The Experts below are selected from a list of 12996 Experts worldwide ranked by ideXlab platform
M R Sims - One of the best experts on this subject based on the ideXlab platform.
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a pilot study of the leicester ed medical infrared imaging protocol in fever and sepsis
PLOS ONE, 2018Co-Authors: Timothy J Coats, Mohamed Morsy, Sana Naseer, K Keresztes, Sarina Hussain, Katie Dexter, M R SimsAbstract:Background Medical Infrared Imaging (MII) is an Investigative Method that can be potentially used in emergency care to non-invasively detect thermal signatures associated with change in blood flow. We have developed a protocol for the use of MII in the Emergency Department (ED) and shown that it is feasible. To derive initial data for sample size calculations, we performed an exploratory study in patients with fever and sepsis. Methods The Leicester MII protocol was used to image the temperature patterns along the arm among three patient groups (control, fever and sepsis) of a total 56 patients. Anatomical markers were used to divide this gradient into upper arm, forearm, hand and finger regions. Variations in measurements within and between these regions were described. Results The thermal gradient down the arm was successfully extracted in all patients. The distribution of values in each region of the arm was described in control, fever and sepsis patients. There was a significant gradient between upper arm and finger in controls (2.75, p < 0.0001), but no gradient in fever (p = 0.944) or sepsis (p = 0.710). This was reflected in the finger/arm difference, which was of -2.74°C (±3.50) in controls, -0.39C (±2.48) in fever, and -1.80°C (±3.09) in sepsis. Conclusions This study found different thermal gradients along the arm in control and febrile groups, and defined the degree of individual variation. It is likely that the difference between upper arm temperature and finger temperature (representing the temperature gradient down the arm) may be more useful than absolute measurements in future studies.
Mohamed Morsy - One of the best experts on this subject based on the ideXlab platform.
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a pilot study of the leicester ed medical infrared imaging protocol in fever and sepsis
PLOS ONE, 2018Co-Authors: Timothy J Coats, Mohamed Morsy, Sana Naseer, K Keresztes, Sarina Hussain, Katie Dexter, M R SimsAbstract:Background Medical Infrared Imaging (MII) is an Investigative Method that can be potentially used in emergency care to non-invasively detect thermal signatures associated with change in blood flow. We have developed a protocol for the use of MII in the Emergency Department (ED) and shown that it is feasible. To derive initial data for sample size calculations, we performed an exploratory study in patients with fever and sepsis. Methods The Leicester MII protocol was used to image the temperature patterns along the arm among three patient groups (control, fever and sepsis) of a total 56 patients. Anatomical markers were used to divide this gradient into upper arm, forearm, hand and finger regions. Variations in measurements within and between these regions were described. Results The thermal gradient down the arm was successfully extracted in all patients. The distribution of values in each region of the arm was described in control, fever and sepsis patients. There was a significant gradient between upper arm and finger in controls (2.75, p < 0.0001), but no gradient in fever (p = 0.944) or sepsis (p = 0.710). This was reflected in the finger/arm difference, which was of -2.74°C (±3.50) in controls, -0.39C (±2.48) in fever, and -1.80°C (±3.09) in sepsis. Conclusions This study found different thermal gradients along the arm in control and febrile groups, and defined the degree of individual variation. It is likely that the difference between upper arm temperature and finger temperature (representing the temperature gradient down the arm) may be more useful than absolute measurements in future studies.
Freddie C Hamdy - One of the best experts on this subject based on the ideXlab platform.
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neural network analysis of combined conventional and experimental prognostic markers in prostate cancer a pilot study
British Journal of Cancer, 1998Co-Authors: R N G Naguib, M C Robinson, D E Neal, Freddie C HamdyAbstract:Prostate cancer is the second most common malignancy in men in the UK. The disease is unpredictable in its behaviour and, at present, no single Investigative Method allows clinicians to differentiate between tumours that will progress and those that will remain quiescent. There is an increasing need for novel means to predict prognosis and outcome of the disease. The aim of this study was to assess the value of artificial neural networks in predicting outcome in prostate cancer in comparison with statistical Methods, using a combination of conventional and experimental biological markers. Forty-one patients with different stages and grades of prostate cancer undergoing a variety of treatments were analysed. Artificial neural networks were used as follows: eight input neurons consisting of six conventional factors (age, stage, bone scan findings, grade, serum PSA, treatment) and two experimental markers (immunostaining for bcl-2 and p53, which are both apoptosis-regulating genes). Twenty-one patients were used for training and 20 for testing. A total of 80% of the patients were correctly classified regarding outcome using the combination of factors. When both bcl-2 and p53 immunoreactivity were excluded from the analysis, correct prediction of the outcome was achieved in only 60% of the patients (P = 0.0032). This study was able to demonstrate the value of artificial neural networks in the analysis of prognostic markers in prostate cancer. In addition, the potential for using this technology to evaluate novel markers is highlighted. Further large-scale analyses are required to incorporate this Methodology into routine clinical practice.
Timothy J Coats - One of the best experts on this subject based on the ideXlab platform.
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a pilot study of the leicester ed medical infrared imaging protocol in fever and sepsis
PLOS ONE, 2018Co-Authors: Timothy J Coats, Mohamed Morsy, Sana Naseer, K Keresztes, Sarina Hussain, Katie Dexter, M R SimsAbstract:Background Medical Infrared Imaging (MII) is an Investigative Method that can be potentially used in emergency care to non-invasively detect thermal signatures associated with change in blood flow. We have developed a protocol for the use of MII in the Emergency Department (ED) and shown that it is feasible. To derive initial data for sample size calculations, we performed an exploratory study in patients with fever and sepsis. Methods The Leicester MII protocol was used to image the temperature patterns along the arm among three patient groups (control, fever and sepsis) of a total 56 patients. Anatomical markers were used to divide this gradient into upper arm, forearm, hand and finger regions. Variations in measurements within and between these regions were described. Results The thermal gradient down the arm was successfully extracted in all patients. The distribution of values in each region of the arm was described in control, fever and sepsis patients. There was a significant gradient between upper arm and finger in controls (2.75, p < 0.0001), but no gradient in fever (p = 0.944) or sepsis (p = 0.710). This was reflected in the finger/arm difference, which was of -2.74°C (±3.50) in controls, -0.39C (±2.48) in fever, and -1.80°C (±3.09) in sepsis. Conclusions This study found different thermal gradients along the arm in control and febrile groups, and defined the degree of individual variation. It is likely that the difference between upper arm temperature and finger temperature (representing the temperature gradient down the arm) may be more useful than absolute measurements in future studies.
Balcar Nathalie - One of the best experts on this subject based on the ideXlab platform.
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L’envers de la marqueterie Boulle : analyse des matériaux de collage
'OpenEdition', 2021Co-Authors: Elie-lefebvre Delphine, Hartmann Daniel, Balcar NathalieAbstract:La restauration d’une œuvre de mobilier offre l’opportunité de s’intéresser à la colle qui assure le maintien des différents éléments sur la structure en bois. Une nouvelle technique d’investigation des colles, jusque-là absente des laboratoires français dédiés à l’étude du patrimoine, a été évaluée et validée pour connaître l’origine animale de ce matériau.The restoration of a piece of furniture offers researchers a chance to study the glue used to hold the different parts of the wooden structure together. A new Investigative Method of determining the adhesive used, previously unavailable in French laboratories reserved for cultural heritage studies, was tested and validated. It confirmed the animal origin of this glue
