The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
John C Magee - One of the best experts on this subject based on the ideXlab platform.
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Intestine transplantation in the united states 1999 2008
American Journal of Transplantation, 2010Co-Authors: George V Mazariegos, Simon Horslen, Jonathan P. Fryer, David R. Grant, D E Steffick, Douglas G. Farmer, Alan Norman Langnas, John C MageeAbstract:Note on sources: The articles in this report are based on the reference tables in the 2009 OPTN/SRTR Annual Report, which are not included in this publication. Many relevant data appear in the figures and tables included here. All of the tables may be found online at: http://www.ustransplant.org. Improving short-term results with Intestine transplantation have allowed more patients to benefit with nearly 700 patients alive in the United States with a functioning alloGraft at the end of 2007. This success has led to an increase in demand. Time to transplant and waiting list mortality have significantly improved over the decade, but mortality remains high, especially for infants and adults with concomitant liver failure. The approximately 200 Intestines recovered annually from deceased donors represent less than 3% of donors who have at least one organ recovered. Consent practice varies widely by OPTN region. Opportunities for improving Intestine recovery and utilization include improving consent rates and standardizing donor selection criteria. One-year patient and Intestine Graft survival is 89% and 79% for Intestineonly recipients and 72% and 69% for liver-Intestine recipients, respectively. By 10 years, patient and Intestine survival falls to 46% and 29% for Intestine-only recipients, and 42% and 39% for liver-Intestine, respectively. Immunosuppression practice employs peri-operative antibody induction therapy in 60% of cases; acute rejection is reported in 30%–40% of recipients at one year. Data on long-term nutritional outcomes and morbidities are limited, while the cause and therapy for late Graft loss from chronic rejection are areas of ongoing investigation.
Lynt B Johnson - One of the best experts on this subject based on the ideXlab platform.
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utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation
Transplantation, 2008Co-Authors: C Matsumoto, Stuart S Kaufman, Raffaele Girlanda, Cheryl M Little, Yuliya Rekhtman, Vandad Raofi, Jaqueline M Laurin, Kirti Shetty, Erin M Fennelly, Lynt B JohnsonAbstract:Background. Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal ischemia. Outcomes of recipients who receive Intestine Grafts that have suffered CPR are unknown. We sought to analyze our clinical experience in using intestinal Grafts from donors who suffered cardiopulmonary arrest and resuscitation and to evaluate the outcome of recipients of organs coming from resuscitated donors when compared with recipients of nonresuscitated donors. Methods. We retrospectively analyzed the donor and recipient charts of all of our intestinal transplants with regard to the performance of donor CPR. Results. Sixty-seven intestinal transplants were performed in 65 patients from November 2003 to December 2007. Twelve donors (18%) were identified as having suffered cardiac arrest and subsequent CPR. Mean duration of CPR was 19.3± 12.7 min. Terminal laboratory profiles of CPR donors and non-CPR donors were similar. Of the 12 resuscitated Grafts, two were used for multivisceral, one for a modified multivisceral, seven for liver-Intestine, and two for isolated intestinal transplant. There were no significant differences in outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival between the 12 resuscitated Grafts and the 55 nonresuscitated Grafts. Conclusion. A donor history of cardiac arrest should not automatically exclude the use of the Intestine Graft for transplantation.
George V Mazariegos - One of the best experts on this subject based on the ideXlab platform.
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Intestine transplantation in the united states 1999 2008
American Journal of Transplantation, 2010Co-Authors: George V Mazariegos, Simon Horslen, Jonathan P. Fryer, David R. Grant, D E Steffick, Douglas G. Farmer, Alan Norman Langnas, John C MageeAbstract:Note on sources: The articles in this report are based on the reference tables in the 2009 OPTN/SRTR Annual Report, which are not included in this publication. Many relevant data appear in the figures and tables included here. All of the tables may be found online at: http://www.ustransplant.org. Improving short-term results with Intestine transplantation have allowed more patients to benefit with nearly 700 patients alive in the United States with a functioning alloGraft at the end of 2007. This success has led to an increase in demand. Time to transplant and waiting list mortality have significantly improved over the decade, but mortality remains high, especially for infants and adults with concomitant liver failure. The approximately 200 Intestines recovered annually from deceased donors represent less than 3% of donors who have at least one organ recovered. Consent practice varies widely by OPTN region. Opportunities for improving Intestine recovery and utilization include improving consent rates and standardizing donor selection criteria. One-year patient and Intestine Graft survival is 89% and 79% for Intestineonly recipients and 72% and 69% for liver-Intestine recipients, respectively. By 10 years, patient and Intestine survival falls to 46% and 29% for Intestine-only recipients, and 42% and 39% for liver-Intestine, respectively. Immunosuppression practice employs peri-operative antibody induction therapy in 60% of cases; acute rejection is reported in 30%–40% of recipients at one year. Data on long-term nutritional outcomes and morbidities are limited, while the cause and therapy for late Graft loss from chronic rejection are areas of ongoing investigation.
Yan Chaoqi - One of the best experts on this subject based on the ideXlab platform.
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perfusion and preservation of isolated piglets small Intestine Graft for transplantation
Chinese Journal of Comparative Medicine, 2008Co-Authors: Yan ChaoqiAbstract:Objective To investigate the perfusion and preservation of small Intestine Graft during perioperation period in piglets small intestinal transplantation.Methods The Graft was treated with a continuous intra-arterial 3% hydroxyethyl starch solution perfusion.The perfusion was carried out at a height of 100 cm and flow rate of 15 mL/min.The Intestine Graft was preserved in 0.9% normal saline at 4℃.The Intestine Graft was assessed by histology before transplantation.Results The perfusion and cold ischemia time lasted 50.5±10.6 min and 80.24±24.62 min,respectively.No change was observed in the small Intestine Graft before transplantation.The transplanted small Intestine survived well.Conclusion The above described measures can well maintain the structure and function of the small Intestine Graft in short time and satisfy the demand of small Intestine transplantation.
Zou Xiao - One of the best experts on this subject based on the ideXlab platform.
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the minimal length of Intestine Graft for normal physical needs of the rats
Chinese Journal of Gastrointestinal Surgery, 2004Co-Authors: Zou XiaoAbstract:Objective To determine the minimal length of Intestine Graft that can maintain the normal physical needs of rats. Method Forty two Wistar rats were divided into two groups randomly,intestinal resection groups and isogeneic orthotopic intestinal transplantation groups. 80%(groupⅠ), 70%(groupⅡ), 60%(groupⅢ) of distal small bowel and cecum respectively were resected in resection groups. The recipients received 20%(groupⅣ), 30%(groupⅤ), 40%(groupⅥ) of proximal Intestine respectively after resecting the total small bowel and cecum in transplantation groups. The body weight, serum total protein(Tp), albumin(Alb), triglyceride(Tg) and cholesterol(T ch) were monitored. Moltose absorption test was performed regularly. Results All the rats in groupⅠand Ⅳdied from malnutrition on (14.8±1.3) and (9.2±1.6)d respectively. 66.7%(4/6) of the rats in groupⅡ, all in groupⅢ, 33.3%(2/6) in groupⅤand 66.7%(4/6) in groupⅥsurvived over 30 days. At the 30th day after the operation, the body weight, Tp, Alb, Tg and T ch values were significantly higher in groupⅡand Ⅴthan those in groupⅢand Ⅵ. Conclusions 30%of proximal Intestine is the minimal length of Graft to maintain the physical needs after resecting the total small bowel and cecum in rats.
