The Experts below are selected from a list of 23976 Experts worldwide ranked by ideXlab platform
Dieter Hoppe - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of (−)-α-Kainic Acid by (−)-Sparteine-Mediated Asymmetric Deprotonation−Cycloalkylation†
Organic letters, 2004Co-Authors: Montserrat M Martinez, Dieter HoppeAbstract:We report a new enantioselective synthesis of (−)-α-Kainic Acid from d-serine methyl ester hydrochloride, based on a (−)-sparteine-mediated asymmetric deprotonation of an intermediate carbamate that, by stereospecific anti SN‘SE‘ intramolecular cycloalkylation, leads to the pyrrolidine ring precursor of (−)-α-Kainic Acid, in high yield and diastereoselectivity. The intermediate pyrrolidine was further transformed to (−)-α-Kainic Acid in three steps.
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total synthesis of α Kainic Acid by sparteine mediated asymmetric deprotonation cycloalkylation
Organic Letters, 2004Co-Authors: Montserrat M Martinez, Dieter HoppeAbstract:We report a new enantioselective synthesis of (−)-α-Kainic Acid from d-serine methyl ester hydrochloride, based on a (−)-sparteine-mediated asymmetric deprotonation of an intermediate carbamate that, by stereospecific anti SN‘SE‘ intramolecular cycloalkylation, leads to the pyrrolidine ring precursor of (−)-α-Kainic Acid, in high yield and diastereoselectivity. The intermediate pyrrolidine was further transformed to (−)-α-Kainic Acid in three steps.
Tetsuro Shinada - One of the best experts on this subject based on the ideXlab platform.
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Short Total Synthesis of (−)-Kainic Acid
Organic letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.
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short total synthesis of Kainic Acid
Organic Letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.
Montserrat M Martinez - One of the best experts on this subject based on the ideXlab platform.
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Total Synthesis of (−)-α-Kainic Acid by (−)-Sparteine-Mediated Asymmetric Deprotonation−Cycloalkylation†
Organic letters, 2004Co-Authors: Montserrat M Martinez, Dieter HoppeAbstract:We report a new enantioselective synthesis of (−)-α-Kainic Acid from d-serine methyl ester hydrochloride, based on a (−)-sparteine-mediated asymmetric deprotonation of an intermediate carbamate that, by stereospecific anti SN‘SE‘ intramolecular cycloalkylation, leads to the pyrrolidine ring precursor of (−)-α-Kainic Acid, in high yield and diastereoselectivity. The intermediate pyrrolidine was further transformed to (−)-α-Kainic Acid in three steps.
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total synthesis of α Kainic Acid by sparteine mediated asymmetric deprotonation cycloalkylation
Organic Letters, 2004Co-Authors: Montserrat M Martinez, Dieter HoppeAbstract:We report a new enantioselective synthesis of (−)-α-Kainic Acid from d-serine methyl ester hydrochloride, based on a (−)-sparteine-mediated asymmetric deprotonation of an intermediate carbamate that, by stereospecific anti SN‘SE‘ intramolecular cycloalkylation, leads to the pyrrolidine ring precursor of (−)-α-Kainic Acid, in high yield and diastereoselectivity. The intermediate pyrrolidine was further transformed to (−)-α-Kainic Acid in three steps.
Yasufumi Ohfune - One of the best experts on this subject based on the ideXlab platform.
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Short Total Synthesis of (−)-Kainic Acid
Organic letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.
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short total synthesis of Kainic Acid
Organic Letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-Kainic Acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (−)-Kainic Acid via the stereoselective 1,4-reduction of the pyrroline double bond in three steps.
Tohru Fukuyama - One of the best experts on this subject based on the ideXlab platform.
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A practical synthesis of (-)-Kainic Acid.
Organic letters, 2011Co-Authors: Satoshi Takita, Satoshi Yokoshima, Tohru FukuyamaAbstract:A highly practical stereoselective total synthesis of (−)-Kainic Acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic Acid by hydrolysis of a nitrile accompanied by epimerizaion. This synthetic route enabled us to obtain 14.6 g of (−)-Kainic Acid.
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stereocontrolled total synthesis of Kainic Acid
Organic Letters, 2007Co-Authors: Hiroshi Sakaguchi, Hidetoshi Tokuyama, Tohru FukuyamaAbstract:[reaction: see text] A stereocontrolled total synthesis of (-)-Kainic Acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity. Two alternative protocols for the construction of the alpha,beta-unsaturated lactone were also developed.