Keshan Disease

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Tong Wang - One of the best experts on this subject based on the ideXlab platform.

  • a spatial study on serum selenoprotein p and Keshan Disease in heilongjiang province china
    Journal of Trace Elements in Medicine and Biology, 2021
    Co-Authors: Yanan Wang, Tong Wang, Huihui Zhou, Xiao Zhang, Xu Liu, Shan Han, Yiyi Zhang, Yuanjie Zou, Hong Liang
    Abstract:

    Abstract Background Few spatial studies on serum selenoprotein P (SELENOP) and Keshan Disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD. Methods Using a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares. Results The mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product. Conclusion Selenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective.

  • A Spatial Ecology Study of Keshan Disease and Hair Selenium
    Biological Trace Element Research, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Zhe Wang, Xiangzhi Gao
    Abstract:

    Few spatial ecological studies on hair selenium (Se) and Keshan Disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann–Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal–Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan Disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

  • overview of Keshan Disease surveillance and trend analysis in china
    Chin J Endemiol, 2019
    Co-Authors: Tong Wang, Hongqi Feng
    Abstract:

    Objective To analyze the situation of Keshan Disease in China and provide a scientific basis for adjustment of the control strategies. Methods Relying on the Keshan Disease surveillance in 2014 and the "Twelfth Five-Year Plan" Final Assessment Project in 2015 and 2016, in each surveillance site of the 12 provinces including Hebei, Shanxi, Inner Mongolia, Liaoning, Jilin, Heilongjiang, Shandong, Chongqing, Sichuan, Yunnan, Shaanxi, and Gansu, the residents were investigated by face-to-face questionnaire interviews, physical measurements and electrocardiography. Echocardiographic examination and chest X-ray examination were conducted for those patients with suspected Keshan Disease. Results In 2014, the data of a total of 171 838 individuals were included in the analyses. A total of 749 cases of Keshan Disease were detected in all the survey sites of 12 provinces. The detection rate was 43.6/10 000. Among them, 160 cases were chronic, the detection rate was 9.3/10 000; the potential type was 589 cases, the detection rate was 34.3/10 000. In 2015 and 2016, the data of a total of 396 977 individuals were included in the analyses. A total of 2 127 cases of Keshan Disease were detected in 12 provinces. The detection rate was 53.6/10 000. Among them, 377 cases (9.5/10 000) were chronic, and the potential type was 1 750 cases (44.1/10 000). Conclusion There are still natural chronic Keshan Disease cases in the endemic area, therefore the prevention and treatment tasks cannot be ignored. Key words: Keshan Disease; Present condition; Surveillance; Elimination

  • echocardiographic a comparison of chronic Keshan Disease between patients in plateau and plain areas
    Chin J Endemiol, 2019
    Co-Authors: Guanfeng Chong, Tong Wang, Hongqi Feng, Xiuhong Wang, Wenming Zhang, Yuanyuan Wang, Hongqiang Gong, Mingliang Wang
    Abstract:

    Objective The echocardiography of patients with chronic Keshan Disease (CKD) in the plateau and plain areas was compared, to analyze the specific manifestations of echocardiography in patients with high altitude CKD, to provide a reference for imaging diagnosis. Methods From October 2014 to December 2016, 34 patients with CKD were selected in the Tibet Autonomous Region [18 males, 16 females, aged (44.5 ± 5.6) years old] as plateau group; 45 patients with CKD were selected in Shandong Province [21 males, 24 females, age (47.3 ± 6.9) years old] as a plain group. Echocardiography was performed on the observed subjects, and cardiac morphology, hemodynamics and cardiac function were analyzed. Results The left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDD), and left ventricular mass (LVM) of the plateau group were (39.2 ± 4.8), (56.5 ± 6.3) mm and (232.4 ± 40.2) g, respectively, which were lower than those of the plain group [(48.3 ± 5.7), (65.2 ± 7.8) mm, (283.7 ± 38.3) g, t=- 7.52, - 5.30, - 5.74, P < 0.01]. The right atrial transverse diameter (RATD), right ventricular transverse diameter (RVTD) and right ventricular lateral wall thickness (RVWT) of the plateau group were (47.6 ±8.5), (50.4 ± 7.3) and (4.8 ± 1.1) mm, respectively, which were higher than those of the plain group [(42.3 ± 7.2), (42.7 ± 6.8), (3.3 ± 0.7) mm, t=2.99, 4.81, 7.36, P < 0.01]. The early diastolic filling velocity (E), the early diastolic peak velocity of the mitral annular (Em) of the plateau group were lower than those of the plain group, E/Em of the plateau group was higher than that of the plain group (t=- 2.64, - 2.35, 2.07, P < 0.05). The fractional area change (FAC) of right ventricular, tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular systolic velocity (S') of the plateau group [(24.9 ± 2.8)%, (13.2 ± 1.2) mm, (6.8 ± 1.0) cm/s] were lower than those of the plain group [(26.3 ± 3.2)%, (14.5 ± 1.3) mm, (7.5 ± 1.2) cm/s, t=- 2.02, - 4.53, - 2.74, P < 0.05 or < 0.01]. The tricuspid annular diastolic velocity(e') of the plateau group was lower than that of the plain group, and tricuspid annular blood flow early diastolic filling velocity maximum(e)/e' was higher than that of the plain group (t=- 2.07, 2.09, P < 0.05). The systolic pulmonary artery pressure (SPAP) of the plateau group [(48.5 ± 12.3) mmHg, 1 mmHg=0.133 kPa] was higher than that of the plain group [ (41.6 ± 13.3) mmHg, t=2.34, P < 0.05]. Conclusion Compared with CKD patients in plain area, CKD patients in plateau area have showed more obvious right heart enlargement and right ventricular failure, and combined with higher SPAP. Key words: Echocardiography; Keshan Disease; Cardiomyopathies

  • a spatial ecological study of selenoprotein p and Keshan Disease
    Journal of Trace Elements in Medicine and Biology, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Xiangzhi Gao, Zhe Wang, Rongxia Zhen
    Abstract:

    Abstract Few spatial ecological studies on selenoprotein P (SePP) and Keshan Disease (KD) have been reported. The main objective of this study is to investigate the relationships of SePP with KD, economic indicators and soil selenium and to visualize the evidence for KD precise prevention and control. An ecological study design was employed. The serum SePP of 2351 subjects living in rural areas, general cities and developed cities in 15 KD endemic provinces and 13 KD non-endemic provinces in China were measured. Spatial description and spatial analysis of SePP were conducted. The subjects were adults aged. The mean serum SePP level of KD endemic area residents was 14.20 mg/L, significantly lower than that in non-endemic areas, 15.30 mg/L (t = − 3.19, P = 0.0010). Serum SePP levels were low among the people in the KD endemic provinces of Shandong, Inner Mongolia, Heilongjiang, etc. The mean serum SePP level of the 2351 people was 15.04 (95% CI: 14.76 and 15.31) mg/L. The mean serum SePP levels of residents in developed cities, general cities and rural areas were 16.54 mg/L, 14.98 mg/L and 14.44 mg/L, respectively, and were significantly different (F = 17.00, P  Selenium deficiency may still exist among residents living in the KD endemic provinces. Shandong, Inner Mongolia, and Heilongjiang should be the target provinces, visualized by spatial analysis, for KD precise prevention and control.

Hong Liang - One of the best experts on this subject based on the ideXlab platform.

  • a spatial ecological study on serum selenium and Keshan Disease in heilongjiang province china
    Biological Trace Element Research, 2021
    Co-Authors: Xu Liu, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Shan Han, Yiyi Zhang, Yuanjie Zou
    Abstract:

    There are no reports on the spatial ecology of serum selenium and Keshan Disease in Heilongjiang Province in China. This study aimed to conduct a spatial assessment of Keshan Disease elimination at the level of the etiological molecular marker. An ecological study design was used. The levels of serum selenium of the 571 residents aged between 17 and 35 years and living in rural areas, townships, and cities in 63 Keshan Disease endemic counties and 46 non-endemic counties in Heilongjiang Province were measured using atomic fluorescence spectrometry. A spatial analysis of serum selenium levels was conducted. The median serum selenium level of the 571 participants was 1.00 μmol/L, and that of participants living in Keshan Disease endemic areas was 0.97 μmol/L, which was significantly lower compared to the level of those living in non-endemic areas (1.01 μmol/L, P = 0.0037). Serum selenium levels of the participants living in rural areas, townships, and cities were significantly different (P < 0.001) at 0.95 μmol/L, 1.00 μmol/L, and 1.04 μmol/L, respectively. Spatial regression analysis showed that the distribution of serum selenium levels was positively correlated with the per capita gross domestic product. The analysis of the spatial distribution of serum selenium levels provided precise visual evidence that selenium deficiency may still be present among residents of Keshan Disease endemic counties of Tangyuan, Mulan, Lingdong, Suiling, and Dongshan. Selenium levels should therefore be included in the national surveillance of Keshan Disease.

  • a spatial study on serum selenoprotein p and Keshan Disease in heilongjiang province china
    Journal of Trace Elements in Medicine and Biology, 2021
    Co-Authors: Yanan Wang, Tong Wang, Huihui Zhou, Xiao Zhang, Xu Liu, Shan Han, Yiyi Zhang, Yuanjie Zou, Hong Liang
    Abstract:

    Abstract Background Few spatial studies on serum selenoprotein P (SELENOP) and Keshan Disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD. Methods Using a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares. Results The mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product. Conclusion Selenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective.

  • A Spatial Ecology Study of Keshan Disease and Hair Selenium
    Biological Trace Element Research, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Zhe Wang, Xiangzhi Gao
    Abstract:

    Few spatial ecological studies on hair selenium (Se) and Keshan Disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann–Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal–Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan Disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

  • a spatial ecological study of selenoprotein p and Keshan Disease
    Journal of Trace Elements in Medicine and Biology, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Xiangzhi Gao, Zhe Wang, Rongxia Zhen
    Abstract:

    Abstract Few spatial ecological studies on selenoprotein P (SePP) and Keshan Disease (KD) have been reported. The main objective of this study is to investigate the relationships of SePP with KD, economic indicators and soil selenium and to visualize the evidence for KD precise prevention and control. An ecological study design was employed. The serum SePP of 2351 subjects living in rural areas, general cities and developed cities in 15 KD endemic provinces and 13 KD non-endemic provinces in China were measured. Spatial description and spatial analysis of SePP were conducted. The subjects were adults aged. The mean serum SePP level of KD endemic area residents was 14.20 mg/L, significantly lower than that in non-endemic areas, 15.30 mg/L (t = − 3.19, P = 0.0010). Serum SePP levels were low among the people in the KD endemic provinces of Shandong, Inner Mongolia, Heilongjiang, etc. The mean serum SePP level of the 2351 people was 15.04 (95% CI: 14.76 and 15.31) mg/L. The mean serum SePP levels of residents in developed cities, general cities and rural areas were 16.54 mg/L, 14.98 mg/L and 14.44 mg/L, respectively, and were significantly different (F = 17.00, P  Selenium deficiency may still exist among residents living in the KD endemic provinces. Shandong, Inner Mongolia, and Heilongjiang should be the target provinces, visualized by spatial analysis, for KD precise prevention and control.

  • spatial distribution characteristics analysis of chronic Keshan Disease in china
    Chin J Endemiol, 2018
    Co-Authors: Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Yani Duan, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Linsheng Yang
    Abstract:

    Objective To explore the spatial distribution clustering and influencing factors of chronic Keshan Disease in China, and to provide evidence for prevention and control of Keshan Disease. Methods Using non-probability sampling methods, combined with case search and key surveys, data on national detection rate of chronic Keshan Disease, on Disease influencing factors in 2013-2014 were collected; a spatial database was established, and ArcGIS 9.0 software was used to perform global Moran's I, local Moran's Ii, local Getis-Ord Gi and inverse distance weighted interpolation analysis for the detection rate of national chronic Keshan Disease. Spatial regression was used to analyze the influencing factors of chronic Keshan Disease. Results Global autocorrelation analysis showed that Moran's I= 0.03, Z= 2.72, P < 0.01, indicating that there was aggregation in the detection rate of Keshan Disease. The results of local Moran's Ii showed that there were local high-detection rate clusters in the wards of Keshan Disease, and the high-high aggregation areas were mainly concentrated in the wards of Gansu, Inner Mongolia, and Shanxi; the high-low aggregation areas were mainly located in the wards of Heilongjiang, Jilin, Shandong; the low-high aggregation area were mainly located in the wards of Heilongjiang. Getis-Ord Gi autocorrelation results showed that Keshan Disease hotspots were mainly located in the wards of Inner Mongolia, Heilongjiang, Gansu, Shandong, Shanxi and Yunnan; the results of reverse distance weighted interpolation showed that the detection rates of the counties in Gansu and Inner Mongolia were higher than that in Heilongjiang, Jilin, Liaoning, Shanxi, Shandong, Shaanxi and Yunnan, the detection rate of wards in other provinces was at a lower level. Spatial regression analysis showed that the spatial distribution of chronic Keshan Disease was negatively related to rural per capita net income and annual average temperature in the ward (Z=-2.808,-2.747, P < 0.05). Conclusions Global chronic Keshan Disease exists spatial aggregation, the local gathering area is mainly located in the wards of Gansu, Inner Mongolia. The spatial distribution of chronic Keshan Disease may be affected by the level of rural per capita net income and annual average temperature in the ward. Key words: Keshan Disease; Spatial autocorrelation; Inverse distance weighted; Spatial regression analysis

Huihui Zhou - One of the best experts on this subject based on the ideXlab platform.

  • a spatial ecological study on serum selenium and Keshan Disease in heilongjiang province china
    Biological Trace Element Research, 2021
    Co-Authors: Xu Liu, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Shan Han, Yiyi Zhang, Yuanjie Zou
    Abstract:

    There are no reports on the spatial ecology of serum selenium and Keshan Disease in Heilongjiang Province in China. This study aimed to conduct a spatial assessment of Keshan Disease elimination at the level of the etiological molecular marker. An ecological study design was used. The levels of serum selenium of the 571 residents aged between 17 and 35 years and living in rural areas, townships, and cities in 63 Keshan Disease endemic counties and 46 non-endemic counties in Heilongjiang Province were measured using atomic fluorescence spectrometry. A spatial analysis of serum selenium levels was conducted. The median serum selenium level of the 571 participants was 1.00 μmol/L, and that of participants living in Keshan Disease endemic areas was 0.97 μmol/L, which was significantly lower compared to the level of those living in non-endemic areas (1.01 μmol/L, P = 0.0037). Serum selenium levels of the participants living in rural areas, townships, and cities were significantly different (P < 0.001) at 0.95 μmol/L, 1.00 μmol/L, and 1.04 μmol/L, respectively. Spatial regression analysis showed that the distribution of serum selenium levels was positively correlated with the per capita gross domestic product. The analysis of the spatial distribution of serum selenium levels provided precise visual evidence that selenium deficiency may still be present among residents of Keshan Disease endemic counties of Tangyuan, Mulan, Lingdong, Suiling, and Dongshan. Selenium levels should therefore be included in the national surveillance of Keshan Disease.

  • a spatial study on serum selenoprotein p and Keshan Disease in heilongjiang province china
    Journal of Trace Elements in Medicine and Biology, 2021
    Co-Authors: Yanan Wang, Tong Wang, Huihui Zhou, Xiao Zhang, Xu Liu, Shan Han, Yiyi Zhang, Yuanjie Zou, Hong Liang
    Abstract:

    Abstract Background Few spatial studies on serum selenoprotein P (SELENOP) and Keshan Disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD. Methods Using a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares. Results The mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product. Conclusion Selenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective.

  • A Spatial Ecology Study of Keshan Disease and Hair Selenium
    Biological Trace Element Research, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Zhe Wang, Xiangzhi Gao
    Abstract:

    Few spatial ecological studies on hair selenium (Se) and Keshan Disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann–Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal–Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan Disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

  • a spatial ecological study of selenoprotein p and Keshan Disease
    Journal of Trace Elements in Medicine and Biology, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Xiangzhi Gao, Zhe Wang, Rongxia Zhen
    Abstract:

    Abstract Few spatial ecological studies on selenoprotein P (SePP) and Keshan Disease (KD) have been reported. The main objective of this study is to investigate the relationships of SePP with KD, economic indicators and soil selenium and to visualize the evidence for KD precise prevention and control. An ecological study design was employed. The serum SePP of 2351 subjects living in rural areas, general cities and developed cities in 15 KD endemic provinces and 13 KD non-endemic provinces in China were measured. Spatial description and spatial analysis of SePP were conducted. The subjects were adults aged. The mean serum SePP level of KD endemic area residents was 14.20 mg/L, significantly lower than that in non-endemic areas, 15.30 mg/L (t = − 3.19, P = 0.0010). Serum SePP levels were low among the people in the KD endemic provinces of Shandong, Inner Mongolia, Heilongjiang, etc. The mean serum SePP level of the 2351 people was 15.04 (95% CI: 14.76 and 15.31) mg/L. The mean serum SePP levels of residents in developed cities, general cities and rural areas were 16.54 mg/L, 14.98 mg/L and 14.44 mg/L, respectively, and were significantly different (F = 17.00, P  Selenium deficiency may still exist among residents living in the KD endemic provinces. Shandong, Inner Mongolia, and Heilongjiang should be the target provinces, visualized by spatial analysis, for KD precise prevention and control.

  • spatial distribution characteristics analysis of chronic Keshan Disease in china
    Chin J Endemiol, 2018
    Co-Authors: Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Yani Duan, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Linsheng Yang
    Abstract:

    Objective To explore the spatial distribution clustering and influencing factors of chronic Keshan Disease in China, and to provide evidence for prevention and control of Keshan Disease. Methods Using non-probability sampling methods, combined with case search and key surveys, data on national detection rate of chronic Keshan Disease, on Disease influencing factors in 2013-2014 were collected; a spatial database was established, and ArcGIS 9.0 software was used to perform global Moran's I, local Moran's Ii, local Getis-Ord Gi and inverse distance weighted interpolation analysis for the detection rate of national chronic Keshan Disease. Spatial regression was used to analyze the influencing factors of chronic Keshan Disease. Results Global autocorrelation analysis showed that Moran's I= 0.03, Z= 2.72, P < 0.01, indicating that there was aggregation in the detection rate of Keshan Disease. The results of local Moran's Ii showed that there were local high-detection rate clusters in the wards of Keshan Disease, and the high-high aggregation areas were mainly concentrated in the wards of Gansu, Inner Mongolia, and Shanxi; the high-low aggregation areas were mainly located in the wards of Heilongjiang, Jilin, Shandong; the low-high aggregation area were mainly located in the wards of Heilongjiang. Getis-Ord Gi autocorrelation results showed that Keshan Disease hotspots were mainly located in the wards of Inner Mongolia, Heilongjiang, Gansu, Shandong, Shanxi and Yunnan; the results of reverse distance weighted interpolation showed that the detection rates of the counties in Gansu and Inner Mongolia were higher than that in Heilongjiang, Jilin, Liaoning, Shanxi, Shandong, Shaanxi and Yunnan, the detection rate of wards in other provinces was at a lower level. Spatial regression analysis showed that the spatial distribution of chronic Keshan Disease was negatively related to rural per capita net income and annual average temperature in the ward (Z=-2.808,-2.747, P < 0.05). Conclusions Global chronic Keshan Disease exists spatial aggregation, the local gathering area is mainly located in the wards of Gansu, Inner Mongolia. The spatial distribution of chronic Keshan Disease may be affected by the level of rural per capita net income and annual average temperature in the ward. Key words: Keshan Disease; Spatial autocorrelation; Inverse distance weighted; Spatial regression analysis

Xiao Zhang - One of the best experts on this subject based on the ideXlab platform.

  • a spatial ecological study on serum selenium and Keshan Disease in heilongjiang province china
    Biological Trace Element Research, 2021
    Co-Authors: Xu Liu, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Shan Han, Yiyi Zhang, Yuanjie Zou
    Abstract:

    There are no reports on the spatial ecology of serum selenium and Keshan Disease in Heilongjiang Province in China. This study aimed to conduct a spatial assessment of Keshan Disease elimination at the level of the etiological molecular marker. An ecological study design was used. The levels of serum selenium of the 571 residents aged between 17 and 35 years and living in rural areas, townships, and cities in 63 Keshan Disease endemic counties and 46 non-endemic counties in Heilongjiang Province were measured using atomic fluorescence spectrometry. A spatial analysis of serum selenium levels was conducted. The median serum selenium level of the 571 participants was 1.00 μmol/L, and that of participants living in Keshan Disease endemic areas was 0.97 μmol/L, which was significantly lower compared to the level of those living in non-endemic areas (1.01 μmol/L, P = 0.0037). Serum selenium levels of the participants living in rural areas, townships, and cities were significantly different (P < 0.001) at 0.95 μmol/L, 1.00 μmol/L, and 1.04 μmol/L, respectively. Spatial regression analysis showed that the distribution of serum selenium levels was positively correlated with the per capita gross domestic product. The analysis of the spatial distribution of serum selenium levels provided precise visual evidence that selenium deficiency may still be present among residents of Keshan Disease endemic counties of Tangyuan, Mulan, Lingdong, Suiling, and Dongshan. Selenium levels should therefore be included in the national surveillance of Keshan Disease.

  • a spatial study on serum selenoprotein p and Keshan Disease in heilongjiang province china
    Journal of Trace Elements in Medicine and Biology, 2021
    Co-Authors: Yanan Wang, Tong Wang, Huihui Zhou, Xiao Zhang, Xu Liu, Shan Han, Yiyi Zhang, Yuanjie Zou, Hong Liang
    Abstract:

    Abstract Background Few spatial studies on serum selenoprotein P (SELENOP) and Keshan Disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD. Methods Using a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares. Results The mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product. Conclusion Selenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective.

  • A Spatial Ecology Study of Keshan Disease and Hair Selenium
    Biological Trace Element Research, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Zhe Wang, Xiangzhi Gao
    Abstract:

    Few spatial ecological studies on hair selenium (Se) and Keshan Disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann–Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal–Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan Disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

  • a spatial ecological study of selenoprotein p and Keshan Disease
    Journal of Trace Elements in Medicine and Biology, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Xiangzhi Gao, Zhe Wang, Rongxia Zhen
    Abstract:

    Abstract Few spatial ecological studies on selenoprotein P (SePP) and Keshan Disease (KD) have been reported. The main objective of this study is to investigate the relationships of SePP with KD, economic indicators and soil selenium and to visualize the evidence for KD precise prevention and control. An ecological study design was employed. The serum SePP of 2351 subjects living in rural areas, general cities and developed cities in 15 KD endemic provinces and 13 KD non-endemic provinces in China were measured. Spatial description and spatial analysis of SePP were conducted. The subjects were adults aged. The mean serum SePP level of KD endemic area residents was 14.20 mg/L, significantly lower than that in non-endemic areas, 15.30 mg/L (t = − 3.19, P = 0.0010). Serum SePP levels were low among the people in the KD endemic provinces of Shandong, Inner Mongolia, Heilongjiang, etc. The mean serum SePP level of the 2351 people was 15.04 (95% CI: 14.76 and 15.31) mg/L. The mean serum SePP levels of residents in developed cities, general cities and rural areas were 16.54 mg/L, 14.98 mg/L and 14.44 mg/L, respectively, and were significantly different (F = 17.00, P  Selenium deficiency may still exist among residents living in the KD endemic provinces. Shandong, Inner Mongolia, and Heilongjiang should be the target provinces, visualized by spatial analysis, for KD precise prevention and control.

  • spatial distribution characteristics analysis of chronic Keshan Disease in china
    Chin J Endemiol, 2018
    Co-Authors: Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Yani Duan, Yanan Wang, Huihui Zhou, Hong Liang, Xiao Zhang, Linsheng Yang
    Abstract:

    Objective To explore the spatial distribution clustering and influencing factors of chronic Keshan Disease in China, and to provide evidence for prevention and control of Keshan Disease. Methods Using non-probability sampling methods, combined with case search and key surveys, data on national detection rate of chronic Keshan Disease, on Disease influencing factors in 2013-2014 were collected; a spatial database was established, and ArcGIS 9.0 software was used to perform global Moran's I, local Moran's Ii, local Getis-Ord Gi and inverse distance weighted interpolation analysis for the detection rate of national chronic Keshan Disease. Spatial regression was used to analyze the influencing factors of chronic Keshan Disease. Results Global autocorrelation analysis showed that Moran's I= 0.03, Z= 2.72, P < 0.01, indicating that there was aggregation in the detection rate of Keshan Disease. The results of local Moran's Ii showed that there were local high-detection rate clusters in the wards of Keshan Disease, and the high-high aggregation areas were mainly concentrated in the wards of Gansu, Inner Mongolia, and Shanxi; the high-low aggregation areas were mainly located in the wards of Heilongjiang, Jilin, Shandong; the low-high aggregation area were mainly located in the wards of Heilongjiang. Getis-Ord Gi autocorrelation results showed that Keshan Disease hotspots were mainly located in the wards of Inner Mongolia, Heilongjiang, Gansu, Shandong, Shanxi and Yunnan; the results of reverse distance weighted interpolation showed that the detection rates of the counties in Gansu and Inner Mongolia were higher than that in Heilongjiang, Jilin, Liaoning, Shanxi, Shandong, Shaanxi and Yunnan, the detection rate of wards in other provinces was at a lower level. Spatial regression analysis showed that the spatial distribution of chronic Keshan Disease was negatively related to rural per capita net income and annual average temperature in the ward (Z=-2.808,-2.747, P < 0.05). Conclusions Global chronic Keshan Disease exists spatial aggregation, the local gathering area is mainly located in the wards of Gansu, Inner Mongolia. The spatial distribution of chronic Keshan Disease may be affected by the level of rural per capita net income and annual average temperature in the ward. Key words: Keshan Disease; Spatial autocorrelation; Inverse distance weighted; Spatial regression analysis

Xiangzhi Gao - One of the best experts on this subject based on the ideXlab platform.

  • A Spatial Ecology Study of Keshan Disease and Hair Selenium
    Biological Trace Element Research, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Zhe Wang, Xiangzhi Gao
    Abstract:

    Few spatial ecological studies on hair selenium (Se) and Keshan Disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann–Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal–Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan Disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

  • a spatial ecological study of selenoprotein p and Keshan Disease
    Journal of Trace Elements in Medicine and Biology, 2019
    Co-Authors: Xiao Zhang, Xiaomin Han, Tong Wang, Zhongying Guo, Jie Hou, Huihui Zhou, Hong Liang, Xiangzhi Gao, Zhe Wang, Rongxia Zhen
    Abstract:

    Abstract Few spatial ecological studies on selenoprotein P (SePP) and Keshan Disease (KD) have been reported. The main objective of this study is to investigate the relationships of SePP with KD, economic indicators and soil selenium and to visualize the evidence for KD precise prevention and control. An ecological study design was employed. The serum SePP of 2351 subjects living in rural areas, general cities and developed cities in 15 KD endemic provinces and 13 KD non-endemic provinces in China were measured. Spatial description and spatial analysis of SePP were conducted. The subjects were adults aged. The mean serum SePP level of KD endemic area residents was 14.20 mg/L, significantly lower than that in non-endemic areas, 15.30 mg/L (t = − 3.19, P = 0.0010). Serum SePP levels were low among the people in the KD endemic provinces of Shandong, Inner Mongolia, Heilongjiang, etc. The mean serum SePP level of the 2351 people was 15.04 (95% CI: 14.76 and 15.31) mg/L. The mean serum SePP levels of residents in developed cities, general cities and rural areas were 16.54 mg/L, 14.98 mg/L and 14.44 mg/L, respectively, and were significantly different (F = 17.00, P  Selenium deficiency may still exist among residents living in the KD endemic provinces. Shandong, Inner Mongolia, and Heilongjiang should be the target provinces, visualized by spatial analysis, for KD precise prevention and control.

  • an approach to assessment of Keshan Disease elimination at the township level
    International Health, 2016
    Co-Authors: Tong Wang, Huihui Zhou, Hong Liu, Zidan Guo, Jing Deng, Xin Jiang, Hongyang Pang, Xiangzhi Gao, Feng Chen
    Abstract:

    Background The aim of this study was to pilot a method of a small-scale survey for the assessment of Keshan Disease (KD) elimination at township level. Methods The prevalence of chronic KD was obtained by case-searching the whole population. The endemic village with the highest prevalence of chronic KD was selected as the key village for the survey of latent KD prevalence rate among permanent residents. The selenium levels in the head hair of individuals in the key village was measured. The professionals of the department of endemic Disease control, the township and village doctors were surveyed by pre-designed questionnaire survey for KD interventions. Results We conducted this study in 2013. Yuanbao township had a population of 16 487 people and 14 862 permanent residents. There were no acute or subacute KD cases in the previous 5 years. The prevalence rate of chronic KD and natural chronic KD were 6.7/10 000 and 3.4/10 000 respectively. The prevalence rate of latent KD was 250.6/10 000, higher than the elimination criterion. The head hair selenium levels were 0.23±0.18 mg/kg. Conclusions The small-scale survey methodology for assessing KD elimination at township level was feasible. KD among the people living in Yuanbao township has not been eliminated.

  • a randomized trial of the effects of increased antioxidant capacity through selenium supplement on the prognosis of chronic Keshan Disease
    Chin J Endemiol, 2016
    Co-Authors: Xiangzhi Gao, Tong Wang, Jie Hou, Zengchao Liu, Na Liang, Hong Liu, Yabin Liu, Jing Deng, Tian Lan, Muzi Liu
    Abstract:

    Objective To evaluate the effects of increased antioxidant capacity through selenium supplement on the prognosis of chronic Keshan Disease (CKD). Methods In a randomized controlled double-blind trial, 139 CKD subjects were divided into the experimental group of 71 subjects who took capsules containing selenium by random number table per day, and the control group of 68 subjects who took 2 yeast capsules without selenium. The effects of intervention were evaluated after 9 months. Blood selenium and serum glutathione peroxidase (GSH-Px) activity, total superoxide dismutase (TSOD), total antioxidant capacity (TAOC) and malondialdehyde (MDA) were measured. Blood selenium level of the two groups and antioxidant lipid oxidation level indicators were examined, and survival analysis was done using the Kaplan-Meier method, the difference between the rate curve generating was analyzed using Log-rank test. Results After 9 months, blood selenium [(141.2 ± 71.0) μg/L], serum GSH-Px activity [(109.7 ± 22.0) U/ml], TSOD [(76.6 ± 31.8) U/ml] of the subjects of the experimental group were statistically significantly higher than those of the control group [(67.9 ± 29.4) μg/L, (93.8 ± 12.9), (62.7 ± 20.9) U/ml, t=-6.93, -4.53, -2.66, all P 0.05]. Kaplan-Meier analysis of survival showed no statistical significant difference between the two groups (χ2= 0.18, P > 0.05) though the survival rates of the two groups showed downward trend. When the subjects had selenium supplementation for 140 days, the survival rate of the experimental group was much higher than that of the control group although the survival rates of the two groups were still not statistically significantly different. Conclusion Supplementation of 200 μg selenium per day for 9 months has significantly increased the antioxidant capacity of the CKD subjects with routine treatment even though it has not extend the survival time of the subjects significantly in statistics. Key words: Selenium; Chronic Keshan Disease; Prognosis; Randomized controlled double-blind trial; Antioxidant capacity

  • the relationship between cardiac single photon emission computed tomography imaging scores of latent Keshan Disease and the parameters of cardiac biomarkers and echocardiography
    Chin J Endemiol, 2016
    Co-Authors: Xiangzhi Gao, Tong Wang, Hong Liu, Hongyang Pang, Gang Jin, Yuting Liu, Bailu Liu
    Abstract:

    Objective To explore the relationship between cardiac single -photon emission computed tomography (SPECT) imaging scores of latent Keshan Disease (LKD) and the parameters of cardiac biomarkers and echocardiography. Methods Ten patients with latent Keshan Disease were examined with 99mTc-MIBI SPECT and echocardiography, left ventricle images were scored with 20 -segment model. The superoxide dismutase (SOD), malondialdehyde (MDA), and cardiac troponin I (cTnI) were measured with colorimetry and ELISA. Spearman correlation between cardiac SPECT image scores and the parameters was analyzed. Results The cardiac SPECT image of the patients with latent Keshan Disease showed varied degrees of reduced intakes,the average of the four-category scores was (17 ± 4), ranged from 11 to 24. The average of the two-category scores was (13 ± 2), ranged from 9 to 17. Spearman correlation analysis showed that SPECT four-category scores and two-category scores were not statistically correlated with SOD, MDA and cTnI (r = -0.35, 0.25, 0.27, 0.00, 0.34 and 0.08, all P > 0.05). Spearman correlation analysis showed that SPECT four-category scores were statistically correlated with left ventricular end-diastolic volume (LVEDV) and left ventricular mass (LVM) (r = 0.71, 0.77, all P < 0.05); two-category scores were significantly correlated with left ventricular posterior wall thickness (LVPWT), left ventricular cardiac output (CO), LVEDV, left ventricular end-systolic volume (LVESV) and LVM (r = 0.81, 0.75, 0.86, 0.79 and 0.83, all P < 0.05). Conclusions The cardiac SPECT images of the patients with LKD have showed reduced uptake by myocardial. SPECT scores are in good consistency with the parameters of echocardiography although they are not correlated significantly in statistics with the parameters of cardiac biomarkers. Key words: Latent Keshan Disease; Single-photon emission computed tomography; Score; Cardiac biomarkers; Echocardiography

Related terms

Keshan Disease - 15 days free trial to Access Experts & Abstracts