Intracardiac Thrombosis

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Andre M. De Wolf - One of the best experts on this subject based on the ideXlab platform.

James D. Boone - One of the best experts on this subject based on the ideXlab platform.

Saadia S. Sherwani - One of the best experts on this subject based on the ideXlab platform.

  • the successful use of low dose recombinant tissue plasminogen activator for treatment of Intracardiac pulmonary Thrombosis during liver transplantation
    Anesthesia & Analgesia, 2011
    Co-Authors: James D. Boone, Saadia S. Sherwani, Joshua C. Herborn, Kinjal M. Patel, Andre M. De Wolf
    Abstract:

    Intracardiac Thrombosis and pulmonary embolism are uncommon complications during liver transplantation but carry a high mortality rate. We report the successful use of low-dose recombinant tissue plasminogen activator (0.5-4 mg) administration in 4 patients. Early diagnosis through transesophageal echocardiography and pulmonary artery catheterization may have contributed to the rapid thrombolysis.

  • The successful use of low-dose recombinant tissue plasminogen activator for treatment of Intracardiac/pulmonary Thrombosis during liver transplantation.
    Anesthesia and analgesia, 2010
    Co-Authors: James D. Boone, Saadia S. Sherwani, Joshua C. Herborn, Kinjal M. Patel, Andre M. De Wolf
    Abstract:

    Intracardiac Thrombosis and pulmonary embolism are uncommon complications during liver transplantation but carry a high mortality rate. We report the successful use of low-dose recombinant tissue plasminogen activator (0.5-4 mg) administration in 4 patients. Early diagnosis through transesophageal echocardiography and pulmonary artery catheterization may have contributed to the rapid thrombolysis.

  • intraoperative pulmonary embolism and Intracardiac Thrombosis complicating liver transplantation a systematic review
    Journal of Thrombosis and Haemostasis, 2008
    Co-Authors: Nienke Warnaar, I. Q. Molenaar, Steven D. Colquhoun, Maarten J. H. Slooff, Saadia S. Sherwani, A M De Wolf, Robert J. Porte
    Abstract:

    BACKGROUND: Pulmonary embolism (PE) and Intracardiac Thrombosis (ICT) are rare but potentially lethal complications during orthotopic liver transplantation (OLT). METHODS: We aimed to review clinical and pathological correlates of PE and ICT in patients undergoing OLT. A systematic review of the literature was conducted using MEDLINE and ISI Web of Science. RESULTS: Seventy-four cases of intraoperative PE and/or ICT were identified; PE alone in 32 patients (43%) and a combination of PE and ICT in 42 patients (57%). Most frequent clinical symptoms included systemic hypotension and concomitant rising pulmonary artery pressure, often leading to complete circulatory collapse. PE and ICT occurred in every stage of the operation and were reported equally in patients with or without the use of venovenous bypass or antifibrinolytics. A large variety of putative risk factors have been suggested in the literature, including the use of pulmonary artery catheters or certain blood products. Nineteen patients underwent urgent thrombectomy or thrombolysis. Overall mortality was 68% (50/74) and 41 patients (82%) died intraoperatively. CONCLUSION: Mortality was significantly higher in patients with an isolated PE, compared to patients with a combination of PE and ICT (91% and 50%, respectively; P < 0.001). Intraoperative PE and ICT during OLT appear to have multiple etiologies and may occur unexpectedly at any time during the procedure.

  • Intraoperative pulmonary embolism and Intracardiac Thrombosis complicating liver transplantation: a systematic review.
    Journal of thrombosis and haemostasis : JTH, 2007
    Co-Authors: Nienke Warnaar, I. Q. Molenaar, Steven D. Colquhoun, Maarten J. H. Slooff, Saadia S. Sherwani, A. De Wolf, Robert J. Porte
    Abstract:

    Summary. Background: Pulmonary embolism (PE) and Intracardiac Thrombosis (ICT) are rare but potentially lethal complications during orthotopic liver transplantation (OLT). Methods: We aimed to review clinical and pathological correlates of PE and ICT in patients undergoing OLT. A systematic review of the literature was conducted using MEDLINE and ISI Web of Science. Results: Seventy-four cases of intraoperative PE and/or ICT were identified; PE alone in 32 patients (43%) and a combination of PE and ICT in 42 patients (57%). Most frequent clinical symptoms included systemic hypotension and concomitant rising pulmonary artery pressure, often leading to complete circulatory collapse. PE and ICT occurred in every stage of the operation and were reported equally in patients with or without the use of venovenous bypass or antifibrinolytics. A large variety of putative risk factors have been suggested in the literature, including the use of pulmonary artery catheters or certain blood products. Nineteen patients underwent urgent thrombectomy or thrombolysis. Overall mortality was 68% (50/74) and 41 patients (82%) died intraoperatively. Conclusion: Mortality was significantly higher in patients with an isolated PE, compared to patients with a combination of PE and ICT (91% and 50%, respectively; P 

Kinjal M. Patel - One of the best experts on this subject based on the ideXlab platform.

Joshua C. Herborn - One of the best experts on this subject based on the ideXlab platform.