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Tom H. Williamson - One of the best experts on this subject based on the ideXlab platform.

Sunir J. Garg - One of the best experts on this subject based on the ideXlab platform.

  • Effect of topical aqueous suppression on Intraocular Gas duration after pure perfluoropropane injection in nonvitrectomized eyes with retinal detachment.
    Retina (Philadelphia Pa.), 2014
    Co-Authors: Jason Hsu, Adam T. Gerstenblith, Nikolas J. S. London, Sunir J. Garg, Marc J. Spirn, Joseph I. Maguire, Carl H. Park, Arunan Sivalingam
    Abstract:

    PURPOSE To determine whether topical aqueous suppressants affect the duration of pure expansile Intraocular Gas in nonvitrectomized eyes. METHODS A prospective randomized controlled trial was performed on nonvitrectomized patients undergoing retinal detachment repair with scleral buckle or pneumatic retinopexy using 0.3 mL of 100% perfluoropropane (C3F8) Gas tamponade. Eyes were randomly assigned to receive topical dorzolamide 2% and timolol 0.5% twice daily postoperatively until Gas dissolution or to observation. RESULTS Twenty-one patients met all inclusion and exclusion criteria. Twelve were randomized to the control group and nine to the dorzolamide-timolol group. In the dorzolamide-timolol group, mean Intraocular pressure was 17.4 on postoperative Day 1 and 12.5 on postoperative Week 1 (P = 0.03). In the control group, mean Intraocular pressure was 14.5 on postoperative Day 1 and 15.1 on postoperative Week 1 (P = 0.73). The mean duration of C3F8 was 37.8 days in the dorzolamide-timolol group and 40.4 days in the control group (P = 0.70). CONCLUSION Topical aqueous suppression does not seem to have a significant effect on the duration of pure expansile Intraocular C3F8 in nonvitrectomized eyes after pneumatic retinopexy or scleral buckling.

  • topical aqueous suppression does not significantly affect duration of Intraocular Gas tamponade after vitrectomy
    Retina-the Journal of Retinal and Vitreous Diseases, 2012
    Co-Authors: Chirag Shah, Jason Hsu, Marc J. Spirn, Larry A Donoso, Sunir J. Garg
    Abstract:

    Purpose: To determine if topical aqueous suppression affects the duration of Intraocular sulfur hexafluoride (SF6) Gas tamponade after pars plana vitrectomy. Methods: A prospective randomized controlled trial was conducted on patients undergoing 23-gauge sutured pars plana vitrectomy with air–fluid exchange and 20% SF6 Gas tamponade. Eyes were randomly assigned to receive either postoperative topical dorzolamide 2%–timolol 0.5% twice a day or no additional drops (control group). Standard postoperative topical antibiotics and corticosteroids were used by all patients. Results: A total of 21 patients were recruited for the study. Four were excluded because of noncompliance with use of dorzolamide–timolol. In the remaining 17 patients, 8 were randomly assigned to the dorzolamide–timolol group and 9 to the control group. Topical dorzolamide–timolol drops twice a day did not affect the duration of SF6 Gas tamponade after pars plana vitrectomy (17.1 vs. 18.1 days with no drops, P = 0.35). The difference in mean Gas duration was −1.0 days with a 95% confidence interval of −3.2 days to 1.2 days. Secondary analyses did not reveal a difference in SF6 duration based on lens status, presence of diabetes or hypertension, vitrectomy versus combined buckle with vitrectomy, or patient age. Conclusion: Topical aqueous suppression with dorzolamide–timolol does not have a large effect on duration of SF6 Gas tamponade after pars plana vitrectomy.

James E. Neffendorf - One of the best experts on this subject based on the ideXlab platform.

Jason Hsu - One of the best experts on this subject based on the ideXlab platform.

  • Effect of topical aqueous suppression on Intraocular Gas duration after pure perfluoropropane injection in nonvitrectomized eyes with retinal detachment.
    Retina (Philadelphia Pa.), 2014
    Co-Authors: Jason Hsu, Adam T. Gerstenblith, Nikolas J. S. London, Sunir J. Garg, Marc J. Spirn, Joseph I. Maguire, Carl H. Park, Arunan Sivalingam
    Abstract:

    PURPOSE To determine whether topical aqueous suppressants affect the duration of pure expansile Intraocular Gas in nonvitrectomized eyes. METHODS A prospective randomized controlled trial was performed on nonvitrectomized patients undergoing retinal detachment repair with scleral buckle or pneumatic retinopexy using 0.3 mL of 100% perfluoropropane (C3F8) Gas tamponade. Eyes were randomly assigned to receive topical dorzolamide 2% and timolol 0.5% twice daily postoperatively until Gas dissolution or to observation. RESULTS Twenty-one patients met all inclusion and exclusion criteria. Twelve were randomized to the control group and nine to the dorzolamide-timolol group. In the dorzolamide-timolol group, mean Intraocular pressure was 17.4 on postoperative Day 1 and 12.5 on postoperative Week 1 (P = 0.03). In the control group, mean Intraocular pressure was 14.5 on postoperative Day 1 and 15.1 on postoperative Week 1 (P = 0.73). The mean duration of C3F8 was 37.8 days in the dorzolamide-timolol group and 40.4 days in the control group (P = 0.70). CONCLUSION Topical aqueous suppression does not seem to have a significant effect on the duration of pure expansile Intraocular C3F8 in nonvitrectomized eyes after pneumatic retinopexy or scleral buckling.

  • topical aqueous suppression does not significantly affect duration of Intraocular Gas tamponade after vitrectomy
    Retina-the Journal of Retinal and Vitreous Diseases, 2012
    Co-Authors: Chirag Shah, Jason Hsu, Marc J. Spirn, Larry A Donoso, Sunir J. Garg
    Abstract:

    Purpose: To determine if topical aqueous suppression affects the duration of Intraocular sulfur hexafluoride (SF6) Gas tamponade after pars plana vitrectomy. Methods: A prospective randomized controlled trial was conducted on patients undergoing 23-gauge sutured pars plana vitrectomy with air–fluid exchange and 20% SF6 Gas tamponade. Eyes were randomly assigned to receive either postoperative topical dorzolamide 2%–timolol 0.5% twice a day or no additional drops (control group). Standard postoperative topical antibiotics and corticosteroids were used by all patients. Results: A total of 21 patients were recruited for the study. Four were excluded because of noncompliance with use of dorzolamide–timolol. In the remaining 17 patients, 8 were randomly assigned to the dorzolamide–timolol group and 9 to the control group. Topical dorzolamide–timolol drops twice a day did not affect the duration of SF6 Gas tamponade after pars plana vitrectomy (17.1 vs. 18.1 days with no drops, P = 0.35). The difference in mean Gas duration was −1.0 days with a 95% confidence interval of −3.2 days to 1.2 days. Secondary analyses did not reveal a difference in SF6 duration based on lens status, presence of diabetes or hypertension, vitrectomy versus combined buckle with vitrectomy, or patient age. Conclusion: Topical aqueous suppression with dorzolamide–timolol does not have a large effect on duration of SF6 Gas tamponade after pars plana vitrectomy.

John T. Thompson - One of the best experts on this subject based on the ideXlab platform.

  • The role of patient age and Intraocular Gas use in cataract progression after vitrectomy for macular holes and epiretinal membranes
    American journal of ophthalmology, 2004
    Co-Authors: John T. Thompson
    Abstract:

    Abstract Purpose To evaluate the rate of increase in nuclear sclerosis and posterior subcapsular cataracts in eyes as a function of patient age and use of intravitreal Gas at the time of vitrectomy. Design Observational case series. Methods Nuclear sclerosis and posterior subcapsular cataracts were evaluated as a function of patient age and use of intravitreal Gas at vitrectomy. Setting A clinical practice. Study population The study population consisted of 301 consecutive eyes. Observational procedure Nuclear sclerotic cataracts and posterior subcapsular cataracts were graded on a scale from 0 to 4.0 before and after vitrectomy. Main outcome measure Linear regression analysis was performed to measure and compare the rate of change in cataract score over time based on patient age and use of Intraocular Gas. Results Nuclear sclerotic cataracts showed minimal increase in patients younger than 50 years of age after vitrectomy (0.13 grades/year). Nuclear sclerotic cataracts increased at a rate of 0.7 to 0.9 grades/year (mean, 0.812) in patients aged 50 to 60 years, 60 to 70 years, 70 to 80 years, and 80+ years, even though the baseline nuclear sclerosis scores were progressively greater for each decade. The increase in nuclear sclerotic cataracts in patients younger than 50 years of age was significantly less ( P P Conclusions Patients older than 50 years of age have a similar rate of increase in nuclear sclerotic cataracts, independent of age. The rate is approximately sixfold greater than in patients younger than 50 years of age. Intravitreal Gas bubbles are associated with a nuclear sclerosis increase of approximately 60% compared with eyes without use of a Gas bubble.

  • Risk factors for elevated Intraocular pressure after the use of Intraocular Gases in vitreoretinal surgery.
    Ophthalmic surgery and lasers, 1997
    Co-Authors: Philip P Chen, John T. Thompson
    Abstract:

    BACKGROUND AND OBJECTIVE: The authors studied the contribution of multiple factors, including Gas type and concentration, to postoperative Intraocular pressure (IOP) elevation following vitreoretinal surgery with Intraocular Gas. PATIENTS AND METHODS: One hundred seventy-one eyes of 134 patients were retrospectively investigated after vitreoretinal surgery using air, sulfur hexafluoride (SF 6 ) (10%-30%), or perfluoropropane (C 3 F 8 ) (5%-35%). RESULTS: IOPs greater than 25 mm Hg occurred in 74 of 171 eyes (43%). Elevated IOP was associated with increasing patient age (P

  • Effects of hyperbaric exposure on eyes with Intraocular Gas bubbles.
    Retina (Philadelphia Pa.), 1995
    Co-Authors: Stephen V. Jackman, John T. Thompson
    Abstract:

    BACKGROUND Air travel is known to be potentially hazardous for patients with Intraocular Gas bubbles, and the external pressure changes associated with hyperbaric oxygen therapy and scuba diving could be similarly dangerous. METHODS Rabbits with a perfluoropropane/air Gas mixture filling approximately 60% of the vitreous cavity of the right eye were exposed to 3 different hyperbaric pressure profiles to an equivalent depth of 33 feet. The first group were a control group and were not exposed to hyperbaric pressures. The second group remained at an equivalent depth of 33 feet for 30 minutes, and the third group remained at 33 feet for 1 minute. Both groups ascended to normal atmospheric pressure at a rate of 1 foot per minute. The fourth group remained at 33 feet for 1 minute and then ascended at a rate of 0.2 feet per minute. RESULTS In all eyes with an Intraocular Gas bubble, Intraocular pressure dropped to zero when the atmospheric pressure was increased, and rose to more than 50 mmHg when the atmospheric pressure was returned to normal. Pressures in excess of 50 mmHg were sustained for 10 minutes or longer in each rabbit exposed to one of the hyperbaric profiles. No significant Intraocular pressure changes were observed in eyes without an Intraocular Gas bubble or eyes not exposed to hyperbaric pressure. CONCLUSION Marked elevation in Intraocular pressure occurs as a result of hyperbaric exposure in eyes with an Intraocular Gas bubble. Hyperbaric exposure is therefore not advisable for patients with Intraocular Gas bubbles.

  • The Absorption of Mixtures of Air and Perfluoropropane After Pars Plana Vitrectomy
    Archives of ophthalmology (Chicago Ill. : 1960), 1992
    Co-Authors: John T. Thompson
    Abstract:

    • The duration of mixtures of perfluoropropane and air (0% to 20% C3F8) were analyzed in 206 eyes following pars plana vitrectomy for a variety of vitreoretinal disorders using a noninvasive model for calculating the Intraocular Gas bubble volume. The accuracy of the noninvasive model was tested by comparing the estimated bubble volume with the actual volume withdrawn from 12 eyes with Intraocular Gas bubbles undergoing a subsequent vitrectomy. The method for estimating Intraocular bubble volume had a mean difference between the actual and estimated bubble volume of 0.1±0.35 mL. The half-life of air (0% C3F8) was 1.3±0.1 days; 5% C3F8, 4.2±0.1 days; 10% C3F8, 6.5±0.2 days; 15% C3F8, 8.0±0.6 days; and 20% C3F8, 12.5±1.1 days. The difference between each half-life was statistically significant (P