The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Kozo Shishido - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with a chiral nitrone derived from l-serine leading to β-amino acid derivatives
Tetrahedron: Asymmetry, 2005Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kozo ShishidoAbstract:Abstract Asymmetric 1,3-dipolar cycloaddition of lithium ynolates with a nitrone derived from Garner’s aldehyde is described. The cycloadducts, 5-Isoxazolidinones, were obtained in good yields with high diastereoselectivity. Alkylation of the intermediates, the 5-Isoxazolidinone enolates, was also achieved with high selectivity, the products of which were converted into the enantiomerically pure β-amino acids, β-lactams, and γ-lactams. In our cycloaddition, lithium ynolates proved to be much better as nucleophiles than lithium enolates.
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Diastereoselective 1,3-dipolar cycloaddition of ynolates with chiral nitrones
Synthesis, 2003Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with chiral nitrones produced 5-Isoxazolidinones with good diastereoselectivity. These products were easily converted into optically pure β-amino acids and chiral γ-butyrolactones.
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Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids
Organic letters, 2002Co-Authors: Mitsuru Shindo, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-Isoxazolidinones with good trans-selectivity. These products were easily converted into β-amino acids.
Mitsuru Shindo - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with a chiral nitrone derived from l-serine leading to β-amino acid derivatives
Tetrahedron: Asymmetry, 2005Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kozo ShishidoAbstract:Abstract Asymmetric 1,3-dipolar cycloaddition of lithium ynolates with a nitrone derived from Garner’s aldehyde is described. The cycloadducts, 5-Isoxazolidinones, were obtained in good yields with high diastereoselectivity. Alkylation of the intermediates, the 5-Isoxazolidinone enolates, was also achieved with high selectivity, the products of which were converted into the enantiomerically pure β-amino acids, β-lactams, and γ-lactams. In our cycloaddition, lithium ynolates proved to be much better as nucleophiles than lithium enolates.
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Diastereoselective 1,3-dipolar cycloaddition of ynolates with chiral nitrones
Synthesis, 2003Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with chiral nitrones produced 5-Isoxazolidinones with good diastereoselectivity. These products were easily converted into optically pure β-amino acids and chiral γ-butyrolactones.
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Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids
Organic letters, 2002Co-Authors: Mitsuru Shindo, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-Isoxazolidinones with good trans-selectivity. These products were easily converted into β-amino acids.
Kotaro Itoh - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective 1,3-dipolar cycloaddition of ynolates with chiral nitrones
Synthesis, 2003Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with chiral nitrones produced 5-Isoxazolidinones with good diastereoselectivity. These products were easily converted into optically pure β-amino acids and chiral γ-butyrolactones.
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Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids
Organic letters, 2002Co-Authors: Mitsuru Shindo, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-Isoxazolidinones with good trans-selectivity. These products were easily converted into β-amino acids.
Chinatsu Tsuchiya - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective 1,3-dipolar cycloaddition of ynolates with chiral nitrones
Synthesis, 2003Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with chiral nitrones produced 5-Isoxazolidinones with good diastereoselectivity. These products were easily converted into optically pure β-amino acids and chiral γ-butyrolactones.
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Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids
Organic letters, 2002Co-Authors: Mitsuru Shindo, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-Isoxazolidinones with good trans-selectivity. These products were easily converted into β-amino acids.
Keiko Ohtsuki - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with a chiral nitrone derived from l-serine leading to β-amino acid derivatives
Tetrahedron: Asymmetry, 2005Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kozo ShishidoAbstract:Abstract Asymmetric 1,3-dipolar cycloaddition of lithium ynolates with a nitrone derived from Garner’s aldehyde is described. The cycloadducts, 5-Isoxazolidinones, were obtained in good yields with high diastereoselectivity. Alkylation of the intermediates, the 5-Isoxazolidinone enolates, was also achieved with high selectivity, the products of which were converted into the enantiomerically pure β-amino acids, β-lactams, and γ-lactams. In our cycloaddition, lithium ynolates proved to be much better as nucleophiles than lithium enolates.
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Diastereoselective 1,3-dipolar cycloaddition of ynolates with chiral nitrones
Synthesis, 2003Co-Authors: Mitsuru Shindo, Keiko Ohtsuki, Kotaro Itoh, Chinatsu Tsuchiya, Kozo ShishidoAbstract:Asymmetric inverse electron-demand 1,3-dipolar cycloaddition of ynolates with chiral nitrones produced 5-Isoxazolidinones with good diastereoselectivity. These products were easily converted into optically pure β-amino acids and chiral γ-butyrolactones.
