The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Aristidis Veves - One of the best experts on this subject based on the ideXlab platform.
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differences in Joint Mobility and foot pressures between black and white diabetic patients
Diabetic Medicine, 1995Co-Authors: Aristidis Veves, Marc R. Sarnow, John M. Giurini, Barry I. Rosenblum, James S. Chrzan, T. E. Lyons, Geoffrey M. HabershawAbstract:Limited Joint Mobility is common in diabetes and is related to high foot pressures and foot ulceration. We have examined the differences in Joint Mobility and foot pressures in four groups matched for age, sex, and duration of diabetes: 31 white diabetic, 33 white non-diabetic, 24 black diabetic, and 22 non-diabetic black subjects. Joint Mobility was assessed using a goniometer at the fifth metacarpal, first metatarsal, and subtalar Joints. In-shoe and without shoes foot pressures were measured using an F-Scan system. Neuropathy was evaluated using clinical symptoms (Neuropathy Symptom Score), signs (Neuropathy Disability Score), and Vibration Perception Threshold. There was no difference between white and black diabetic patients in Neuropathy Symptom Score, Neuropathy Disability Score, and Vibration Perception Threshold. Subtalar Joint Mobility was significantly reduced in white diabetic patients (22 ± 7°) compared to white controls (26 ± 4°, black diabetic patients (25 ± 5°), and black controls (29 ± 7°), and increased in black controls compared to white controls and black diabetic patients (level of statistical significance p < 0.05). Without shoes foot pressures were higher in white diabetic patients (8.31 ± 400 kg cm−2) compared to white controls (6.81 ± 2.31 kg cma2), black diabetic patients (6.2 ± 2.53 kg cm−2) and black controls (5.00 ± 1.24 kg cm−2) and lower in black controls compared to white and black diabetic patients (p < 0.05 in all cases). We conclude that racial differences exist in Joint Mobility and foot pressures between black and white subjects. Thus, in black diabetic patients the Joint Mobility, although reduced compared to black healthy subjects, is increased when compared to white diabetic patients. This contributes to lower foot pressures, comparable to non-diabetic white subjects and probably reduces the risk of foot ulceration in black diabetic patients.
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Differences in Joint Mobility and Foot Pressures Between Black and White Diabetic Patients
Diabetic Medicine, 1995Co-Authors: Aristidis Veves, Marc R. Sarnow, John M. Giurini, Barry I. Rosenblum, James S. Chrzan, T. E. Lyons, Geoffrey M. HabershawAbstract:Limited Joint Mobility is common in diabetes and is related to high foot pressures and foot ulceration. We have examined the differences in Joint Mobility and foot pressures in four groups matched for age, sex, and duration of diabetes: 31 white diabetic, 33 white non-diabetic, 24 black diabetic, and 22 non-diabetic black subjects. Joint Mobility was assessed using a goniometer at the fifth metacarpal, first metatarsal, and subtalar Joints. In-shoe and without shoes foot pressures were measured using an F-Scan system. Neuropathy was evaluated using clinical symptoms (Neuropathy Symptom Score), signs (Neuropathy Disability Score), and Vibration Perception Threshold. There was no difference between white and black diabetic patients in Neuropathy Symptom Score, Neuropathy Disability Score, and Vibration Perception Threshold. Subtalar Joint Mobility was significantly reduced in white diabetic patients (22 +/- 7 degrees) compared to white controls (26 +/- 4 degrees, black diabetic patients (25 +/- 5 degrees), and black controls (29 +/- 7 degrees), and increased in black controls compared to white controls and black diabetic patients (level of statistical significance p < 0.05). Without shoes foot pressures were higher in white diabetic patients (8.31 +/- 400 kg cm-2) compared to white controls (6.81 +/- 2.31 kg cma2), black diabetic patients (6.2 +/- 2.53 kg cm-2) and black controls (5.00 +/- 1.24 kg cm-2) and lower in black controls compared to white and black diabetic patients (p < 0.05 in all cases). We conclude that racial differences exist in Joint Mobility and foot pressures between black and white subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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relationship of limited Joint Mobility to abnormal foot pressures and diabetic foot ulceration
Diabetes Care, 1991Co-Authors: D. J. S. Fernando, Aristidis Veves, E A Masson, Andrew J M BoultonAbstract:Objective To investigate the role of limited Joint Mobility (LJM) in causing abnormal foot pressures and foot ulceration. Research Design and Methods The subjects were recruited from a general diabetes clinic where patients were screened for neuropathy, retinopathy, and elevated plantar foot pressure. Sixty-four patients in five groups were matched by age and sex in the following groups: group 1, patients with LJM and neuropathy; group 2, nonneuropathic diabetic patients with LJM; group 3, patients with neuropathy and no LJM; group 4, diabetic control subjects; and group 5, nondiabetic control subjects. Joint Mobility was assessed in the foot at subtalar and metatarsophalangeal Joints; plantar foot pressures were assessed by optical pedobarography and neuropathic status by a Biothesiometer and electrophysiology. Results Joint Mobility was reduced at both sites in groups 1 and 2 compared with groups 3, 4, and 5 ( P P r = −0.7, P Conclusions 1) LJM may be a major factor in causing abnormally high plantar foot pressures, 2) abnormal plantar foot pressures alone do not lead to foot ulceration, and 3) LJM contributes to foot ulceration in the susceptible neuropathic foot.
Paldeep S Atwal - One of the best experts on this subject based on the ideXlab platform.
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novel x linked syndrome of cardiac valvulopathy keloid scarring and reduced Joint Mobility due to filamin a substitution g1576r
American Journal of Medical Genetics Part A, 2016Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A BernsteinAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome. © 2015 Wiley Periodicals, Inc.
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Novel X‐linked syndrome of cardiac valvulopathy, keloid scarring, and reduced Joint Mobility due to filamin A substitution G1576R
American Journal of Medical Genetics Part A, 2015Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A Bernstein, Louanne HudginsAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome. © 2015 Wiley Periodicals, Inc.
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Novel X-linked syndrome of cardiac valvulopathy, keloid scarring, and reduced Joint Mobility due to filamin A substitution G1576R.
American journal of medical genetics. Part A, 2015Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A Bernstein, Louanne HudginsAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome.
Geoffrey M. Habershaw - One of the best experts on this subject based on the ideXlab platform.
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differences in Joint Mobility and foot pressures between black and white diabetic patients
Diabetic Medicine, 1995Co-Authors: Aristidis Veves, Marc R. Sarnow, John M. Giurini, Barry I. Rosenblum, James S. Chrzan, T. E. Lyons, Geoffrey M. HabershawAbstract:Limited Joint Mobility is common in diabetes and is related to high foot pressures and foot ulceration. We have examined the differences in Joint Mobility and foot pressures in four groups matched for age, sex, and duration of diabetes: 31 white diabetic, 33 white non-diabetic, 24 black diabetic, and 22 non-diabetic black subjects. Joint Mobility was assessed using a goniometer at the fifth metacarpal, first metatarsal, and subtalar Joints. In-shoe and without shoes foot pressures were measured using an F-Scan system. Neuropathy was evaluated using clinical symptoms (Neuropathy Symptom Score), signs (Neuropathy Disability Score), and Vibration Perception Threshold. There was no difference between white and black diabetic patients in Neuropathy Symptom Score, Neuropathy Disability Score, and Vibration Perception Threshold. Subtalar Joint Mobility was significantly reduced in white diabetic patients (22 ± 7°) compared to white controls (26 ± 4°, black diabetic patients (25 ± 5°), and black controls (29 ± 7°), and increased in black controls compared to white controls and black diabetic patients (level of statistical significance p < 0.05). Without shoes foot pressures were higher in white diabetic patients (8.31 ± 400 kg cm−2) compared to white controls (6.81 ± 2.31 kg cma2), black diabetic patients (6.2 ± 2.53 kg cm−2) and black controls (5.00 ± 1.24 kg cm−2) and lower in black controls compared to white and black diabetic patients (p < 0.05 in all cases). We conclude that racial differences exist in Joint Mobility and foot pressures between black and white subjects. Thus, in black diabetic patients the Joint Mobility, although reduced compared to black healthy subjects, is increased when compared to white diabetic patients. This contributes to lower foot pressures, comparable to non-diabetic white subjects and probably reduces the risk of foot ulceration in black diabetic patients.
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Differences in Joint Mobility and Foot Pressures Between Black and White Diabetic Patients
Diabetic Medicine, 1995Co-Authors: Aristidis Veves, Marc R. Sarnow, John M. Giurini, Barry I. Rosenblum, James S. Chrzan, T. E. Lyons, Geoffrey M. HabershawAbstract:Limited Joint Mobility is common in diabetes and is related to high foot pressures and foot ulceration. We have examined the differences in Joint Mobility and foot pressures in four groups matched for age, sex, and duration of diabetes: 31 white diabetic, 33 white non-diabetic, 24 black diabetic, and 22 non-diabetic black subjects. Joint Mobility was assessed using a goniometer at the fifth metacarpal, first metatarsal, and subtalar Joints. In-shoe and without shoes foot pressures were measured using an F-Scan system. Neuropathy was evaluated using clinical symptoms (Neuropathy Symptom Score), signs (Neuropathy Disability Score), and Vibration Perception Threshold. There was no difference between white and black diabetic patients in Neuropathy Symptom Score, Neuropathy Disability Score, and Vibration Perception Threshold. Subtalar Joint Mobility was significantly reduced in white diabetic patients (22 +/- 7 degrees) compared to white controls (26 +/- 4 degrees, black diabetic patients (25 +/- 5 degrees), and black controls (29 +/- 7 degrees), and increased in black controls compared to white controls and black diabetic patients (level of statistical significance p < 0.05). Without shoes foot pressures were higher in white diabetic patients (8.31 +/- 400 kg cm-2) compared to white controls (6.81 +/- 2.31 kg cma2), black diabetic patients (6.2 +/- 2.53 kg cm-2) and black controls (5.00 +/- 1.24 kg cm-2) and lower in black controls compared to white and black diabetic patients (p < 0.05 in all cases). We conclude that racial differences exist in Joint Mobility and foot pressures between black and white subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Jonathan A Bernstein - One of the best experts on this subject based on the ideXlab platform.
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novel x linked syndrome of cardiac valvulopathy keloid scarring and reduced Joint Mobility due to filamin a substitution g1576r
American Journal of Medical Genetics Part A, 2016Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A BernsteinAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome. © 2015 Wiley Periodicals, Inc.
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Novel X‐linked syndrome of cardiac valvulopathy, keloid scarring, and reduced Joint Mobility due to filamin A substitution G1576R
American Journal of Medical Genetics Part A, 2015Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A Bernstein, Louanne HudginsAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome. © 2015 Wiley Periodicals, Inc.
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Novel X-linked syndrome of cardiac valvulopathy, keloid scarring, and reduced Joint Mobility due to filamin A substitution G1576R.
American journal of medical genetics. Part A, 2015Co-Authors: Paldeep S Atwal, Sophie Blease, Alicia Braxton, Julia Graves, Weimin He, Richard Person, Leah Slattery, Jonathan A Bernstein, Louanne HudginsAbstract:Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced Joint Mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased Joint Mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome.
Andrew J M Boulton - One of the best experts on this subject based on the ideXlab platform.
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relationship of limited Joint Mobility to abnormal foot pressures and diabetic foot ulceration
Diabetes Care, 1991Co-Authors: D. J. S. Fernando, Aristidis Veves, E A Masson, Andrew J M BoultonAbstract:Objective To investigate the role of limited Joint Mobility (LJM) in causing abnormal foot pressures and foot ulceration. Research Design and Methods The subjects were recruited from a general diabetes clinic where patients were screened for neuropathy, retinopathy, and elevated plantar foot pressure. Sixty-four patients in five groups were matched by age and sex in the following groups: group 1, patients with LJM and neuropathy; group 2, nonneuropathic diabetic patients with LJM; group 3, patients with neuropathy and no LJM; group 4, diabetic control subjects; and group 5, nondiabetic control subjects. Joint Mobility was assessed in the foot at subtalar and metatarsophalangeal Joints; plantar foot pressures were assessed by optical pedobarography and neuropathic status by a Biothesiometer and electrophysiology. Results Joint Mobility was reduced at both sites in groups 1 and 2 compared with groups 3, 4, and 5 ( P P r = −0.7, P Conclusions 1) LJM may be a major factor in causing abnormally high plantar foot pressures, 2) abnormal plantar foot pressures alone do not lead to foot ulceration, and 3) LJM contributes to foot ulceration in the susceptible neuropathic foot.
