The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

Thomas N. Tozer - One of the best experts on this subject based on the ideXlab platform.

  • First-pass elimination. Basic concepts and clinical consequences.
    Clinical Pharmacokinectics, 2012
    Co-Authors: Susan M. Pond, Thomas N. Tozer
    Abstract:

    First-pass elimination takes place when a Drug is metabolised between its site of Administration and the site of sampling for measurement of Drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. The liver is usually assumed to be the major site of first-pass metabolism of a Drug administered orally, but other potential sites are the gastrointestinal tract, blood, vascular endothelium, lungs, and the arm from which venous samples are taken. Bioavailability, defined as the ratio of the areas under the blood concentration-time curves, after extra- and Intravascular Drug Administration (corrected for dosage if necessary), is often used as a measure of the extent of first-pass metabolism. When several sites of first-pass metabolism are in series, the bioavailability is the product of the fractions of Drug entering the tissue that escape loss at each site.

Marek Penhaker - One of the best experts on this subject based on the ideXlab platform.

  • Model of Drugs Penetration Through Biological Membrane
    Lecture Notes in Electrical Engineering, 2015
    Co-Authors: Martin Augustynek, Adela Zemanova, Jan Kubicek, Marek Penhaker
    Abstract:

    This work deals with pharmacokinetics modeling and compilation of functional models. There are three mathematical models representing actions beginning Intravascular Drug Administration until the elimination from the body. Graphics dependences are outputs of these models, provide a quick idea about behavior of Drugs in the body and time period, when is medicine completely eliminated. The main model illustrates the penetration of Drug across biological membrane using the same principles, but the model tells of what happens to take place on bio membranes and its surrounding area.

Susan M. Pond - One of the best experts on this subject based on the ideXlab platform.

  • First-pass elimination. Basic concepts and clinical consequences.
    Clinical Pharmacokinectics, 2012
    Co-Authors: Susan M. Pond, Thomas N. Tozer
    Abstract:

    First-pass elimination takes place when a Drug is metabolised between its site of Administration and the site of sampling for measurement of Drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. The liver is usually assumed to be the major site of first-pass metabolism of a Drug administered orally, but other potential sites are the gastrointestinal tract, blood, vascular endothelium, lungs, and the arm from which venous samples are taken. Bioavailability, defined as the ratio of the areas under the blood concentration-time curves, after extra- and Intravascular Drug Administration (corrected for dosage if necessary), is often used as a measure of the extent of first-pass metabolism. When several sites of first-pass metabolism are in series, the bioavailability is the product of the fractions of Drug entering the tissue that escape loss at each site.

Martin Augustynek - One of the best experts on this subject based on the ideXlab platform.

  • Model of Drugs Penetration Through Biological Membrane
    Lecture Notes in Electrical Engineering, 2015
    Co-Authors: Martin Augustynek, Adela Zemanova, Jan Kubicek, Marek Penhaker
    Abstract:

    This work deals with pharmacokinetics modeling and compilation of functional models. There are three mathematical models representing actions beginning Intravascular Drug Administration until the elimination from the body. Graphics dependences are outputs of these models, provide a quick idea about behavior of Drugs in the body and time period, when is medicine completely eliminated. The main model illustrates the penetration of Drug across biological membrane using the same principles, but the model tells of what happens to take place on bio membranes and its surrounding area.

Adela Zemanova - One of the best experts on this subject based on the ideXlab platform.

  • Model of Drugs Penetration Through Biological Membrane
    Lecture Notes in Electrical Engineering, 2015
    Co-Authors: Martin Augustynek, Adela Zemanova, Jan Kubicek, Marek Penhaker
    Abstract:

    This work deals with pharmacokinetics modeling and compilation of functional models. There are three mathematical models representing actions beginning Intravascular Drug Administration until the elimination from the body. Graphics dependences are outputs of these models, provide a quick idea about behavior of Drugs in the body and time period, when is medicine completely eliminated. The main model illustrates the penetration of Drug across biological membrane using the same principles, but the model tells of what happens to take place on bio membranes and its surrounding area.