The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
A A Shihab - One of the best experts on this subject based on the ideXlab platform.
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identification and quantitative determination of some metabolites of methadone Isomethadone and normethadone
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A H Beckett, M Mitchard, A A ShihabAbstract:Isomethadone and normethadone are metabolized by microsomal preparations of guinea-pig liver to yield 2-ethyl-1,4-dimethyl-3,3-diphenyl-1-pyrroline and 2-ethyl-1-methyl-3,3-diphenyl-1-pyrroline respectively. The structures of the pyrrolines were established (by comparison with the pyrroline derived from methadone) by thin-layer chromatography and by infrared and nuclear magnetic resonance spectral data. Methadone, Isomethadone and normethadone are also metabolized to the corresponding N-oxides. A gas chromatographic procedure for the quantitative determination of unchanged drugs, cyclic metabolites and N-oxides of methadone, Isomethadone and normethadone in microsomal homogenates is described. The N-oxides were reduced before analysis.
A H Beckett - One of the best experts on this subject based on the ideXlab platform.
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identification and quantitative determination of some metabolites of methadone Isomethadone and normethadone
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A H Beckett, M Mitchard, A A ShihabAbstract:Isomethadone and normethadone are metabolized by microsomal preparations of guinea-pig liver to yield 2-ethyl-1,4-dimethyl-3,3-diphenyl-1-pyrroline and 2-ethyl-1-methyl-3,3-diphenyl-1-pyrroline respectively. The structures of the pyrrolines were established (by comparison with the pyrroline derived from methadone) by thin-layer chromatography and by infrared and nuclear magnetic resonance spectral data. Methadone, Isomethadone and normethadone are also metabolized to the corresponding N-oxides. A gas chromatographic procedure for the quantitative determination of unchanged drugs, cyclic metabolites and N-oxides of methadone, Isomethadone and normethadone in microsomal homogenates is described. The N-oxides were reduced before analysis.
M Mitchard - One of the best experts on this subject based on the ideXlab platform.
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identification and quantitative determination of some metabolites of methadone Isomethadone and normethadone
Journal of Pharmacy and Pharmacology, 2011Co-Authors: A H Beckett, M Mitchard, A A ShihabAbstract:Isomethadone and normethadone are metabolized by microsomal preparations of guinea-pig liver to yield 2-ethyl-1,4-dimethyl-3,3-diphenyl-1-pyrroline and 2-ethyl-1-methyl-3,3-diphenyl-1-pyrroline respectively. The structures of the pyrrolines were established (by comparison with the pyrroline derived from methadone) by thin-layer chromatography and by infrared and nuclear magnetic resonance spectral data. Methadone, Isomethadone and normethadone are also metabolized to the corresponding N-oxides. A gas chromatographic procedure for the quantitative determination of unchanged drugs, cyclic metabolites and N-oxides of methadone, Isomethadone and normethadone in microsomal homogenates is described. The N-oxides were reduced before analysis.
