The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Hp Soyer - One of the best experts on this subject based on the ideXlab platform.
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Verrucous cysts: histopathologic characterization and molecular detection of human papillomavirus‐specific DNA
Journal of cutaneous pathology, 1993Co-Authors: Hp Soyer, D Schadendorf, Lorenzo Cerroni, Helmut KerlAbstract:Verrucous cyst is an uncommon newly described benign epithelial cyst which may be associated with human papillomavirus infection. The purpose of this project was to study the clinicopathological features of verrucous cysts and to demonstrate human papillomavirus (HPV) by polymerase chain reaction (PCR) in these lesions. We have analyzed 5 examples of verrucous cysts: the age range of the patients was between 37-82 years and the most common locations were face and extremities. Clinically the lesions were interpreted as cyst (2), dermatofibroma (2) and basal-cell carcinoma (1). Histopathologic examination of the biopsy specimens showed in all cases an intradermal infundibular cyst lined by a papillated and/or digitated epithelium with focal prominent hypergranulosis and irregular keratohyalin granules. Furthermore, numerous whorls of keratinocytes (so-called squamous eddies) were present within the squamous areas of the hyperplastic epithelium of the cyst, morphologically reminiscent of Inverted Follicular Keratosis. Architectural and cytological features of malignancy were not present. Sections of paraffin-embedded tissue of the 5 verrucous cysts and of 5 "conventional" Follicular cysts, infundibular type, were investigated for the presence of HPV DNA sequences by PCR using consensus primers. In all 5 cases of verrucous cysts, HPV-specific DNA sequences were detected, whereas all Follicular cysts, infundibular type, were negative. These results support the concept that verrucous cysts can be added to the large spectrum of HPV-induced cutaneous neoplasms. Further studies are needed to identify the specified HPV-type in these distinctive benign cystic proliferations.
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Verrucous Cysts - Histopathologic Characterization and Molecular-Detection of Human Papillomavirus-Specific Dna
MUNKSGAARD INT PUBL LTD, 1993Co-Authors: Hp Soyer, Schadendorf D, Cerroni L, Kerl HAbstract:Verrucous cyst is an uncommon newly described benign epithelial cyst which may be associated with human papillomavirus infection. The purpose of this project was to study the clinico-pathological features of verrucous cysts and to demonstrate human papillomavirus (HPV) by polymerase chain reaction (PCR) in these lesions. We have analyzed 5 examples of verrucous cysts: the age range of the patients was between 37-82 years and the most common locations were face and extremities. Clinically the lesions were interpreted as cyst (2), dermatofibroma (2) and basal-cell carcinoma (1). Histopathologic examination of the biopsy specimens showed in all cases an intradermal infundibular cyst lined by a papillated and/or digitated epithelium with focal prominent hypergranulosis and irregular keratohyalin granules. Furthermore, numerous whorls of keratinocytes (so-called squamous eddies) were present within the squamous areas of the hyperplastic epithelium of the cyst, morphologically reminiscent of Inverted Follicular Keratosis. Architectural and cytological features of malignancy were not present. Sections of paraffin-embedded tissue of the 5 verrucous cysts and of 5 ''conventional'' Follicular cysts, infundibular type, were investigated for the presence of HPV DNA sequences by PCR using consensus primers. In all 5 cases of verrucous cysts, HPV-specific DNA sequences were detected, whereas all Follicular cysts, infundibular type, were negative. These results support the concept that verrucous cysts can be added to the large spectrum of HPV-induced cutaneous neoplasms. Further studies are needed to identify the specific HPV-type in these distinctive benign cystic proliferations
Hyun Deuk Cho - One of the best experts on this subject based on the ideXlab platform.
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Composite trichoblastoma and Inverted Follicular Keratosis: a case report.
International journal of clinical and experimental pathology, 2018Co-Authors: Junhun Cho, Soon Auck Hong, Hyun Deuk ChoAbstract:Composite trichoblastoma and Inverted Follicular Keratosis is extremely rare and the histogenesis is unclear. To date, only four cases have been described in a report. We report a case of 62-year-old woman patient with a palpable cutaneous nodule on the buttock. The patient had a history of squamous cell carcinoma on the lower lip 13 months ago. Excisional biopsy was done, and the microscopic examination revealed composite tumor of trichoblastoma and Inverted Follicular Keratosis. The patient has not been experienced recurrence after surgery.
Alicia Galindo-ferreiro - One of the best experts on this subject based on the ideXlab platform.
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Periocular Inverted Follicular Keratosis: a retrospective series over 17 years
Japanese Journal of Ophthalmology, 2019Co-Authors: Cecilia Díez-montero, Diego González González, Elena Pérez Martínez, Silvana Schellini, Alicia Galindo-ferreiroAbstract:Purpose To evaluate the demographic, clinical, and histopathologic characteristics of periocular Inverted Follicular Keratosis (IFK), a very rare lesion with poorly defined characteristics. Study design Retrospective case series. Methods We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Data were collected on the patients’ demographics, clinical presentation and course of the disease, signs and symptoms, location of the lesion, and outcomes of treatment. Results The patients’ mean age was 71 years (range, 32–91 years). Seven (64%) of the patients were female. Eight of the patients (72.7%) had no symptoms, two (18.2%) reported itching, and one (9.1%) had edema and bleeding of the lesion. The lesion affected the upper eyelid in 4 of the patients (36%), the lower lid in 3 of the patients (27%), and the inner canthus in 4 of the patients (36%). Conclusions IFK has no specific clinical characteristic and thus requires histologic confirmation for its diagnosis and appropriate management.
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Periocular Inverted Follicular Keratosis: a retrospective series over 17 years.
Japanese journal of ophthalmology, 2019Co-Authors: Cecilia Díez-montero, Silvana Schellini, Diego González González, Elena Pérez Martínez, Alicia Galindo-ferreiroAbstract:PURPOSE To evaluate the demographic, clinical, and histopathologic characteristics of periocular Inverted Follicular Keratosis (IFK), a very rare lesion with poorly defined characteristics. STUDY DESIGN Retrospective case series. METHODS We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Data were collected on the patients' demographics, clinical presentation and course of the disease, signs and symptoms, location of the lesion, and outcomes of treatment. RESULTS The patients' mean age was 71 years (range, 32-91 years). Seven (64%) of the patients were female. Eight of the patients (72.7%) had no symptoms, two (18.2%) reported itching, and one (9.1%) had edema and bleeding of the lesion. The lesion affected the upper eyelid in 4 of the patients (36%), the lower lid in 3 of the patients (27%), and the inner canthus in 4 of the patients (36%). CONCLUSIONS IFK has no specific clinical characteristic and thus requires histologic confirmation for its diagnosis and appropriate management.
Kerl H - One of the best experts on this subject based on the ideXlab platform.
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Verrucous Cysts - Histopathologic Characterization and Molecular-Detection of Human Papillomavirus-Specific Dna
MUNKSGAARD INT PUBL LTD, 1993Co-Authors: Hp Soyer, Schadendorf D, Cerroni L, Kerl HAbstract:Verrucous cyst is an uncommon newly described benign epithelial cyst which may be associated with human papillomavirus infection. The purpose of this project was to study the clinico-pathological features of verrucous cysts and to demonstrate human papillomavirus (HPV) by polymerase chain reaction (PCR) in these lesions. We have analyzed 5 examples of verrucous cysts: the age range of the patients was between 37-82 years and the most common locations were face and extremities. Clinically the lesions were interpreted as cyst (2), dermatofibroma (2) and basal-cell carcinoma (1). Histopathologic examination of the biopsy specimens showed in all cases an intradermal infundibular cyst lined by a papillated and/or digitated epithelium with focal prominent hypergranulosis and irregular keratohyalin granules. Furthermore, numerous whorls of keratinocytes (so-called squamous eddies) were present within the squamous areas of the hyperplastic epithelium of the cyst, morphologically reminiscent of Inverted Follicular Keratosis. Architectural and cytological features of malignancy were not present. Sections of paraffin-embedded tissue of the 5 verrucous cysts and of 5 ''conventional'' Follicular cysts, infundibular type, were investigated for the presence of HPV DNA sequences by PCR using consensus primers. In all 5 cases of verrucous cysts, HPV-specific DNA sequences were detected, whereas all Follicular cysts, infundibular type, were negative. These results support the concept that verrucous cysts can be added to the large spectrum of HPV-induced cutaneous neoplasms. Further studies are needed to identify the specific HPV-type in these distinctive benign cystic proliferations
Helmut Kerl - One of the best experts on this subject based on the ideXlab platform.
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Verrucous cysts: histopathologic characterization and molecular detection of human papillomavirus‐specific DNA
Journal of cutaneous pathology, 1993Co-Authors: Hp Soyer, D Schadendorf, Lorenzo Cerroni, Helmut KerlAbstract:Verrucous cyst is an uncommon newly described benign epithelial cyst which may be associated with human papillomavirus infection. The purpose of this project was to study the clinicopathological features of verrucous cysts and to demonstrate human papillomavirus (HPV) by polymerase chain reaction (PCR) in these lesions. We have analyzed 5 examples of verrucous cysts: the age range of the patients was between 37-82 years and the most common locations were face and extremities. Clinically the lesions were interpreted as cyst (2), dermatofibroma (2) and basal-cell carcinoma (1). Histopathologic examination of the biopsy specimens showed in all cases an intradermal infundibular cyst lined by a papillated and/or digitated epithelium with focal prominent hypergranulosis and irregular keratohyalin granules. Furthermore, numerous whorls of keratinocytes (so-called squamous eddies) were present within the squamous areas of the hyperplastic epithelium of the cyst, morphologically reminiscent of Inverted Follicular Keratosis. Architectural and cytological features of malignancy were not present. Sections of paraffin-embedded tissue of the 5 verrucous cysts and of 5 "conventional" Follicular cysts, infundibular type, were investigated for the presence of HPV DNA sequences by PCR using consensus primers. In all 5 cases of verrucous cysts, HPV-specific DNA sequences were detected, whereas all Follicular cysts, infundibular type, were negative. These results support the concept that verrucous cysts can be added to the large spectrum of HPV-induced cutaneous neoplasms. Further studies are needed to identify the specified HPV-type in these distinctive benign cystic proliferations.
