The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Artur Kwiatkowski - One of the best experts on this subject based on the ideXlab platform.
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Association of MYH9 rs3752462 and rs5756168 Polymorphisms With Transplanted Kidney Artery Stenosis.
Transplantation proceedings, 2016Co-Authors: Joanna Pazik, Zbigniew Lewandowski, Monika Ołdak, Dominika Oziębło, A. Perkowska Ptasińska, Anna Sadowska, E Nowacka-cieciura, Maria Nowaczyk, Jacek Malejczyk, Artur KwiatkowskiAbstract:Allelic variants of the MYH9 gene, encoding myosin nonmuscle heavy chain type IIA, have been shown to correlate with diminished glomerular filtration rates and end-stage Kidney disease in individuals of Caucasian ancestry. Myosin nonmuscle heavy chain type IIA is expressed during development as well as in injured vessels and Kidney structures. We hypothesized that MYH9 risk variants may correlate with Kidney Artery injury and dysfunctional healing, such as transplant renal Artery Stenosis (TRAS). Our study aimed at evaluating the association of MYH9 risk allelic variants (rs4821480, rs4821481, rs3752462, rs11089788, rs136211, rs5756168, rs2032487, and rs2239784) with TRAS, defined as >50% renal Artery lumen reduction. Genotyping was performed with the use of custom Taqman genotyping assays on DNA samples (n = 295) from white deceased-donor Kidney transplant recipients and genomic DNA from the corresponding donors. Statistical analysis was performed with the use of Kaplan-Meier estimates, log-rank tests, and proportional hazard Cox models. Recipients carrying TT in rs5756168 experienced diminished risk of TRAS (hazard ratio [HR], 0.31; P < .009), whereas organs carrying CC in rs3752462 were exposed to excessive TRAS risk (HR, 2.54; P < .047). In multivariate stepwise analysis TRAS was 10.9-fold increased in Kidneys originating from rs3752462 CC, whereas the risk was decreased 3.45-fold (adjusted HR, 0.29) in recipients carrying rs5756168 TT (P < .007 and P < .033, respectively). Intracranial bleeding or trauma compared with other mechanisms of donor death diminished TRAS risk by 87% and 91%, respectively (P < .030 and P < .017). Our study is the first to identify genetic predisposition to transplant renal Artery Stenosis.
D. Regent - One of the best experts on this subject based on the ideXlab platform.
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Three-Dimensional Display Techniques in the Evaluation of Urinary Pathology Excluding Native Kidney Artery Stenosis
Advances in CT III, 1994Co-Authors: A. Blum, J. Hubert, M. Deneuville, F. Delfau, E. Renoult, M. Claudon, D. RegentAbstract:Spiral computed tomography (SCT) allows high quality performance three-dimensional (3D) surface reconstruction and maximum intensity projection (MIP) images of vessels [1, 5, 7]. These techniques should also be suited for the analysis of the opacified urinary tract and of renal calcifications. Therefore, they could produce in a single examination a complete morphological evaluation of the urinary system.
Joanna Pazik - One of the best experts on this subject based on the ideXlab platform.
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Association of MYH9 rs3752462 and rs5756168 Polymorphisms With Transplanted Kidney Artery Stenosis.
Transplantation proceedings, 2016Co-Authors: Joanna Pazik, Zbigniew Lewandowski, Monika Ołdak, Dominika Oziębło, A. Perkowska Ptasińska, Anna Sadowska, E Nowacka-cieciura, Maria Nowaczyk, Jacek Malejczyk, Artur KwiatkowskiAbstract:Allelic variants of the MYH9 gene, encoding myosin nonmuscle heavy chain type IIA, have been shown to correlate with diminished glomerular filtration rates and end-stage Kidney disease in individuals of Caucasian ancestry. Myosin nonmuscle heavy chain type IIA is expressed during development as well as in injured vessels and Kidney structures. We hypothesized that MYH9 risk variants may correlate with Kidney Artery injury and dysfunctional healing, such as transplant renal Artery Stenosis (TRAS). Our study aimed at evaluating the association of MYH9 risk allelic variants (rs4821480, rs4821481, rs3752462, rs11089788, rs136211, rs5756168, rs2032487, and rs2239784) with TRAS, defined as >50% renal Artery lumen reduction. Genotyping was performed with the use of custom Taqman genotyping assays on DNA samples (n = 295) from white deceased-donor Kidney transplant recipients and genomic DNA from the corresponding donors. Statistical analysis was performed with the use of Kaplan-Meier estimates, log-rank tests, and proportional hazard Cox models. Recipients carrying TT in rs5756168 experienced diminished risk of TRAS (hazard ratio [HR], 0.31; P < .009), whereas organs carrying CC in rs3752462 were exposed to excessive TRAS risk (HR, 2.54; P < .047). In multivariate stepwise analysis TRAS was 10.9-fold increased in Kidneys originating from rs3752462 CC, whereas the risk was decreased 3.45-fold (adjusted HR, 0.29) in recipients carrying rs5756168 TT (P < .007 and P < .033, respectively). Intracranial bleeding or trauma compared with other mechanisms of donor death diminished TRAS risk by 87% and 91%, respectively (P < .030 and P < .017). Our study is the first to identify genetic predisposition to transplant renal Artery Stenosis.
A. Blum - One of the best experts on this subject based on the ideXlab platform.
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Three-Dimensional Display Techniques in the Evaluation of Urinary Pathology Excluding Native Kidney Artery Stenosis
Advances in CT III, 1994Co-Authors: A. Blum, J. Hubert, M. Deneuville, F. Delfau, E. Renoult, M. Claudon, D. RegentAbstract:Spiral computed tomography (SCT) allows high quality performance three-dimensional (3D) surface reconstruction and maximum intensity projection (MIP) images of vessels [1, 5, 7]. These techniques should also be suited for the analysis of the opacified urinary tract and of renal calcifications. Therefore, they could produce in a single examination a complete morphological evaluation of the urinary system.
Monika Ołdak - One of the best experts on this subject based on the ideXlab platform.
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Association of MYH9 rs3752462 and rs5756168 Polymorphisms With Transplanted Kidney Artery Stenosis.
Transplantation proceedings, 2016Co-Authors: Joanna Pazik, Zbigniew Lewandowski, Monika Ołdak, Dominika Oziębło, A. Perkowska Ptasińska, Anna Sadowska, E Nowacka-cieciura, Maria Nowaczyk, Jacek Malejczyk, Artur KwiatkowskiAbstract:Allelic variants of the MYH9 gene, encoding myosin nonmuscle heavy chain type IIA, have been shown to correlate with diminished glomerular filtration rates and end-stage Kidney disease in individuals of Caucasian ancestry. Myosin nonmuscle heavy chain type IIA is expressed during development as well as in injured vessels and Kidney structures. We hypothesized that MYH9 risk variants may correlate with Kidney Artery injury and dysfunctional healing, such as transplant renal Artery Stenosis (TRAS). Our study aimed at evaluating the association of MYH9 risk allelic variants (rs4821480, rs4821481, rs3752462, rs11089788, rs136211, rs5756168, rs2032487, and rs2239784) with TRAS, defined as >50% renal Artery lumen reduction. Genotyping was performed with the use of custom Taqman genotyping assays on DNA samples (n = 295) from white deceased-donor Kidney transplant recipients and genomic DNA from the corresponding donors. Statistical analysis was performed with the use of Kaplan-Meier estimates, log-rank tests, and proportional hazard Cox models. Recipients carrying TT in rs5756168 experienced diminished risk of TRAS (hazard ratio [HR], 0.31; P < .009), whereas organs carrying CC in rs3752462 were exposed to excessive TRAS risk (HR, 2.54; P < .047). In multivariate stepwise analysis TRAS was 10.9-fold increased in Kidneys originating from rs3752462 CC, whereas the risk was decreased 3.45-fold (adjusted HR, 0.29) in recipients carrying rs5756168 TT (P < .007 and P < .033, respectively). Intracranial bleeding or trauma compared with other mechanisms of donor death diminished TRAS risk by 87% and 91%, respectively (P < .030 and P < .017). Our study is the first to identify genetic predisposition to transplant renal Artery Stenosis.
