombosis and Vascular Biology, 26 (1), pp. 136-142Hurley, D.J., Parks, R.J., Reber, A.J., Donovan, D.C., Okinaga, T., Vandenplas, M.L., Peroni, J.F., Moore, J.N., Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract (2006) Vet. Immunol. Immunopathol., 110 (3-4), pp. 195-206Johnson, P.J., Slight, S.H., Ganjam, V.K., Kreeger, J.M., Glucocorticoids and laminitis in the horse (2002) Vet. Clin. North Am., Equine Pract., 18 (2), pp. 219-236Johnson, P.J., Bowles, D.K., Messer, N.T., Dexamethasone alters equine digital artery smooth muscle ion channel activity and contractility: Role in glucocorticoid associated laminitis? (2003) J. Vet. Intern. Med., 17 (3), pp. 457-458Kaufmann, I., Briegel, J., Schliephake, F., Hoelzl, A., Chouker, A., Hummel, T., Schelling, G., Thiel, M., Stress doses of hydrocortisone in septic shock: Beneficial effects on opsonization-dependent neutrophil functions (2008) Intensive Care Medicine, 34 (2), pp. 344-349Kumar, S., Allen, D.A., Kieswich, J.E., Patel, N.S.A., Harwood, S., Mazzon, E., Cuzzocrea, S., Yaqoob, M.A., Dexamethasona ameliorates renal ischemia-reperfusion injury (2009) J. Am. Soc. Nephronol., 20 (11), pp. 2412-2425Laskoski, L.M., Valadão, C.A.A., Vasconcelos, R.O., Pereira, R.N., Dias, A.D.P.U., Alessi, A.C., Alterações morfológicas de tecido laminar do casco e parâmetros clínicos e laboratoriais de equinos com síndrome cólica letal (2009) Pesq. Vet. Bras., 29 (9), pp. 731-735Leise, B.S., Faleiros, R.R., Watts, M., Johnson, P.J., Black, S.J., Belknap, J.K., Laminar Inflammatory gene expression in the carbohydrate overload model of equine laminitis (2011) Equine Vet. J., 43 (1), pp. 54-61Loftus, J.P., Belknap, J.K., Black, S.J., Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance (2006) Vet. Immunol. Immunopathol., 113, pp. 267-276Loftus, J.P., Black, S.J., Pettigrew, A., Abrahansen, E.J., Belknap, J.K., Early laminar events involving endothelial activation in horses with black walnut-induced laminitis (2007) Am. J. Vet. Res., 68 (11), pp. 1205-1211Lorencini, M., Silva, J.A., De La Hoz, C.L., Carvalho, H.F., Stach-Machado, D.R., Changes in MMPs in inflammatory cells in experimental gingivitis (2009) Histology Histopathol., 24 (2), pp. 157-166Maisel, A.S., Mueller, C., Fitzgerald, R., Brikhan, R., Hiestand, B.C., Iqbal, N., Clopton, P., Van Veldhuisen, D.J., Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL evaluation along with B-type natriuretic peptide in acutely decompensated heart failure (GALLANT) trial (2011) Eur. J. Heart Failure, 13 (8), pp. 846-851Mikami, Y., Dobschutz, E.V., Sommer, O., Wellner, U., Unno, M., Hopt, U., Keck, T., Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis (2009) Surgery, 145 (2), pp. 147-156Nielsen, B.S., Borregaard, N., Bundgaard, J.R., Timshel, S., Sehested, M., Kjeldsen, L., Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases (1996) Gut, 38, pp. 414-420Noschka, E., Vandenplas, M.L., Hurley, D.J., Moore, J.N., Temporal aspects of laminar gene expression during the developmental stages of equine laminitis (2009) Vet. Immunol. Immunopathol., 129 (3-4), pp. 242-253Parsons, C.S., Orsini, J.A., Krafty, R., Capewell, L., Boston, R., Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997-2004) (2007) J. Am. Vet. Med. Assoc., 230 (6), pp. 885-889Pollitt, C.C., The basement membrane at the equine hoof dermal epidermal junction (1994) Equine Vet. J., 26 (5), pp. 399-407Pollitt, C.C., Basement membrane pathology: a feature of acute equine laminitis (1996) Equine Vet. J., 28 (1), pp. 38-46Pollitt, C.C., Daradka, M., Equine laminitis basement membrane pathology: loss of type IV collagen, type VII collagen and laminin immunostaining (1998) Equine Vet. J., 26 (SUPPL.), pp. 139-144Pollitt, C.C., Equine laminitis: A revised pathophysiology (1999) Am. Assoc. Equine Pract. Proc., 45, pp. 188-192Pollitt, C.C., Pathophysiology of laminitis (2003) Diagnosis and Management of Lameness in the Horse, pp. 325-329. , Dyson S.J. & Ross M.W. (Eds), W.B. Saunders, PhiladelphiaRiggs, L.M., Franck, T., Moore, J.N., Krunkosky, T.M., Hurley, D.J., Peroni, J.F., De La Rebiere, G., Serteyn, D.A., Neutrophil myeloperoxidase measurements in plasma, laminar tissue, and skin of horses given black walnut extract (2007) Am. J. Vet. Res., 68, pp. 81-86Rio Tinto, J.J.M., Alves, G.E.S., Faleiros, R.R., Santos, R.L., Marques Júnior, A.P., Melo, E.G., Utilização de hidrocortisona em equinos submetidos a isquemia e reperfusão no jejuno e suas conseqüências sob o cório laminar (2004) Arq. Bras. Med. Vet. Zootec., 56 (3), pp. 292-299Ryu, S., Kim, B., Lee, C., Yoon, J., Lee, Y., Glucocorticoide-induced laminitis with hepatopathy in a thoroughbred filly (2004) J. Vet. Sci., 5 (3), pp. 271-274Shapiro, N.I., Trzeciak, S., Hollander, J.E., Birkhahn, R., Otero, R., Osborn, T.M., Moretti, E., Rivers, E.P., A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis (2009) Critical Care Medicine, 37 (1), pp. 96-104Smith, E.R., Zurakowski, D., Saad, A., Scott, R.M., Moses, M.A., Urinary biomarkers predict brain tumor presence and response to therapy (2008) Clin. Cancer Res., 14 (8), pp. 2378-2386Stetler-Stevenson, W.G., Type IV collagenases in tumor invasion and metastasis (1990) Cancer and Metastasis Reviews, 9 (4), pp. 289-303Suagee, J.K., Corl, B.A., Crisman, M.V., Hulver, M.W., McCutcheon, L.J., Geor, R.J., Effects of acute hyperinsulinemia on inflammatory proteins in Horses (2011) Vet. Immunol. Immunopathol., 142 (3-4), pp. 141-146Sun, W., Watanabe, Y., Toki, A., Wang, Z.Q., Beneficial Effects of hydrocortisone in induced acute pancreatitis of rats (2007) Chinese Med. J., 120 (20), pp. 1757-1761Tiley, H.A., Geor, R.J., McCutcheon, L.J., Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses (2007) Am. J. Vet. Res., 68 (7), pp. 753-759Venugopal, C.S., Eades, S., Holmes, E.P., Beadle, R.E., Insulin resistance in equine digital vessel rings: An in vitro model to study vascular dysfunction in equine laminitis (2011) Equine Vet. J., 43 (6), pp. 744-749Visser, M.B., Pollitt, C.C., Lamellar leukocyte infiltration and involvement of IL-6 during oligofrutose-induced equine laminitis development (2011) Vet. Immunol. Immunopathol., , doi:10.1016/j.vetimm.2011.07.016Visser, M.B., Pollitt, C.C., The timeline of metalloprotease eventis during Olifructose induced equine laminitis development (2011) Equine Vet. J., , doi:10.1111/j.2042-3306.2011.00393.xVisser, M.B., Pollitt, C.C., Immunohistochemical distribution of laminin-332 and collagen Type IV in the basement membrane of normal horses and horses with induced laminitis (2011) J. Comp.Pathol., 145 (1), pp. 80-87Yazar, E., Bulbul, A., Avci, G.E., Er, A., Uney, K., Elmas, M., Tras, B., Effects of enrofloxacin, flunixim meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats (2010) Acta Vet. Hungarica, 58 (3), pp. 357-367Zabron, A.A., Sluis, V.M.H.-V., Wadsworth, C.A., Laird, F., Gierula, M., Thillainayagam, A.V., Vlavianos, P., Khan, S.A., Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease (2011) Am. J. Gastroenterol., 106, pp. 1711-171
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction
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Neutrophil Gelatinase Associated Lipocalin (ngal) And Calprotectin In Equine Laminar Tissue After Jejunal Obstruction, Treated Or Not With Hidrocortisone [lipocalina Associada à Gelatinase De Neutrófilos (ngal) Ecalprotectina No Tecido Laminar De Equinos Após Obstrução Jejunal, Tratados Ou Não Com Hidrocortisona]
2015Co-Authors: Laskoski L.m., Valadao C.a.a., Vasconcelos R.o., Faleiros R.r., Mendes H.m.f., Ferrucci D., Silva J.a.f., Machado D.d.r.s.Abstract:Laminitis is a severe hoof condition in horses that may cause intense suffering. In this study, leukocyte infiltration in hoof laminar tissue was investigated in horses subject to intestinal obstruction using immunohistochemistry to detect calprotectin, and zymography to detect neutrophil gelatinase associated lipocalin (NGAL). There were four groups: the Control Group (Gc), with seven horses, without surgical procedures; the Sham-operated Group (Gi), with five horses that were subjected to surgical procedure without intestinal obstruction; the No Treat group (Gnt), with four horses subjected to intestinal obstruction (jejunal distention using an intraluminal balloon) without treatment; and Treated group (Gt), with four horses subjected to intestinal obstruction and treated with hydrocortisone. Positive calprotectin imunostaining was detected in all experimental groups, with increase cell counts in horses of the distended group compared with the control group. NGAL expression was increased in Gd compared with Gc e Gi. The Gt did not differ from the others. In conclusion, small Intestine Distension can promote leukocyte infiltration in equine hoof laminar tissue, and NGAL zymography was considered a useful method for leukocyte tissue detection in horses. New studies will be conducted to verify the possible beneficial anti-inflammatory effects of hydrocortisone in hoof of horses with intestinal obstruction.329817823Aljada, A., Ganhim, H., Mohanty, P., Hofmeyer, D., Tripathy, D., Dandona, P., Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) (2001) J. Clin. Endocrinol. 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Res., 68, pp. 81-86Rio Tinto, J.J.M., Alves, G.E.S., Faleiros, R.R., Santos, R.L., Marques Júnior, A.P., Melo, E.G., Utilização de hidrocortisona em equinos submetidos a isquemia e reperfusão no jejuno e suas conseqüências sob o cório laminar (2004) Arq. Bras. Med. Vet. Zootec., 56 (3), pp. 292-299Ryu, S., Kim, B., Lee, C., Yoon, J., Lee, Y., Glucocorticoide-induced laminitis with hepatopathy in a thoroughbred filly (2004) J. Vet. Sci., 5 (3), pp. 271-274Shapiro, N.I., Trzeciak, S., Hollander, J.E., Birkhahn, R., Otero, R., Osborn, T.M., Moretti, E., Rivers, E.P., A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis (2009) Critical Care Medicine, 37 (1), pp. 96-104Smith, E.R., Zurakowski, D., Saad, A., Scott, R.M., Moses, M.A., Urinary biomarkers predict brain tumor presence and response to therapy (2008) Clin. Cancer Res., 14 (8), pp. 2378-2386Stetler-Stevenson, W.G., Type IV collagenases in tumor invasion and metastasis (1990) Cancer and Metastasis Reviews, 9 (4), pp. 289-303Suagee, J.K., Corl, B.A., Crisman, M.V., Hulver, M.W., McCutcheon, L.J., Geor, R.J., Effects of acute hyperinsulinemia on inflammatory proteins in Horses (2011) Vet. Immunol. Immunopathol., 142 (3-4), pp. 141-146Sun, W., Watanabe, Y., Toki, A., Wang, Z.Q., Beneficial Effects of hydrocortisone in induced acute pancreatitis of rats (2007) Chinese Med. J., 120 (20), pp. 1757-1761Tiley, H.A., Geor, R.J., McCutcheon, L.J., Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses (2007) Am. J. Vet. Res., 68 (7), pp. 753-759Venugopal, C.S., Eades, S., Holmes, E.P., Beadle, R.E., Insulin resistance in equine digital vessel rings: An in vitro model to study vascular dysfunction in equine laminitis (2011) Equine Vet. J., 43 (6), pp. 744-749Visser, M.B., Pollitt, C.C., Lamellar leukocyte infiltration and involvement of IL-6 during oligofrutose-induced equine laminitis development (2011) Vet. Immunol. Immunopathol., , doi:10.1016/j.vetimm.2011.07.016Visser, M.B., Pollitt, C.C., The timeline of metalloprotease eventis during Olifructose induced equine laminitis development (2011) Equine Vet. J., , doi:10.1111/j.2042-3306.2011.00393.xVisser, M.B., Pollitt, C.C., Immunohistochemical distribution of laminin-332 and collagen Type IV in the basement membrane of normal horses and horses with induced laminitis (2011) J. Comp.Pathol., 145 (1), pp. 80-87Yazar, E., Bulbul, A., Avci, G.E., Er, A., Uney, K., Elmas, M., Tras, B., Effects of enrofloxacin, flunixim meglumine and dexamethasone on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activity in endotoxaemia in rats (2010) Acta Vet. Hungarica, 58 (3), pp. 357-367Zabron, A.A., Sluis, V.M.H.-V., Wadsworth, C.A., Laird, F., Gierula, M., Thillainayagam, A.V., Vlavianos, P., Khan, S.A., Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease (2011) Am. J. Gastroenterol., 106, pp. 1711-171
