The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
A. J. Burke - One of the best experts on this subject based on the ideXlab platform.
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Transition-Metal-Catalyzed Intramolecular Cyclization of Amido(hetero)arylboronic Acid Aldehydes to Isoquinolinones and Derivatives.
ChemInform, 2015Co-Authors: C. S. Marques, D. Peixoto, A. J. BurkeAbstract:The efficient metal-catalyzed intramolecular cyclization of amidoarylboronic acid aldehydes (I), (III), (V) is the key step in the simple three step synthesis of a library of chiral Isoquinolinone derivatives with aryl (II), pyridyl (IV), and thiophene (VI) cores.
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Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to Isoquinolinones and derivatives
RSC Advances, 2015Co-Authors: C. S. Marques, D. Peixoto, A. J. BurkeAbstract:We report an innovative and simple three step high yielding synthesis of a library of 14 chiral Isoquinolinone and azepinone derivatives with benzyl, pyridyl and thiophene cores starting from amidoarylboronic acid aldehydes. These products have potential for treating neurodegenerative diseases. The key reaction in this synthetic pathway was an efficient metal-catalyzed (with Rh, Cu and Pd catalysts) intramolecular cyclization. A maximum yield of 87% was obtained using a Rh(I) catalyst.
Ramasamy Anandhan - One of the best experts on this subject based on the ideXlab platform.
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photoredox catalyzed chemoselective aerobic cα h oxidation of propargylamines synthesis of substituted 2 ynamide and oxazolo 2 3 a Isoquinolinone derivatives
Organic chemistry frontiers, 2021Co-Authors: Mandapati Bhargava Reddy, Nalladhambi Neerathilingam, Ramasamy AnandhanAbstract:An efficient approach for visible-light-induced chemoselective aerobic Cα–H oxidation of propargylamines via molecular oxygen as an oxidant using rose bengal as a photoredox catalyst is reported. The photochemical protocol was employed for the direct oxygenation of Cα–H 2-propynyl-tertiary amines to 2-ynamides and further cyclization of oxazolo[2,3-a]Isoquinolinone derivatives from phenylpropynyltetrahydroisoquinoline was established.
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Photoredox-catalyzed chemoselective aerobic Cα–H oxidation of propargylamines: synthesis of substituted 2-ynamide and oxazolo[2,3-a]Isoquinolinone derivatives
Organic Chemistry Frontiers, 2021Co-Authors: Mandapati Bhargava Reddy, Nalladhambi Neerathilingam, Ramasamy AnandhanAbstract:An efficient approach for visible-light-induced chemoselective aerobic Cα–H oxidation of propargylamines via molecular oxygen as an oxidant using rose bengal as a photoredox catalyst is reported. The photochemical protocol was employed for the direct oxygenation of Cα–H 2-propynyl-tertiary amines to 2-ynamides and further cyclization of oxazolo[2,3-a]Isoquinolinone derivatives from phenylpropynyltetrahydroisoquinoline was established.
C. S. Marques - One of the best experts on this subject based on the ideXlab platform.
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Transition-Metal-Catalyzed Intramolecular Cyclization of Amido(hetero)arylboronic Acid Aldehydes to Isoquinolinones and Derivatives.
ChemInform, 2015Co-Authors: C. S. Marques, D. Peixoto, A. J. BurkeAbstract:The efficient metal-catalyzed intramolecular cyclization of amidoarylboronic acid aldehydes (I), (III), (V) is the key step in the simple three step synthesis of a library of chiral Isoquinolinone derivatives with aryl (II), pyridyl (IV), and thiophene (VI) cores.
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Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to Isoquinolinones and derivatives
RSC Advances, 2015Co-Authors: C. S. Marques, D. Peixoto, A. J. BurkeAbstract:We report an innovative and simple three step high yielding synthesis of a library of 14 chiral Isoquinolinone and azepinone derivatives with benzyl, pyridyl and thiophene cores starting from amidoarylboronic acid aldehydes. These products have potential for treating neurodegenerative diseases. The key reaction in this synthetic pathway was an efficient metal-catalyzed (with Rh, Cu and Pd catalysts) intramolecular cyclization. A maximum yield of 87% was obtained using a Rh(I) catalyst.
Zhi-zhen Huang - One of the best experts on this subject based on the ideXlab platform.
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A Cascade Dehydrogenative Cross-Coupling/Annulation Reaction of Benzamides with β-Keto Esters for the Synthesis of Isoquinolinone Derivatives
Organic letters, 2017Co-Authors: Zhi-zhen HuangAbstract:A novel cascade DCC/annulation reaction of N-alkoxybenzamides with β-keto esters has been developed for the synthesis of Isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving α-C(sp2)–H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed.
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a cascade dehydrogenative cross coupling annulation reaction of benzamides with β keto esters for the synthesis of Isoquinolinone derivatives
Organic Letters, 2017Co-Authors: Zhi-zhen HuangAbstract:A novel cascade DCC/annulation reaction of N-alkoxybenzamides with β-keto esters has been developed for the synthesis of Isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving α-C(sp2)–H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed.
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A Cascade Dehydrogenative Cross-Coupling/Annulation Reaction of Benzamides with β‑Keto Esters for the Synthesis of Isoquinolinone Derivatives
2017Co-Authors: Zhi-zhen HuangAbstract:A novel cascade DCC/annulation reaction of N-alkoxybenzamides with β-keto esters has been developed for the synthesis of Isoquinolinone derivatives under palladium catalysis. A plausible mechanism involving α-C(sp2)–H activation and a Pd(II)/Pd(IV) catalytic cycle is also proposed
Mandapati Bhargava Reddy - One of the best experts on this subject based on the ideXlab platform.
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photoredox catalyzed chemoselective aerobic cα h oxidation of propargylamines synthesis of substituted 2 ynamide and oxazolo 2 3 a Isoquinolinone derivatives
Organic chemistry frontiers, 2021Co-Authors: Mandapati Bhargava Reddy, Nalladhambi Neerathilingam, Ramasamy AnandhanAbstract:An efficient approach for visible-light-induced chemoselective aerobic Cα–H oxidation of propargylamines via molecular oxygen as an oxidant using rose bengal as a photoredox catalyst is reported. The photochemical protocol was employed for the direct oxygenation of Cα–H 2-propynyl-tertiary amines to 2-ynamides and further cyclization of oxazolo[2,3-a]Isoquinolinone derivatives from phenylpropynyltetrahydroisoquinoline was established.
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Photoredox-catalyzed chemoselective aerobic Cα–H oxidation of propargylamines: synthesis of substituted 2-ynamide and oxazolo[2,3-a]Isoquinolinone derivatives
Organic Chemistry Frontiers, 2021Co-Authors: Mandapati Bhargava Reddy, Nalladhambi Neerathilingam, Ramasamy AnandhanAbstract:An efficient approach for visible-light-induced chemoselective aerobic Cα–H oxidation of propargylamines via molecular oxygen as an oxidant using rose bengal as a photoredox catalyst is reported. The photochemical protocol was employed for the direct oxygenation of Cα–H 2-propynyl-tertiary amines to 2-ynamides and further cyclization of oxazolo[2,3-a]Isoquinolinone derivatives from phenylpropynyltetrahydroisoquinoline was established.
