The Experts below are selected from a list of 465 Experts worldwide ranked by ideXlab platform
Anders Mattiasson - One of the best experts on this subject based on the ideXlab platform.
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urobynamic effects of Intravesical instillation of atropine and phentolamine in patients with detrusor hyperactivity
1993Co-Authors: Bjorn Ekstrom, Karlerik Andersson, Anders MattiassonAbstract:Abstract The effects of Intravesical instillation of atropine (10 −6 M) and phentolamine (10 −6 M) on urodynamic parameters were investigated in patients with detrusor hyperactivity of neurogenic or non-neurogenic origin. A modified cystometric technique with slow intermittent filling was used. The reproducibility of the investigative procedure was first verified in 17 patients. Eighteen patients, 12 with detrusor hyperreflexia and 6 with detrusor instability, were then investigated with atropine and 17 patients, 11 with detrusor hyperreflexia and 6 with detrusor instability, were investigated with phentolamine. In individual patients clinically relevant improvements, such as an increased bladder capacity and a decreased detrusor pressure, were found. Five/12 neurogenic and 1/6 non-neurogenic patients responded to instillation of atropine. Five/11 neurogenic but none of the non-neurogenic patients responded to phentolamine. In the neurogenic group phentolamine caused an increase of the bladder capacity from 247 ± 57 ml. to 378 ± 57 ml. (p It is suggested that the different sensitivities to Intravesical Drug Administration in patients with detrusor hyperreflexia and detrusor instability can be explained by pathophysiological differences and concluded that Intravesical instillation of Drugs may be of therapeutic value in selected groups of patients.
Fry, Christopher H. - One of the best experts on this subject based on the ideXlab platform.
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The validation of a functional, isolated pig bladder model for physiological experimentation
2012Co-Authors: Gammie Andrew, Parsons, Brian A., Drake, Marcus J., Vahabi Bahareh, Fry, Christopher H.Abstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at vary-ing volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure. © 2012 Parsons, Drake, Gammie, Fry and Vahabi
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The Validation of a Functional, Isolated Pig Bladder Model for Physiological Experimentation
2024Co-Authors: Parsons, Brian A., Drake, Marcus J., Gammie Andrew, Fry, Christopher H., Vahabi BaharehAbstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at varying volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure
Vahabi Bahareh - One of the best experts on this subject based on the ideXlab platform.
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The validation of a functional, isolated pig bladder model for physiological experimentation
2012Co-Authors: Gammie Andrew, Parsons, Brian A., Drake, Marcus J., Vahabi Bahareh, Fry, Christopher H.Abstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at vary-ing volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure. © 2012 Parsons, Drake, Gammie, Fry and Vahabi
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The Validation of a Functional, Isolated Pig Bladder Model for Physiological Experimentation
2024Co-Authors: Parsons, Brian A., Drake, Marcus J., Gammie Andrew, Fry, Christopher H., Vahabi BaharehAbstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at varying volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure
Bjorn Ekstrom - One of the best experts on this subject based on the ideXlab platform.
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urobynamic effects of Intravesical instillation of atropine and phentolamine in patients with detrusor hyperactivity
1993Co-Authors: Bjorn Ekstrom, Karlerik Andersson, Anders MattiassonAbstract:Abstract The effects of Intravesical instillation of atropine (10 −6 M) and phentolamine (10 −6 M) on urodynamic parameters were investigated in patients with detrusor hyperactivity of neurogenic or non-neurogenic origin. A modified cystometric technique with slow intermittent filling was used. The reproducibility of the investigative procedure was first verified in 17 patients. Eighteen patients, 12 with detrusor hyperreflexia and 6 with detrusor instability, were then investigated with atropine and 17 patients, 11 with detrusor hyperreflexia and 6 with detrusor instability, were investigated with phentolamine. In individual patients clinically relevant improvements, such as an increased bladder capacity and a decreased detrusor pressure, were found. Five/12 neurogenic and 1/6 non-neurogenic patients responded to instillation of atropine. Five/11 neurogenic but none of the non-neurogenic patients responded to phentolamine. In the neurogenic group phentolamine caused an increase of the bladder capacity from 247 ± 57 ml. to 378 ± 57 ml. (p It is suggested that the different sensitivities to Intravesical Drug Administration in patients with detrusor hyperreflexia and detrusor instability can be explained by pathophysiological differences and concluded that Intravesical instillation of Drugs may be of therapeutic value in selected groups of patients.
Gammie Andrew - One of the best experts on this subject based on the ideXlab platform.
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The validation of a functional, isolated pig bladder model for physiological experimentation
2012Co-Authors: Gammie Andrew, Parsons, Brian A., Drake, Marcus J., Vahabi Bahareh, Fry, Christopher H.Abstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at vary-ing volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure. © 2012 Parsons, Drake, Gammie, Fry and Vahabi
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The Validation of a Functional, Isolated Pig Bladder Model for Physiological Experimentation
2024Co-Authors: Parsons, Brian A., Drake, Marcus J., Gammie Andrew, Fry, Christopher H., Vahabi BaharehAbstract:Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and Intravesical Drug Administration, Intravesical pressure recording, and filming of surface micromotions. Female pig bladders were obtained from the local abattoir and arterially perfused in vitro. Arterial and Intravesical pressures were recorded at varying volumes. Bladder viability was assessed histologically and by monitoring inflow and outflow pH. Arterial Drug Administration employed boluses introduced into the perfusate. Intravesical Administration involved slow instillation and a prolonged dwell-time. Surface micromotions were recorded by filming the separation of surface markers concurrently with Intravesical pressure measurement. Adequate perfusion to all bladder layers was achieved for up to 8 h; there was no structural deterioration nor alteration in inflow and effluent perfusate pH. Arterial Drug Administration (carbachol and potassium chloride) showed consistent dose-dependent responses. Localized movements (micromotions) occurred over the bladder surface, with variable correlation with fluctuations of Intravesical pressure. The isolated pig bladder is a valid approach to study integrative bladder physiology. It remains viable when perfused in vitro, responds to different routes of Drug Administration and provides a model to correlate movements of the bladder wall directly to variation of Intravesical pressure
