The Experts below are selected from a list of 405 Experts worldwide ranked by ideXlab platform
Mark Lautens - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective Friedel–Crafts Alkylation of Hydronaphthalenes
2016Co-Authors: Jennifer Tsoung, Adam Zajdlik, Katja Krämer, Clemence Liébert, Mark LautensAbstract:An efficient and versatile synthesis of chiral tetralins has been developed using both inter- and Intramolecular Friedel–Crafts Alkylation as a key step. The readily available hydronaphthalene substrates were prepared via a highly enantioselective metal-catalyzed ring opening of meso-oxabicyclic alkenes followed by hydrogenation. A wide variety of complex tetracyclic compounds have been isolated with high levels of regio-, diastereo-, and enantioselectivity
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Diastereoselective Friedel–Crafts Alkylation of Hydronaphthalenes
The Journal of organic chemistry, 2011Co-Authors: Jennifer Tsoung, Katja Krämer, Adam Zajdlik, Clémence Liébert, Mark LautensAbstract:An efficient and versatile synthesis of chiral tetralins has been developed using both inter- and Intramolecular Friedel–Crafts Alkylation as a key step. The readily available hydronaphthalene substrates were prepared via a highly enantioselective metal-catalyzed ring opening of meso-oxabicyclic alkenes followed by hydrogenation. A wide variety of complex tetracyclic compounds have been isolated with high levels of regio-, diastereo-, and enantioselectivity.
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Diastereoselective Intramolecular Friedel—Crafts Alkylation of Tetralins.
ChemInform, 2011Co-Authors: Clémence Liébert, Marion Kristina Brinks, Andrew G. Capacci, Matthew J. Fleming, Mark LautensAbstract:A wide range of cis-hexahydrobenzophenanthridine-derived cyclic compounds is prepared in a mild reaction from the corresponding chiral tetralin substrates with retention of optical purity.
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Diastereoselective Intramolecular Friedel–Crafts Alkylation of Tetralins
Organic letters, 2011Co-Authors: Clémence Liébert, Marion Kristina Brinks, Andrew G. Capacci, Matthew J. Fleming, Mark LautensAbstract:An efficient and versatile synthesis of cis-hexahydrobenzophenanthridines starting from readily available tetralins has been developed using an Intramolecular Friedel–Crafts Alkylation as a key step. The substrates were prepared via a highly stereocontrolled rhodium-catalyzed ring-opening reaction of meso-oxabicyclic alkenes and a hydrogenation sequence. Thus, a wide variety of complex tetracyclic compounds have been isolated with a high level of regio-, diastereo-, and enantioselectivity.
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Diastereoselective Intramolecular Friedel–Crafts Alkylation of Tetralins
Organic letters, 2011Co-Authors: Clémence Liébert, Marion Kristina Brinks, Andrew G. Capacci, Matthew J. Fleming, Mark LautensAbstract:An efficient and versatile synthesis of cis-hexahydrobenzophenanthridines starting from readily available tetralins has been developed using an Intramolecular Friedel–Crafts Alkylation as a key ste...
Lin Dong - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of polysubstituted spirofluorene indene via ru ii catalyzed 3 2 annulation and Intramolecular friedel crafts cyclization
Journal of Organic Chemistry, 2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then Intramolecular Friedel-Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.
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One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization.
The Journal of organic chemistry, 2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then Intramolecular Friedel-Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.
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One-Pot Synthesis of Polysubstituted Spirofluorene–Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel–Crafts Cyclization
2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene–indenes via [3 + 2] annulation and then Intramolecular Friedel–Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields
Masami Kamigaito - One of the best experts on this subject based on the ideXlab platform.
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cycloolefin copolymer analogues from styrene and isoprene cationic cyclization of the random copolymers prepared by living anionic polymerization
Macromolecules, 2009Co-Authors: Atsuhiro Nakahara, Kotaro Satoh, Masami KamigaitoAbstract:This paper reports a novel and practical method for the synthesis of styrene-isoprene-derived cycloolefin copolymer analogues via the Intramolecular Friedel−Crafts Alkylation of well-defined random...
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cycloolefin copolymer analogues from styrene and isoprene cationic cyclization of the random copolymers prepared by living anionic polymerization
Macromolecules, 2009Co-Authors: Atsuhiro Nakahara, Kotaro Satoh, Masami KamigaitoAbstract:This paper reports a novel and practical method for the synthesis of styrene-isoprene-derived cycloolefin copolymer analogues via the Intramolecular Friedel−Crafts Alkylation of well-defined random copolymers of styrene and isoprene prepared by living anionic copolymerization in the presence of a small amount of tetrahydrofuran as a randomizer. The random copolymers with an almost equimolar amount of the two monomers (styrene:isoprene = 48:52) and a predominant 1,4-isoprene-enchainment (1,4-:1,2-:3,4- = 67:1:32) were Intramolecularly cyclized with CF3SO3H efficiently to give the soluble cycloolefin copolymer analogues with a high glass transition temperature (Tg). The Tg increased dramatically (Tg = 20 vs 130 °C) on cyclization between the aromatic ring of the styrene unit and the adjacent C═C bond in the isoprene unit via the Intramolecular Friedel−Crafts Alkylation that results in the tetrahydronaphtyl bicyclic unit in the backbone chain, for which the highest Tg was observed at the equimolar content of...
Meike Niggemann - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective Synthesis of Indanes and Tetralins via Intramolecular Friedel–Crafts Reaction
2016Co-Authors: Jeannemarie Begouin, Francesca Capitta, Meike NiggemannAbstract:An easy access to tetralin and indane skeletons has been developed using a diastereoselective Intramolecular Friedel–Crafts Alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf2)2/Bu4NPF6 yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity
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calcium catalyzed synthesis of 1 2 disubstituted 3 benzazepines
European Journal of Organic Chemistry, 2015Co-Authors: Helena Damsen, Meike NiggemannAbstract:A short and highly stereoselective chiral pool synthesis of tetrahydro-3-benzazepines as potential drug molecules is described, using simple enantiopure amino acids as the chiral building blocks. Intramolecular Friedel–Crafts Alkylation towards seven-membered rings was achieved with high diastereoselectivity for the first time and accomplished by a biocompatible calcium catalyst. The simple and cost efficient approach allows for the variation of all substituents in the 3-benzazepine by a change of the substitution pattern in one or more of the reagents, while leaving the general synthetic route unchanged. Furthermore, assignment of the absolute configuration of the 3-benzazepine derivative is straightforward, based on the amino acid building block employed.
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Calcium‐Catalyzed Synthesis of 1,2‐Disubstituted 3‐Benzazepines
European Journal of Organic Chemistry, 2015Co-Authors: Helena Damsen, Meike NiggemannAbstract:A short and highly stereoselective chiral pool synthesis of tetrahydro-3-benzazepines as potential drug molecules is described, using simple enantiopure amino acids as the chiral building blocks. Intramolecular Friedel–Crafts Alkylation towards seven-membered rings was achieved with high diastereoselectivity for the first time and accomplished by a biocompatible calcium catalyst. The simple and cost efficient approach allows for the variation of all substituents in the 3-benzazepine by a change of the substitution pattern in one or more of the reagents, while leaving the general synthetic route unchanged. Furthermore, assignment of the absolute configuration of the 3-benzazepine derivative is straightforward, based on the amino acid building block employed.
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diastereoselective synthesis of indanes and tetralins via Intramolecular friedel crafts reaction
Organic Letters, 2013Co-Authors: Jeannemarie Begouin, Francesca Capitta, Meike NiggemannAbstract:An easy access to tetralin and indane skeletons has been developed using a diastereoselective Intramolecular Friedel-Crafts Alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf2)2/Bu4NPF6 yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity.
Yuqin Zhu - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of polysubstituted spirofluorene indene via ru ii catalyzed 3 2 annulation and Intramolecular friedel crafts cyclization
Journal of Organic Chemistry, 2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then Intramolecular Friedel-Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.
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One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization.
The Journal of organic chemistry, 2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then Intramolecular Friedel-Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.
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One-Pot Synthesis of Polysubstituted Spirofluorene–Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel–Crafts Cyclization
2015Co-Authors: Yuqin Zhu, Lin DongAbstract:Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene–indenes via [3 + 2] annulation and then Intramolecular Friedel–Crafts Alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields