Kidney Infarction

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Pierrefrancois Plouin - One of the best experts on this subject based on the ideXlab platform.

Bruno Paris - One of the best experts on this subject based on the ideXlab platform.

Marc R. Hammerman - One of the best experts on this subject based on the ideXlab platform.

  • Enhanced renal IGF-I expression following partial Kidney Infarction.
    The American journal of physiology, 1993
    Co-Authors: Sharon A. Rogers, Steven B. Miller, Marc R. Hammerman
    Abstract:

    Renal insulin-like growth factor (IGF)-I expression is enhanced in tissue that remains following removal of Kidney mass. To characterize the expression of renal IGF-I after reduction of Kidney mass by partial unilateral Infarction, we measured levels of IGF-I extracted from noninfarcted (remnant) renal tissue that remained after one-half unilateral Kidney Infarction that was performed without (1/2NX) or with (1 1/2NX) contralateral nephrectomy. Levels of IGF-I extracted from remnant renal tissue after 1/2NX increased significantly, peaking on day 3 after renal mass reduction, and then returned toward baseline. Steady-state levels of IGF-I mRNA were also elevated on day 3, suggesting that the increase in IGF-I results from enhanced synthesis. A similar pattern of increased extracted IGF-I and elevated IGF-I mRNA occurred after 1 1/2NX. Levels of IGF-I extracted from remnant renal tissue 3 days after 1 1/2NX were not higher than levels extracted from remnant tissue 3 days after 1/2NX, and both were higher than levels of IGF-I extracted from contralateral Kidneys 3 days after unilateral nephrectomy. Therefore, levels of IGF-I did not correlate with the extent of reduction of renal mass per se. We conclude that partial renal Infarction provides a stimulus to enhance IGF-I expression. Increased renal IGF-I must be considered in the interpretation of findings originating from use of remnant Kidney models of chronic renal failure.

  • Enhanced renal IGF-I expression following partial Kidney Infarction
    American Journal of Physiology-renal Physiology, 1993
    Co-Authors: Sharon A. Rogers, Steven B. Miller, Marc R. Hammerman
    Abstract:

    Renal insulin-like growth factor (IGF)-I expression is enhanced in tissue that remains following removal of Kidney mass. To characterize the expression of renal IGF-I after reduction of Kidney mass by partial unilateral Infarction, we measured levels of IGF-I extracted from noninfarcted (remnant) renal tissue that remained after one-half unilateral Kidney Infarction that was performed without (1/2NX) or with (1 1/2NX) contralateral nephrectomy. Levels of IGF-I extracted from remnant renal tissue after 1/2NX increased significantly, peaking on day 3 after renal mass reduction, and then returned toward baseline. Steady-state levels of IGF-I mRNA were also elevated on day 3, suggesting that the increase in IGF-I results from enhanced synthesis. A similar pattern of increased extracted IGF-I and elevated IGF-I mRNA occurred after 1 1/2NX. Levels of IGF-I extracted from remnant renal tissue 3 days after 1 1/2NX were not higher than levels extracted from remnant tissue 3 days after 1/2NX, and both were higher t...

Enrique Quintero - One of the best experts on this subject based on the ideXlab platform.

  • Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure
    Digestive Diseases and Sciences, 1994
    Co-Authors: Helen E. Raybould, Victor Plourde, Tilman Zittel, Jordi Bover, Enrique Quintero
    Abstract:

    Severe gastric complications occur in uremic patients, yet few studies have addressed the effect of chronic renal failure (RF) on gastric physiology. In the present study, we investigated: (1) the effect of RF on gastric emptying of liquids and solids in awake rats, (2) the motor function in the gastric corpus, and (3) the role of nitric oxide in any alterations in gastric motor function in uremic rats. RF was induced by partial Kidney Infarction. RF had no effect on gastric emptying of liquids but significantly inhibited gastric emptying of solids by 68%. N -Nitro- l -arginine, an inhibitor of nitric oxide (NO) synthesis, had no effect on the reduced gastric emptying of solids in RF rats. RF rats showed an altered pattern of gastric motility compared to sham-operated rats. These data suggest that RF induced an inhibition of gastric emptying of solids, but not liquids. However, NO does not seem to play a role in this inhibition.

G Bobrie - One of the best experts on this subject based on the ideXlab platform.