Intestine Mucosa

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Krzysztof Chomiczewski - One of the best experts on this subject based on the ideXlab platform.

  • The effect of exercise associated with acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-Xyplose in rats
    Archives of Environmental Contamination and Toxicology, 1991
    Co-Authors: I Grudziński, A Szymański, Krzysztof Chomiczewski
    Abstract:

    The intestinal absorption of D-xylose was studied during acute poisoning of male Wistar rats receiving intragastrically potassium nitrate and sodium nitrite and small Intestine perfusion with these compounds. The metabolic parameters, Na^+/K^+-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level, were assessed in the small Intestine Mucosa one hour after administration of these compounds. Exercise was demonstrated to reduce the intestinal absorption of D-xylose, to raise the level of lactic acid, and to increase the oxygen uptake by the small Intestine Mucosa, but caused no changes in the activity of Na^+/K^+-ATPase or alkaline phosphatase. Also, exercise failed to change the direction of the toxic effects of sodium nitrite but increased potassium nitrate toxicity as evidenced by reduced absorption of D-xylose from the Intestine despite lack of changes of the enzymes Na^+/K^+-ATPase and alkaline phosphatase in the Mucosa.

I Grudziński - One of the best experts on this subject based on the ideXlab platform.

  • The effect of exercise associated with acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-Xyplose in rats
    Archives of Environmental Contamination and Toxicology, 1991
    Co-Authors: I Grudziński, A Szymański, Krzysztof Chomiczewski
    Abstract:

    The intestinal absorption of D-xylose was studied during acute poisoning of male Wistar rats receiving intragastrically potassium nitrate and sodium nitrite and small Intestine perfusion with these compounds. The metabolic parameters, Na^+/K^+-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level, were assessed in the small Intestine Mucosa one hour after administration of these compounds. Exercise was demonstrated to reduce the intestinal absorption of D-xylose, to raise the level of lactic acid, and to increase the oxygen uptake by the small Intestine Mucosa, but caused no changes in the activity of Na^+/K^+-ATPase or alkaline phosphatase. Also, exercise failed to change the direction of the toxic effects of sodium nitrite but increased potassium nitrate toxicity as evidenced by reduced absorption of D-xylose from the Intestine despite lack of changes of the enzymes Na^+/K^+-ATPase and alkaline phosphatase in the Mucosa.

  • The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
    Archives of Environmental Contamination and Toxicology, 1991
    Co-Authors: I Grudziński, A Szymański
    Abstract:

    The intestinal transport of D-xylose was studied during subchronic poisoning of male Wistar rats with the oral administration of potassium nitrate and sodium nitrite. The metabolic parameters of small Intestine Mucosa were determined one hour after xylose administration,i.e., Na+/K+ -ATPase, alkaline phosphatase, oxygen consumption, and lactic acid level. Nitrite reduced the absorption of xylose and decreased the activity of Na+/K+ -ATPase and alkaline phosphatase. No effect of sodium nitrite was demonstrated on the aerobic metabolism of intestinal Mucosa with an increased lactic acid level. Potassium nitrate did not effect the processes of intestinal absorption of xylose nor the metabolic parameters of small Intestine Mucosa.

  • The effect of acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
    Archives of environmental contamination and toxicology, 1991
    Co-Authors: I Grudziński, A Szymański
    Abstract:

    The intestinal transport of D-xylose was studied during the acute poisoning of male Wistar rats with orally administered potassium nitrate and sodium nitrite. At the peak of xylose absorption, the metabolic parameters of Na+/K(+)-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level were determined in the small Intestine Mucosa. Nitrite in a dose of 80 mg NaNO2/kg b.w. increased the permeability of gastric Mucosa for D-xylose and raised the uptake of oxygen by the small Intestine Mucosa. No changes were observed in the activity of Na+/K(+)-ATPase and alkaline phosphatase. A dose of 10 mg NaNO2/kg b.w. was not followed by increased absorption of this sugar. It was also demonstrated that potassium nitrate had no effect on the process of intestinal absorption of D-xylose and failed to change the determined metabolic parameters of the small Intestine Mucosa.

A Szymański - One of the best experts on this subject based on the ideXlab platform.

  • The effect of exercise associated with acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-Xyplose in rats
    Archives of Environmental Contamination and Toxicology, 1991
    Co-Authors: I Grudziński, A Szymański, Krzysztof Chomiczewski
    Abstract:

    The intestinal absorption of D-xylose was studied during acute poisoning of male Wistar rats receiving intragastrically potassium nitrate and sodium nitrite and small Intestine perfusion with these compounds. The metabolic parameters, Na^+/K^+-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level, were assessed in the small Intestine Mucosa one hour after administration of these compounds. Exercise was demonstrated to reduce the intestinal absorption of D-xylose, to raise the level of lactic acid, and to increase the oxygen uptake by the small Intestine Mucosa, but caused no changes in the activity of Na^+/K^+-ATPase or alkaline phosphatase. Also, exercise failed to change the direction of the toxic effects of sodium nitrite but increased potassium nitrate toxicity as evidenced by reduced absorption of D-xylose from the Intestine despite lack of changes of the enzymes Na^+/K^+-ATPase and alkaline phosphatase in the Mucosa.

  • The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
    Archives of Environmental Contamination and Toxicology, 1991
    Co-Authors: I Grudziński, A Szymański
    Abstract:

    The intestinal transport of D-xylose was studied during subchronic poisoning of male Wistar rats with the oral administration of potassium nitrate and sodium nitrite. The metabolic parameters of small Intestine Mucosa were determined one hour after xylose administration,i.e., Na+/K+ -ATPase, alkaline phosphatase, oxygen consumption, and lactic acid level. Nitrite reduced the absorption of xylose and decreased the activity of Na+/K+ -ATPase and alkaline phosphatase. No effect of sodium nitrite was demonstrated on the aerobic metabolism of intestinal Mucosa with an increased lactic acid level. Potassium nitrate did not effect the processes of intestinal absorption of xylose nor the metabolic parameters of small Intestine Mucosa.

  • The effect of acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
    Archives of environmental contamination and toxicology, 1991
    Co-Authors: I Grudziński, A Szymański
    Abstract:

    The intestinal transport of D-xylose was studied during the acute poisoning of male Wistar rats with orally administered potassium nitrate and sodium nitrite. At the peak of xylose absorption, the metabolic parameters of Na+/K(+)-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level were determined in the small Intestine Mucosa. Nitrite in a dose of 80 mg NaNO2/kg b.w. increased the permeability of gastric Mucosa for D-xylose and raised the uptake of oxygen by the small Intestine Mucosa. No changes were observed in the activity of Na+/K(+)-ATPase and alkaline phosphatase. A dose of 10 mg NaNO2/kg b.w. was not followed by increased absorption of this sugar. It was also demonstrated that potassium nitrate had no effect on the process of intestinal absorption of D-xylose and failed to change the determined metabolic parameters of the small Intestine Mucosa.

K Singh - One of the best experts on this subject based on the ideXlab platform.

  • functional and morphological alterations in small Intestine Mucosa of chronic alcoholics
    Journal of Gastroenterology and Hepatology, 2008
    Co-Authors: Sonia Bhonchal, Chander K Nain, Kaushal K Prasad, Ritambhara Nada, Saroj K Sinha, Arun Sharma, K Singh
    Abstract:

    Background and Aim:  Alcohol-related diseases constitute the third largest health problem after heart disease and cancer in the world. The objective was to study the effects of chronic alcohol intake on small bowel cellular functions with focus on brush border enzymes, membrane enzymes, cellular enzymes and their relationship with structural changes in small bowel Mucosa of chronic alcoholics. Methods:  Duodenal biopsies were obtained by upper gastrointestinal endoscopy of chronic alcoholics having alcoholic liver disease (ALD) with and without cirrhosis. The biopsies were then processed for enzymatic assays to analyze the status of cellular functions. Light microscopy, transmission electron microscopy, and scanning electron microscopy were done to study the morphological alterations. Control group consisted of nonalcoholic gastroesophageal reflux disease patients reporting for routine endoscopy. Results:  The experimental group consisted of ALD patients which showed significant difference (P < 0.01) in cellular functions when compared with controls. The light microscopy showed partial villous atrophy, increase in lamina propria infiltrate, and intraepithelial lymphocytes as main findings in the alcoholic group. Ultrastructural evaluation revealed changes like widened intercellular junction, distorted microvilli, increased rough endoplasmic reticulum, and increased and dilated mitochondria. The enzyme parameters correlated positively with the Mucosal morphology parameters indicating a direct relationship. Conclusion:  The study brought out the changes in small bowel of chronic alcoholics having ALD at both cellular and subcellular levels which correlated significantly.

  • Functional and morphological alterations in small Intestine Mucosa of chronic alcoholics
    Journal of Gastroenterology and Hepatology, 2007
    Co-Authors: Sonia Bhonchal, Chander K Nain, Kaushal K Prasad, Ritambhara Nada, Saroj K Sinha, Arun Sharma, K Singh
    Abstract:

    Background and Aim:  Alcohol-related diseases constitute the third largest health problem after heart disease and cancer in the world. The objective was to study the effects of chronic alcohol intake on small bowel cellular functions with focus on brush border enzymes, membrane enzymes, cellular enzymes and their relationship with structural changes in small bowel Mucosa of chronic alcoholics. Methods:  Duodenal biopsies were obtained by upper gastrointestinal endoscopy of chronic alcoholics having alcoholic liver disease (ALD) with and without cirrhosis. The biopsies were then processed for enzymatic assays to analyze the status of cellular functions. Light microscopy, transmission electron microscopy, and scanning electron microscopy were done to study the morphological alterations. Control group consisted of nonalcoholic gastroesophageal reflux disease patients reporting for routine endoscopy. Results:  The experimental group consisted of ALD patients which showed significant difference (P 

Sonia Bhonchal - One of the best experts on this subject based on the ideXlab platform.

  • functional and morphological alterations in small Intestine Mucosa of chronic alcoholics
    Journal of Gastroenterology and Hepatology, 2008
    Co-Authors: Sonia Bhonchal, Chander K Nain, Kaushal K Prasad, Ritambhara Nada, Saroj K Sinha, Arun Sharma, K Singh
    Abstract:

    Background and Aim:  Alcohol-related diseases constitute the third largest health problem after heart disease and cancer in the world. The objective was to study the effects of chronic alcohol intake on small bowel cellular functions with focus on brush border enzymes, membrane enzymes, cellular enzymes and their relationship with structural changes in small bowel Mucosa of chronic alcoholics. Methods:  Duodenal biopsies were obtained by upper gastrointestinal endoscopy of chronic alcoholics having alcoholic liver disease (ALD) with and without cirrhosis. The biopsies were then processed for enzymatic assays to analyze the status of cellular functions. Light microscopy, transmission electron microscopy, and scanning electron microscopy were done to study the morphological alterations. Control group consisted of nonalcoholic gastroesophageal reflux disease patients reporting for routine endoscopy. Results:  The experimental group consisted of ALD patients which showed significant difference (P < 0.01) in cellular functions when compared with controls. The light microscopy showed partial villous atrophy, increase in lamina propria infiltrate, and intraepithelial lymphocytes as main findings in the alcoholic group. Ultrastructural evaluation revealed changes like widened intercellular junction, distorted microvilli, increased rough endoplasmic reticulum, and increased and dilated mitochondria. The enzyme parameters correlated positively with the Mucosal morphology parameters indicating a direct relationship. Conclusion:  The study brought out the changes in small bowel of chronic alcoholics having ALD at both cellular and subcellular levels which correlated significantly.

  • Functional and morphological alterations in small Intestine Mucosa of chronic alcoholics
    Journal of Gastroenterology and Hepatology, 2007
    Co-Authors: Sonia Bhonchal, Chander K Nain, Kaushal K Prasad, Ritambhara Nada, Saroj K Sinha, Arun Sharma, K Singh
    Abstract:

    Background and Aim:  Alcohol-related diseases constitute the third largest health problem after heart disease and cancer in the world. The objective was to study the effects of chronic alcohol intake on small bowel cellular functions with focus on brush border enzymes, membrane enzymes, cellular enzymes and their relationship with structural changes in small bowel Mucosa of chronic alcoholics. Methods:  Duodenal biopsies were obtained by upper gastrointestinal endoscopy of chronic alcoholics having alcoholic liver disease (ALD) with and without cirrhosis. The biopsies were then processed for enzymatic assays to analyze the status of cellular functions. Light microscopy, transmission electron microscopy, and scanning electron microscopy were done to study the morphological alterations. Control group consisted of nonalcoholic gastroesophageal reflux disease patients reporting for routine endoscopy. Results:  The experimental group consisted of ALD patients which showed significant difference (P 

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