The Experts below are selected from a list of 1416 Experts worldwide ranked by ideXlab platform
Joseph M Hoxworth - One of the best experts on this subject based on the ideXlab platform.
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mri based texture analysis to differentiate sinonasal squamous cell carcinoma from Inverted Papilloma
American Journal of Neuroradiology, 2017Co-Authors: S Ramkumar, Sara Ranjbar, Shuluo Ning, Devyani Lal, Christine M Zwart, Christopher P Wood, Steven M Weindling, Joseph Ross Mitchell, Joseph M HoxworthAbstract:BACKGROUND AND PURPOSE: Because sinonasal Inverted Papilloma can harbor squamous cell carcinoma, differentiating these tumors is relevant. The objectives of this study were to determine whether MR imaging–based texture analysis can accurately classify cases of noncoexistent squamous cell carcinoma and Inverted Papilloma and to compare this classification performance with neuroradiologists9 review. MATERIALS AND METHODS: Adult patients who had Inverted Papilloma or squamous cell carcinoma resected were eligible (coexistent Inverted Papilloma and squamous cell carcinoma were excluded). Inclusion required tumor size of >1.5 cm and preoperative MR imaging with axial T1, axial T2, and axial T1 postcontrast sequences. Five well-established texture analysis algorithms were applied to an ROI from the largest tumor cross-section. For a training dataset, machine-learning algorithms were used to identify the most accurate model, and performance was also evaluated in a validation dataset. On the basis of 3 separate blinded reviews of the ROI, isolated tumor, and entire images, 2 neuroradiologists predicted tumor type in consensus. RESULTS: The Inverted Papilloma (n = 24) and squamous cell carcinoma (n = 22) cohorts were matched for age and sex, while squamous cell carcinoma tumor volume was larger (P = .001). The best classification model achieved similar accuracies for training (17 squamous cell carcinomas, 16 Inverted Papillomas) and validation (7 squamous cell carcinomas, 6 Inverted Papillomas) datasets of 90.9% and 84.6%, respectively (P = .537). For the combined training and validation cohorts, the machine-learning accuracy (89.1%) was better than that of the neuroradiologists9 ROI review (56.5%, P = .0004) but not significantly different from the neuroradiologists9 review of the tumors (73.9%, P = .060) or entire images (87.0%, P = .748). CONCLUSIONS: MR imaging–based texture analysis has the potential to differentiate squamous cell carcinoma from Inverted Papilloma and may, in the future, provide incremental information to the neuroradiologist.
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mri based texture analysis to differentiate sinonasal squamous cell carcinoma from Inverted Papilloma
American Journal of Neuroradiology, 2017Co-Authors: S Ramkumar, Sara Ranjbar, Shuluo Ning, Devyani Lal, Christine M Zwart, Christopher P Wood, Steven M Weindling, Joseph Ross Mitchell, Joseph M HoxworthAbstract:BACKGROUND AND PURPOSE: Because sinonasal Inverted Papilloma can harbor squamous cell carcinoma, differentiating these tumors is relevant. The objectives of this study were to determine whether MR imaging–based texture analysis can accurately classify cases of noncoexistent squamous cell carcinoma and Inverted Papilloma and to compare this classification performance with neuroradiologists' review. MATERIALS AND METHODS: Adult patients who had Inverted Papilloma or squamous cell carcinoma resected were eligible (coexistent Inverted Papilloma and squamous cell carcinoma were excluded). Inclusion required tumor size of >1.5 cm and preoperative MR imaging with axial T1, axial T2, and axial T1 postcontrast sequences. Five well-established texture analysis algorithms were applied to an ROI from the largest tumor cross-section. For a training dataset, machine-learning algorithms were used to identify the most accurate model, and performance was also evaluated in a validation dataset. On the basis of 3 separate blinded reviews of the ROI, isolated tumor, and entire images, 2 neuroradiologists predicted tumor type in consensus. RESULTS: The Inverted Papilloma ( n = 24) and squamous cell carcinoma ( n = 22) cohorts were matched for age and sex, while squamous cell carcinoma tumor volume was larger ( P = .001). The best classification model achieved similar accuracies for training (17 squamous cell carcinomas, 16 Inverted Papillomas) and validation (7 squamous cell carcinomas, 6 Inverted Papillomas) datasets of 90.9% and 84.6%, respectively ( P = .537). For the combined training and validation cohorts, the machine-learning accuracy (89.1%) was better than that of the neuroradiologists' ROI review (56.5%, P = .0004) but not significantly different from the neuroradiologists' review of the tumors (73.9%, P = .060) or entire images (87.0%, P = .748). CONCLUSIONS: MR imaging–based texture analysis has the potential to differentiate squamous cell carcinoma from Inverted Papilloma and may, in the future, provide incremental information to the neuroradiologist. ### Abbreviations DOST : Discrete Orthonormal Stockwell Transform GFB : Gabor Filter Banks GLCM : Gray-Level Co-occurrence Matrix IP : Inverted Papilloma LBP : local binary patterns LoGHist : Laplacian of Gaussian histogram PC : principal component SCC : squamous cell carcinoma T1 : axial T1-weighted MRI pulse sequence T2 : axial T2-weighted MRI pulse sequence with frequency-selective fat suppression T1C : axial T1-weighted postcontrast MRI pulse sequence with frequency-selective fat suppression
S Ramkumar - One of the best experts on this subject based on the ideXlab platform.
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mri based texture analysis to differentiate sinonasal squamous cell carcinoma from Inverted Papilloma
American Journal of Neuroradiology, 2017Co-Authors: S Ramkumar, Sara Ranjbar, Shuluo Ning, Devyani Lal, Christine M Zwart, Christopher P Wood, Steven M Weindling, Joseph Ross Mitchell, Joseph M HoxworthAbstract:BACKGROUND AND PURPOSE: Because sinonasal Inverted Papilloma can harbor squamous cell carcinoma, differentiating these tumors is relevant. The objectives of this study were to determine whether MR imaging–based texture analysis can accurately classify cases of noncoexistent squamous cell carcinoma and Inverted Papilloma and to compare this classification performance with neuroradiologists9 review. MATERIALS AND METHODS: Adult patients who had Inverted Papilloma or squamous cell carcinoma resected were eligible (coexistent Inverted Papilloma and squamous cell carcinoma were excluded). Inclusion required tumor size of >1.5 cm and preoperative MR imaging with axial T1, axial T2, and axial T1 postcontrast sequences. Five well-established texture analysis algorithms were applied to an ROI from the largest tumor cross-section. For a training dataset, machine-learning algorithms were used to identify the most accurate model, and performance was also evaluated in a validation dataset. On the basis of 3 separate blinded reviews of the ROI, isolated tumor, and entire images, 2 neuroradiologists predicted tumor type in consensus. RESULTS: The Inverted Papilloma (n = 24) and squamous cell carcinoma (n = 22) cohorts were matched for age and sex, while squamous cell carcinoma tumor volume was larger (P = .001). The best classification model achieved similar accuracies for training (17 squamous cell carcinomas, 16 Inverted Papillomas) and validation (7 squamous cell carcinomas, 6 Inverted Papillomas) datasets of 90.9% and 84.6%, respectively (P = .537). For the combined training and validation cohorts, the machine-learning accuracy (89.1%) was better than that of the neuroradiologists9 ROI review (56.5%, P = .0004) but not significantly different from the neuroradiologists9 review of the tumors (73.9%, P = .060) or entire images (87.0%, P = .748). CONCLUSIONS: MR imaging–based texture analysis has the potential to differentiate squamous cell carcinoma from Inverted Papilloma and may, in the future, provide incremental information to the neuroradiologist.
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mri based texture analysis to differentiate sinonasal squamous cell carcinoma from Inverted Papilloma
American Journal of Neuroradiology, 2017Co-Authors: S Ramkumar, Sara Ranjbar, Shuluo Ning, Devyani Lal, Christine M Zwart, Christopher P Wood, Steven M Weindling, Joseph Ross Mitchell, Joseph M HoxworthAbstract:BACKGROUND AND PURPOSE: Because sinonasal Inverted Papilloma can harbor squamous cell carcinoma, differentiating these tumors is relevant. The objectives of this study were to determine whether MR imaging–based texture analysis can accurately classify cases of noncoexistent squamous cell carcinoma and Inverted Papilloma and to compare this classification performance with neuroradiologists' review. MATERIALS AND METHODS: Adult patients who had Inverted Papilloma or squamous cell carcinoma resected were eligible (coexistent Inverted Papilloma and squamous cell carcinoma were excluded). Inclusion required tumor size of >1.5 cm and preoperative MR imaging with axial T1, axial T2, and axial T1 postcontrast sequences. Five well-established texture analysis algorithms were applied to an ROI from the largest tumor cross-section. For a training dataset, machine-learning algorithms were used to identify the most accurate model, and performance was also evaluated in a validation dataset. On the basis of 3 separate blinded reviews of the ROI, isolated tumor, and entire images, 2 neuroradiologists predicted tumor type in consensus. RESULTS: The Inverted Papilloma ( n = 24) and squamous cell carcinoma ( n = 22) cohorts were matched for age and sex, while squamous cell carcinoma tumor volume was larger ( P = .001). The best classification model achieved similar accuracies for training (17 squamous cell carcinomas, 16 Inverted Papillomas) and validation (7 squamous cell carcinomas, 6 Inverted Papillomas) datasets of 90.9% and 84.6%, respectively ( P = .537). For the combined training and validation cohorts, the machine-learning accuracy (89.1%) was better than that of the neuroradiologists' ROI review (56.5%, P = .0004) but not significantly different from the neuroradiologists' review of the tumors (73.9%, P = .060) or entire images (87.0%, P = .748). CONCLUSIONS: MR imaging–based texture analysis has the potential to differentiate squamous cell carcinoma from Inverted Papilloma and may, in the future, provide incremental information to the neuroradiologist. ### Abbreviations DOST : Discrete Orthonormal Stockwell Transform GFB : Gabor Filter Banks GLCM : Gray-Level Co-occurrence Matrix IP : Inverted Papilloma LBP : local binary patterns LoGHist : Laplacian of Gaussian histogram PC : principal component SCC : squamous cell carcinoma T1 : axial T1-weighted MRI pulse sequence T2 : axial T2-weighted MRI pulse sequence with frequency-selective fat suppression T1C : axial T1-weighted postcontrast MRI pulse sequence with frequency-selective fat suppression
Peter H Hwang - One of the best experts on this subject based on the ideXlab platform.
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endoscopic resection of sinonasal Inverted Papilloma a meta analysis
Otolaryngology-Head and Neck Surgery, 2006Co-Authors: Jose M Busquets, Peter H HwangAbstract:OBJECTIVES: Endoscopic resection has become an increasingly popular method of treating sinonasal Inverted Papillomas. The literature on endoscopic approaches to Inverted Papilloma consists primarily of relatively small case series (grade C evidence). This study aims to systematically review and integrate the available literature to objectively compare success rates of endoscopic versus nonendoscopic tumor resection techniques.STUDY DESIGN: A systematic review of the literature on resection of Inverted Papillomas.METHODS: Comprehensive review of the English-language literature on resection of Inverted Papillomas was performed. The reports were subdivided into endoscopic approaches versus nonendoscopic approaches, applying strict inclusion and exclusion criteria. Our institution's experience with endoscopic treatment of Inverted Papilloma was also included. Studies from the era of endoscopic sinus surgery (1992-2004) formed a “contemporary” cohort and were compared with a “historical” cohort developed from ...
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endoscopic resection of sinonasal Inverted Papilloma a meta analysis
Otolaryngology-Head and Neck Surgery, 2006Co-Authors: Jose M Busquets, Peter H HwangAbstract:Objectives Endoscopic resection has become an increasingly popular method of treating sinonasal Inverted Papillomas. The literature on endoscopic approaches to Inverted Papilloma consists primarily of relatively small case series (grade C evidence). This study aims to systematically review and integrate the available literature to objectively compare success rates of endoscopic versus nonendoscopic tumor resection techniques. Study design A systematic review of the literature on resection of Inverted Papillomas. Methods Comprehensive review of the English-language literature on resection of Inverted Papillomas was performed. The reports were subdivided into endoscopic approaches versus nonendoscopic approaches, applying strict inclusion and exclusion criteria. Our institution’s experience with endoscopic treatment of Inverted Papilloma was also included. Studies from the era of endoscopic sinus surgery (1992-2004) formed a “contemporary” cohort and were compared with a “historical” cohort developed from the literature between 1970 and 1995. Results Thirty-two studies were included in the contemporary cohort, comprising 714 patients treated endoscopically and 346 patients treated nonendoscopically. Thirteen studies in the historical cohort yielded 692 patients treated nonendoscopically. There was a significantly lower recurrence rate in the contemporary cohort compared with the historical cohort (15% v 20%, P = 0.02). Within the contemporary cohort, endoscopically treated patients had significantly lower recurrences than nonendoscopically treated patients (12% v 20%, P Conclusions A systematic review of the literature supports endoscopic resection as a favorable treatment option for most cases of sinonasal Inverted Papilloma. EBM rating: B-3a
Stacey T Gray - One of the best experts on this subject based on the ideXlab platform.
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surgical risk factors for recurrence of Inverted Papilloma
Laryngoscope, 2016Co-Authors: David Y Healy, Nipun Chhabra, Ralph Metson, Eric H Holbrook, Stacey T GrayAbstract:Objectives/Hypothesis To identify variations in surgical technique that impact the recurrence of Inverted Papilloma following endoscopic excision. Study Design Retrospective cohort. Methods Data from 127 consecutive patients who underwent endoscopic excision of Inverted Papilloma and oncocytic Papilloma at a tertiary care medical center from 1998 to 2011 were reviewed. Patient demographics, comorbidities, tumor stage, and intraoperative details, including tumor location and management of the base, were evaluated to identify factors associated with tumor recurrence. Results Recurrence of Papilloma occurred in 16 patients (12.6%). Mean time to recurrence was 31.0 months (range, 5.2–110.0 months). Mucosal stripping alone was associated with a recurrence rate of 52.2% (12/23 patients), compared to 4.9% (3/61 patients) when the tumor base was drilled, 4.7% (1/21 patients) when it was cauterized, and 0.0% (0/22 patients) when it was completely excised (P = .001). Increased recurrence rate was associated with tumors located in the maxillary sinus (P = .03), as well as the performance of endoscopic medial maxillectomy (P = .001) and external frontal approaches (P = .02). Conclusions Drilling, cauterizing, or completely excising the bone underlying the tumor base during endoscopic resection reduces the recurrence rate of Inverted and oncocytic Papilloma, when compared to mucosal stripping alone. Surgeons who perform endoscopic resection of these tumors should consider utilization of these techniques when possible. Level of Evidence 4 Laryngoscope, 126:796–801, 2016
Peleg M Horowitz - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma arising from sinonasal Inverted Papilloma
American Journal of Neuroradiology, 2020Co-Authors: Daniel Thomas Ginat, A Trzcinska, Peleg M HorowitzAbstract:Sinonasal Inverted Papillomas occasionally undergo malignant transformation into squamous cell carcinoma, which can be associated with EGFR mutations. Since biopsy can potentially under-sample the tumor, CT and MRI can provide clues as to the presence of malignant transformation. In particular, this entity tends to appear different from benign Inverted Papilloma on imaging, including prominent bone erosions, necrosis, low diffusivity in the solid tumor components, and absence of the cerebriform pattern on MRI. The radiology findings, pathology features, and management of squamous cell carcinoma arising from Inverted Papilloma are described.
