The Experts below are selected from a list of 7473 Experts worldwide ranked by ideXlab platform
Pesus Chou - One of the best experts on this subject based on the ideXlab platform.
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enhancing the early differential diagnosis of plateau Iris and pupillary block using a scan ultrasonography
PLOS ONE, 2015Co-Authors: Yuyen Chen, Pesus ChouAbstract:Purpose To distinguish the frequently misdiagnosed plateau Iris Eyes from pupillary block group and normal group, we compared the ocular biometrical parameters of them by A-scan ultrasongraphy.
Yuyen Chen - One of the best experts on this subject based on the ideXlab platform.
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enhancing the early differential diagnosis of plateau Iris and pupillary block using a scan ultrasonography
PLOS ONE, 2015Co-Authors: Yuyen Chen, Pesus ChouAbstract:Purpose To distinguish the frequently misdiagnosed plateau Iris Eyes from pupillary block group and normal group, we compared the ocular biometrical parameters of them by A-scan ultrasongraphy.
João Melo Beirão - One of the best experts on this subject based on the ideXlab platform.
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Subclinical retinal angiopathy associated with hereditary transthyretin amyloidosis - assessed with optical coherence tomography angiography.
Amyloid, 2020Co-Authors: João Heitor Marques, João Coelho, Jorge Malheiro, Bernardete Pessoa, João Melo BeirãoAbstract:BACKGROUND Retinal angiopathy is a known ocular manifestation of hereditary transthyretin amyloidosis (ATTRv). Optical coherence tomography angiography (OCT-A) is a recent noninvasive imaging technique, used in other retinal vascular diseases. Our purpose was to analyse subclinical changes in retinal vessels, with OCT-A, in patients with ATTRv amyloidosis. METHODS Observational cross-sectional study in Centro Hospitalar e Universitario do Porto in the cohort of patients with genetic diagnosis of ATTRv. Patients were included if they had just one eye with scalloped Iris (the other eye without scalloped Iris), postulating Eyes were at different stages, in the same patient. Patients were excluded if they had other manifestations of ocular ATTRv amyloidosis, namely clinical retinal angiopathy and/or vitreous opacities. The group of Eyes with scalloped Iris were compared with Eyes without scalloped Iris, using paired tests. Values are shown as Δ = mean difference between groups; p = p-value, d = Cohen's d for effect size measurement. RESULTS Twenty-four patients (24 Eyes in each group) were included. Mean age was 46.5 ± 5.0 years. Eyes with scalloped Iris showed attenuated retinal vascular network: larger foveal avascular zone (FAZ) area (Δ = +0.02 mm2, p = 0.002, d = 0.70); decreased foveal vascular density (Δ = -3.57%, p = 0.001, d = -0.75); superficial (Δ = -1.50%, p = 0.049, d = -0.43) and deep (Δ = -2.53%, p = 0.023, d = -0.50) plexus vascular density. Acircularity index was superior in scalloped Iris Eyes (Δ = 0.04, p = 0.004, d = -0.65), representing an abnormal FAZ morphology. CONCLUSION Scalloped Iris in ATTRv Eyes are associated with a more advanced subclinical retinal angiopathy, than Eyes without scalloped Iris. Our results identify for the first time and in vivo, early changes in retinal vessels in ATTRv amyloidosis. Henceforward, OCT-A may play a role in the evaluation of ATTRv patients oculopathy and the effectiveness of future eye targeting treatments.
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Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients.
Journal of Ophthalmology, 2018Co-Authors: João Melo Beirão, Vasco Miranda, Beatriz Pinheiro-torres, João Coelho, Maria-joão Menéres, Pedro MenéresAbstract:Purpose. Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods. This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped Iris. For comparative analysis, the fellow eye, the nonscalloped Iris eye, from each patient was used as control. All patients underwent aqueous humor flare meter and intraocular pressure (IOP) measurements. Results. Mean aqueous humor flare was significantly higher in the Eyes with the scalloped Iris than the control group with the nonscalloped Iris (14.1 ± 2.2 versus 6.5 ± 0.9 pc/ms, respectively). No significant differences in IOP were found in the scalloped Iris Eyes than those in the nonscalloped Iris control group (17.1 ± 0.8 versus 16.8 ± 0.7 mmHg, respectively). No significant correlation was not found between the flare and the IOP value within groups. Conclusions. In this study, aqueous humor flare values in the scalloped Iris Eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients.
João Coelho - One of the best experts on this subject based on the ideXlab platform.
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Subclinical retinal angiopathy associated with hereditary transthyretin amyloidosis - assessed with optical coherence tomography angiography.
Amyloid, 2020Co-Authors: João Heitor Marques, João Coelho, Jorge Malheiro, Bernardete Pessoa, João Melo BeirãoAbstract:BACKGROUND Retinal angiopathy is a known ocular manifestation of hereditary transthyretin amyloidosis (ATTRv). Optical coherence tomography angiography (OCT-A) is a recent noninvasive imaging technique, used in other retinal vascular diseases. Our purpose was to analyse subclinical changes in retinal vessels, with OCT-A, in patients with ATTRv amyloidosis. METHODS Observational cross-sectional study in Centro Hospitalar e Universitario do Porto in the cohort of patients with genetic diagnosis of ATTRv. Patients were included if they had just one eye with scalloped Iris (the other eye without scalloped Iris), postulating Eyes were at different stages, in the same patient. Patients were excluded if they had other manifestations of ocular ATTRv amyloidosis, namely clinical retinal angiopathy and/or vitreous opacities. The group of Eyes with scalloped Iris were compared with Eyes without scalloped Iris, using paired tests. Values are shown as Δ = mean difference between groups; p = p-value, d = Cohen's d for effect size measurement. RESULTS Twenty-four patients (24 Eyes in each group) were included. Mean age was 46.5 ± 5.0 years. Eyes with scalloped Iris showed attenuated retinal vascular network: larger foveal avascular zone (FAZ) area (Δ = +0.02 mm2, p = 0.002, d = 0.70); decreased foveal vascular density (Δ = -3.57%, p = 0.001, d = -0.75); superficial (Δ = -1.50%, p = 0.049, d = -0.43) and deep (Δ = -2.53%, p = 0.023, d = -0.50) plexus vascular density. Acircularity index was superior in scalloped Iris Eyes (Δ = 0.04, p = 0.004, d = -0.65), representing an abnormal FAZ morphology. CONCLUSION Scalloped Iris in ATTRv Eyes are associated with a more advanced subclinical retinal angiopathy, than Eyes without scalloped Iris. Our results identify for the first time and in vivo, early changes in retinal vessels in ATTRv amyloidosis. Henceforward, OCT-A may play a role in the evaluation of ATTRv patients oculopathy and the effectiveness of future eye targeting treatments.
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Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients.
Journal of Ophthalmology, 2018Co-Authors: João Melo Beirão, Vasco Miranda, Beatriz Pinheiro-torres, João Coelho, Maria-joão Menéres, Pedro MenéresAbstract:Purpose. Assess the aqueous humor flare in transthyretin V30M amyloidosis patients (ATTRV30M). Materials and Methods. This is a retrospective, cross-sectional, noninterventional comparative study including 28 ATTRV30M patients with a unilateral scalloped Iris. For comparative analysis, the fellow eye, the nonscalloped Iris eye, from each patient was used as control. All patients underwent aqueous humor flare meter and intraocular pressure (IOP) measurements. Results. Mean aqueous humor flare was significantly higher in the Eyes with the scalloped Iris than the control group with the nonscalloped Iris (14.1 ± 2.2 versus 6.5 ± 0.9 pc/ms, respectively). No significant differences in IOP were found in the scalloped Iris Eyes than those in the nonscalloped Iris control group (17.1 ± 0.8 versus 16.8 ± 0.7 mmHg, respectively). No significant correlation was not found between the flare and the IOP value within groups. Conclusions. In this study, aqueous humor flare values in the scalloped Iris Eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients.
João Heitor Marques - One of the best experts on this subject based on the ideXlab platform.
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Subclinical retinal angiopathy associated with hereditary transthyretin amyloidosis - assessed with optical coherence tomography angiography.
Amyloid, 2020Co-Authors: João Heitor Marques, João Coelho, Jorge Malheiro, Bernardete Pessoa, João Melo BeirãoAbstract:BACKGROUND Retinal angiopathy is a known ocular manifestation of hereditary transthyretin amyloidosis (ATTRv). Optical coherence tomography angiography (OCT-A) is a recent noninvasive imaging technique, used in other retinal vascular diseases. Our purpose was to analyse subclinical changes in retinal vessels, with OCT-A, in patients with ATTRv amyloidosis. METHODS Observational cross-sectional study in Centro Hospitalar e Universitario do Porto in the cohort of patients with genetic diagnosis of ATTRv. Patients were included if they had just one eye with scalloped Iris (the other eye without scalloped Iris), postulating Eyes were at different stages, in the same patient. Patients were excluded if they had other manifestations of ocular ATTRv amyloidosis, namely clinical retinal angiopathy and/or vitreous opacities. The group of Eyes with scalloped Iris were compared with Eyes without scalloped Iris, using paired tests. Values are shown as Δ = mean difference between groups; p = p-value, d = Cohen's d for effect size measurement. RESULTS Twenty-four patients (24 Eyes in each group) were included. Mean age was 46.5 ± 5.0 years. Eyes with scalloped Iris showed attenuated retinal vascular network: larger foveal avascular zone (FAZ) area (Δ = +0.02 mm2, p = 0.002, d = 0.70); decreased foveal vascular density (Δ = -3.57%, p = 0.001, d = -0.75); superficial (Δ = -1.50%, p = 0.049, d = -0.43) and deep (Δ = -2.53%, p = 0.023, d = -0.50) plexus vascular density. Acircularity index was superior in scalloped Iris Eyes (Δ = 0.04, p = 0.004, d = -0.65), representing an abnormal FAZ morphology. CONCLUSION Scalloped Iris in ATTRv Eyes are associated with a more advanced subclinical retinal angiopathy, than Eyes without scalloped Iris. Our results identify for the first time and in vivo, early changes in retinal vessels in ATTRv amyloidosis. Henceforward, OCT-A may play a role in the evaluation of ATTRv patients oculopathy and the effectiveness of future eye targeting treatments.
