The Experts below are selected from a list of 642 Experts worldwide ranked by ideXlab platform
Keiji Wakabayashi - One of the best experts on this subject based on the ideXlab platform.
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Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous Polyposis coli gene knockout mice.
Cancer science, 2003Co-Authors: Tomohiro Kitamura, Kousuke Tani, Michiyoshi Kobayashi, Shuichi Ohuchida, Kaoru Kobayashi, Takayuki Maruyama, Takashi Sugimura, Masaki Itoh, Tetsuo Noda, Keiji WakabayashiAbstract:Previous studies have shown that prostaglandin E(2) (PGE(2)) is involved in intestinal carcinogenesis through its binding to the PGE(2) receptor subtypes EP(1) and EP(4) and activation of downstream pathways. ONO-8711 and ONO-AE2-227, prostaglandin E receptor subtype EP(1)- and EP(4)-selective antagonists, respectively, are known to suppress formation of intestinal Polyps in adenomatous Polyposis coli gene-deficient mice. The present study was designed to investigate the combined effects of EP(1) and EP(4) antagonists on spontaneous Polyp formation in APC1309 mice in order to determine the contribution of each receptor to intestinal tumorigenesis. APC1309 mice were treated with 400 ppm of ONO-8711 alone, 400 ppm of ONO-AE2-227 alone or both in combination in the diet for 6 weeks. The mean area of Polyps found in the Intestine, calculated as the longer diameter x the shorter diameter x pi, was reduced by 12%, 43% (P < 0.01) and 56% (P < 0.01) of the mean control value (8.8 mm(2)) in the ONO-8711 alone, ONO-AE2-227 alone and combination treatment groups, respectively, suggesting clear additive effects of the combination. The same additive tendency for suppression was also observed with respect to the numbers of Polyps in the Intestine. Polyp size reduction was more remarkable with the EP(4) antagonist, while the number reduction was more pronounced with the EP(1) antagonist. Our results indicate that EP(1) and EP(4) may have separate intrinsic roles and, to some extent, contribute to Polyp formation independently. Thus, combination treatment has potential for the chemoprevention of colon carcinogenesis.
Hong Gao - One of the best experts on this subject based on the ideXlab platform.
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endoscopic therapy of small bowel Polyps by double balloon enteroscopy in patients with peutz jeghers syndrome
Gastrointestinal Endoscopy, 2010Co-Authors: Hong Gao, Margot G Van Lier, Jan Werner Poley, Ernst J Kuipers, Monique E Van Leerdam, Peter MensinkAbstract:Background: Peutz-Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations and hamartomatous Polyps mainly in the small bowel. These Polyps may cause complications such as intussusception. Objective: To assess therapeutic efficacy and safety of double-balloon enteroscopy (DBE) for detection and treatment of small-bowel Polyps in patients with PJS. Design: Prospective cohort study. Setting: Tertiary-care referral center. Patients: This study involved 13 patients with PJS, defined as a proven STK11 gene mutation or according to international diagnostic criteria. Intervention: DBE with enteroscopic removal of pedunculated Polyps of ≥10 mm. Main Outcome Measurements: Location, number and size of small-bowel Polyps, Polypectomy data, and complications and long-term complications associated with development of small-Intestine Polyps. Results: Thirteen patients with PJS (8 male, mean age 31 years) underwent 29 DBE procedures. Ten patients (77%) had a history of partial small-bowel resection because of small-bowel Polyps. Small-bowel Polyps were found in all 13 patients. The majority of Polyps (94%) were located in the proximal jejunum. A total of 82 Polyps of ≥10 mm were detected, and 79 (96%) were endoscopically removed without complications. After the introduction of DBE, no small-Intestine-Polyp-related complications occurred during a follow-up period of 356 person-months. Limitations: Small number of patients. Conclusion: DBE is clinically useful and safe for diagnosis and therapy of small-bowel Polyps in patients with PJS, even in patients with a history of extensive abdominal surgery. DBE may decrease the need for laparotomy in patients with PJS.
Tomohiro Kitamura - One of the best experts on this subject based on the ideXlab platform.
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Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous Polyposis coli gene knockout mice.
Cancer science, 2003Co-Authors: Tomohiro Kitamura, Kousuke Tani, Michiyoshi Kobayashi, Shuichi Ohuchida, Kaoru Kobayashi, Takayuki Maruyama, Takashi Sugimura, Masaki Itoh, Tetsuo Noda, Keiji WakabayashiAbstract:Previous studies have shown that prostaglandin E(2) (PGE(2)) is involved in intestinal carcinogenesis through its binding to the PGE(2) receptor subtypes EP(1) and EP(4) and activation of downstream pathways. ONO-8711 and ONO-AE2-227, prostaglandin E receptor subtype EP(1)- and EP(4)-selective antagonists, respectively, are known to suppress formation of intestinal Polyps in adenomatous Polyposis coli gene-deficient mice. The present study was designed to investigate the combined effects of EP(1) and EP(4) antagonists on spontaneous Polyp formation in APC1309 mice in order to determine the contribution of each receptor to intestinal tumorigenesis. APC1309 mice were treated with 400 ppm of ONO-8711 alone, 400 ppm of ONO-AE2-227 alone or both in combination in the diet for 6 weeks. The mean area of Polyps found in the Intestine, calculated as the longer diameter x the shorter diameter x pi, was reduced by 12%, 43% (P < 0.01) and 56% (P < 0.01) of the mean control value (8.8 mm(2)) in the ONO-8711 alone, ONO-AE2-227 alone and combination treatment groups, respectively, suggesting clear additive effects of the combination. The same additive tendency for suppression was also observed with respect to the numbers of Polyps in the Intestine. Polyp size reduction was more remarkable with the EP(4) antagonist, while the number reduction was more pronounced with the EP(1) antagonist. Our results indicate that EP(1) and EP(4) may have separate intrinsic roles and, to some extent, contribute to Polyp formation independently. Thus, combination treatment has potential for the chemoprevention of colon carcinogenesis.
Jianying Bai - One of the best experts on this subject based on the ideXlab platform.
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robust prototypical networks for small Intestine Polyp recognition in wireless capsule endoscopy images
Proceedings of the Third International Symposium on Image Computing and Digital Medicine, 2019Co-Authors: Chao Liao, Chengliang Wang, Jianying BaiAbstract:Wireless capsule endoscopy (WCE) is a gastrointestinal examination technology, which can help find the Polyps in small bowel noninvasively. The computer-aided Polyp recognition systems based on deep learning require large amounts of manually annotated data, which is often unavailable for WCE images. Meanwhile, there is a serious imbalance between normal and Polypoid samples in WCE image database. We proposed a few-shot learning method of automatic Polyp recognition under the circumstance of absolute lack of data, named Robust Prototypical Networks (RPNs), and RPNs made adjustments to Polyp position changing. Trained with an imbalanced Polypoid WCE image dataset and a Polypoid colon endoscopy (CE) image dataset, RPNs can extract their common features by introducing a multi-task learning scheme, separating-diffusing, to overcome imbalance problem. RPNs outperforms the previous work, and the best average AUC-PR score is 0.87.
Peter Mensink - One of the best experts on this subject based on the ideXlab platform.
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endoscopic therapy of small bowel Polyps by double balloon enteroscopy in patients with peutz jeghers syndrome
Gastrointestinal Endoscopy, 2010Co-Authors: Hong Gao, Margot G Van Lier, Jan Werner Poley, Ernst J Kuipers, Monique E Van Leerdam, Peter MensinkAbstract:Background: Peutz-Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations and hamartomatous Polyps mainly in the small bowel. These Polyps may cause complications such as intussusception. Objective: To assess therapeutic efficacy and safety of double-balloon enteroscopy (DBE) for detection and treatment of small-bowel Polyps in patients with PJS. Design: Prospective cohort study. Setting: Tertiary-care referral center. Patients: This study involved 13 patients with PJS, defined as a proven STK11 gene mutation or according to international diagnostic criteria. Intervention: DBE with enteroscopic removal of pedunculated Polyps of ≥10 mm. Main Outcome Measurements: Location, number and size of small-bowel Polyps, Polypectomy data, and complications and long-term complications associated with development of small-Intestine Polyps. Results: Thirteen patients with PJS (8 male, mean age 31 years) underwent 29 DBE procedures. Ten patients (77%) had a history of partial small-bowel resection because of small-bowel Polyps. Small-bowel Polyps were found in all 13 patients. The majority of Polyps (94%) were located in the proximal jejunum. A total of 82 Polyps of ≥10 mm were detected, and 79 (96%) were endoscopically removed without complications. After the introduction of DBE, no small-Intestine-Polyp-related complications occurred during a follow-up period of 356 person-months. Limitations: Small number of patients. Conclusion: DBE is clinically useful and safe for diagnosis and therapy of small-bowel Polyps in patients with PJS, even in patients with a history of extensive abdominal surgery. DBE may decrease the need for laparotomy in patients with PJS.
