The Experts below are selected from a list of 801 Experts worldwide ranked by ideXlab platform
William R. Freeman - One of the best experts on this subject based on the ideXlab platform.
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lidocaine gel anesthesia for Intravitreal Drug Administration
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Igor Kozak, Lingyun Cheng, William R. FreemanAbstract:PURPOSE To describe the use of topical gel anesthesia for Intravitreal injection Drug delivery. METHODS The first group (n=12) of patients is a crossover group of patients who on separate occasions received Intravitreal injections after both 2% lidocaine subconjunctival injection (SC) and 2% lidocaine topical gel anesthesia using 30-gauge needle. The second group (n=16) is a consecutive group of patients who received either SC (n=8) or gel (n=8) anesthesia before Intravitreal injection of triamcinolone using 27.5-gauge needle. Descriptive and numerical pain analog scale was used to assess pain sensation. RESULTS : There was no difference in pain score between gel and SC within the first group (P=0.67, paired, nonparametric test) and no difference in pain score comparing patients who had either SC or gel anesthesia before 27.5-gauge Intravitreal injections (P=0.82, unpaired t-test) in the second group. However, there were significant differences in incidence of chemosis (P<0.001) and subconjunctival hemorrhage (P<0.001) after injection versus gel anesthesia in both groups. CONCLUSION Anesthesia with lidocaine 2% gel provides satisfactory patient comfort for Administration of Intravitreal injection and causes less chemosis and hemorrhage than SC anesthesia.
Rajiv Anand - One of the best experts on this subject based on the ideXlab platform.
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Intravitreal Drug Administration with depot devices
Current Opinion in Ophthalmology, 1994Co-Authors: David C Metrikin, Rajiv AnandAbstract:The Administration of medications by depot devices is a rapidly developing technology in ocular therapeutics. Sustained delivery of ophthalmic medications is a novel approach to treating chronic ocular conditions where systemic therapy may be accompanied by unwanted side effects and where repeated Intravitreal Drug Administration carries significant risks. Eye diseases particularly suitable to this form of treatment include proliferative vitreoretinopathy and chronic intraocular infections such as cytomegalovirus retinitis. Liposomes, which have been extensively investigated over the last two decades, have not found any acceptable clinical application. Nonerodible polymers such as the ethylvinyl acetate/poly vinyl alcohol cup are in advanced phase III human trials. The current status of microsphere development in the treatment of posterior segment disease is examined in the review and studies investigating the potential uses of the osmotic minipump are mentioned.
Igor Kozak - One of the best experts on this subject based on the ideXlab platform.
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lidocaine gel anesthesia for Intravitreal Drug Administration
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Igor Kozak, Lingyun Cheng, William R. FreemanAbstract:PURPOSE To describe the use of topical gel anesthesia for Intravitreal injection Drug delivery. METHODS The first group (n=12) of patients is a crossover group of patients who on separate occasions received Intravitreal injections after both 2% lidocaine subconjunctival injection (SC) and 2% lidocaine topical gel anesthesia using 30-gauge needle. The second group (n=16) is a consecutive group of patients who received either SC (n=8) or gel (n=8) anesthesia before Intravitreal injection of triamcinolone using 27.5-gauge needle. Descriptive and numerical pain analog scale was used to assess pain sensation. RESULTS : There was no difference in pain score between gel and SC within the first group (P=0.67, paired, nonparametric test) and no difference in pain score comparing patients who had either SC or gel anesthesia before 27.5-gauge Intravitreal injections (P=0.82, unpaired t-test) in the second group. However, there were significant differences in incidence of chemosis (P<0.001) and subconjunctival hemorrhage (P<0.001) after injection versus gel anesthesia in both groups. CONCLUSION Anesthesia with lidocaine 2% gel provides satisfactory patient comfort for Administration of Intravitreal injection and causes less chemosis and hemorrhage than SC anesthesia.
David C Metrikin - One of the best experts on this subject based on the ideXlab platform.
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Intravitreal Drug Administration with depot devices
Current Opinion in Ophthalmology, 1994Co-Authors: David C Metrikin, Rajiv AnandAbstract:The Administration of medications by depot devices is a rapidly developing technology in ocular therapeutics. Sustained delivery of ophthalmic medications is a novel approach to treating chronic ocular conditions where systemic therapy may be accompanied by unwanted side effects and where repeated Intravitreal Drug Administration carries significant risks. Eye diseases particularly suitable to this form of treatment include proliferative vitreoretinopathy and chronic intraocular infections such as cytomegalovirus retinitis. Liposomes, which have been extensively investigated over the last two decades, have not found any acceptable clinical application. Nonerodible polymers such as the ethylvinyl acetate/poly vinyl alcohol cup are in advanced phase III human trials. The current status of microsphere development in the treatment of posterior segment disease is examined in the review and studies investigating the potential uses of the osmotic minipump are mentioned.
Lingyun Cheng - One of the best experts on this subject based on the ideXlab platform.
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lidocaine gel anesthesia for Intravitreal Drug Administration
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Igor Kozak, Lingyun Cheng, William R. FreemanAbstract:PURPOSE To describe the use of topical gel anesthesia for Intravitreal injection Drug delivery. METHODS The first group (n=12) of patients is a crossover group of patients who on separate occasions received Intravitreal injections after both 2% lidocaine subconjunctival injection (SC) and 2% lidocaine topical gel anesthesia using 30-gauge needle. The second group (n=16) is a consecutive group of patients who received either SC (n=8) or gel (n=8) anesthesia before Intravitreal injection of triamcinolone using 27.5-gauge needle. Descriptive and numerical pain analog scale was used to assess pain sensation. RESULTS : There was no difference in pain score between gel and SC within the first group (P=0.67, paired, nonparametric test) and no difference in pain score comparing patients who had either SC or gel anesthesia before 27.5-gauge Intravitreal injections (P=0.82, unpaired t-test) in the second group. However, there were significant differences in incidence of chemosis (P<0.001) and subconjunctival hemorrhage (P<0.001) after injection versus gel anesthesia in both groups. CONCLUSION Anesthesia with lidocaine 2% gel provides satisfactory patient comfort for Administration of Intravitreal injection and causes less chemosis and hemorrhage than SC anesthesia.
