Kainic Acid

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 23976 Experts worldwide ranked by ideXlab platform

Dieter Hoppe - One of the best experts on this subject based on the ideXlab platform.

Tetsuro Shinada - One of the best experts on this subject based on the ideXlab platform.

  • Short Total Synthesis of (−)-Kainic Acid
    Organic letters, 2014
    Co-Authors: Yasufumi Ohfune, Tetsuro Shinada
    Abstract:

    A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.

  • short total synthesis of Kainic Acid
    Organic Letters, 2014
    Co-Authors: Yasufumi Ohfune, Tetsuro Shinada
    Abstract:

    A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.

Montserrat M Martinez - One of the best experts on this subject based on the ideXlab platform.

Yasufumi Ohfune - One of the best experts on this subject based on the ideXlab platform.

  • Short Total Synthesis of (−)-Kainic Acid
    Organic letters, 2014
    Co-Authors: Yasufumi Ohfune, Tetsuro Shinada
    Abstract:

    A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.

  • short total synthesis of Kainic Acid
    Organic Letters, 2014
    Co-Authors: Yasufumi Ohfune, Tetsuro Shinada
    Abstract:

    A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.

Tohru Fukuyama - One of the best experts on this subject based on the ideXlab platform.

  • A practical synthesis of (-)-Kainic Acid.
    Organic letters, 2011
    Co-Authors: Satoshi Takita, Satoshi Yokoshima, Tohru Fukuyama
    Abstract:

    A highly practical stereoselective total synthesis of (−)-Kainic Acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic Acid by hydrolysis of a nitrile accompanied by epimerizaion. This synthetic route enabled us to obtain 14.6 g of (−)-Kainic Acid.

  • stereocontrolled total synthesis of Kainic Acid
    Organic Letters, 2007
    Co-Authors: Hiroshi Sakaguchi, Hidetoshi Tokuyama, Tohru Fukuyama
    Abstract:

    [reaction: see text] A stereocontrolled total synthesis of (-)-Kainic Acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity. Two alternative protocols for the construction of the alpha,beta-unsaturated lactone were also developed.