The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Hanqing Wang - One of the best experts on this subject based on the ideXlab platform.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Abstract Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate–methanol–water (7:3:5:5, v/v). Salfredin B11 (22.1 mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9 mg, HPLC purity 97.3%) and crude sample 2 (555 mg) were separated from 600 mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12 mg) and 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin (45 mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12 mg of hederagenin and 45 mg of 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, 1H NMR and 13C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate-methanol-water (7:3:5:5, v/v). Salfredin B(11) (22.1mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9mg, HPLC purity 97.3%) and crude sample 2 (555mg) were separated from 600mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12mg) and 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin (45mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12mg of hederagenin and 45mg of 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, (1)H NMR and (13)C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
Xuelei Xin - One of the best experts on this subject based on the ideXlab platform.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Abstract Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate–methanol–water (7:3:5:5, v/v). Salfredin B11 (22.1 mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9 mg, HPLC purity 97.3%) and crude sample 2 (555 mg) were separated from 600 mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12 mg) and 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin (45 mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12 mg of hederagenin and 45 mg of 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, 1H NMR and 13C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate-methanol-water (7:3:5:5, v/v). Salfredin B(11) (22.1mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9mg, HPLC purity 97.3%) and crude sample 2 (555mg) were separated from 600mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12mg) and 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin (45mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12mg of hederagenin and 45mg of 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, (1)H NMR and (13)C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
Takuma Yasuda - One of the best experts on this subject based on the ideXlab platform.
-
Isobenzofuranone and chromone based blue delayed fluorescence emitters with low efficiency roll off in organic light emitting diodes
Chemistry of Materials, 2017Co-Authors: Jiyoung Lee, Naoya Aizawa, Takuma YasudaAbstract:Significant efforts have been devoted to the development of novel efficient blue-emitting molecules for organic light-emitting diode (OLED) applications. Blue organic emitters exhibiting thermally activated delayed fluorescence (TADF) have the potential to achieve ∼100% internal electroluminescence quantum efficiency in OLEDs. In this paper, we report a promising molecular design strategy for obtaining appropriate high singlet and triplet excited energies, short exciton lifetimes, and high quantum efficiencies in blue TADF emitters. We introduce Isobenzofuranone and chromone containing a cyclic ketone or lactone moiety as effective acceptor building units to construct donor–acceptor TADF emitters. Owing to their small singlet–triplet energy splitting, properly contracted π-conjugation, and weakened intramolecular charge-transfer character, these new emitters display strong blue TADF emissions with high photoluminescence quantum yields (53–92%) and notably short TADF emission lifetimes (2.8–4.3 μs) in thin...
-
Isobenzofuranone- and Chromone-Based Blue Delayed Fluorescence Emitters with Low Efficiency Roll-Off in Organic Light-Emitting Diodes
2017Co-Authors: Jiyoung Lee, Naoya Aizawa, Takuma YasudaAbstract:Significant efforts have been devoted to the development of novel efficient blue-emitting molecules for organic light-emitting diode (OLED) applications. Blue organic emitters exhibiting thermally activated delayed fluorescence (TADF) have the potential to achieve ∼100% internal electroluminescence quantum efficiency in OLEDs. In this paper, we report a promising molecular design strategy for obtaining appropriate high singlet and triplet excited energies, short exciton lifetimes, and high quantum efficiencies in blue TADF emitters. We introduce Isobenzofuranone and chromone containing a cyclic ketone or lactone moiety as effective acceptor building units to construct donor–acceptor TADF emitters. Owing to their small singlet–triplet energy splitting, properly contracted π-conjugation, and weakened intramolecular charge-transfer character, these new emitters display strong blue TADF emissions with high photoluminescence quantum yields (53–92%) and notably short TADF emission lifetimes (2.8–4.3 μs) in thin films. Blue TADF-OLEDs utilizing these emitters exhibit external electroluminescence quantum efficiencies of up to 16.2% and extremely low efficiency roll-off even at practical high luminance. The current findings open new avenues for designing practically usable high-performance blue TADF emitters with simple molecular structures
Haji Akber Aisa - One of the best experts on this subject based on the ideXlab platform.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Abstract Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate–methanol–water (7:3:5:5, v/v). Salfredin B11 (22.1 mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9 mg, HPLC purity 97.3%) and crude sample 2 (555 mg) were separated from 600 mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12 mg) and 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin (45 mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12 mg of hederagenin and 45 mg of 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, 1H NMR and 13C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate-methanol-water (7:3:5:5, v/v). Salfredin B(11) (22.1mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9mg, HPLC purity 97.3%) and crude sample 2 (555mg) were separated from 600mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12mg) and 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin (45mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12mg of hederagenin and 45mg of 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, (1)H NMR and (13)C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
Yi Yang - One of the best experts on this subject based on the ideXlab platform.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Abstract Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate–methanol–water (7:3:5:5, v/v). Salfredin B11 (22.1 mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9 mg, HPLC purity 97.3%) and crude sample 2 (555 mg) were separated from 600 mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12 mg) and 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin (45 mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12 mg of hederagenin and 45 mg of 3-O-[β- d -xylopyranosyl-(1 → 3)-α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, 1H NMR and 13C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
-
preparative isolation and purification of Isobenzofuranone derivatives and saponins from seeds of nigella glandulifera freyn by high speed counter current chromatography combined with gel filtration
Journal of Chromatography A, 2009Co-Authors: Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing WangAbstract:Although the medicinal plant and food Nigella glandulifera Freyn has been researched for decades, Isobenzofuranones have never been isolated before. Two Isobenzofuranone derivatives and two saponins were successfully separated and purified from seeds of N. glandulifera Freyn by high-speed counter-current chromatography (HSCCC) with the optimized two-phase solvent system, n-hexane-ethyl acetate-methanol-water (7:3:5:5, v/v). Salfredin B(11) (22.1mg, HPLC purity 95.3%), 5, 7-dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one (18.9mg, HPLC purity 97.3%) and crude sample 2 (555mg) were separated from 600mg of ethyl acetate extract of N. glandulifera Freyn. Following a cleaning-up step by chromatography on Sephadex LH-20, hederagenin (12mg) and 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin (45mg) were separated from sample 2. All of the fractions before peak II were collected and subjected to a Sephadex LH-20 column and eluted by methanol, two of triterpene saponins (12mg of hederagenin and 45mg of 3-O-[beta-d-xylopyranosyl-(1-->3)-alpha-l-rhamnopyranosyl-(1-->2)-alpha-l-arabinopyranosyl]-hederagenin) were isolated. The structures of peak fractions were identified by IR, electron ionization MS, (1)H NMR and (13)C NMR. 5, 7-Dihydroxy-6-(3-methybut-2-enyl) isobenzofuran-1(3H)-one was isolated for the first time from higher plant and salfredin B11 was isolated for the first time in this plant.
