The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Zohar Barzilay - One of the best experts on this subject based on the ideXlab platform.
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Epinephrine blood concentrations after peripheral bronchial versus endotracheal Administration of epinephrine in dogs.
Critical Care Medicine, 1992Co-Authors: Ram Mazkereth, Gideon Paret, David Ezra, Shraga Aviner, Edna Peleg, Talma Rosenthal, Zohar BarzilayAbstract:BACKGROUND AND METHODS: Emergency endotracheal Drug Administration has become an acceptable route for Drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each Intratracheal Drug Administration. RESULTS: Both routes of epinephrine Administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine Administration (maximal concentration 8.9 +/- 3.2 vs. 2.0 +/- 0.4 ng/mL), and the total dose absorbed was significantly (76.5 +/- 13.5 vs. 36.7 +/- 6.5 ng/min/mL, p 2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. CONCLUSIONS: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.
Ram Mazkereth - One of the best experts on this subject based on the ideXlab platform.
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Epinephrine blood concentrations after peripheral bronchial versus endotracheal Administration of epinephrine in dogs.
Critical Care Medicine, 1992Co-Authors: Ram Mazkereth, Gideon Paret, David Ezra, Shraga Aviner, Edna Peleg, Talma Rosenthal, Zohar BarzilayAbstract:BACKGROUND AND METHODS: Emergency endotracheal Drug Administration has become an acceptable route for Drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each Intratracheal Drug Administration. RESULTS: Both routes of epinephrine Administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine Administration (maximal concentration 8.9 +/- 3.2 vs. 2.0 +/- 0.4 ng/mL), and the total dose absorbed was significantly (76.5 +/- 13.5 vs. 36.7 +/- 6.5 ng/min/mL, p 2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. CONCLUSIONS: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.
James P. Orlowski - One of the best experts on this subject based on the ideXlab platform.
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Emergency alternatives to intravenous access. Intraosseous, Intratracheal, sublingual, and other-site Drug Administration.
Pediatric Clinics of North America, 1994Co-Authors: James P. OrlowskiAbstract:Difficulties and delays in establishing intravenous access are not uncommon in emergency situations in pediatrics. Alternatives to venous cannulation exist, including intraosseous access, Intratracheal Drug Administration, sublingual and intralingual injection, the intrapenile route, and intracardiac injection. Each of these emergency alternatives to intravenous access is discussed from the historical, technical, utilitarian, and risk-benefit aspects. It is concluded that the intraosseous effective alternative to intravenous access in emergency situations.
Gideon Paret - One of the best experts on this subject based on the ideXlab platform.
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Epinephrine blood concentrations after peripheral bronchial versus endotracheal Administration of epinephrine in dogs.
Critical Care Medicine, 1992Co-Authors: Ram Mazkereth, Gideon Paret, David Ezra, Shraga Aviner, Edna Peleg, Talma Rosenthal, Zohar BarzilayAbstract:BACKGROUND AND METHODS: Emergency endotracheal Drug Administration has become an acceptable route for Drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each Intratracheal Drug Administration. RESULTS: Both routes of epinephrine Administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine Administration (maximal concentration 8.9 +/- 3.2 vs. 2.0 +/- 0.4 ng/mL), and the total dose absorbed was significantly (76.5 +/- 13.5 vs. 36.7 +/- 6.5 ng/min/mL, p 2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. CONCLUSIONS: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.
Talma Rosenthal - One of the best experts on this subject based on the ideXlab platform.
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Epinephrine blood concentrations after peripheral bronchial versus endotracheal Administration of epinephrine in dogs.
Critical Care Medicine, 1992Co-Authors: Ram Mazkereth, Gideon Paret, David Ezra, Shraga Aviner, Edna Peleg, Talma Rosenthal, Zohar BarzilayAbstract:BACKGROUND AND METHODS: Emergency endotracheal Drug Administration has become an acceptable route for Drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each Intratracheal Drug Administration. RESULTS: Both routes of epinephrine Administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine Administration (maximal concentration 8.9 +/- 3.2 vs. 2.0 +/- 0.4 ng/mL), and the total dose absorbed was significantly (76.5 +/- 13.5 vs. 36.7 +/- 6.5 ng/min/mL, p 2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. CONCLUSIONS: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.