The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Yasuhito Ohkubo - One of the best experts on this subject based on the ideXlab platform.
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the involvement of transferrin in the uptake of Iron 59 by hepatocytes of carbon tetrachloride damaged rats
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Satoko Suyama, Shinya Abe, Yoshihiro Inoue, Ai Toukairin, Yosuke Ohtake, Yasuhito OhkuboAbstract:We have reported that transferrin (Tf)-unbound Gallium-67 (67Ga) was taken up into hepatocytes 1 d after carbon tetrachloride (CCl4)-treatment in rats. It had been reported that the binding affinity of Iron-59 (59Fe) to Tf was greater than that of 67Ga. In the present study, we investigated whether or not Tf was involved in 59Fe uptake by hepatocytes of CCl4-damaged rats. The results showed that the uptake of 59Fe by hepatocytes and the number of Tf-receptor decreased 1 d after CCl4-treatment and increased 2 d after the treatment. Our data demonstrated that the uptake of 59Fe by hepatocytes differed from that of 67Ga and Tf was involved in that of 59Fe. We expect that these finding could serve to analyze the inflammatory stages, disorder stage at 1 d and regeneration stage at 2 d after CCl4-treatment.
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the entering of indium 111 and Iron 59 into the hepatocytes from partially hepatectomized rats differ from that of gallium 67
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Ryota Sato, Shinya Abe, Yosuke Ohtake, Yuji Yamada, Daiki Toyama, Naoko Sato, Yasuhito OhkuboAbstract:We recently suggested that the transferrin (Tf)–gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and Iron-59 (59Fe) with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy. 111In was almost taken by the plasma and little taken by the red blood cell. On the other hand, the uptake of 59Fe by the red blood cell was higher than plasma. The uptake of 59Fe by the bone marrow was significantly higher than that of 111In. The uptake of 111In and 59Fe by the liver tissue was reached a maximum 2 d after partial hepatectomy but the uptake ratio of 111In was lower than that of 59Fe. We suspected that the uptake of 59Fe by the liver tissue was the highest because of the high binding affinity of Tf–59Fe to Tf-receptor. The entering of 111In and 59Fe into the hepatocytes was also reached a maximum 2 d after partial hepatectomy but the ratio of 59Fe was slightly lower than that of 111In. These results suggested that the binding affinity to Tf could have played a crucial role in the differences of the entering of 111In, 59Fe and 67Ga into the hepatocytes of partially hepatectomized rats.
R C Srivastava - One of the best experts on this subject based on the ideXlab platform.
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the effect of cadmium and manganese on the distribution of Iron 59 in partially hepatectomized rats
Pharmacology & Toxicology, 2009Co-Authors: R C Srivastava, G Kaur, R S DwivediAbstract:The distribution of Iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of Iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in Iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.
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the effect of metal salts on the distribution of Iron 59 in rats manganese ii nickel ii and tin ii
Pharmacology & Toxicology, 2009Co-Authors: R S Dwivedi, G Kaur, R K Jaiswal, R C SrivastavaAbstract:: The disappearance and reappearance of Iron-59 in plasma and blood at various time intervals has been studied in control, manganese, nickel and tin administered and anaemic rats after a single intravenous injection of an aqueous solution of radioactive Iron (III) citrate. Significant difference was observed in the rate of reappearance of Iron-59 in the circulation between control and manganese treated animals. The disappearance of Iron-59 from the plasma of control and treated animals however did not show any appreciable difference. A significant increase in the radio-Iron content was observed in bone marrow, liver and kidney of treated animals as compared to control group forty eight hours after Fe-59.
R S Dwivedi - One of the best experts on this subject based on the ideXlab platform.
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the effect of cadmium and manganese on the distribution of Iron 59 in partially hepatectomized rats
Pharmacology & Toxicology, 2009Co-Authors: R C Srivastava, G Kaur, R S DwivediAbstract:The distribution of Iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of Iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in Iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.
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the effect of metal salts on the distribution of Iron 59 in rats manganese ii nickel ii and tin ii
Pharmacology & Toxicology, 2009Co-Authors: R S Dwivedi, G Kaur, R K Jaiswal, R C SrivastavaAbstract:: The disappearance and reappearance of Iron-59 in plasma and blood at various time intervals has been studied in control, manganese, nickel and tin administered and anaemic rats after a single intravenous injection of an aqueous solution of radioactive Iron (III) citrate. Significant difference was observed in the rate of reappearance of Iron-59 in the circulation between control and manganese treated animals. The disappearance of Iron-59 from the plasma of control and treated animals however did not show any appreciable difference. A significant increase in the radio-Iron content was observed in bone marrow, liver and kidney of treated animals as compared to control group forty eight hours after Fe-59.
Shinya Abe - One of the best experts on this subject based on the ideXlab platform.
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the involvement of transferrin in the uptake of Iron 59 by hepatocytes of carbon tetrachloride damaged rats
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Satoko Suyama, Shinya Abe, Yoshihiro Inoue, Ai Toukairin, Yosuke Ohtake, Yasuhito OhkuboAbstract:We have reported that transferrin (Tf)-unbound Gallium-67 (67Ga) was taken up into hepatocytes 1 d after carbon tetrachloride (CCl4)-treatment in rats. It had been reported that the binding affinity of Iron-59 (59Fe) to Tf was greater than that of 67Ga. In the present study, we investigated whether or not Tf was involved in 59Fe uptake by hepatocytes of CCl4-damaged rats. The results showed that the uptake of 59Fe by hepatocytes and the number of Tf-receptor decreased 1 d after CCl4-treatment and increased 2 d after the treatment. Our data demonstrated that the uptake of 59Fe by hepatocytes differed from that of 67Ga and Tf was involved in that of 59Fe. We expect that these finding could serve to analyze the inflammatory stages, disorder stage at 1 d and regeneration stage at 2 d after CCl4-treatment.
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the entering of indium 111 and Iron 59 into the hepatocytes from partially hepatectomized rats differ from that of gallium 67
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Ryota Sato, Shinya Abe, Yosuke Ohtake, Yuji Yamada, Daiki Toyama, Naoko Sato, Yasuhito OhkuboAbstract:We recently suggested that the transferrin (Tf)–gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and Iron-59 (59Fe) with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy. 111In was almost taken by the plasma and little taken by the red blood cell. On the other hand, the uptake of 59Fe by the red blood cell was higher than plasma. The uptake of 59Fe by the bone marrow was significantly higher than that of 111In. The uptake of 111In and 59Fe by the liver tissue was reached a maximum 2 d after partial hepatectomy but the uptake ratio of 111In was lower than that of 59Fe. We suspected that the uptake of 59Fe by the liver tissue was the highest because of the high binding affinity of Tf–59Fe to Tf-receptor. The entering of 111In and 59Fe into the hepatocytes was also reached a maximum 2 d after partial hepatectomy but the ratio of 59Fe was slightly lower than that of 111In. These results suggested that the binding affinity to Tf could have played a crucial role in the differences of the entering of 111In, 59Fe and 67Ga into the hepatocytes of partially hepatectomized rats.
Yosuke Ohtake - One of the best experts on this subject based on the ideXlab platform.
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the involvement of transferrin in the uptake of Iron 59 by hepatocytes of carbon tetrachloride damaged rats
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Satoko Suyama, Shinya Abe, Yoshihiro Inoue, Ai Toukairin, Yosuke Ohtake, Yasuhito OhkuboAbstract:We have reported that transferrin (Tf)-unbound Gallium-67 (67Ga) was taken up into hepatocytes 1 d after carbon tetrachloride (CCl4)-treatment in rats. It had been reported that the binding affinity of Iron-59 (59Fe) to Tf was greater than that of 67Ga. In the present study, we investigated whether or not Tf was involved in 59Fe uptake by hepatocytes of CCl4-damaged rats. The results showed that the uptake of 59Fe by hepatocytes and the number of Tf-receptor decreased 1 d after CCl4-treatment and increased 2 d after the treatment. Our data demonstrated that the uptake of 59Fe by hepatocytes differed from that of 67Ga and Tf was involved in that of 59Fe. We expect that these finding could serve to analyze the inflammatory stages, disorder stage at 1 d and regeneration stage at 2 d after CCl4-treatment.
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the entering of indium 111 and Iron 59 into the hepatocytes from partially hepatectomized rats differ from that of gallium 67
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Ryota Sato, Shinya Abe, Yosuke Ohtake, Yuji Yamada, Daiki Toyama, Naoko Sato, Yasuhito OhkuboAbstract:We recently suggested that the transferrin (Tf)–gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and Iron-59 (59Fe) with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy. 111In was almost taken by the plasma and little taken by the red blood cell. On the other hand, the uptake of 59Fe by the red blood cell was higher than plasma. The uptake of 59Fe by the bone marrow was significantly higher than that of 111In. The uptake of 111In and 59Fe by the liver tissue was reached a maximum 2 d after partial hepatectomy but the uptake ratio of 111In was lower than that of 59Fe. We suspected that the uptake of 59Fe by the liver tissue was the highest because of the high binding affinity of Tf–59Fe to Tf-receptor. The entering of 111In and 59Fe into the hepatocytes was also reached a maximum 2 d after partial hepatectomy but the ratio of 59Fe was slightly lower than that of 111In. These results suggested that the binding affinity to Tf could have played a crucial role in the differences of the entering of 111In, 59Fe and 67Ga into the hepatocytes of partially hepatectomized rats.
