The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Han Mei - One of the best experts on this subject based on the ideXlab platform.
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Comparison of the MMP-2 and MMP-9 in the Knee Joint Synovial Fluid and Synovial Membrane in Patients with active Rheumatoid Arthritis and Osteoarthritis
Journal of Ningxia Medical University, 2013Co-Authors: Han MeiAbstract:Objective To compare matrix metalloproteinases-2(MMP-2) and matrix metalloproteinases-9(MMP-9) in knee Joint synovial fluid and synovial membrane in patients with active rheumatoid arthritis(RA) and active osteoarthritis(OA),and to explore the effects of MMP-2 and MMP-9 on lesion of RA and OA.Methods Knee Joint synovial fluid and synovial membrane were collected from 14 and 24 patients with final diagnosis of RA and OA,and underwent surgery at the General Hospital of Ningxia Medical University.MMP-2 and MMP-9 in the synovial fluid were measured by enzyme linked immunosorbent assay(ELISA).The distributions of MMP-9 in the synovial membrane were analyzed using immunohistochemistry.Student's t-test was used for intergroup comparison.Results The level of MMP-2 and MMP-9 in synovial fluid of active RA was significantly higher than that of active OA(P0.01);the relative expression of MMP-9 in synovial membrane was stronger in active RA than that in active OA(P0.01).Conclusion High expression of MMP-2 and MMP-9 in active RA synovial fluid,and high expression of MMP-9 in active RA synovial membrane may suggested that MMP-2 and MMP-9 as the remodel enzymes that participate in chronic synovitis,bone destruction and Joint Malformation.
Ricardo D. Coletta - One of the best experts on this subject based on the ideXlab platform.
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Goldenhar syndrome: clinical features with orofacial emphasis
Journal of applied oral science : revista FOB, 2010Co-Authors: Hercílio Martelli-júnior, Roseli Teixeira De Miranda, Cassandro Moreira Fernandes, Paulo Rogério Ferreti Bonan, Lívia Máris Ribeiro Paranaíba, Edgard Graner, Ricardo D. ColettaAbstract:OBJECTIVES: Goldenhar syndrome (GS) is a relatively common developmental disorder characterized by craniofacial anomalies in association with vertebral, cardiac, renal, and central nervous system defects. This paper describes GS features with special emphasis on oral characteristics. MATERIAL AND METHODS: The clinical features of 6 patients with GS aged 3 months to 12 years are described, and a brief review of the literature about this genetic disorder is presented. RESULTS: All patients demonstrated the classical triad of GS, including mandibular hypoplasia resulting in facial asymmetry, ear and/or eye Malformation, and vertebral anomalies. In addition, renal and gastrointestinal abnormalities were observed in 2 patients. Regarding the oral involvement, 2 patients presented cleft lip and palate, and 1 patient had temporomandibular Joint Malformation. Malocclusion was found in all patients. CONCLUSION: Our orofacial findings correlate with the reported cases in the literature, and point out that after diagnosis GS patients need to be examined for systemic abnormalities.
Rd Coletta - One of the best experts on this subject based on the ideXlab platform.
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Goldenhar syndrome: clinical features with orofacial emphasis
Brasil, 2015Co-Authors: Martelli H, Rt ,de Miranda, Cm Fernandes, Bonan Prf, Paranaiba Lmr, Graner E, Rd ColettaAbstract:Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Objectives: Goldenhar syndrome (GS) is a relatively common developmental disorder characterized by craniofacial anomalies in association with vertebral, cardiac, renal, and central nervous system defects. This paper describes GS features with special emphasis on oral characteristics. Material and Methods: The clinical features of 6 patients with GS aged 3 months to 12 years are described, and a brief review of the literature about this genetic disorder is presented. Results: All patients demonstrated the classical triad of GS, including mandibular hypoplasia resulting in facial asymmetry, ear and/or eye Malformation, and vertebral anomalies. In addition, renal and gastrointestinal abnormalities were observed in 2 patients. Regarding the oral involvement, 2 patients presented cleft lip and palate, and 1 patient had temporomandibular Joint Malformation. Malocclusion was found in all patients. Conclusion: Our orofacial findings correlate with the reported cases in the literature, and point out that after diagnosis GS patients need to be examined for systemic abnormalities.186646649State of Minas Gerais Research FoundationFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
Peter C. Potthoff - One of the best experts on this subject based on the ideXlab platform.
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Malformation of a cervical facet Joint with inclusion of an arthrolith: Case report
Journal of neurosurgery, 1994Co-Authors: Franz Jürgen Prestar, Peter C. PotthoffAbstract:The authors present the case of a 49-year-old man with an isolated Malformation of the left cervical facet Joint at C5-6, with secondary spondylarthrotic hypertrophy of the Joint leading to involvement of the C-6 nerve root. The etiology of this cervical Joint Malformation is discussed.
R Dennis - One of the best experts on this subject based on the ideXlab platform.
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Heritability and epidemiology of canine hip-dysplasia score in flat-coated retrievers and Newfoundlands in the United Kingdom.
Preventive veterinary medicine, 2000Co-Authors: James L. N. Wood, K.h Lakhani, R DennisAbstract:Hip dysplasia (Malformation of the coxofemoral Joint) in dogs is a major health problem for which the British Veterinary Association (BVA) had set up a control scheme in 1965. Based on scoring nine components of the radiographs of both the left and right Joints, the degree of hip Joint Malformation is now quantified by an overall hip score (a measure of the condition of the hip Joint). The hip scores of 1258 flat-coated retrievers and 1566 Newfoundlands (registered with The Kennel Club in the United Kingdom) were analysed after merging with Kennel Club pedigree data for 19036 flat-coated retrievers registered by 1995 and 14336 Newfoundlands registered by 1997. The merged data included the animal's identity, date of birth, sex and hip scores and also similar records for the dog's relatives including the hip score if the relative had been tested. In recent years, breeding has been increasingly from tested parents. There has been some reduction in offspring hip scores - presumably because breeders avoided breeding from males with very high scores. However, a much greater reduction in offspring hip score would be achieved by stricter science-based selection of potential sires and dams. Regression modelling quantified the positive relationship between offspring and parental hip scores. The genetic heritability of hip scores was large and significant in both breeds (particularly from dams). The breeders in UK tended to use healthy sires for breeding but they have taken less care in selecting dams. Our regression models emphasise the need for both sires and dams, particularly dams, to be healthy with very small hip scores.
