The Experts below are selected from a list of 1305 Experts worldwide ranked by ideXlab platform
Isaac Van Der Waal - One of the best experts on this subject based on the ideXlab platform.
-
primary intraosseous squamous cell carcinoma arising in an odontogenic Cyst a clinicopathologic analysis of 116 reported cases
Journal of Oral Pathology & Medicine, 2011Co-Authors: Lipa Bodner, Esther Manor, Mervyn Shear, Isaac Van Der WaalAbstract:Purpose: To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic Cyst. Methods: All well-documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic Cyst, including the keratoCystic odontogenic tumor, were selected. Age, sex, signs and symptoms, affected Jaw, Cyst type, treatment, histopathology, and outcome were recorded. Results: The mean age was 60.2 years (range 1.3-90). There were 80 (69%) men and 36 (31%) women. Mass and pain were the most common presenting symptoms. The mandible was affected in 92 (79%) patients and the maxilla in 24 (21%). It was a residual/radicular Cyst in 70 (60%) patients and a dentigerous Cyst or a keratoCystic odontogenic tumor in the remaining 40%. The histopathology was well-differentiated SCC in 53 (46%) patients and moderately differentiated SCC in 47 (40%) patients. Fifty-three (46%) patients were treated with surgery alone and 44 (38%) with surgery and radiotherapy. Fifty-eight (62%) patients survived 2 years and 36 (38%) survived 5 years. Conclusion: PIOSCC has a predilection for men (M/F ratio of 2.22:1), affects mainly adults in their 6-8th decades, occurs most frequently (79%) in the mandible, and is associated mainly with a residual/radicular Cyst. Histologically, the well-to-moderately differentiated SCC was the most common. Surgery alone or combined therapy of surgery and radiation was the most common approach. The prognosis is 62% surviving 2 years and 38% 5 years.
Dummer Reinhard - One of the best experts on this subject based on the ideXlab platform.
-
Nevoid Basal Cell Carcinoma Syndrome: Report from the Zurich Nevoid Basal Cell Carcinoma Syndrome Cohort
Karger, 2016Co-Authors: Rehefeldt-erne Susanne, Nägeli, Mirjam C, Winterton Nina, Felderer Lea, Weibel Lisa, Hafner Jürg, Dummer ReinhardAbstract:Background: Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin-Goltz syndrome) presents various symptoms and can disfigure patients. The estimated prevalence is around 1:100,000. Objective: To systematically investigate the clinical manifestations of NBCCS patients of the Zurich register and compare them with those described in 4 epidemiological studies performed in other countries. Methods: We analyzed patient characteristics and clinical manifestations in a register of 30 NBCCS patients in Zurich, Switzerland. We compared our findings to the results of 4 epidemiological studies performed in America, Australia, Japan and the UK. Results: We obtained information concerning basal cell carcinomas (BCCs) and Jaw Cysts from 28 patients out of our population of 30 NBCCS patients. The mean age at onset of the first BCC was 24 years, and the mean age at diagnosis of the first Jaw Cyst was 15.6 years. The average number of Jaw Cysts was 8.4; the average number of BCCs was 207. 72.5% of the examined BCCs showed a nodular histology, but we also found scirrhous and superficial types. Conclusion: The disease burden associated with NBCCS diagnosed in Swiss patients is significant and comparable to that of other countries. Regular skin examination and oromaxillary examinations should be performed early in diagnosis, and patients should undergo early UV protection. Nodular BCC is the most common BCC subtype in this patient population
Dummer R. - One of the best experts on this subject based on the ideXlab platform.
-
Supplementary Material for: Nevoid Basal Cell Carcinoma Syndrome: Report from the Zurich Nevoid Basal Cell Carcinoma Syndrome Cohort
2016Co-Authors: Rehefeldt-erne S., Nägeli M.c., Winterton N., Felderer L., Weibel L., Hafner J., Dummer R.Abstract:Background: Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin-Goltz syndrome) presents various symptoms and can disfigure patients. The estimated prevalence is around 1:100,000. Objective: To systematically investigate the clinical manifestations of NBCCS patients of the Zurich register and compare them with those described in 4 epidemiological studies performed in other countries. Methods: We analyzed patient characteristics and clinical manifestations in a register of 30 NBCCS patients in Zurich, Switzerland. We compared our findings to the results of 4 epidemiological studies performed in America, Australia, Japan and the UK. Results: We obtained information concerning basal cell carcinomas (BCCs) and Jaw Cysts from 28 patients out of our population of 30 NBCCS patients. The mean age at onset of the first BCC was 24 years, and the mean age at diagnosis of the first Jaw Cyst was 15.6 years. The average number of Jaw Cysts was 8.4; the average number of BCCs was 207. 72.5% of the examined BCCs showed a nodular histology, but we also found scirrhous and superficial types. Conclusion: The disease burden associated with NBCCS diagnosed in Swiss patients is significant and comparable to that of other countries. Regular skin examination and oromaxillary examinations should be performed early in diagnosis, and patients should undergo early UV protection. Nodular BCC is the most common BCC subtype in this patient population
Kei Sakamoto - One of the best experts on this subject based on the ideXlab platform.
-
Comprehensive keratin profiling reveals different histopathogenesis of keratoCystic odontogenic tumor and orthokeratinized odontogenic Cyst
Human pathology, 2010Co-Authors: Tadanobu Aragaki, Ken-ichi Katsube, Akira Yamaguchi, Yasuyuki Michi, Narikazu Uzawa, Norihiko Okada, Takumi Akashi, Teruo Amagasa, Kei SakamotoAbstract:KeratoCystic odontogenic tumor is a Cystic lesion that behaves more aggressively than other Jaw Cysts. One of its characteristic histologic features is a parakeratinized uniform layer of lining epithelium. A Jaw Cyst lined with orthokeratinized epithelium is called an orthokeratinized odontogenic Cyst. These keratinized Jaw Cysts are thought to be separate entities, although their histopathogenesis has not been fully assessed. To better understand these lesions, we performed comprehensive immunohistochemical profiling of the keratin expression of each. Orthokeratinized odontogenic Cysts expressed keratin 1, keratin 2, keratin 10, and loricrin, suggesting differentiation toward normal epidermis. KeratoCystic odontogenic tumors expressed keratin 4, keratin 13, keratin 17, and keratin 19, which is a unique expression pattern reminiscent of a mucosal squamous epithelium and an epithelial appendage. In neonatal rat tooth germ, cells strongly positive for keratin 17 and keratin 19 were observed, specifically in the dental lamina, implying the origin of keratoCystic odontogenic tumor. GLI2, a downstream effector of hedgehog signaling, was significantly expressed in keratoCystic odontogenic tumor and basal cell carcinoma, accompanied with robust expression of keratin 17, mammalian target of rapamycin, and BCL2. The expression of these GLI2- or keratin 17-related factors was not significantly observed in orthokeratinized odontogenic Cysts. These findings provide evidence to support the viewpoint that keratoCystic odontogenic tumor and orthokeratinized odontogenic Cyst are separate entities, and furthermore suggest their characteristic histology, pathogenesis, and biological behaviors.
Xinming Chen - One of the best experts on this subject based on the ideXlab platform.
-
central mucoepidermoid carcinoma a clinicopathologic and immunohistochemical study of 39 chinese patients
The American Journal of Surgical Pathology, 2012Co-Authors: Chuanxiang Zhou, Xinming ChenAbstract:Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the Jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node metastasis, and 1 developed distant metastasis. Of 11 cases with a clinical history of the Jaw Cyst, 8 initially showed a typical odontogenic Cyst with local MEC-like proliferation. In summary, the most likely pathogenesis of central MEC is neoplastic transformation of the epithelial lining of an odontogenic Cyst, diagnosis of which should be based on clinical, radiographic, and histopathologic findings. The immunohistochemical profile of keratins is helpful in differential diagnosis. Radical surgery is the treatment of choice, whereas the role of radiotherapy or chemotherapy is still controversial, and careful long-term follow-up is necessary.