The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
Alessandra Bianco - One of the best experts on this subject based on the ideXlab platform.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Journal of Biomedical Materials Research Part B, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(e-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surface. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε-caprolactone) with poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(ε-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surfac
Costantino Del Gaudio - One of the best experts on this subject based on the ideXlab platform.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Journal of Biomedical Materials Research Part B, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(e-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surface. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε-caprolactone) with poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(ε-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surfac
Alan E Tonelli - One of the best experts on this subject based on the ideXlab platform.
-
Intimate Blending of binary polymer systems from their common cyclodextrin inclusion compounds
Journal of Polymer Science Part B, 2005Co-Authors: Tamer Uyar, Cristian C Rusa, Xingwu Wang, Mariana Rusa, Jale Hacaloglu, Alan E TonelliAbstract:A procedure for the formation of Intimate blends of three binary polymer systems polycarbonate (PC)/poly(methyl methacrylate) (PMMA), PC/poly(vinyl acetate) (PVAc) and PMMA/PVAc is described. PC/PMMA, PC/PVAc, and PMMA/PVAc pairs were included in γ-cyclodextrin (γ-CD) channels and were then simultaneously coalesced from their common γ-CD inclusion compounds (ICs) to obtain Intimately mixed blends. The formation of ICs between polymer pairs and γ-CD were confirmed by wide-angle X-ray diffraction (WAXD), fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). It was observed [solution 1H nuclear magnetic resonance (NMR)] that the ratios of polymers in coalesced PC/PMMA and PC/PVAc binary blends are significantly different than the starting ratios, and PC was found to be preferentially included in γ-CD channels when compared with PMMA or PVAc. Physical mixtures of polymer pairs were also prepared by coprecipitation and solution casting methods for comparison. DSC, solid-state 1H NMR, thermogravimetric analysis (TGA), and direct insertion probe pyrolysis mass spectrometry (DIP-MS) data indicated that the PC/PMMA, PC/PVAc, and PMMA/PVAc binary polymer blends were homogeneously mixed when they were coalesced from their ICs. A single, common glass transition temperature (Tg) recorded by DSC heating scans strongly suggested the presence of a homogeneous amorphous phase in the coalesced binary polymer blends, which is retained after thermal cycling to 270 °C. The physical mixture samples showed two distinct Tgs and 1H T1ρ values for the polymer components, which indicated phase-separated blends with domain sizes above 5 nm, while the coalesced blends exhibited uniform 1H spin-lattice relaxation values, indicating Intimate Blending in the coalesced samples. The TGA results of coalesced and physical binary blends of PC/PMMA and PC/PVAc reveal that in the presence of PC, the thermal stability of both PMMA and PVAc increases. Yet, the presence of PMMA and PVAc decreases the thermal stability of PC itself. DIP-MS observations suggested that the degradation mechanisms of the polymers changed in the coalesced blends, which was attributed to the presence of molecular interactions between the well-mixed polymer components in the coalesced samples. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2578–2593, 2005
-
Intimate blend of poly(ethylene terephthalate) and poly(ethylene 2,6‐naphthalate) via formation with and coalescence from their common inclusion compound with γ‐cyclodextrin
Journal of Polymer Science Part B, 2002Co-Authors: T. A. Bullions, Cristian C Rusa, E. M. Edeki, Francis E. Porbeni, Xintao Shuai, Alan E TonelliAbstract:The experimental procedures to place poly(ethylene 2,6-naphthalate) (PEN) guest molecules within γ-cyclodextrin (γ-CD) host molecules are described along with the subsequent verification of inclusion-compound (IC) formation. In addition, the simultaneous complexing of PEN and poly(ethylene terephthalate) (PET) with γ-CD to form their common IC is documented. Coalescence from their common γ-CD IC generates an Intimate blend of the PET and PEN polymers contained therein. Thermal analysis via differential scanning calorimetry reveals thermal behavior indicative of an Intimate blend of PET and PEN. 1H NMR analysis confirms that the Intimate Blending of PET and PEN achieved by coalescence from their common γ-CD IC is not due to transesterification into a PET/PEN copolymer during thermal analysis. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 139–148, 2003
Enrico Ercolani - One of the best experts on this subject based on the ideXlab platform.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Journal of Biomedical Materials Research Part B, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(e-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surface. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε-caprolactone) with poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(ε-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surfac
Lara Fioravanzo - One of the best experts on this subject based on the ideXlab platform.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Journal of Biomedical Materials Research Part B, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(e-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surface. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
-
Electrospun tubular scaffolds: On the effectiveness of Blending poly(ε-caprolactone) with poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2012Co-Authors: Costantino Del Gaudio, Lara Fioravanzo, Marcella Folin, Fabiana Marchi, Enrico Ercolani, Alessandra BiancoAbstract:Tissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well-known drawbacks of small-diameter grafts. To date, poly(ε-caprolactone) (PCL), a bioresorbable synthetic poly(α-hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of Intimate Blending soft PCL and hard poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small-diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL-based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surfac
