The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Blanca Rodriguez - One of the best experts on this subject based on the ideXlab platform.
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human ventricular activation sequence and the simulation of the electrocardiographic qrs complex and its variability in healthy and Intraventricular Block conditions
Europace, 2016Co-Authors: Louie Cardonenoott, Alfonso Buenoorovio, Ana Minchole, Nejib Zemzemi, Blanca RodriguezAbstract:Aims To investigate how variability in activation sequence and passive conduction properties translates into clinical variability in QRS biomarkers, and gain novel physiological knowledge on the information contained in the human QRS complex. Methods and results Multiscale bidomain simulations using a detailed heart-torso human anatomical model are performed to investigate the impact of activation sequence characteristics on clinical QRS biomarkers. Activation sequences are built and validated against experimentally-derived ex vivo and in vivo human activation data. R-peak amplitude exhibits the largest variability in terms of QRS morphology, due to its simultaneous modulation by activation sequence speed, myocardial intracellular and extracellular conductivities, and propagation through the human torso. QRS width, however, is regulated by endocardial activation speed and intracellular myocardial conductivities, whereas QR intervals are only affected by the endocardial activation profile. Variability in the apico-basal location of activation sites on the anterior and posterior left ventricular wall is associated with S-wave progression in limb and precordial leads, respectively, and occasional notched QRS complexes in precordial derivations. Variability in the number of early activation sites successfully reproduces pathological abnormalities of the human conduction system in the QRS complex. Conclusion Variability in activation sequence and passive conduction properties captures and explains a large part of the clinical variability observed in the human QRS complex. Our physiological insights allow for a deeper interpretation of human QRS biomarkers in terms of QRS morphology and location of early endocardial activation sites. This might be used to attain a better patient-specific knowledge of activation sequence from routine body-surface electrocardiograms.
Louie Cardonenoott - One of the best experts on this subject based on the ideXlab platform.
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human ventricular activation sequence and the simulation of the electrocardiographic qrs complex and its variability in healthy and Intraventricular Block conditions
Europace, 2016Co-Authors: Louie Cardonenoott, Alfonso Buenoorovio, Ana Minchole, Nejib Zemzemi, Blanca RodriguezAbstract:Aims To investigate how variability in activation sequence and passive conduction properties translates into clinical variability in QRS biomarkers, and gain novel physiological knowledge on the information contained in the human QRS complex. Methods and results Multiscale bidomain simulations using a detailed heart-torso human anatomical model are performed to investigate the impact of activation sequence characteristics on clinical QRS biomarkers. Activation sequences are built and validated against experimentally-derived ex vivo and in vivo human activation data. R-peak amplitude exhibits the largest variability in terms of QRS morphology, due to its simultaneous modulation by activation sequence speed, myocardial intracellular and extracellular conductivities, and propagation through the human torso. QRS width, however, is regulated by endocardial activation speed and intracellular myocardial conductivities, whereas QR intervals are only affected by the endocardial activation profile. Variability in the apico-basal location of activation sites on the anterior and posterior left ventricular wall is associated with S-wave progression in limb and precordial leads, respectively, and occasional notched QRS complexes in precordial derivations. Variability in the number of early activation sites successfully reproduces pathological abnormalities of the human conduction system in the QRS complex. Conclusion Variability in activation sequence and passive conduction properties captures and explains a large part of the clinical variability observed in the human QRS complex. Our physiological insights allow for a deeper interpretation of human QRS biomarkers in terms of QRS morphology and location of early endocardial activation sites. This might be used to attain a better patient-specific knowledge of activation sequence from routine body-surface electrocardiograms.
W Liu - One of the best experts on this subject based on the ideXlab platform.
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changes in transmembrane action potentials and monophasic action potentials of phase 3 Intraventricular Block in rabbits
Chinese journal of cardiovascular diseases, 1991Co-Authors: W LiuAbstract:The model of phase 3 Intraventricular Block was produced in 10 rabbits by giving 2.5% solution of potassium chloride intravenously under natural breathing and sinus rhythm. Transmembrane action potentials and monophasic action potentials were recorded respectively. The results showed that RP, APA, Vmax, MAPA and MVmax all decreased and both APD and MAPD shortened at the time of ventricular conduction Block, when ventricular conduction was improved by vagal stimulation, RP, APA, Vmax, MAPA and MVmax all increased and both APD and MAPD lengthened. In addition, APD and MAPD measured at the same site in normal conduction, conduction Block and conduction improved by vagal stimulation were in consensus.
Nejib Zemzemi - One of the best experts on this subject based on the ideXlab platform.
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human ventricular activation sequence and the simulation of the electrocardiographic qrs complex and its variability in healthy and Intraventricular Block conditions
Europace, 2016Co-Authors: Louie Cardonenoott, Alfonso Buenoorovio, Ana Minchole, Nejib Zemzemi, Blanca RodriguezAbstract:Aims To investigate how variability in activation sequence and passive conduction properties translates into clinical variability in QRS biomarkers, and gain novel physiological knowledge on the information contained in the human QRS complex. Methods and results Multiscale bidomain simulations using a detailed heart-torso human anatomical model are performed to investigate the impact of activation sequence characteristics on clinical QRS biomarkers. Activation sequences are built and validated against experimentally-derived ex vivo and in vivo human activation data. R-peak amplitude exhibits the largest variability in terms of QRS morphology, due to its simultaneous modulation by activation sequence speed, myocardial intracellular and extracellular conductivities, and propagation through the human torso. QRS width, however, is regulated by endocardial activation speed and intracellular myocardial conductivities, whereas QR intervals are only affected by the endocardial activation profile. Variability in the apico-basal location of activation sites on the anterior and posterior left ventricular wall is associated with S-wave progression in limb and precordial leads, respectively, and occasional notched QRS complexes in precordial derivations. Variability in the number of early activation sites successfully reproduces pathological abnormalities of the human conduction system in the QRS complex. Conclusion Variability in activation sequence and passive conduction properties captures and explains a large part of the clinical variability observed in the human QRS complex. Our physiological insights allow for a deeper interpretation of human QRS biomarkers in terms of QRS morphology and location of early endocardial activation sites. This might be used to attain a better patient-specific knowledge of activation sequence from routine body-surface electrocardiograms.
Ana Minchole - One of the best experts on this subject based on the ideXlab platform.
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human ventricular activation sequence and the simulation of the electrocardiographic qrs complex and its variability in healthy and Intraventricular Block conditions
Europace, 2016Co-Authors: Louie Cardonenoott, Alfonso Buenoorovio, Ana Minchole, Nejib Zemzemi, Blanca RodriguezAbstract:Aims To investigate how variability in activation sequence and passive conduction properties translates into clinical variability in QRS biomarkers, and gain novel physiological knowledge on the information contained in the human QRS complex. Methods and results Multiscale bidomain simulations using a detailed heart-torso human anatomical model are performed to investigate the impact of activation sequence characteristics on clinical QRS biomarkers. Activation sequences are built and validated against experimentally-derived ex vivo and in vivo human activation data. R-peak amplitude exhibits the largest variability in terms of QRS morphology, due to its simultaneous modulation by activation sequence speed, myocardial intracellular and extracellular conductivities, and propagation through the human torso. QRS width, however, is regulated by endocardial activation speed and intracellular myocardial conductivities, whereas QR intervals are only affected by the endocardial activation profile. Variability in the apico-basal location of activation sites on the anterior and posterior left ventricular wall is associated with S-wave progression in limb and precordial leads, respectively, and occasional notched QRS complexes in precordial derivations. Variability in the number of early activation sites successfully reproduces pathological abnormalities of the human conduction system in the QRS complex. Conclusion Variability in activation sequence and passive conduction properties captures and explains a large part of the clinical variability observed in the human QRS complex. Our physiological insights allow for a deeper interpretation of human QRS biomarkers in terms of QRS morphology and location of early endocardial activation sites. This might be used to attain a better patient-specific knowledge of activation sequence from routine body-surface electrocardiograms.
