The Experts below are selected from a list of 13962 Experts worldwide ranked by ideXlab platform
Lei Wang - One of the best experts on this subject based on the ideXlab platform.
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a catalyst controlled switchable reaction of β Keto Acids to silyl glyoxylates
Organic and Biomolecular Chemistry, 2018Co-Authors: Manyi Han, Lei Wang, Hong Pan, Jing LinAbstract:A catalyst-controlled switchable reaction of β-Keto Acids to silyl glyoxylates was developed under mild conditions, providing two distinct products in good yields. Compared to decarboxylative addition-Brook rearrangement, the decarboxylative addition products could be controlled by using a simple bifunctional organocatalyst thiourea derivative instead of DABCO. This new reaction model of silyl glyoxylates offered a facile and alternative route to organosilicon compounds.
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merging visible light photocatalysis and palladium catalysis for c h acylation of azo and azoxybenzenes with α Keto Acids
ChemInform, 2016Co-Authors: Zuguang Xie, Lei WangAbstract:An efficient C—H acylation of azo- and azoxybenzenes with aromatic α-Keto Acids is developed combining palladium and visible-light photoredox catalysis under blue LED irradiation.
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merging visible light photocatalysis and palladium catalysis for c h acylation of azo and azoxybenzenes with α Keto Acids
Chemistry: A European Journal, 2016Co-Authors: Zuguang Xie, Lei WangAbstract:An efficient C-H acylation of azo- and azoxybenzenes with α-Keto Acids has been developed by a combination of palladium catalysis and visible-light photoredox catalysis at room temperature under 1.5 W blue LED irradiation. This method tolerates a variety of disubstituted azo- and azoxybenzenes, as well as α-Keto Acids regardless of the nature of the substituents. A number of aryl Ketones were obtained in good yields under mild reaction conditions.
Congde Huo - One of the best experts on this subject based on the ideXlab platform.
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Visible-Light-Mediated Hydroacylation of Azobenzenes with α-Keto Acids.
Organic letters, 2020Co-Authors: Jingya Yang, Menghui Song, Hongyan Zhou, Ganggang Wang, Congde HuoAbstract:A visible-light-mediated protocol for the hydroacylation of azobenzenes with α-Keto Acids has been developed. In the absence of any catalyst or additive, decarboxylative hydroacylation proceeded smoothly under visible-light irradiation at room temperature. A wide range of azobenzenes and α-Keto Acids were well-tolerated and afforded hydroacylation products in high to excellent yields. Preliminary investigations indicated that photoactive azobenzenes absorb visible light to enable the transformation.
Jian Chen - One of the best experts on this subject based on the ideXlab platform.
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identification and application of Keto Acids transporters in yarrowia lipolytica
Scientific Reports, 2015Co-Authors: Hongwei Guo, Peiran Liu, Catherine Madzak, Jingwen Zhou, Jian ChenAbstract:Production of organic Acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic Acids involved a series of transporters, which play important roles in the accumulation of specific organic acid while lack of systematic demonstration in eukaryotic microorganisms. To circumvent accumulation of by-product, efforts have being orchestrated to carboxylate transport mechanism for potential clue in Yarrowia lipolytica WSH-Z06. Six endogenous putative transporter genes, YALI0B19470g, YALI0C15488g, YALI0C21406g, YALI0D24607g, YALI0D20108g and YALI0E32901g, were identified. Transport characteristics and substrate specificities were further investigated using a carboxylate-transport-deficient Saccharomyces cerevisiae strain. These transporters were expressed in Y. lipolytica WSH-Z06 to assess their roles in regulating extracellular Keto Acids accumulation. In a Y. lipolytica T1 line over expressing YALI0B19470g, α-Ketoglutarate accumulated to 46.7 g·L−1, whereas the concentration of pyruvate decreased to 12.3 g·L−1. Systematic identification of these Keto Acids transporters would provide clues to further improve the accumulation of specific organic Acids with higher efficiency in eukaryotic microorganisms.
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Identification and application of Keto Acids transporters in Yarrowia lipolytica
Scientific Reports, 2015Co-Authors: Hongwei Guo, Peiran Liu, Catherine Madzak, Jingwen Zhou, Jian ChenAbstract:Production of organic Acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic Acids involved a series of transporters, which play important roles in the accumulation of specific organic acid while lack of systematic demonstration in eukaryotic microorganisms. To circumvent accumulation of by-product, efforts have being orchestrated to carboxylate transport mechanism for potential clue in Yarrowia lipolytica WSH-Z06. Six endogenous putative transporter genes, YALI0B19470g, YALI0C15488g, YALI0C21406g, YALI0D24607g, YALI0D20108g and YALI0E32901g, were identified. Transport characteristics and substrate specificities were further investigated using a carboxylate-transport-deficient Saccharomyces cerevisiae strain. These transporters were expressed in Y. lipolytica WSH-Z06 to assess their roles in regulating extracellular Keto Acids accumulation. In a Y. lipolytica T1 line over expressing YALI0B19470g, α-Ketoglutarate accumulated to 46.7 g\textperiodcenteredL(-1), whereas the concentration of pyruvate decreased to 12.3 g\textperiodcenteredL(-1). Systematic identification of these Keto Acids transporters would provide clues to further improve the accumulation of specific organic Acids with higher efficiency in eukaryotic microorganisms.
Chuanjin Hou - One of the best experts on this subject based on the ideXlab platform.
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enantioselective copper catalyzed decarboxylative propargylic alkylation of propargylic esters with β Keto Acids
Advanced Synthesis & Catalysis, 2014Co-Authors: Fulin Zhu, Yahui Wang, Deyang Zhang, Song Chen, Chuanjin HouAbstract:The first copper-catalyzed intermolecular enantioselective decarboxylative propargylic alkyla- tion of propargylic esters with b-Keto Acids as surro- gates of Ketones has been successfully developed by using a ketimine P,N,N-ligand. High yields and ex- cellent enantioselectivities (up to 98% ee) have been achieved under the mild reaction conditions.
Jingya Yang - One of the best experts on this subject based on the ideXlab platform.
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Visible-Light-Mediated Hydroacylation of Azobenzenes with α-Keto Acids.
Organic letters, 2020Co-Authors: Jingya Yang, Menghui Song, Hongyan Zhou, Ganggang Wang, Congde HuoAbstract:A visible-light-mediated protocol for the hydroacylation of azobenzenes with α-Keto Acids has been developed. In the absence of any catalyst or additive, decarboxylative hydroacylation proceeded smoothly under visible-light irradiation at room temperature. A wide range of azobenzenes and α-Keto Acids were well-tolerated and afforded hydroacylation products in high to excellent yields. Preliminary investigations indicated that photoactive azobenzenes absorb visible light to enable the transformation.
