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James W Thomas - One of the best experts on this subject based on the ideXlab platform.
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2m) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2m Polymorphism is a complex Inversion spanning >100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2m Polymorphism, we generated sequence from 8 ZAL2m and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2m, resulting in uniformly high levels of genetic differentiation (FST=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ∼104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2m homozygotes are exceedingly rare in the population, occurring at a frequency of
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2(m)) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2(m) Polymorphism is a complex Inversion spanning > 100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2(m) Polymorphism, we generated sequence from 8 ZAL2(m) and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2(m), resulting in uniformly high levels of genetic differentiation (F(ST)=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ~104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequency of < 1%, we detected evidence of historical recombination between ZAL2(m) chromosomes inside the Inversion, refuting its potential status as a non-recombining autosome.
Lynn Y. Huynh - One of the best experts on this subject based on the ideXlab platform.
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2m) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2m Polymorphism is a complex Inversion spanning >100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2m Polymorphism, we generated sequence from 8 ZAL2m and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2m, resulting in uniformly high levels of genetic differentiation (FST=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ∼104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2m homozygotes are exceedingly rare in the population, occurring at a frequency of
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2(m)) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2(m) Polymorphism is a complex Inversion spanning > 100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2(m) Polymorphism, we generated sequence from 8 ZAL2(m) and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2(m), resulting in uniformly high levels of genetic differentiation (F(ST)=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ~104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequency of < 1%, we detected evidence of historical recombination between ZAL2(m) chromosomes inside the Inversion, refuting its potential status as a non-recombining autosome.
Donna L. Maney - One of the best experts on this subject based on the ideXlab platform.
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2m) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2m Polymorphism is a complex Inversion spanning >100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2m Polymorphism, we generated sequence from 8 ZAL2m and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2m, resulting in uniformly high levels of genetic differentiation (FST=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ∼104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2m homozygotes are exceedingly rare in the population, occurring at a frequency of
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Chromosome-wide linkage disequilibrium caused by an Inversion Polymorphism in the white-throated sparrow ( Zonotrichia albicollis )
Heredity, 2010Co-Authors: Lynn Y. Huynh, Donna L. Maney, James W ThomasAbstract:Chromosomal Inversions have been of long-standing interest to geneticists because they are capable of suppressing recombination and facilitating the formation of adaptive gene complexes. An exceptional Inversion Polymorphism (ZAL2(m)) in the white-throated sparrow (Zonotrichia albicollis) is linked to variation in plumage, social behavior and mate choice, and is maintained in the population by negative assortative mating. The ZAL2(m) Polymorphism is a complex Inversion spanning > 100 Mb and has been proposed to be a strong suppressor of recombination, as well as a potential model for studying neo-sex chromosome evolution. To quantify and evaluate these features of the ZAL2(m) Polymorphism, we generated sequence from 8 ZAL2(m) and 16 ZAL2 chromosomes at 58 loci inside and 4 loci outside the Inversion. Inside the Inversion we found that recombination was completely suppressed between ZAL2 and ZAL2(m), resulting in uniformly high levels of genetic differentiation (F(ST)=0.94), the formation of two distinct haplotype groups representing the alternate chromosome arrangements and extensive linkage disequilibrium spanning ~104 Mb within the Inversion, whereas gene flow was not suppressed outside the Inversion. Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequency of < 1%, we detected evidence of historical recombination between ZAL2(m) chromosomes inside the Inversion, refuting its potential status as a non-recombining autosome.
Maren Wellenreuther - One of the best experts on this subject based on the ideXlab platform.
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Balancing selection via life-history trade-offs maintains an Inversion Polymorphism in a seaweed fly
Nature Communications, 2020Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Maren Wellenreuther, Louis BernatchezAbstract:How natural diversity is maintained is an evolutionary puzzle. Genetic variation can be eroded by drift and directional selection but some Polymorphisms persist for long time periods, implicating a role for balancing selection. Here, we investigate the maintenance of a chro-mosomal Inversion Polymorphism in the seaweed fly Coelopa frigida. Using experimental evolution and quantifying fitness, we show that the Inversion underlies a life-history trade-off, whereby each haplotype has opposing effects on larval survival and adult reproduction. Numerical simulations confirm that such antagonistic pleiotropy can maintain Polymorphism. Our results also highlight the importance of sex-specific effects, dominance and environmental heterogeneity, whose interaction enhances the maintenance of Polymorphism through antagonistic pleiotropy. Overall, our findings directly demonstrate how over-dominance and sexual antagonism can emerge from a life-history trade-off, inviting reconsideration of antagonistic pleiotropy as a key part of multi-headed balancing selection processes that enable the persistence of genetic variation.
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Balancing selection via life-history trade-offs maintains an Inversion Polymorphism in a seaweed fly.
Nature communications, 2020Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Louis Bernatchez, Maren WellenreutherAbstract:How natural diversity is maintained is an evolutionary puzzle. Genetic variation can be eroded by drift and directional selection but some Polymorphisms persist for long time periods, implicating a role for balancing selection. Here, we investigate the maintenance of a chromosomal Inversion Polymorphism in the seaweed fly Coelopa frigida. Using experimental evolution and quantifying fitness, we show that the Inversion underlies a life-history trade-off, whereby each haplotype has opposing effects on larval survival and adult reproduction. Numerical simulations confirm that such antagonistic pleiotropy can maintain Polymorphism. Our results also highlight the importance of sex-specific effects, dominance and environmental heterogeneity, whose interaction enhances the maintenance of Polymorphism through antagonistic pleiotropy. Overall, our findings directly demonstrate how overdominance and sexual antagonism can emerge from a life-history trade-off, inviting reconsideration of antagonistic pleiotropy as a key part of multi-headed balancing selection processes that enable the persistence of genetic variation. Few studies empirically pinpoint how balanced Polymorphisms are maintained. “Merot et al”. identify an Inversion Polymorphism that is maintained in seaweed fly populations because of antagonistic pleiotropy that mediates a classic life history tradeoff between larval survival and adult reproduction.
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balancing selection via life history trade offs maintains an Inversion Polymorphism in a seaweed fly
bioRxiv, 2019Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Maren Wellenreuther, Louis BernatchezAbstract:Abstract How genetic diversity is maintained in natural populations is an evolutionary puzzle. Over time, genetic variation within species can be eroded by drift and directional selection, leading to the fixation or elimination of alleles. However, some loci show persistent variants at intermediate frequencies for long evolutionary time-scales, implicating a role of balancing selection, but studies are seldom set up to uncover the underlying processes. Here, we identify and quantify the selective pressures involved in the widespread maintenance of an Inversion Polymorphism in the seaweed fly Coelopa frigida, using an experimental evolution approach to estimate fitness associated with different allelic combinations. By precisely evaluating reproductive success and survival rates separately, we show that the maintenance of the Polymorphism is governed by a life-history trade-off, whereby each inverted haplotype has opposed pleiotropic effects on survival and reproduction. Using numerical simulations, we confirm that this uncovered antagonism between natural and sexual selection can maintain Inversion variation in natural populations of C. frigida. Moreover, our experimental data highlights that Inversion-associated fitness is affected differently by sex, dominance and environmental heterogeneity. The interaction between these factors promotes Polymorphism maintenance through antagonistic pleiotropy. Taken together, our findings indicate that combinations of natural and sexual selective mechanisms enable the persistence of diverse trait in nature. The joint dynamics of life history trade-offs and antagonistic pleiotropy documented here is likely to apply to other species where large phenotypic variation is controlled by structural variants. Significance statement Persistence of chromosomal rearrangements is widespread in nature and often associated with divergent life-history traits. Understanding how contrasted life-history strategies are maintained in wild populations has implications for food production, health and biodiversity in a changing environment. Using the seaweed fly Coelopa frigida, we show that a polymorphic chromosomal Inversion is maintained by a trade-off between survival and reproduction, and thus provide empirical support for a role of balancing selection via antagonistic pleiotropy. This mechanism has long been overlooked because it was thought to only apply to a narrow range of ecological scenarios. These findings empirically reinforce the recent theoretical predictions that co-interacting factors (dominance, environment and sex) can lead to Polymorphism maintenance by antagonistic pleiotropy and favour life-history variation.
Louis Bernatchez - One of the best experts on this subject based on the ideXlab platform.
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Balancing selection via life-history trade-offs maintains an Inversion Polymorphism in a seaweed fly
Nature Communications, 2020Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Maren Wellenreuther, Louis BernatchezAbstract:How natural diversity is maintained is an evolutionary puzzle. Genetic variation can be eroded by drift and directional selection but some Polymorphisms persist for long time periods, implicating a role for balancing selection. Here, we investigate the maintenance of a chro-mosomal Inversion Polymorphism in the seaweed fly Coelopa frigida. Using experimental evolution and quantifying fitness, we show that the Inversion underlies a life-history trade-off, whereby each haplotype has opposing effects on larval survival and adult reproduction. Numerical simulations confirm that such antagonistic pleiotropy can maintain Polymorphism. Our results also highlight the importance of sex-specific effects, dominance and environmental heterogeneity, whose interaction enhances the maintenance of Polymorphism through antagonistic pleiotropy. Overall, our findings directly demonstrate how over-dominance and sexual antagonism can emerge from a life-history trade-off, inviting reconsideration of antagonistic pleiotropy as a key part of multi-headed balancing selection processes that enable the persistence of genetic variation.
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Balancing selection via life-history trade-offs maintains an Inversion Polymorphism in a seaweed fly.
Nature communications, 2020Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Louis Bernatchez, Maren WellenreutherAbstract:How natural diversity is maintained is an evolutionary puzzle. Genetic variation can be eroded by drift and directional selection but some Polymorphisms persist for long time periods, implicating a role for balancing selection. Here, we investigate the maintenance of a chromosomal Inversion Polymorphism in the seaweed fly Coelopa frigida. Using experimental evolution and quantifying fitness, we show that the Inversion underlies a life-history trade-off, whereby each haplotype has opposing effects on larval survival and adult reproduction. Numerical simulations confirm that such antagonistic pleiotropy can maintain Polymorphism. Our results also highlight the importance of sex-specific effects, dominance and environmental heterogeneity, whose interaction enhances the maintenance of Polymorphism through antagonistic pleiotropy. Overall, our findings directly demonstrate how overdominance and sexual antagonism can emerge from a life-history trade-off, inviting reconsideration of antagonistic pleiotropy as a key part of multi-headed balancing selection processes that enable the persistence of genetic variation. Few studies empirically pinpoint how balanced Polymorphisms are maintained. “Merot et al”. identify an Inversion Polymorphism that is maintained in seaweed fly populations because of antagonistic pleiotropy that mediates a classic life history tradeoff between larval survival and adult reproduction.
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balancing selection via life history trade offs maintains an Inversion Polymorphism in a seaweed fly
bioRxiv, 2019Co-Authors: Claire Mérot, Violaine Llaurens, Eric Normandeau, Maren Wellenreuther, Louis BernatchezAbstract:Abstract How genetic diversity is maintained in natural populations is an evolutionary puzzle. Over time, genetic variation within species can be eroded by drift and directional selection, leading to the fixation or elimination of alleles. However, some loci show persistent variants at intermediate frequencies for long evolutionary time-scales, implicating a role of balancing selection, but studies are seldom set up to uncover the underlying processes. Here, we identify and quantify the selective pressures involved in the widespread maintenance of an Inversion Polymorphism in the seaweed fly Coelopa frigida, using an experimental evolution approach to estimate fitness associated with different allelic combinations. By precisely evaluating reproductive success and survival rates separately, we show that the maintenance of the Polymorphism is governed by a life-history trade-off, whereby each inverted haplotype has opposed pleiotropic effects on survival and reproduction. Using numerical simulations, we confirm that this uncovered antagonism between natural and sexual selection can maintain Inversion variation in natural populations of C. frigida. Moreover, our experimental data highlights that Inversion-associated fitness is affected differently by sex, dominance and environmental heterogeneity. The interaction between these factors promotes Polymorphism maintenance through antagonistic pleiotropy. Taken together, our findings indicate that combinations of natural and sexual selective mechanisms enable the persistence of diverse trait in nature. The joint dynamics of life history trade-offs and antagonistic pleiotropy documented here is likely to apply to other species where large phenotypic variation is controlled by structural variants. Significance statement Persistence of chromosomal rearrangements is widespread in nature and often associated with divergent life-history traits. Understanding how contrasted life-history strategies are maintained in wild populations has implications for food production, health and biodiversity in a changing environment. Using the seaweed fly Coelopa frigida, we show that a polymorphic chromosomal Inversion is maintained by a trade-off between survival and reproduction, and thus provide empirical support for a role of balancing selection via antagonistic pleiotropy. This mechanism has long been overlooked because it was thought to only apply to a narrow range of ecological scenarios. These findings empirically reinforce the recent theoretical predictions that co-interacting factors (dominance, environment and sex) can lead to Polymorphism maintenance by antagonistic pleiotropy and favour life-history variation.
