The Experts below are selected from a list of 120 Experts worldwide ranked by ideXlab platform
Li Xiao-jing - One of the best experts on this subject based on the ideXlab platform.
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Effect of indomethacin-loaded micelles on rheumatoid arthritis in rats
2006Co-Authors: Li Xiao-jingAbstract:Objective To investigate the effect of indomethacin (IND)-loaded micelles on rheumatoid arthritis and its mechanism. Methods Freund’s-induced adjuvant arthritis and carrageenan-induced acute arthritis in SD rats were employed to evaluate the therapeutic effect of IND-loaded polymeric micelles after intraarticuar Drug Administration. Fifty-six SD rats were randomly divided to receive IND-loaded micelles at a dose of 4.5, 1.5, 0.5 mg/kg respectively, IND injection, oral Administration of IND, blank PNIPAm/EAB-PPP-1 micelles at the 8~ th day once a day for a week after subcutaneous injection of 0.1 ml Freund’s into voix pedis of the right hind foot. The normal control rats took normal saline instead of Freund’s. There were 8 rats in each group. Results IND-loaded micelles could inhibit the swollen joint. No rats of Intraarticular Drug Administration developed ulceration. Conclusion The sustained therapeutic efficacy could be achieved through Intraarticular injection of IND-loaded micelles. Local delivery of IND can avoid severe gastrointestinal stimulation that frequently results from oral Administration of IND.
Rubén Torres-gonzález - One of the best experts on this subject based on the ideXlab platform.
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Effect of acute gouty arthritis on sleep patterns: a preclinical study.
European journal of pain (London England), 2008Co-Authors: Uriah Guevara-lópez, Fructuoso Ayala-guerrero, Alfredo Covarrubias-gómez, Francisco Javier López-muñoz, Rubén Torres-gonzálezAbstract:Background: It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. Aims: This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. Methods: Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular Administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after Intraarticular Drug Administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. Results: Intra-articular Administration of uric acid induced: (i) an increased duration of wakefulness (p = 0.014), (ii) a decrement in the duration (p = 0.001) and number of events (p = 0.027) in REM sleep, and (iii) a decrement in the total sleep time (p = 0.001). SWS did not present statistical differences between groups. Conclusions: These data suggest that a nociceptive stimulus, induced by the intra-articular Administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain–sleep interaction is needed. 2008 European Federation of Chapters of the International Association for the Study of Pain. Published
Uriah Guevara-lópez - One of the best experts on this subject based on the ideXlab platform.
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Effect of acute gouty arthritis on sleep patterns: a preclinical study.
European journal of pain (London England), 2008Co-Authors: Uriah Guevara-lópez, Fructuoso Ayala-guerrero, Alfredo Covarrubias-gómez, Francisco Javier López-muñoz, Rubén Torres-gonzálezAbstract:Background: It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. Aims: This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. Methods: Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular Administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after Intraarticular Drug Administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. Results: Intra-articular Administration of uric acid induced: (i) an increased duration of wakefulness (p = 0.014), (ii) a decrement in the duration (p = 0.001) and number of events (p = 0.027) in REM sleep, and (iii) a decrement in the total sleep time (p = 0.001). SWS did not present statistical differences between groups. Conclusions: These data suggest that a nociceptive stimulus, induced by the intra-articular Administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain–sleep interaction is needed. 2008 European Federation of Chapters of the International Association for the Study of Pain. Published
Fructuoso Ayala-guerrero - One of the best experts on this subject based on the ideXlab platform.
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Effect of acute gouty arthritis on sleep patterns: a preclinical study.
European journal of pain (London England), 2008Co-Authors: Uriah Guevara-lópez, Fructuoso Ayala-guerrero, Alfredo Covarrubias-gómez, Francisco Javier López-muñoz, Rubén Torres-gonzálezAbstract:Background: It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. Aims: This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. Methods: Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular Administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after Intraarticular Drug Administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. Results: Intra-articular Administration of uric acid induced: (i) an increased duration of wakefulness (p = 0.014), (ii) a decrement in the duration (p = 0.001) and number of events (p = 0.027) in REM sleep, and (iii) a decrement in the total sleep time (p = 0.001). SWS did not present statistical differences between groups. Conclusions: These data suggest that a nociceptive stimulus, induced by the intra-articular Administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain–sleep interaction is needed. 2008 European Federation of Chapters of the International Association for the Study of Pain. Published
Alfredo Covarrubias-gómez - One of the best experts on this subject based on the ideXlab platform.
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Effect of acute gouty arthritis on sleep patterns: a preclinical study.
European journal of pain (London England), 2008Co-Authors: Uriah Guevara-lópez, Fructuoso Ayala-guerrero, Alfredo Covarrubias-gómez, Francisco Javier López-muñoz, Rubén Torres-gonzálezAbstract:Background: It has been demonstrated that the interrelation between pain and sleep produces changes in sleep patterns and pain perception. Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number. Aims: This study was carried out in order to evaluate the effect of intra-articular knee injection of uric acid on sleep-wake patterns. Methods: Surgical electrode implantation was performed in seven anesthetized Wistar rats to carry out 10 h polysomnographic recordings. Acute nociception was induced by the intra-articular Administration of 30% uric acid crystals into the knee joint of the right hind limb. Two recordings before and after Intraarticular Drug Administration were obtained. Sleep-wake parameters were classified as (i) wakefulness (W), (ii) slow wave sleep (SWS), and (iii) rapid eye movement (REM) sleep. Frequency and duration from each parameter were evaluated under the two above-mentioned conditions. Results: Intra-articular Administration of uric acid induced: (i) an increased duration of wakefulness (p = 0.014), (ii) a decrement in the duration (p = 0.001) and number of events (p = 0.027) in REM sleep, and (iii) a decrement in the total sleep time (p = 0.001). SWS did not present statistical differences between groups. Conclusions: These data suggest that a nociceptive stimulus, induced by the intra-articular Administration of uric acid, alters the sleep-wake equilibrium with REM sleep being particularly altered. However, further research concerning pain–sleep interaction is needed. 2008 European Federation of Chapters of the International Association for the Study of Pain. Published
