The Experts below are selected from a list of 183 Experts worldwide ranked by ideXlab platform
Cassiemarie Peigne - One of the best experts on this subject based on the ideXlab platform.
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Key Implication of cd277 butyrophilin 3 btn3a in cellular stress sensing by a major human γδ t cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie PeigneAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
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Key Implication of CD277/Butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie Peigne, Hannu Mönkkönen, Jukka Mönkkönen, Jianqiang Li, Jürgen Kuball, Erin J. Adams, Sonia NetzerAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
Christelle Harly - One of the best experts on this subject based on the ideXlab platform.
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Key Implication of cd277 butyrophilin 3 btn3a in cellular stress sensing by a major human γδ t cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie PeigneAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
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Key Implication of CD277/Butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie Peigne, Hannu Mönkkönen, Jukka Mönkkönen, Jianqiang Li, Jürgen Kuball, Erin J. Adams, Sonia NetzerAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
Steven Nedellec - One of the best experts on this subject based on the ideXlab platform.
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Key Implication of cd277 butyrophilin 3 btn3a in cellular stress sensing by a major human γδ t cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie PeigneAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
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Key Implication of CD277/Butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T cell subset
Blood, 2012Co-Authors: Christelle Harly, Yves Guillaume, Steven Nedellec, Cassiemarie Peigne, Hannu Mönkkönen, Jukka Mönkkönen, Jianqiang Li, Jürgen Kuball, Erin J. Adams, Sonia NetzerAbstract:Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate pathways accumulated by infected or metabolically distressed cells. The underlying mechanisms are unknown. We show that treatment of nonsusceptible target cells with antibody 20.1 against CD277, a member of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vγ9Vδ2 T-cell activation and that the Vγ9Vδ2 T-cell receptor is implicated in this effect. Vγ9Vδ2 T-cell activation can be abrogated by exposing susceptible cells (tumor and mycobacteria-infected cells, or aminobisphosphonate-treated cells with up-regulated PAg levels) to antibody 103.2 against CD277. CD277 knockdown and domain-shuffling approaches confirm the Key Implication of the CD277 isoform BTN3A1 in PAg sensing by Vγ9Vδ2 T cells. Fluorescence recovery after photobleaching (FRAP) experiments support a causal link between intracellular PAg accumulation, decreased BTN3A1 membrane mobility, and ensuing Vγ9Vδ2 T-cell activation. This study demonstrates a novel role played by B7-like molecules in human γδ T-cell antigenic activation and paves the way for new strategies to improve the efficiency of immunotherapies using Vγ9Vδ2 T cells.
Alhassan G Abdul-muhmin - One of the best experts on this subject based on the ideXlab platform.
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International Journal of Retail & Distribution Management Transaction size effects on consumers' retail payment mode choice Transaction size effects on consumers' retail payment mode choice
International Journal of Retail & Distribution Management Internet Research International Journal of Bank Marketing International Journal of Bank Mark, 2010Co-Authors: Alhassan G Abdul-muhmin, Wendy Ming-yen Teoh, Siong Choy Chong, Jiat Wei Chua, Cesar Maloles, Thomas Foscht, Bernhard Swoboda, Binshan Lin, Swee-lim ChiaAbstract:Access to this document was granted through an Emerald subscription provided by emerald-srm:426046 [] For Authors If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.com Emerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation. Abstract Purpose – The purpose of this paper is to examine how the monetary value of a retail transaction (transaction size) impacts consumers' preferences for cash, debit and credit card payment modes. Design/methodology/approach – Drawing on the analytical and empirical literature on retail payment mode choice and the related literature on differences in payment mode attributes, the author develops and tests a hypothesis that at retail point of purchase, cash, debit and credit card will be preferred payment modes for low-, medium-and high-value transactions, respectively. The hypothesis is tested in an experimental survey in which a sample of 477 respondents indicate which payment mode they would most likely use for each of ten products that vary systematically in list prices. Findings – The results offer broad support for the hypothesis. They also show that preferences for debit and credit card payment modes are similar at low transaction values (both are less preferred), whilst those for debit and cash payment are similar at large transaction values (again, both are less preferred). This suggests that electronic payment modes are collectively a substitute for cash for low transaction values, whilst credit cards are a substitute for cash and debit cards for high transaction values. Research limitations/Implications – A Key Implication of the results is that it may be possible to persuade consumers in the study context to use electronic payments for small-value transactions by invoking and making salient, convenience considerations that are purported to drive preferences for cash payment for such purchases. Originality/value – The results also offer an alternative explanation for the continuing dominance of cash transactions in modern economies, and outlines Implications for promoting consumer use of electronic payment modes at retail point of purchase.
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International Journal of Retail & Distribution Management Transaction size effects on consumers' retail payment mode choice Transaction size effects on consumers' retail payment mode choice
International Journal of Retail & Distribution Management Internet Research International Journal of Bank Marketing, 2010Co-Authors: Alhassan G Abdul‐muhmin, Alhassan G Abdul-muhminAbstract:Access to this document was granted through an Emerald subscription provided by emerald-srm:394461 [] For Authors If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.com Emerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. Abstract Purpose – The purpose of this paper is to examine how the monetary value of a retail transaction (transaction size) impacts consumers' preferences for cash, debit and credit card payment modes. Design/methodology/approach – Drawing on the analytical and empirical literature on retail payment mode choice and the related literature on differences in payment mode attributes, the author develops and tests a hypothesis that at retail point of purchase, cash, debit and credit card will be preferred payment modes for low-, medium-and high-value transactions, respectively. The hypothesis is tested in an experimental survey in which a sample of 477 respondents indicate which payment mode they would most likely use for each of ten products that vary systematically in list prices. Findings – The results offer broad support for the hypothesis. They also show that preferences for debit and credit card payment modes are similar at low transaction values (both are less preferred), whilst those for debit and cash payment are similar at large transaction values (again, both are less preferred). This suggests that electronic payment modes are collectively a substitute for cash for low transaction values, whilst credit cards are a substitute for cash and debit cards for high transaction values. Research limitations/Implications – A Key Implication of the results is that it may be possible to persuade consumers in the study context to use electronic payments for small-value transactions by invoking and making salient, convenience considerations that are purported to drive preferences for cash payment for such purchases. Originality/value – The results also offer an alternative explanation for the continuing dominance of cash transactions in modern economies, and outlines Implications for promoting consumer use of electronic payment modes at retail point of purchase.
Swee-lim Chia - One of the best experts on this subject based on the ideXlab platform.
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International Journal of Retail & Distribution Management Transaction size effects on consumers' retail payment mode choice Transaction size effects on consumers' retail payment mode choice
International Journal of Retail & Distribution Management Internet Research International Journal of Bank Marketing International Journal of Bank Mark, 2010Co-Authors: Alhassan G Abdul-muhmin, Wendy Ming-yen Teoh, Siong Choy Chong, Jiat Wei Chua, Cesar Maloles, Thomas Foscht, Bernhard Swoboda, Binshan Lin, Swee-lim ChiaAbstract:Access to this document was granted through an Emerald subscription provided by emerald-srm:426046 [] For Authors If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.com Emerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services. Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation. Abstract Purpose – The purpose of this paper is to examine how the monetary value of a retail transaction (transaction size) impacts consumers' preferences for cash, debit and credit card payment modes. Design/methodology/approach – Drawing on the analytical and empirical literature on retail payment mode choice and the related literature on differences in payment mode attributes, the author develops and tests a hypothesis that at retail point of purchase, cash, debit and credit card will be preferred payment modes for low-, medium-and high-value transactions, respectively. The hypothesis is tested in an experimental survey in which a sample of 477 respondents indicate which payment mode they would most likely use for each of ten products that vary systematically in list prices. Findings – The results offer broad support for the hypothesis. They also show that preferences for debit and credit card payment modes are similar at low transaction values (both are less preferred), whilst those for debit and cash payment are similar at large transaction values (again, both are less preferred). This suggests that electronic payment modes are collectively a substitute for cash for low transaction values, whilst credit cards are a substitute for cash and debit cards for high transaction values. Research limitations/Implications – A Key Implication of the results is that it may be possible to persuade consumers in the study context to use electronic payments for small-value transactions by invoking and making salient, convenience considerations that are purported to drive preferences for cash payment for such purchases. Originality/value – The results also offer an alternative explanation for the continuing dominance of cash transactions in modern economies, and outlines Implications for promoting consumer use of electronic payment modes at retail point of purchase.
