The Experts below are selected from a list of 5167932 Experts worldwide ranked by ideXlab platform
Jianren Mao - One of the best experts on this subject based on the ideXlab platform.
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an improved rodent model of trigeminal neuropathic pain by unilateral chronic constrictIon injury of distal infraorbital nerve
The Journal of Pain, 2017Co-Authors: Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Lucy Chen, Shengmei Zhu, Jianren MaoAbstract:Abstract The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constrictIon injury (CCI) is induced by ligatIon of the infraorbital nerve (Ion). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligatIon of peripheral nerves (eg, sciatic nerve). The aim of this study was to improve on the current surgical procedure of Ion ligatIon to induce trigeminal neuropathic pain in rats. We show that the Ion can be readily accessed through a small facial incisIon. CCI can be induced by ligatIon of a segment at the distal Ion (dIon). This dIon-CCI procedure is simple, minimally invasive, and time-saving. Our data show that the dIon-CCI procedure consistently induced acute as well as chronic nociceptive behaviors in rats. Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIon-CCI rats. Perspective The orofacial pain caused by trigeminal nerve damage is severe and perhaps more debilitating than other types of neuropathic pain. However, studies on trigeminal neuropathic pain remain limited. This is largely because of the lack of proper animal models because of the complexity of the existing surgical procedures required to induce trigeminal nerve injury. Our improved dIon-CCI model is likely to make it more accessible to study the cellular and molecular mechanisms of neuropathic pain caused by trigeminal nerve damage.
Weihua Ding - One of the best experts on this subject based on the ideXlab platform.
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an improved rodent model of trigeminal neuropathic pain by unilateral chronic constrictIon injury of distal infraorbital nerve
The Journal of Pain, 2017Co-Authors: Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Lucy Chen, Shengmei Zhu, Jianren MaoAbstract:Abstract The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constrictIon injury (CCI) is induced by ligatIon of the infraorbital nerve (Ion). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligatIon of peripheral nerves (eg, sciatic nerve). The aim of this study was to improve on the current surgical procedure of Ion ligatIon to induce trigeminal neuropathic pain in rats. We show that the Ion can be readily accessed through a small facial incisIon. CCI can be induced by ligatIon of a segment at the distal Ion (dIon). This dIon-CCI procedure is simple, minimally invasive, and time-saving. Our data show that the dIon-CCI procedure consistently induced acute as well as chronic nociceptive behaviors in rats. Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIon-CCI rats. Perspective The orofacial pain caused by trigeminal nerve damage is severe and perhaps more debilitating than other types of neuropathic pain. However, studies on trigeminal neuropathic pain remain limited. This is largely because of the lack of proper animal models because of the complexity of the existing surgical procedures required to induce trigeminal nerve injury. Our improved dIon-CCI model is likely to make it more accessible to study the cellular and molecular mechanisms of neuropathic pain caused by trigeminal nerve damage.
Urs Von Gunten - One of the best experts on this subject based on the ideXlab platform.
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quantificatIon and characterizatIon of dissolved organic nitrogen in wastewater effluents by electrodialysis treatment followed by size exclusIon chromatography with nitrogen detectIon
Water Research, 2013Co-Authors: Kangmin Chon, Yunho Lee, Jacqueline Traber, Urs Von GuntenAbstract:Dissolved organic nitrogen (DON) can act as a precursor of nitrogenous disinfectIon byproducts during oxidative water treatment. QuantificatIon and characterizatIon of DON are still challenging for waters with high concentratIons of dissolved inorganic nitrogen (DIN, including ammonia, nitrate and nitrite) relative to total dissolved nitrogen (TDN) due to the cumulative analytical errors of independently measured nitrogen species (i.e., DON = TDN − NO2− − NO3− − NH4+/NH3) and interference of DIN species to TDN quantificatIon. In this study, a novel electrodialysis (ED)-based treatment for selective DIN removal was developed and optimized with respect to type of Ion-exchange membrane, sample pH, and ED duratIon. The optimized ED method was then coupled with size-exclusIon chromatography with organic carbon, UV, and nitrogen detectIon (SEC-OCD-ND) for advanced DON analysis in wastewater effluents. Among the tested Ion-exchange membranes, the PC-AR anIon- and CMT catIon-exchange membranes showed the lowest DOC loss (1–7%) during ED treatment of a wastewater effluent at ambient pH (8.0). A good correlatIon was found between the decrease of the DIN/TDN ratio and conductivity. Therefore, conductivity has been adopted as a convenient way to determine the optimal duratIon of the ED treatment. In the pH range of 7.0–8.3, ED treatment of various wastewater effluents with the PC-AR/CMT membranes showed that the relative residual conductivity could be reduced to less than 0.50 (DIN removal >90%; DIN/TDN ratio ≤0.60) with lower DOC losses (6%) than the previous dialysis and nanofiltratIon methods (DOC loss >10%). In additIon, the ED method is shorter (0.5 h) than the previous methods (>1–24 h). The relative residual conductivity was further reduced to ∼0.20 (DIN removal >95%; DIN/TDN ratio ≤0.35) by increasing the ED duratIon to 0.7 h (DOC loss = 8%) for analysis by SEC-OCD-ND, which provided new informatIon on distributIon and ratio of organic carbon and nitrogen in different molecular weight fractIons of effluent organic matter.
Shiqian Shen - One of the best experts on this subject based on the ideXlab platform.
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an improved rodent model of trigeminal neuropathic pain by unilateral chronic constrictIon injury of distal infraorbital nerve
The Journal of Pain, 2017Co-Authors: Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Lucy Chen, Shengmei Zhu, Jianren MaoAbstract:Abstract The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constrictIon injury (CCI) is induced by ligatIon of the infraorbital nerve (Ion). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligatIon of peripheral nerves (eg, sciatic nerve). The aim of this study was to improve on the current surgical procedure of Ion ligatIon to induce trigeminal neuropathic pain in rats. We show that the Ion can be readily accessed through a small facial incisIon. CCI can be induced by ligatIon of a segment at the distal Ion (dIon). This dIon-CCI procedure is simple, minimally invasive, and time-saving. Our data show that the dIon-CCI procedure consistently induced acute as well as chronic nociceptive behaviors in rats. Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIon-CCI rats. Perspective The orofacial pain caused by trigeminal nerve damage is severe and perhaps more debilitating than other types of neuropathic pain. However, studies on trigeminal neuropathic pain remain limited. This is largely because of the lack of proper animal models because of the complexity of the existing surgical procedures required to induce trigeminal nerve injury. Our improved dIon-CCI model is likely to make it more accessible to study the cellular and molecular mechanisms of neuropathic pain caused by trigeminal nerve damage.
Zerong You - One of the best experts on this subject based on the ideXlab platform.
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an improved rodent model of trigeminal neuropathic pain by unilateral chronic constrictIon injury of distal infraorbital nerve
The Journal of Pain, 2017Co-Authors: Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Lucy Chen, Shengmei Zhu, Jianren MaoAbstract:Abstract The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constrictIon injury (CCI) is induced by ligatIon of the infraorbital nerve (Ion). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligatIon of peripheral nerves (eg, sciatic nerve). The aim of this study was to improve on the current surgical procedure of Ion ligatIon to induce trigeminal neuropathic pain in rats. We show that the Ion can be readily accessed through a small facial incisIon. CCI can be induced by ligatIon of a segment at the distal Ion (dIon). This dIon-CCI procedure is simple, minimally invasive, and time-saving. Our data show that the dIon-CCI procedure consistently induced acute as well as chronic nociceptive behaviors in rats. Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIon-CCI rats. Perspective The orofacial pain caused by trigeminal nerve damage is severe and perhaps more debilitating than other types of neuropathic pain. However, studies on trigeminal neuropathic pain remain limited. This is largely because of the lack of proper animal models because of the complexity of the existing surgical procedures required to induce trigeminal nerve injury. Our improved dIon-CCI model is likely to make it more accessible to study the cellular and molecular mechanisms of neuropathic pain caused by trigeminal nerve damage.
