The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Fleta B Asin - One of the best experts on this subject based on the ideXlab platform.
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Keratosis Pilaris rubra and Keratosis Pilaris Atrophicans faciei treated with pulsed dye laser report of 10 cases
Journal of The European Academy of Dermatology and Venereology, 2011Co-Authors: Alcantara J Gonzalez, P Boixeda, M Truchuelo T Diez, Fleta B AsinAbstract:Background Keratosis Pilaris rubra (KPR) and Keratosis Pilaris Atrophicans faciei (KPAF) are both keratinization disorders characterized by erythema and keratotic follicular papules usually located on cheeks, forehead, chin and eyebrows. Topical keratolytics, vitamin D3 analogues, antibiotics, topical and oral retinoids have been used with limited results. As this condition can be socially very limiting, the need for an effective treatment has led to the use of other technologies such as pulsed dye laser (PDL) or intense pulsed light. Objective The aim of this study was to assess the efficacy and safety of PDL in patients with KPR or KPAF. Methods Ten patients with KPR or KPAF were treated with two to seven sessions of PDL at 595-nm wavelength. Laser therapy was performed using a spot size of 7 or 10 mm, a pulse duration of 0.5 or 1.5 ms and a fluence from 5 to 9 J/cm2. Two dermatologists evaluated treatment effectiveness by means of photographs of the patients before starting and after finishing the therapy. Results Complete resolution of erythema was achieved in three patients; clearance of erythema was > 75% in the other seven patients. Transient purpura was present in all patients for about 2 weeks and one patient presented postinflammatory hyperpigmentation for 7 months. Conclusion We consider that PDL is a good option for the treatment of KPR and KPAF. A marked reduction in erythema is achieved in all patients with a low incidence of side effects.
Stanislaw A. Buechner - One of the best experts on this subject based on the ideXlab platform.
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Keratosis Pilaris and Keratosis Pilaris Atrophicans faciei
Journal Der Deutschen Dermatologischen Gesellschaft, 2006Co-Authors: Andreas Arnold, Stanislaw A. BuechnerAbstract:Keratosis Pilaris and ulerythema ophryogenes (Keratosis Pilaris Atrophicans faciei) are hereditary disorders with altered follicular keratinization that show follicular, horny papules surrounded by an erythematous halo. Ulerythema ophryogenes is an uncommon variant of Keratosis Pilaris characterized by erythematous follicular papules of the eyebrows and cheeks followed by a gradual loss of hair. On the background of 15-year-old boy who presented with Keratosis Pilaris and ulerythema ophryogenes, we discuss the various clinical manifestations of Keratosis Pilaris.
Alcantara J Gonzalez - One of the best experts on this subject based on the ideXlab platform.
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Keratosis Pilaris rubra and Keratosis Pilaris Atrophicans faciei treated with pulsed dye laser report of 10 cases
Journal of The European Academy of Dermatology and Venereology, 2011Co-Authors: Alcantara J Gonzalez, P Boixeda, M Truchuelo T Diez, Fleta B AsinAbstract:Background Keratosis Pilaris rubra (KPR) and Keratosis Pilaris Atrophicans faciei (KPAF) are both keratinization disorders characterized by erythema and keratotic follicular papules usually located on cheeks, forehead, chin and eyebrows. Topical keratolytics, vitamin D3 analogues, antibiotics, topical and oral retinoids have been used with limited results. As this condition can be socially very limiting, the need for an effective treatment has led to the use of other technologies such as pulsed dye laser (PDL) or intense pulsed light. Objective The aim of this study was to assess the efficacy and safety of PDL in patients with KPR or KPAF. Methods Ten patients with KPR or KPAF were treated with two to seven sessions of PDL at 595-nm wavelength. Laser therapy was performed using a spot size of 7 or 10 mm, a pulse duration of 0.5 or 1.5 ms and a fluence from 5 to 9 J/cm2. Two dermatologists evaluated treatment effectiveness by means of photographs of the patients before starting and after finishing the therapy. Results Complete resolution of erythema was achieved in three patients; clearance of erythema was > 75% in the other seven patients. Transient purpura was present in all patients for about 2 weeks and one patient presented postinflammatory hyperpigmentation for 7 months. Conclusion We consider that PDL is a good option for the treatment of KPR and KPAF. A marked reduction in erythema is achieved in all patients with a low incidence of side effects.
Andreas Arnold - One of the best experts on this subject based on the ideXlab platform.
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Keratosis Pilaris and Keratosis Pilaris Atrophicans faciei
Journal Der Deutschen Dermatologischen Gesellschaft, 2006Co-Authors: Andreas Arnold, Stanislaw A. BuechnerAbstract:Keratosis Pilaris and ulerythema ophryogenes (Keratosis Pilaris Atrophicans faciei) are hereditary disorders with altered follicular keratinization that show follicular, horny papules surrounded by an erythematous halo. Ulerythema ophryogenes is an uncommon variant of Keratosis Pilaris characterized by erythematous follicular papules of the eyebrows and cheeks followed by a gradual loss of hair. On the background of 15-year-old boy who presented with Keratosis Pilaris and ulerythema ophryogenes, we discuss the various clinical manifestations of Keratosis Pilaris.
H R Byers - One of the best experts on this subject based on the ideXlab platform.
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clinical findings cutaneous pathology and response to therapy in 21 patients with Keratosis Pilaris Atrophicans
Archives of Dermatology, 1994Co-Authors: Howard P Baden, H R ByersAbstract:Background: Keratosis Pilaris Atrophicans defines a group of cutaneous disorders characterized by follicular hyperKeratosis and scarring. X-linked dominant inheritance has recently been reported in a Dutch family with a form of Keratosis Pilaris Atrophicans defined as Keratosis follicularis spinulosa decalvans , with males more severely affected and having corneal involvement. The clinical manifestations observed in different families by others and ourselves did not follow that pattern, suggesting genetic heterogeneity. We report our experience with 21 unrelated individuals. Results: There were 15 male and six female patients whose onset of the skin disease was in early childhood but with scalp involvement occurring in the teen years. The cutaneous lesions consisted of follicular papules with scalp involvement present in eight individuals. Half the women had scalp involvement, and one female and one male had eye changes. Familial involvement was observed in three patients and was compatible with dominant inheritance. Histopathologic examination revealed hyperKeratosis of the upper follicle with an inflammatory response that resulted in follicular destruction. Response to therapy including keratolytics, antibiotics, corticosteroids and retinoids was limited. Conclusions: Our findings support the hypothesis that there is genetic and clinical heterogeneity among the disorders represented by the term Keratosis Pilaris Atrophicans. The cause of these diseases may be a disorder of the keratinocyte, which is responsible for inducing both the hyperKeratosis and inflammatory changes. (Arch Dermatol. 1994;130:469-475)
