The Experts below are selected from a list of 8250 Experts worldwide ranked by ideXlab platform
S E Holm - One of the best experts on this subject based on the ideXlab platform.
-
quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure
Inhalation Toxicology, 2011Co-Authors: Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The marked difference in biopersistence and pathological response between chrysotile and amphibole asbestos has been well documented. This study is unique in that it has examined a commercial chrysotile product that was used as a Joint Compound. The pathological response was quantified in the lung and translocation of fibers to and pathological response in the pleural cavity determined. This paper presents the final results from the study. Rats were exposed by inhalation 6 h/day for 5 days to a well-defined fiber aerosol. Subgroups were examined through 1 year. The translocation to and pathological response in the pleura was examined by scanning electron microscopy and confocal microscopy (CM) using noninvasive methods. The number and size of fibers was quantified using transmission electron microscopy and CM. This is the first study to use such techniques to characterize fiber translocation to and the response of the pleural cavity. Amosite fibers were found to remain partly or fully imbedded in the inte...
-
the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure interim results
Inhalation Toxicology, 2010Co-Authors: D M Bernstein, P Kunzendorf, Rick A Rogers, Ken Donaldson, Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a Joint Compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded Joint Compound consisting of both chrysotile fibers and sanded Joint Compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 µm) cleared rapidly (T1/2 of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response ...
-
a biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
Inhalation Toxicology, 2008Co-Authors: D M Bernstein, U Decker, P Kunzendorf, Ken Donaldson, S Gaering, Jorg Chevalier, S E HolmAbstract:In designing a study to evaluate the inhalation biopersistence of a chrysotile asbestos that was used as a component of a Joint-Compound, a feasibility study was initiated to evaluate the shortterm biopersistence of the chrysotile alone and of the chrysotile in combination witht the sanded reformulated Joint-Compound. Two groups of Wistar rats were exposed to either 7RF3 chrysotile (Group 2) or to 7RF3 chrysotile combined with aerosolized sanded Joint-Compound (Group 3). In addition, a control group was exposed to filtered-air. The chrysotile used in the Ready Mix Joint Compound is rapidly removed from the lung. The chrysotile alone exposure group had a clearance half-time of fibers L > 20 µm of 2.2 days; in the chrysotile plus sanded exposure group the clearance half-time of fibers L > 20 µm was 2.8 days. However, across all size ranges there was approximately an order of magnitude decrease in the mean number of fibers remaining in the lungs of Group 3 as compared to Group 2 despite similiar aerosol exposures. Histopathological examination showed that the chrysotile exposed lungs had the same appearance as the filtered-air controls. This study uniquely illustrates that additional concurrent exposure to an aerosol of the sanded Joint-Compound, with large numbers of fine-particles depositing in the lungs, accelerates the recruitment of macrophages, resulting in a tenfold decrease in the number of fibers remaining in the lung. The increased number of macrophages in the chrysotile/sanded Joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported.
Jorg Chevalier - One of the best experts on this subject based on the ideXlab platform.
-
quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure
Inhalation Toxicology, 2011Co-Authors: Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The marked difference in biopersistence and pathological response between chrysotile and amphibole asbestos has been well documented. This study is unique in that it has examined a commercial chrysotile product that was used as a Joint Compound. The pathological response was quantified in the lung and translocation of fibers to and pathological response in the pleural cavity determined. This paper presents the final results from the study. Rats were exposed by inhalation 6 h/day for 5 days to a well-defined fiber aerosol. Subgroups were examined through 1 year. The translocation to and pathological response in the pleura was examined by scanning electron microscopy and confocal microscopy (CM) using noninvasive methods. The number and size of fibers was quantified using transmission electron microscopy and CM. This is the first study to use such techniques to characterize fiber translocation to and the response of the pleural cavity. Amosite fibers were found to remain partly or fully imbedded in the inte...
-
the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure interim results
Inhalation Toxicology, 2010Co-Authors: D M Bernstein, P Kunzendorf, Rick A Rogers, Ken Donaldson, Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a Joint Compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded Joint Compound consisting of both chrysotile fibers and sanded Joint Compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 µm) cleared rapidly (T1/2 of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response ...
-
a biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
Inhalation Toxicology, 2008Co-Authors: D M Bernstein, U Decker, P Kunzendorf, Ken Donaldson, S Gaering, Jorg Chevalier, S E HolmAbstract:In designing a study to evaluate the inhalation biopersistence of a chrysotile asbestos that was used as a component of a Joint-Compound, a feasibility study was initiated to evaluate the shortterm biopersistence of the chrysotile alone and of the chrysotile in combination witht the sanded reformulated Joint-Compound. Two groups of Wistar rats were exposed to either 7RF3 chrysotile (Group 2) or to 7RF3 chrysotile combined with aerosolized sanded Joint-Compound (Group 3). In addition, a control group was exposed to filtered-air. The chrysotile used in the Ready Mix Joint Compound is rapidly removed from the lung. The chrysotile alone exposure group had a clearance half-time of fibers L > 20 µm of 2.2 days; in the chrysotile plus sanded exposure group the clearance half-time of fibers L > 20 µm was 2.8 days. However, across all size ranges there was approximately an order of magnitude decrease in the mean number of fibers remaining in the lungs of Group 3 as compared to Group 2 despite similiar aerosol exposures. Histopathological examination showed that the chrysotile exposed lungs had the same appearance as the filtered-air controls. This study uniquely illustrates that additional concurrent exposure to an aerosol of the sanded Joint-Compound, with large numbers of fine-particles depositing in the lungs, accelerates the recruitment of macrophages, resulting in a tenfold decrease in the number of fibers remaining in the lung. The increased number of macrophages in the chrysotile/sanded Joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported.
S Gaering - One of the best experts on this subject based on the ideXlab platform.
-
quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure
Inhalation Toxicology, 2011Co-Authors: Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The marked difference in biopersistence and pathological response between chrysotile and amphibole asbestos has been well documented. This study is unique in that it has examined a commercial chrysotile product that was used as a Joint Compound. The pathological response was quantified in the lung and translocation of fibers to and pathological response in the pleural cavity determined. This paper presents the final results from the study. Rats were exposed by inhalation 6 h/day for 5 days to a well-defined fiber aerosol. Subgroups were examined through 1 year. The translocation to and pathological response in the pleura was examined by scanning electron microscopy and confocal microscopy (CM) using noninvasive methods. The number and size of fibers was quantified using transmission electron microscopy and CM. This is the first study to use such techniques to characterize fiber translocation to and the response of the pleural cavity. Amosite fibers were found to remain partly or fully imbedded in the inte...
-
the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure interim results
Inhalation Toxicology, 2010Co-Authors: D M Bernstein, P Kunzendorf, Rick A Rogers, Ken Donaldson, Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a Joint Compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded Joint Compound consisting of both chrysotile fibers and sanded Joint Compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 µm) cleared rapidly (T1/2 of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response ...
-
a biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
Inhalation Toxicology, 2008Co-Authors: D M Bernstein, U Decker, P Kunzendorf, Ken Donaldson, S Gaering, Jorg Chevalier, S E HolmAbstract:In designing a study to evaluate the inhalation biopersistence of a chrysotile asbestos that was used as a component of a Joint-Compound, a feasibility study was initiated to evaluate the shortterm biopersistence of the chrysotile alone and of the chrysotile in combination witht the sanded reformulated Joint-Compound. Two groups of Wistar rats were exposed to either 7RF3 chrysotile (Group 2) or to 7RF3 chrysotile combined with aerosolized sanded Joint-Compound (Group 3). In addition, a control group was exposed to filtered-air. The chrysotile used in the Ready Mix Joint Compound is rapidly removed from the lung. The chrysotile alone exposure group had a clearance half-time of fibers L > 20 µm of 2.2 days; in the chrysotile plus sanded exposure group the clearance half-time of fibers L > 20 µm was 2.8 days. However, across all size ranges there was approximately an order of magnitude decrease in the mean number of fibers remaining in the lungs of Group 3 as compared to Group 2 despite similiar aerosol exposures. Histopathological examination showed that the chrysotile exposed lungs had the same appearance as the filtered-air controls. This study uniquely illustrates that additional concurrent exposure to an aerosol of the sanded Joint-Compound, with large numbers of fine-particles depositing in the lungs, accelerates the recruitment of macrophages, resulting in a tenfold decrease in the number of fibers remaining in the lung. The increased number of macrophages in the chrysotile/sanded Joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported.
D M Bernstein - One of the best experts on this subject based on the ideXlab platform.
-
the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure interim results
Inhalation Toxicology, 2010Co-Authors: D M Bernstein, P Kunzendorf, Rick A Rogers, Ken Donaldson, Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a Joint Compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded Joint Compound consisting of both chrysotile fibers and sanded Joint Compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 µm) cleared rapidly (T1/2 of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response ...
-
a biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
Inhalation Toxicology, 2008Co-Authors: D M Bernstein, U Decker, P Kunzendorf, Ken Donaldson, S Gaering, Jorg Chevalier, S E HolmAbstract:In designing a study to evaluate the inhalation biopersistence of a chrysotile asbestos that was used as a component of a Joint-Compound, a feasibility study was initiated to evaluate the shortterm biopersistence of the chrysotile alone and of the chrysotile in combination witht the sanded reformulated Joint-Compound. Two groups of Wistar rats were exposed to either 7RF3 chrysotile (Group 2) or to 7RF3 chrysotile combined with aerosolized sanded Joint-Compound (Group 3). In addition, a control group was exposed to filtered-air. The chrysotile used in the Ready Mix Joint Compound is rapidly removed from the lung. The chrysotile alone exposure group had a clearance half-time of fibers L > 20 µm of 2.2 days; in the chrysotile plus sanded exposure group the clearance half-time of fibers L > 20 µm was 2.8 days. However, across all size ranges there was approximately an order of magnitude decrease in the mean number of fibers remaining in the lungs of Group 3 as compared to Group 2 despite similiar aerosol exposures. Histopathological examination showed that the chrysotile exposed lungs had the same appearance as the filtered-air controls. This study uniquely illustrates that additional concurrent exposure to an aerosol of the sanded Joint-Compound, with large numbers of fine-particles depositing in the lungs, accelerates the recruitment of macrophages, resulting in a tenfold decrease in the number of fibers remaining in the lung. The increased number of macrophages in the chrysotile/sanded Joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported.
Rosalinda Sepulveda - One of the best experts on this subject based on the ideXlab platform.
-
quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure
Inhalation Toxicology, 2011Co-Authors: Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The marked difference in biopersistence and pathological response between chrysotile and amphibole asbestos has been well documented. This study is unique in that it has examined a commercial chrysotile product that was used as a Joint Compound. The pathological response was quantified in the lung and translocation of fibers to and pathological response in the pleural cavity determined. This paper presents the final results from the study. Rats were exposed by inhalation 6 h/day for 5 days to a well-defined fiber aerosol. Subgroups were examined through 1 year. The translocation to and pathological response in the pleura was examined by scanning electron microscopy and confocal microscopy (CM) using noninvasive methods. The number and size of fibers was quantified using transmission electron microscopy and CM. This is the first study to use such techniques to characterize fiber translocation to and the response of the pleural cavity. Amosite fibers were found to remain partly or fully imbedded in the inte...
-
the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure interim results
Inhalation Toxicology, 2010Co-Authors: D M Bernstein, P Kunzendorf, Rick A Rogers, Ken Donaldson, Rosalinda Sepulveda, D Schuler, S Gaering, Jorg Chevalier, S E HolmAbstract:The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a Joint Compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded Joint Compound consisting of both chrysotile fibers and sanded Joint Compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 µm) cleared rapidly (T1/2 of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response ...
