The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
Leon Fogelfeld - One of the best experts on this subject based on the ideXlab platform.
-
ethnic differences predicting Ketonuria in patients with type 2 diabetes
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P<.05). Among Hispanic/Latino patients, Ketonuria was also independently associated with low HDL-cholesterol (adjusted OR: 6.6; 95% CI: 2-20), but this relationship was not seen in African American patients. CONCLUSIONS: Ketonuria is common among newly diagnosed or untreated patients with Type 2 diabetes in a public hospital serving a predominantly minority population. Some correlates of Ketonuria differ among ethnic groups, suggesting potential ethnic differences in ketogenesis. Prospective identification and study of patients with Ketonuria may have important implications for appropriate therapy, especially if it is shown that Ketonuria is a predictor of symptomatic ketoacidosis.
-
Ethnic differences predicting Ketonuria in patients with Type 2 diabetes.
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P
Rasa Kazlauskaite - One of the best experts on this subject based on the ideXlab platform.
-
ethnic differences predicting Ketonuria in patients with type 2 diabetes
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P<.05). Among Hispanic/Latino patients, Ketonuria was also independently associated with low HDL-cholesterol (adjusted OR: 6.6; 95% CI: 2-20), but this relationship was not seen in African American patients. CONCLUSIONS: Ketonuria is common among newly diagnosed or untreated patients with Type 2 diabetes in a public hospital serving a predominantly minority population. Some correlates of Ketonuria differ among ethnic groups, suggesting potential ethnic differences in ketogenesis. Prospective identification and study of patients with Ketonuria may have important implications for appropriate therapy, especially if it is shown that Ketonuria is a predictor of symptomatic ketoacidosis.
-
Ethnic differences predicting Ketonuria in patients with Type 2 diabetes.
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P
Arthur T Evans - One of the best experts on this subject based on the ideXlab platform.
-
ethnic differences predicting Ketonuria in patients with type 2 diabetes
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P<.05). Among Hispanic/Latino patients, Ketonuria was also independently associated with low HDL-cholesterol (adjusted OR: 6.6; 95% CI: 2-20), but this relationship was not seen in African American patients. CONCLUSIONS: Ketonuria is common among newly diagnosed or untreated patients with Type 2 diabetes in a public hospital serving a predominantly minority population. Some correlates of Ketonuria differ among ethnic groups, suggesting potential ethnic differences in ketogenesis. Prospective identification and study of patients with Ketonuria may have important implications for appropriate therapy, especially if it is shown that Ketonuria is a predictor of symptomatic ketoacidosis.
-
Ethnic differences predicting Ketonuria in patients with Type 2 diabetes.
Journal of Diabetes and Its Complications, 2005Co-Authors: Rasa Kazlauskaite, Arthur T Evans, Theodore Mazzone, Leon FogelfeldAbstract:UNLABELLED: Ketonuria occurs more frequently than ketoacidosis does in patients with Type 2 diabetes and may portend serious future events. We studied the correlates of Ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis. METHODS: We performed a retrospective cross-sectional study of patients referred for diabetes education from the emergency department or the urgent care clinic of a large, public, urban hospital from 2001 until 2003. Eligible patients had newly diagnosed Type 2 diabetes or diabetes diagnosed within 15 years but without treatment for the previous 2 months. Using logistic regression analysis, we analyzed the predictors of Ketonuria and assessed whether they varied by ethnic group. RESULTS: Of 228 adult African American and Hispanic/Latino patients, 112 (49%) had Ketonuria. Independent predictors of Ketonuria were younger age (OR: 2.3), higher hemoglobin A(1c) (OR: 3.0), and a history of substance abuse (OR: 1.9) (for all: P
Ele Ferrannini - One of the best experts on this subject based on the ideXlab platform.
-
1531 p spontaneous Ketonuria is associated with reduced incidence of diabetes
Diabetes, 2019Co-Authors: Eun Seok Kang, Ele FerranniniAbstract:Objective: Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance still remains unclear. We investigated the association between spontaneous fasting Ketonuria and incident diabetes in conjunction with changes in metabolic parameters in a large population-based, observational study. Research Design and Methods: We analyzed a total of 8,703 individuals free of diabetes at baseline in the Korean Genome and Epidemiology Study, a community-based, 12-year prospective study. Subjects with (n=195) or without fasting Ketonuria were 1:4 matched by propensity score. Incident diabetes was defined as: fasting plasma glucose ≥126 mg/dL, 2-hour glucose ≥200 mg/dL on biennial 75g oral glucose tolerance test, or current antidiabetic medication. Using Cox regression models, hazard ratios for developing diabetes associated with the presence of Ketonuria at baseline were analyzed. Results: Over 12 years, of the 925 subjects in the propensity score matched cohort, 190 (20.5%) developed diabetes. The incidence rate of diabetes was significantly lower in subjects with spontaneous Ketonuria compared to those without Ketonuria (adjusted hazard ratio 0.64 [95% confidence interval=0.42-0.99]. This result was replicated in the whole cohort (HR 0.67 [95% CI: 0.46-0.98] after multivariate adjustment). During follow-up, subjects with Ketonuria at baseline maintained lower 1-hour and 2-hour glucose levels, and a higher insulinogenic index during follow-up despite comparable baseline values. Conclusions: The presence of spontaneous fasting Ketonuria was significantly associated with a reduced incidence rate of diabetes, independently of metabolic parameters. Our findings suggest spontaneous fasting Ketonuria is a stable phenotype and a novel signature in the modulation of glucose metabolism. Disclosure S.J. Cho: None. I. Lee: None. S. Lee: None. E. Kang: None. E. Ferrannini: None. Y. Lee: None. G. Kim: None. B. Cha: None.
-
spontaneous Ketonuria and risk of incident diabetes a 12 year prospective study
Diabetologia, 2019Co-Authors: Eun Seok Kang, Ele FerranniniAbstract:Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance remains unclear. We investigated the association between spontaneous fasting Ketonuria and incident diabetes in conjunction with changes in metabolic variables in a large population-based observational study. We analysed 8703 individuals free of diabetes at baseline enrolled in the Korean Genome and Epidemiology Study, a community-based 12 year prospective study. Individuals with (n = 195) or without fasting Ketonuria were matched 1:4 by propensity score. Incident diabetes was defined as fasting plasma glucose ≥7.0 mmol/l, post-load 2 h glucose ≥11.1 mmol/l on biennial OGTTs, or current use of glucose-lowering medication. Using Cox regression models, HRs for developing diabetes associated with the presence of Ketonuria at baseline were analysed. Over 12 years, of the 925 participants in the propensity score-matched cohort, 190 (20.5%) developed diabetes. The incidence rate of diabetes was significantly lower in participants with spontaneous Ketonuria compared with those without Ketonuria (HR 0.63; 95% CI 0.41, 0.97). Results were virtually identical when participants with fasting Ketonuria were compared against all participants without Ketonuria (after multivariate adjustment, HR 0.66; 95% CI 0.45, 0.96). During follow-up, participants with baseline Ketonuria maintained lower post-load 1 h and 2 h glucose levels and a higher insulinogenic index despite comparable baseline values. The presence of spontaneous fasting Ketonuria was significantly associated with a reduced risk of diabetes, independently of metabolic variables. Our findings suggest that spontaneous fasting Ketonuria may have a potential preventive role in the development of diabetes.
Toshihiro Suda - One of the best experts on this subject based on the ideXlab platform.
-
clinical characteristics of japanese youth onset type 2 diabetes with Ketonuria
Diabetes Research and Clinical Practice, 2005Co-Authors: Jun Matsui, Naoki Tamasawa, Jutaro Tanabe, Nobuhiko Kasai, Hiroshi Murakami, Kota Matsuki, Toshihiro SudaAbstract:Abstract The study analyzed the clinical background and eating habits of Japanese youth-onset type 2 diabetes. Thirty-six patients with type 2 diabetes (22 males, 14 females) with onset in less than 20-year-old were studied. All patients were negative for anti-glutamic acid decarboxylase (GAD) antibody and islet cell antibody. Cases diagnosed as having abnormalities in the mitochondrial gene, maturity onset diabetes of the young (MODY), and apparent type 1 diabetes were excluded from the study. Urinary ketone was detected positive in 11 cases among 36 patients at the onset of diabetes. We compared the clinical characteristics and food compositions between the patients with Ketonuria and those without Ketonuria. Age and urinary C-peptide secretion did not show any significant difference between both groups. In the patients with Ketonuria, male to female ratio was remarkably high (10:1) compared with the group without Ketonuria (12:13). Positive diabetic family history was predominantly higher in the group with Ketonuria (11/11) than that in the group without Ketonuria (17/25). All these were identical to previously reported characteristics of soft-drink ketosis. However, we in this study, revealed the difference of total calorie intake and dietary composition between youth-onset type 2 diabetes with and without Ketonuria. As a result dietary contents such as carbohydrate, fat and confectionery in the former group were also 1.5, 1.4–2.4 times higher, respectively, than those in the latter group.
