The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Hiroharu Noda - One of the best experts on this subject based on the ideXlab platform.
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Fastigiofugal fibers encoding horizontal and vertical components of saccades as determined by microstimulation in monkeys.
Neuroscience research, 1992Co-Authors: Hiroharu Noda, Hitoshi Sato, Yoichi Ikeda, Shoei SugitaAbstract:To identify the routes by which oculomotor vermis signals control eye movements (saccadic signals), saccades evoked by microstimulation were studied in the region of the uncinate fasciculus (UF) and Juxtarestiform Body (JB) in the macaque monkey. Anatomical pathways of axons from the fastigial oculomotor region (FOR) were studied by anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP). The routes were identified by comparing maps of low threshold for evoking saccades with the anatomical map of anterogradely labeled axons arising from the FOR. Microstimulation of a region of the UF and JB demonstrated that saccadic signals are carried exclusively by decussated FOR axons which leave the cerebellum via the contralateral UF. The fibers in the JB do not carry saccadic signals. The horizontal component of saccadic signals is conveyed by fibers in the descending limb of the UF, while the vertical component is conveyed by a smaller group of fibers which separate from the UF and enter the midbrain with the contralateral superior cerebellar peduncle.
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Pathways and terminations of axons arising in the fastigial oculomotor region of macaque monkeys.
Neuroscience research, 1991Co-Authors: Shoei Sugita, Hiroharu NodaAbstract:Abstract The majority of axons from the fastigial oculomotor region (FOR) decussated in the cerebellum at all rostrocaudal levels of the fastigial nucleus (FN) and entered the brainstem via the contralateral uncinate fasciculus (UF). Some decussated axons separated from the UF and ran medial to the contralateral superior cerebellar peduncle and ascended to the midbrain. Uncrossed FOR axons advanced rostrolaterally in the ipsilateral FN and entered the brainstem via the Juxtarestiform Body. The decussated fibers terminated in the brainstem nuclei that are implicated in the control of saccadic eye movements. In the midbrain, labeled terminals were found in the rostral interstitial nucleus of the medial longitudinal fasciculus, a medial part of Forel's H-field, the periaqueductal gray, the posterior commissure nucleus, and the superior colliculus of the contralateral side. In the pons and medulla, FOR fibers terminated in a caudal part of the pontine raphe, the paramedian pontine reticular formation, the nucleus reticularis tegmenti pontis, the dorsomedial pontine nucleus of the contralateral side, and the dorsomedial medullary reticular formation of both sides. In contrast, FOR projections to the vestibular complex were bilateral and were mainly to the ventral portions of the lateral and inferior vestibular nuclei. No labeled terminals were found in the following brainstem nuclei which are considered to be involved in oculomotor function: oculomotor and trochlear nuclei, interstitial nucleus of Cajal, medial and superior vestibular nuclei, perihypoglossal nuclei, and dorsolateral pontine nucleus. Labeling appeared in the red nucleus only when HRP encroached upon the posterior interposed nucleus.
Shoei Sugita - One of the best experts on this subject based on the ideXlab platform.
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Fastigiofugal fibers encoding horizontal and vertical components of saccades as determined by microstimulation in monkeys.
Neuroscience research, 1992Co-Authors: Hiroharu Noda, Hitoshi Sato, Yoichi Ikeda, Shoei SugitaAbstract:To identify the routes by which oculomotor vermis signals control eye movements (saccadic signals), saccades evoked by microstimulation were studied in the region of the uncinate fasciculus (UF) and Juxtarestiform Body (JB) in the macaque monkey. Anatomical pathways of axons from the fastigial oculomotor region (FOR) were studied by anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP). The routes were identified by comparing maps of low threshold for evoking saccades with the anatomical map of anterogradely labeled axons arising from the FOR. Microstimulation of a region of the UF and JB demonstrated that saccadic signals are carried exclusively by decussated FOR axons which leave the cerebellum via the contralateral UF. The fibers in the JB do not carry saccadic signals. The horizontal component of saccadic signals is conveyed by fibers in the descending limb of the UF, while the vertical component is conveyed by a smaller group of fibers which separate from the UF and enter the midbrain with the contralateral superior cerebellar peduncle.
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Pathways and terminations of axons arising in the fastigial oculomotor region of macaque monkeys.
Neuroscience research, 1991Co-Authors: Shoei Sugita, Hiroharu NodaAbstract:Abstract The majority of axons from the fastigial oculomotor region (FOR) decussated in the cerebellum at all rostrocaudal levels of the fastigial nucleus (FN) and entered the brainstem via the contralateral uncinate fasciculus (UF). Some decussated axons separated from the UF and ran medial to the contralateral superior cerebellar peduncle and ascended to the midbrain. Uncrossed FOR axons advanced rostrolaterally in the ipsilateral FN and entered the brainstem via the Juxtarestiform Body. The decussated fibers terminated in the brainstem nuclei that are implicated in the control of saccadic eye movements. In the midbrain, labeled terminals were found in the rostral interstitial nucleus of the medial longitudinal fasciculus, a medial part of Forel's H-field, the periaqueductal gray, the posterior commissure nucleus, and the superior colliculus of the contralateral side. In the pons and medulla, FOR fibers terminated in a caudal part of the pontine raphe, the paramedian pontine reticular formation, the nucleus reticularis tegmenti pontis, the dorsomedial pontine nucleus of the contralateral side, and the dorsomedial medullary reticular formation of both sides. In contrast, FOR projections to the vestibular complex were bilateral and were mainly to the ventral portions of the lateral and inferior vestibular nuclei. No labeled terminals were found in the following brainstem nuclei which are considered to be involved in oculomotor function: oculomotor and trochlear nuclei, interstitial nucleus of Cajal, medial and superior vestibular nuclei, perihypoglossal nuclei, and dorsolateral pontine nucleus. Labeling appeared in the red nucleus only when HRP encroached upon the posterior interposed nucleus.
Georg Auburger - One of the best experts on this subject based on the ideXlab platform.
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Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significance
Neuropathology and applied neurobiology, 2004Co-Authors: Udo Rüb, Ewout R. Brunt, R. A. I. De Vos, D. Del Turco, K. Del Tredici, K. Gierga, Christian Schultz, Estifanos Ghebremedhin, Katrin Bürk, Georg AuburgerAbstract:Although the vestibular complex represents an important component of the neural circuits crucial for the maintenance of truncal and postural stability, and it is integrated into specialized oculomotor circuits, knowledge regarding the extent of the involvement of its nuclei and associated fibre tracts in cases with spinocerebellar ataxia type 3 (SCA3) is incomplete. Accordingly, we performed a pathoanatomical analysis of the vestibular complex and its associated fibre tracts in four clinically diagnosed and genetically confirmed SCA3 patients with the aim of providing more exact information as to the involvement of the vestibular system in this disorder. By means of unconventionally thick serial sections through the vestibular nuclei stained for lipofuscin pigment and Nissl material, we could show that all five nuclei of this complex (interstitial, lateral, medial, spinal, and superior vestibular nuclei) are subject to neurodegenerative processes in SCA3, whereby examination of thick serial sections stained for myelin revealed that all associated fibre tracts (ascending tract of Deiters, Juxtarestiform Body, lateral and medial vestibulospinal tracts, medial longitudinal fascicle, vestibular portion of the eighth cranial nerve) underwent atrophy and demyelinization in all four of the patients studied. The reported lesions can help to explain the truncal and postural instability as well as the impaired optokinetic nystagmus, vestibulo-ocular reaction, and horizontal gaze-holding present in SCA3 cases.
Yoichi Ikeda - One of the best experts on this subject based on the ideXlab platform.
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Fastigiofugal fibers encoding horizontal and vertical components of saccades as determined by microstimulation in monkeys.
Neuroscience research, 1992Co-Authors: Hiroharu Noda, Hitoshi Sato, Yoichi Ikeda, Shoei SugitaAbstract:To identify the routes by which oculomotor vermis signals control eye movements (saccadic signals), saccades evoked by microstimulation were studied in the region of the uncinate fasciculus (UF) and Juxtarestiform Body (JB) in the macaque monkey. Anatomical pathways of axons from the fastigial oculomotor region (FOR) were studied by anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP). The routes were identified by comparing maps of low threshold for evoking saccades with the anatomical map of anterogradely labeled axons arising from the FOR. Microstimulation of a region of the UF and JB demonstrated that saccadic signals are carried exclusively by decussated FOR axons which leave the cerebellum via the contralateral UF. The fibers in the JB do not carry saccadic signals. The horizontal component of saccadic signals is conveyed by fibers in the descending limb of the UF, while the vertical component is conveyed by a smaller group of fibers which separate from the UF and enter the midbrain with the contralateral superior cerebellar peduncle.
Hitoshi Sato - One of the best experts on this subject based on the ideXlab platform.
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Fastigiofugal fibers encoding horizontal and vertical components of saccades as determined by microstimulation in monkeys.
Neuroscience research, 1992Co-Authors: Hiroharu Noda, Hitoshi Sato, Yoichi Ikeda, Shoei SugitaAbstract:To identify the routes by which oculomotor vermis signals control eye movements (saccadic signals), saccades evoked by microstimulation were studied in the region of the uncinate fasciculus (UF) and Juxtarestiform Body (JB) in the macaque monkey. Anatomical pathways of axons from the fastigial oculomotor region (FOR) were studied by anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP). The routes were identified by comparing maps of low threshold for evoking saccades with the anatomical map of anterogradely labeled axons arising from the FOR. Microstimulation of a region of the UF and JB demonstrated that saccadic signals are carried exclusively by decussated FOR axons which leave the cerebellum via the contralateral UF. The fibers in the JB do not carry saccadic signals. The horizontal component of saccadic signals is conveyed by fibers in the descending limb of the UF, while the vertical component is conveyed by a smaller group of fibers which separate from the UF and enter the midbrain with the contralateral superior cerebellar peduncle.
