The Experts below are selected from a list of 5472 Experts worldwide ranked by ideXlab platform
Adam Becalski - One of the best experts on this subject based on the ideXlab platform.
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Determination of Iodoacetic Acid using liquid chromatography/electrospray tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM, 2008Co-Authors: Benjamin P.-y. Lau, Adam BecalskiAbstract:A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized Iodoacetic Acid in water. The method was applied to model reaction mixtures in the study of the formation of Iodoacetic Acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 µg/L (or 0.3 ng/mL) and limit of quantitation was about 1 µg/L (1 ng/mL). Copyright © 2008 John Wiley & Sons, Ltd.
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determination of Iodoacetic Acid using liquid chromatography electrospray tandem mass spectrometry
Rapid Communications in Mass Spectrometry, 2008Co-Authors: Benjamin P.-y. Lau, Adam BecalskiAbstract:A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized Iodoacetic Acid in water. The method was applied to model reaction mixtures in the study of the formation of Iodoacetic Acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 µg/L (or 0.3 ng/mL) and limit of quantitation was about 1 µg/L (1 ng/mL). Copyright © 2008 John Wiley & Sons, Ltd.
Wansong Zong - One of the best experts on this subject based on the ideXlab platform.
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Superoxide dismutase response and the underlying molecular mechanism induced by Iodoacetic Acid
Chemosphere, 2019Co-Authors: Jing Wang, Rui Jia, Xiaolin Zheng, Rutao Liu, Wansong ZongAbstract:Given the ubiquity of iodinated disinfection by-products (I-DBPs) in drinking water and their prominent toxicity, it is of vital significance to evaluate I-DBPs toxicity and explore the underlying mechanism. The toxicity of Iodoacetic Acid (IAA), a typical type of I-DBPs, might be linked with oxidative stress. However, it remains unknown for the response of antioxidant enzyme superoxide dismutase (SOD) in the mouse primary hepatocytes when exposed to IAA and the underlying mechanism. This study explored SOD response to IAA and the underlying mechanisms at the molecular and cellular levels. Under IAA exposure, the observed increase of SOD activity in the hepatocytes was caused by the increase of SOD production via ROS stimulation and the increase of SOD molecular activity. Molecular experiments showed that IAA binds to SOD molecule mainly via electrostatic forces with one binding site around the active site and six binding sites in the surface of protein. The binding interaction leads to the conformational changes of SOD and the disruption of protein aggregates. This work could offer basic data for the comprehensive understanding of the adverse effects of IAA and references for assessing the harmful effects of DBPs.
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drinking water disinfection byproduct Iodoacetic Acid interacts with catalase and induces cytotoxicity in mouse primary hepatocytes
Chemosphere, 2018Co-Authors: Jing Wang, Rui Jia, Xiaolin Zheng, Rutao Liu, Zhiqiang Sun, Wansong ZongAbstract:Abstract Disinfection byproducts (DBPs) are produced during the disinfection of drinking water and pose a hazard to human health. As a typical type of DBPs, Iodoacetic Acid (IAA) exhibits prominent cytotoxicity in mammalian cell systems which links with oxidative stress. However, little is known about the relationship of catalase (CAT) with the cytotoxicity of IAA and the adverse effects of IAA to CAT. This study investigated the effects of IAA on the cell viability and CAT activity in the mouse primary hepatocytes. It was shown that IAA exposure induced the loss of cell viability and the increase of intracellular CAT activity. Intracellular CAT activity significantly increased due to the stimulation of CAT production under IAA exposure. The molecular CAT activity was inhibited due to the direct interaction of IAA with HIS 74 and TYR 357 around the active sites of CAT. IAA binds to CAT with (4.05 ± 1.98) sites via van der Waals and hydrogen bonding interactions, resulting in the loosening of protein skeletons and the change of protein size.
A Ravi - One of the best experts on this subject based on the ideXlab platform.
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retracted microwave assisted synthesis of trifluoro substituted 2 aminobenzimidazole derivatives via Iodoacetic Acid mediated one pot condensation
Journal of Heterocyclic Chemistry, 2017Co-Authors: R Sriram, R Sapthagiri, L Ilavarasan, A RaviAbstract:Microwave-assisted efficient one-pot syntheses of trifluoro substituted 2-aminobenzimidazole derivative were synthesized using Iodoacetic Acid mediated cyclodesulfurization of thioureas. This method eliminates need to handle preformed substituted thioureas, requires lesser reaction time and temperature, is facile, and also gives higher yields of the target molecules.
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Retracted: Microwave Assisted Synthesis of Trifluoro Substituted 2‐Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One‐pot Condensation
Journal of Heterocyclic Chemistry, 2017Co-Authors: R Sriram, R Sapthagiri, L Ilavarasan, A RaviAbstract:Microwave-assisted efficient one-pot syntheses of trifluoro substituted 2-aminobenzimidazole derivative were synthesized using Iodoacetic Acid mediated cyclodesulfurization of thioureas. This method eliminates need to handle preformed substituted thioureas, requires lesser reaction time and temperature, is facile, and also gives higher yields of the target molecules.
Benjamin P.-y. Lau - One of the best experts on this subject based on the ideXlab platform.
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Determination of Iodoacetic Acid using liquid chromatography/electrospray tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM, 2008Co-Authors: Benjamin P.-y. Lau, Adam BecalskiAbstract:A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized Iodoacetic Acid in water. The method was applied to model reaction mixtures in the study of the formation of Iodoacetic Acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 µg/L (or 0.3 ng/mL) and limit of quantitation was about 1 µg/L (1 ng/mL). Copyright © 2008 John Wiley & Sons, Ltd.
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determination of Iodoacetic Acid using liquid chromatography electrospray tandem mass spectrometry
Rapid Communications in Mass Spectrometry, 2008Co-Authors: Benjamin P.-y. Lau, Adam BecalskiAbstract:A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized Iodoacetic Acid in water. The method was applied to model reaction mixtures in the study of the formation of Iodoacetic Acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 µg/L (or 0.3 ng/mL) and limit of quantitation was about 1 µg/L (1 ng/mL). Copyright © 2008 John Wiley & Sons, Ltd.
Edgars Suna - One of the best experts on this subject based on the ideXlab platform.
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Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles
Synthesis, 2013Co-Authors: Andrejs Krasikovs, Vita Ozola, Scott L. Dax, Edgars SunaAbstract:Chiral, nonracemic, N-unprotected amino Acids were converted into the corresponding N -benzimidazol-2-yl derivatives by a sequential procedure involving initial formation of isothiocyanates, their reaction with arene-1,2-diamines, and cyclization–desulfurization of the intermediate thioureas with Iodoacetic Acid. The simplified workup and the lack of volatile or toxic byproducts in the key desulfurization step renders Iodoacetic Acid a superior reagent to the usual reagent, iodomethane.
