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Viktor Czaika - One of the best experts on this subject based on the ideXlab platform.
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misdiagnosed zoophile tinea faciei and tinea corporis effectively treated with Isoconazole nitrate and diflucortolone valerate combination therapy
Mycoses, 2013Co-Authors: Viktor CzaikaAbstract:Summary There have been few published reports on the human transmission of Trichophyton mentagrophytes, a zoophilic fungus frequently occurring in pets. Here we report on 2 girls, living with a pet dwarf rabbit, who presented with inflammatory skin lesions positive for T. mentagrophytes and subsequently diagnosed as zoophile tinea faciei and tinea corporis. The patients were successfully treated with systemic terbinafine and 2-week therapy with Travocort cream containing Isoconazole nitrate 1% and diflucortolone valerate 0.1%.
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Trichophyton mentagrophytes cause underestimated contagious zoophilic fungal infection.
Mycoses, 2013Co-Authors: Viktor Czaika, Phi-anh LamAbstract:Summary Trichophytia infection, paraphrased cuddly toy mycosis, occurs primarily in prepubertal children, occasionally in infants and adults. The presented case shows the highly contagious infection of four family members with Trichophyton mentagrophytes. Effective treatment requires detailed diagnostic: identifying the dermatophyte, finding the infection source, treating the infection carriers. Tinea must be treated systemically and topically because of infectivity and ignitability. Systemic terbinafine or fluconazole treatment and topical fixed combination Isoconazole nitrate/diflucortolone valerate are recommended.
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Reactive oxygen species and the bacteriostatic and bactericidal effects of Isoconazole nitrate.
Mycoses, 2013Co-Authors: Viktor Czaika, Jan Siebenbrock, Frank Czekalla, Torsten Zuberbier, Martin A. SieberAbstract:Summary Bacterial superinfections often occur in dermatomycoses, resulting in greatly inflamed or eczematous skin. The objective of this study was to evaluate the antibacterial efficacy of Isoconazole nitrate (ISN), a broad-spectrum antimicrobial imidazole, commonly used to treat dermatomycoses. Several gram-positive bacteria minimal inhibitory concentrations (MICs) for ISN (ISN solution or ISN-containing creams: Travogen® or corticosteroid-containing Travocort®) and ampicillin were obtained using the broth-dilution method. Speed of onset of the bactericidal effect was determined with bacterial killing curves. Reactive oxygen species (ROS) were visualised by staining cells with singlet oxygen detector stain. Compared with ampicillin MICs, ISN MICs for Bacillus cereus, Staphylococcus haemolyticus and Staphylococcus hominis were lower and ISN MICs for Corynebacterium tuberculostearicum and Streptococcus salivarius were similar. Incubation with ISN led to a 50% kill rate for Staphylococcus aureus and methicillin-resistant strains (MRSA). Post-ISN incubation, 36% (30 min) and 90% (60 min) of S. aureus cells were positive for ROS. Isoconazole nitrate has a broad bacteriostatic and bactericidal action, also against a MRSA strain that was not reduced by the corticosteroid in the Travocort cream. Data suggest that the antibacterial effect of ISN may be ROS dependent. An antifungal agent with robust antibacterial activity can provide a therapeutic advantage in treating dermatomycoses with suspected bacterial superinfections.
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Effective treatment of tinea corporis due to Trichophyton mentagrophytes with combined Isoconazole nitrate and diflucortolone valerate therapy.
Mycoses, 2013Co-Authors: Viktor CzaikaAbstract:Trichophyton mentagrophytes is the dermatophyte species most commonly reported in cases of guinea pig-associated dermatophytosis (or guinea pig fungus) a condition that more often affects children than adults. In this case, a 13-year-old girl with recent direct contact with guinea pigs presented with a previously undertreated inflammatory skin lesion on the left side of her upper body, which was positive both for Trichophyton mentagrophytes and Staphylococcus epidermidis. The condition was subsequently diagnosed as tinea corporis due to Trichophyton mentagrophytes with concomitant bacterial infection and effectively treated with 2 weeks of twice-daily application of Travocort cream containing Isoconazole nitrate 1% and diflucortolone valerate 0.1%. Visible improvement in the lesion was apparent after only 1 week of treatment.
Harish C. Gugnani - One of the best experts on this subject based on the ideXlab platform.
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Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.
Mycoses, 2009Co-Authors: C. A. Oyeka, Harish C. GugnaniAbstract:Zusammenfassung. Ein Kollektiv von 40 Kohlengrubenarbeitern, davon 35 mit kulturell gesicherten Fusmykosen und funf mit Nagelinfektionen, bedingt durch Hendersonula toruloidea, Scytalidium hyalinum und Dermatophyten, wurde entweder mit Isoconazolnitrat (TravogenrG) oder Clotrimazol (Canestenr) vier Wochen lang behandelt. Die klinischen Heilungsraten fur die Symptome Juckreiz, Entzundung, Schuppung und Mazeration waren in der Isoconazol-Gruppe bei den Fusinfektionen 89%, 88%, 83% und 83%. In der Clotrimazol-Gruppe lagen die entsprechenden Heilungsraten bei 76%, 71%, 82% und 80%. Der Zwischenzehenbereich war die haufigste Infektlokalisation und konnte auch am leichtesten sowohl mit Clotrimazol wie auch Isoconazol behandelt werden. Die klinische Heilungsrate sechs Wochen nach Behandlung betrug 80% in der Isoconazol-Gruppe und 70% in der Clotrimazol-Gruppe, aber die Differenz konnte nicht statistisch gesichert werden (P > 0.01). Keine der Nagelinfektionen konnte mit den eingesetzten Antimykotika erfolgreich behandelt werden. Summary. A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1 % cream of either Isoconazole nitrate (Travogenr) or clotrimazole (Canestanr) for 4 weeks. The clinical cure rates for the Isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. For the clotrimazole-treated group, the cure rates were 76, 71, 82 and 80% respectively, for the similar symptoms. Toe web was the commonest site of infection and also most easily treated with either clotrimazole or Isoconazole. The clinical and mycological cure rates 6 weeks after treatment were 80% for the isoconaz-ole-treated group and 70% for the clotrimazole-treated group but the difference was not statistically significant (P
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Isoconazole nitrate versus clotrimazole in foot and nail infections due to hendersonula toruloidea scytalidium hyalinum and dermatophytes
Mycoses, 2009Co-Authors: C. A. Oyeka, Harish C. GugnaniAbstract:Zusammenfassung. Ein Kollektiv von 40 Kohlengrubenarbeitern, davon 35 mit kulturell gesicherten Fusmykosen und funf mit Nagelinfektionen, bedingt durch Hendersonula toruloidea, Scytalidium hyalinum und Dermatophyten, wurde entweder mit Isoconazolnitrat (TravogenrG) oder Clotrimazol (Canestenr) vier Wochen lang behandelt. Die klinischen Heilungsraten fur die Symptome Juckreiz, Entzundung, Schuppung und Mazeration waren in der Isoconazol-Gruppe bei den Fusinfektionen 89%, 88%, 83% und 83%. In der Clotrimazol-Gruppe lagen die entsprechenden Heilungsraten bei 76%, 71%, 82% und 80%. Der Zwischenzehenbereich war die haufigste Infektlokalisation und konnte auch am leichtesten sowohl mit Clotrimazol wie auch Isoconazol behandelt werden. Die klinische Heilungsrate sechs Wochen nach Behandlung betrug 80% in der Isoconazol-Gruppe und 70% in der Clotrimazol-Gruppe, aber die Differenz konnte nicht statistisch gesichert werden (P > 0.01). Keine der Nagelinfektionen konnte mit den eingesetzten Antimykotika erfolgreich behandelt werden. Summary. A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1 % cream of either Isoconazole nitrate (Travogenr) or clotrimazole (Canestanr) for 4 weeks. The clinical cure rates for the Isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. For the clotrimazole-treated group, the cure rates were 76, 71, 82 and 80% respectively, for the similar symptoms. Toe web was the commonest site of infection and also most easily treated with either clotrimazole or Isoconazole. The clinical and mycological cure rates 6 weeks after treatment were 80% for the isoconaz-ole-treated group and 70% for the clotrimazole-treated group but the difference was not statistically significant (P<0.01). None of the cases of toenail infection could be cured by treatment with either of the two drugs.
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Isoconazole nitrate in the treatment of tropical dermatomycoses
Mycoses, 1994Co-Authors: Harish C. Gugnani, L. E. Akpata, M. K. Gugnani, R. C. SrivastavaAbstract:A total of 54 patients with culturally proven tropical dermatomycoses, comprising 23 with various types of dermatophytoses, one with foot infection due to Trichosporon beigelii and one with foot infection due to Geotrichum candidum, two with candidosis of the groin and 27 with pityriasis versicolor, were included in a clinical trial of efficacy of 1% Isoconazole cream (Travogen, Schering, Berlin, Germany). Five patients were not evaluable. A clinical and mycological cure was achieved in 29 cases in 3-4 weeks. In 15 (31%) of the remaining patients treatment was required for 5-6 weeks, while another three patients required treatment for 8 weeks. In two patients the disease proved to be resistant to treatment with the drug.
Markus Friedrich - One of the best experts on this subject based on the ideXlab platform.
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Inflammatory tinea pedis with bacterial superinfection effectively treated with Isoconazole nitrate and diflucortolone valerate combination therapy.
Mycoses, 2013Co-Authors: Markus FriedrichAbstract:Undetected tinea pedis in a patient with diabetes can lead to serious bacterial infections with potentially serious consequences, such as foot amputations. Here we report on a 60-year-old patient with diabetes presenting with pain, severe pruritus, and malodour in the foot's interdigital area, and subsequently, diagnosed with inflammatory tinea pedis with bacterial superinfection. The patient was successfully treated with Travocort cream containing Isoconazole nitrate 1% and diflucortolone valerate 0.1%; marked improvement occurred within 5 days.
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The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses.
Mycoses, 2008Co-Authors: Blanka Havlickova, Markus FriedrichAbstract:Dermatomycoses are contagious superficial fungal infections, which are highly prevalent in developed and developing countries. Caused by a range of Epidermophyton, Microsporum and Trichophyton species, dermatomycoses manifest on glabrous skin as 'ringworm', an annular scaly lesion with a variable inflammatory component. Itch is the chief subjective symptom, particularly in tinea cruris. Unless lesions are extensive or resistant to local therapy, dermatomycoses of glabrous skin are treated with topical antifungal agents, such as imidazoles and allylamines. Studies show, however, that the addition of a topical corticosteroid to imidazole therapy increases the bioavailability and prolongs the activity of the antimycotic, while rapidly reducing inflammatory symptoms. Travocort is a combination of 1% Isoconazole nitrate (ISN), a broad-spectrum imidazole with established antimicrobial activity and antimycotic efficacy, and 0.1% diflucortolone valerate (DFV), a potent topical corticosteroid with low systemic absorption and therefore a low risk of systemic glucocorticoid side-effects. In randomised, double-blind controlled clinical trials, Travocort therapy showed a more rapid onset of action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and better mycological cure rate during the first 2 weeks of treatment compared with ISN monotherapy. Travocort is well tolerated and, because of prolonged ISN retention in the skin, provides antifungal protection against reinfection for some weeks after therapy.
Stefano Veraldi - One of the best experts on this subject based on the ideXlab platform.
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the association of Isoconazole diflucortolone in the treatment of pediatric tinea corporis
Journal of Dermatological Treatment, 2018Co-Authors: Stefano Veraldi, Rossana Schianchi, Paolo Pontini, A GoraniAbstract:AbstractBackground: Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching.Objective: From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus.Methods: In 2012, we decided to treat all children with a single lesion of tinea corporis with a combination of 1% Isoconazole nitrate and 0.1% diflucortolone valerate cream (one application/day for 5–7 days), followed by a treatment with Isoconazole or clotrimazole or ciclopirox cream (two applications/day for two weeks).Results: From 2012 to 2014, we observed 108 children with tinea corporis confirmed by mycological examinations. Clinical and mycological recovery w...
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The association of Isoconazole-diflucortolone in the treatment of pediatric tinea corporis
'Informa UK Limited', 2018Co-Authors: Stefano Veraldi, Paolo Pontini, R. Schianci, A GoraniAbstract:Background: Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching. Objective: From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus. Methods: In 2012, we decided to treat all children with a single lesion of tinea corporis with a combination of 1% Isoconazole nitrate and 0.1% diflucortolone valerate cream (one application/day for 5\ue2\u80\u937\uc2\ua0days), followed by a treatment with Isoconazole or clotrimazole or ciclopirox cream (two applications/day for two weeks). Results: From 2012 to 2014, we observed 108 children with tinea corporis confirmed by mycological examinations. Clinical and mycological recovery was observed in 93 of them (86.1%). Only four of these children (3.7%) developed S. aureus superinfections. Conclusions: Our study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association Isoconazole\ue2\u80\u93diflucortolone is useful and safe
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rapid relief of intertrigo associated pruritus due to candida albicans with Isoconazole nitrate and diflucortolone valerate combination therapy
Mycoses, 2013Co-Authors: Stefano VeraldiAbstract:Summary A 43-year-old male, with intertrigo due to Candida albicans located at the inguinal folds and accompanied by severe pruritus, was treated with topical 1% Isoconazole nitrate and 0.1% diflucortolone valerate (2 applications/day for 7 days). An improvement of pruritus was reported 2 days after the beginning of the treatment. Skin lesions improved after 3 days of treatment. Complete remission of both skin lesions and pruritus was observed at day 7. No side effects were observed.
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Isoconazole nitrate vs Isoconazole nitrate and diflucortolone valerate in the treatment of tinea inguinalis: results of a multicenter retrospective study.
Journal of drugs in dermatology : JDD, 2012Co-Authors: Stefano Veraldi, M.c. Persico, Rossana SchianchiAbstract:Background and objective Many tinea inguinalis infections are characterized by pronounced inflammatory lesions and pruritus. Therefore, a therapy with a topical corticosteroid in addition to a topical antimycotic agent might be beneficial. In this multicenter, retrospective study, we compared the mycological and clinical efficacy and tolerability of Isoconazole nitrate alone vs Isoconazole nitrate and diflucortolone valerate in 58 adult patients with tinea inguinalis. Patients and methods Treatment duration was three weeks. The efficacy of the treatment was based on the assessment of several signs and symptoms, which were collected on a 4-point scale. All patients were examined clinically before the beginning of the treatment, one week later, two weeks later, and at the end of the treatment. Mycological examinations were performed before the beginning of the treatment and at the end of the study. Results Treatment results with the combination of Isoconazole nitrate and diflucortolone valerate were superior regarding erythema and pruritus. Both erythema and pruritus resolved in a larger percentage of patients and more quickly. Both regimens were well tolerated. Mycological cure rates were similar in both groups of patients. Conclusions Combination therapy with Isoconazole nitrate and diflucortolone valerate is an effective and well-tolerated regimen in adult patients with tinea inguinalis.
C. A. Oyeka - One of the best experts on this subject based on the ideXlab platform.
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Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.
Mycoses, 2009Co-Authors: C. A. Oyeka, Harish C. GugnaniAbstract:Zusammenfassung. Ein Kollektiv von 40 Kohlengrubenarbeitern, davon 35 mit kulturell gesicherten Fusmykosen und funf mit Nagelinfektionen, bedingt durch Hendersonula toruloidea, Scytalidium hyalinum und Dermatophyten, wurde entweder mit Isoconazolnitrat (TravogenrG) oder Clotrimazol (Canestenr) vier Wochen lang behandelt. Die klinischen Heilungsraten fur die Symptome Juckreiz, Entzundung, Schuppung und Mazeration waren in der Isoconazol-Gruppe bei den Fusinfektionen 89%, 88%, 83% und 83%. In der Clotrimazol-Gruppe lagen die entsprechenden Heilungsraten bei 76%, 71%, 82% und 80%. Der Zwischenzehenbereich war die haufigste Infektlokalisation und konnte auch am leichtesten sowohl mit Clotrimazol wie auch Isoconazol behandelt werden. Die klinische Heilungsrate sechs Wochen nach Behandlung betrug 80% in der Isoconazol-Gruppe und 70% in der Clotrimazol-Gruppe, aber die Differenz konnte nicht statistisch gesichert werden (P > 0.01). Keine der Nagelinfektionen konnte mit den eingesetzten Antimykotika erfolgreich behandelt werden. Summary. A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1 % cream of either Isoconazole nitrate (Travogenr) or clotrimazole (Canestanr) for 4 weeks. The clinical cure rates for the Isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. For the clotrimazole-treated group, the cure rates were 76, 71, 82 and 80% respectively, for the similar symptoms. Toe web was the commonest site of infection and also most easily treated with either clotrimazole or Isoconazole. The clinical and mycological cure rates 6 weeks after treatment were 80% for the isoconaz-ole-treated group and 70% for the clotrimazole-treated group but the difference was not statistically significant (P
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Isoconazole nitrate versus clotrimazole in foot and nail infections due to hendersonula toruloidea scytalidium hyalinum and dermatophytes
Mycoses, 2009Co-Authors: C. A. Oyeka, Harish C. GugnaniAbstract:Zusammenfassung. Ein Kollektiv von 40 Kohlengrubenarbeitern, davon 35 mit kulturell gesicherten Fusmykosen und funf mit Nagelinfektionen, bedingt durch Hendersonula toruloidea, Scytalidium hyalinum und Dermatophyten, wurde entweder mit Isoconazolnitrat (TravogenrG) oder Clotrimazol (Canestenr) vier Wochen lang behandelt. Die klinischen Heilungsraten fur die Symptome Juckreiz, Entzundung, Schuppung und Mazeration waren in der Isoconazol-Gruppe bei den Fusinfektionen 89%, 88%, 83% und 83%. In der Clotrimazol-Gruppe lagen die entsprechenden Heilungsraten bei 76%, 71%, 82% und 80%. Der Zwischenzehenbereich war die haufigste Infektlokalisation und konnte auch am leichtesten sowohl mit Clotrimazol wie auch Isoconazol behandelt werden. Die klinische Heilungsrate sechs Wochen nach Behandlung betrug 80% in der Isoconazol-Gruppe und 70% in der Clotrimazol-Gruppe, aber die Differenz konnte nicht statistisch gesichert werden (P > 0.01). Keine der Nagelinfektionen konnte mit den eingesetzten Antimykotika erfolgreich behandelt werden. Summary. A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1 % cream of either Isoconazole nitrate (Travogenr) or clotrimazole (Canestanr) for 4 weeks. The clinical cure rates for the Isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. For the clotrimazole-treated group, the cure rates were 76, 71, 82 and 80% respectively, for the similar symptoms. Toe web was the commonest site of infection and also most easily treated with either clotrimazole or Isoconazole. The clinical and mycological cure rates 6 weeks after treatment were 80% for the isoconaz-ole-treated group and 70% for the clotrimazole-treated group but the difference was not statistically significant (P<0.01). None of the cases of toenail infection could be cured by treatment with either of the two drugs.
